JP2007505127A5

JP2007505127A5 -

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Publication number: JP2007505127A5
Authority: JP; Japan
Prior art keywords: tert; butyl; oxo; naphthalen; morpholin
Prior art date: 2004-09-10
Legal status : Granted

Application number

JP2006526272A

Other languages

English (en)

Japanese (ja)

Other versions

JP4895811B2 (ja

JP2007505127A (ja

Filing date

2004-09-10

Publication date

2007-10-25

2004-09-10 Application filed filed Critical

2004-09-10 Priority claimed from PCT/US2004/029372 external-priority patent/WO2005023761A2/en

2007-03-08 Publication of JP2007505127A publication Critical patent/JP2007505127A/ja

2007-10-25 Publication of JP2007505127A5 publication Critical patent/JP2007505127A5/ja

2012-03-14 Application granted granted Critical

2012-03-14 Publication of JP4895811B2 publication Critical patent/JP4895811B2/ja

2024-09-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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-1 benzoisoxazolyl Chemical group 0.000 claims 55
125000000217 alkyl group Chemical group 0.000 claims 25
150000001875 compounds Chemical class 0.000 claims 23
125000000623 heterocyclic group Chemical group 0.000 claims 9
201000010099 disease Diseases 0.000 claims 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
125000004076 pyridyl group Chemical group 0.000 claims 8
229910052760 oxygen Inorganic materials 0.000 claims 7
239000002253 acid Substances 0.000 claims 6
125000003545 alkoxy group Chemical group 0.000 claims 6
125000003118 aryl group Chemical group 0.000 claims 6
125000005842 heteroatom Chemical group 0.000 claims 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
125000004093 cyano group Chemical group *C#N 0.000 claims 5
229910052739 hydrogen Inorganic materials 0.000 claims 5
239000001257 hydrogen Substances 0.000 claims 5
125000003226 pyrazolyl group Chemical group 0.000 claims 5
208000011580 syndromic disease Diseases 0.000 claims 5
102000004127 Cytokines Human genes 0.000 claims 4
108090000695 Cytokines Proteins 0.000 claims 4
208000002193 Pain Diseases 0.000 claims 4
206010003246 arthritis Diseases 0.000 claims 4
125000003710 aryl alkyl group Chemical group 0.000 claims 4
229910052794 bromium Inorganic materials 0.000 claims 4
229910052801 chlorine Inorganic materials 0.000 claims 4
208000029078 coronary artery disease Diseases 0.000 claims 4
229910052731 fluorine Inorganic materials 0.000 claims 4
125000004415 heterocyclylalkyl group Chemical group 0.000 claims 4
125000002883 imidazolyl group Chemical group 0.000 claims 4
125000000842 isoxazolyl group Chemical group 0.000 claims 4
230000001404 mediated effect Effects 0.000 claims 4
239000008194 pharmaceutical composition Substances 0.000 claims 4
229910052717 sulfur Inorganic materials 0.000 claims 4
125000001544 thienyl group Chemical group 0.000 claims 4
125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims 3
208000030507 AIDS Diseases 0.000 claims 3
206010006895 Cachexia Diseases 0.000 claims 3
230000001154 acute effect Effects 0.000 claims 3
125000000304 alkynyl group Chemical group 0.000 claims 3
125000000753 cycloalkyl group Chemical group 0.000 claims 3
125000002541 furyl group Chemical group 0.000 claims 3
229910052740 iodine Inorganic materials 0.000 claims 3
201000006417 multiple sclerosis Diseases 0.000 claims 3
125000001624 naphthyl group Chemical group 0.000 claims 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
125000000168 pyrrolyl group Chemical group 0.000 claims 3
229920006395 saturated elastomer Polymers 0.000 claims 3
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
201000001320 Atherosclerosis Diseases 0.000 claims 2
208000009137 Behcet syndrome Diseases 0.000 claims 2
208000014644 Brain disease Diseases 0.000 claims 2
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
206010007558 Cardiac failure chronic Diseases 0.000 claims 2
208000000094 Chronic Pain Diseases 0.000 claims 2
206010009900 Colitis ulcerative Diseases 0.000 claims 2
206010010904 Convulsion Diseases 0.000 claims 2
208000011231 Crohn disease Diseases 0.000 claims 2
208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
206010059866 Drug resistance Diseases 0.000 claims 2
201000009273 Endometriosis Diseases 0.000 claims 2
208000037487 Endotoxemia Diseases 0.000 claims 2
206010018364 Glomerulonephritis Diseases 0.000 claims 2
201000005569 Gout Diseases 0.000 claims 2
206010019280 Heart failures Diseases 0.000 claims 2
208000035150 Hypercholesterolemia Diseases 0.000 claims 2
208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
206010028289 Muscle atrophy Diseases 0.000 claims 2
206010028980 Neoplasm Diseases 0.000 claims 2
206010033645 Pancreatitis Diseases 0.000 claims 2
201000004681 Psoriasis Diseases 0.000 claims 2
201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
206010063837 Reperfusion injury Diseases 0.000 claims 2
206010040070 Septic Shock Diseases 0.000 claims 2
201000002661 Spondylitis Diseases 0.000 claims 2
208000006011 Stroke Diseases 0.000 claims 2
208000007536 Thrombosis Diseases 0.000 claims 2
206010044248 Toxic shock syndrome Diseases 0.000 claims 2
231100000650 Toxic shock syndrome Toxicity 0.000 claims 2
206010048873 Traumatic arthritis Diseases 0.000 claims 2
201000006704 Ulcerative Colitis Diseases 0.000 claims 2
208000005298 acute pain Diseases 0.000 claims 2
125000003342 alkenyl group Chemical group 0.000 claims 2
125000005037 alkyl phenyl group Chemical group 0.000 claims 2
230000033115 angiogenesis Effects 0.000 claims 2
230000023555 blood coagulation Effects 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
208000033679 diabetic kidney disease Diseases 0.000 claims 2
206010013663 drug dependence Diseases 0.000 claims 2
206010015037 epilepsy Diseases 0.000 claims 2
230000020764 fibrinolysis Effects 0.000 claims 2
150000002431 hydrogen Chemical class 0.000 claims 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
208000015181 infectious disease Diseases 0.000 claims 2
230000004968 inflammatory condition Effects 0.000 claims 2
208000014674 injury Diseases 0.000 claims 2
208000002551 irritable bowel syndrome Diseases 0.000 claims 2
230000000302 ischemic effect Effects 0.000 claims 2
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
208000031225 myocardial ischemia Diseases 0.000 claims 2
229910052757 nitrogen Inorganic materials 0.000 claims 2
201000008482 osteoarthritis Diseases 0.000 claims 2
125000002971 oxazolyl group Chemical group 0.000 claims 2
125000004043 oxo group Chemical group O=* 0.000 claims 2
125000002098 pyridazinyl group Chemical group 0.000 claims 2
125000000714 pyrimidinyl group Chemical group 0.000 claims 2
201000002793 renal fibrosis Diseases 0.000 claims 2
230000010410 reperfusion Effects 0.000 claims 2
208000037803 restenosis Diseases 0.000 claims 2
206010039073 rheumatoid arthritis Diseases 0.000 claims 2
201000005404 rubella Diseases 0.000 claims 2
208000011117 substance-related disease Diseases 0.000 claims 2
201000004595 synovitis Diseases 0.000 claims 2
201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
230000008733 trauma Effects 0.000 claims 2
230000003519 ventilatory effect Effects 0.000 claims 2
FIOPRTSYUJREPD-GNVQSUKOSA-N (2z)-2-hydroxyimino-n-[3-(methanesulfonamido)-2-methoxy-5-methylphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=C(C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 FIOPRTSYUJREPD-GNVQSUKOSA-N 0.000 claims 1
XFEYYYMOFOIOMZ-MJPNWULPSA-N (2z)-n-(3,5-ditert-butyl-2-methoxyphenyl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(C(C)(C)C)C(OC)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XFEYYYMOFOIOMZ-MJPNWULPSA-N 0.000 claims 1
LOZJAKOSZXAODA-VYIQYICTSA-N (2z)-n-(3-tert-butyl-1,2-oxazol-5-yl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound O1N=C(C(C)(C)C)C=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 LOZJAKOSZXAODA-VYIQYICTSA-N 0.000 claims 1
NLIMXUNBSLMMQV-VYIQYICTSA-N (2z)-n-(5-tert-butyl-1,2-oxazol-3-yl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=N1 NLIMXUNBSLMMQV-VYIQYICTSA-N 0.000 claims 1
LBFAETFSVGRHHJ-OLFWJLLRSA-N (2z)-n-(5-tert-butyl-1,2-oxazol-3-yl)-2-methoxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/OC)/C(=O)NC=1C=C(C(C)(C)C)ON=1 LBFAETFSVGRHHJ-OLFWJLLRSA-N 0.000 claims 1
QKCDSVWYUHNEKE-RRAHZORUSA-N (2z)-n-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound S1C(C(C)(C)C)=NN=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QKCDSVWYUHNEKE-RRAHZORUSA-N 0.000 claims 1
ZUOWTCVJYIRIPR-MXNGAVTRSA-N (2z)-n-(5-tert-butyl-2,3-dimethoxyphenyl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound COC1=CC(C(C)(C)C)=CC(NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC ZUOWTCVJYIRIPR-MXNGAVTRSA-N 0.000 claims 1
VJTUADNIZJWAJY-MXNGAVTRSA-N (2z)-n-(5-tert-butyl-2-methoxy-3-methylphenyl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound COC1=C(C)C=C(C(C)(C)C)C=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 VJTUADNIZJWAJY-MXNGAVTRSA-N 0.000 claims 1
FZPWZRHCNJOTMU-OLFWJLLRSA-N (2z)-n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 FZPWZRHCNJOTMU-OLFWJLLRSA-N 0.000 claims 1
ILBSWLHSOGCVRE-COOPMVRXSA-N (2z)-n-(5-tert-butylthiophen-3-yl)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 ILBSWLHSOGCVRE-COOPMVRXSA-N 0.000 claims 1
ONMATCJBAPYTPN-GXVXDJONSA-N (2z)-n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 ONMATCJBAPYTPN-GXVXDJONSA-N 0.000 claims 1
DXRHGFRATJIZSK-MDVFONAFSA-N (2z)-n-[5-tert-butyl-3-(ethylsulfonylamino)-2-methoxyphenyl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound CCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC DXRHGFRATJIZSK-MDVFONAFSA-N 0.000 claims 1
YCPRWSPJNGTTTQ-MXNGAVTRSA-N (2z)-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=N/O)\C(C=1CCCCC=11)=CC=C1OCCN1CCOCC1 YCPRWSPJNGTTTQ-MXNGAVTRSA-N 0.000 claims 1
JEGCITZKCCZDDI-MXNGAVTRSA-N (2z)-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JEGCITZKCCZDDI-MXNGAVTRSA-N 0.000 claims 1
MWQODJRMEOMZMO-DKJXEYTPSA-N (2z)-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 MWQODJRMEOMZMO-DKJXEYTPSA-N 0.000 claims 1
MONCFYOVICFCLP-GPFIVKHLSA-N (2z)-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-methoxyimino-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]acetamide Chemical compound C=1C=C(OC=2N=C(N=CC=2)N2CCOCC2)C2=CC=CC=C2C=1C(=N/OC)/C(=O)NC1=CC(C(C)(C)C)=CC(NS(C)(=O)=O)=C1OC MONCFYOVICFCLP-GPFIVKHLSA-N 0.000 claims 1
WZOWCBIJAFRMDW-JTHRFTPNSA-N (2z)-n-[5-tert-butyl-4-methyl-2-(3-methylphenyl)pyrazol-3-yl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C=1C=CC(C)=CC=1N1N=C(C(C)(C)C)C(C)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 WZOWCBIJAFRMDW-JTHRFTPNSA-N 0.000 claims 1
METKAUILGHGXLG-JTHRFTPNSA-N (2z)-n-[5-tert-butyl-4-methyl-2-(4-methylphenyl)pyrazol-3-yl]-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(C(C)(C)C)C(C)=C1NC(=O)C(=N/O)\C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 METKAUILGHGXLG-JTHRFTPNSA-N 0.000 claims 1
125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 1
CFLNQDUMSGRFDC-UHFFFAOYSA-N 2-(2-phenylcyclopropyl)acetamide Chemical compound NC(=O)CC1CC1C1=CC=CC=C1 CFLNQDUMSGRFDC-UHFFFAOYSA-N 0.000 claims 1
OVBJDDPPXDUTSM-UHFFFAOYSA-N 2-(4-bromonaphthalen-1-yl)-n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C1=CC=C(Br)C2=CC=CC=C12 OVBJDDPPXDUTSM-UHFFFAOYSA-N 0.000 claims 1
RJEPRODGSSWEIO-RPWUZVMVSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-[(1s,2r)-2-phenylcyclopropyl]acetamide Chemical compound C1([C@H]2C[C@@H]2NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC=CC=C1 RJEPRODGSSWEIO-RPWUZVMVSA-N 0.000 claims 1
AEDKRWDICCQKIH-UHFFFAOYSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-[3-(trifluoromethyl)phenyl]acetamide Chemical compound FC(F)(F)C1=CC=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 AEDKRWDICCQKIH-UHFFFAOYSA-N 0.000 claims 1
BSSSIIUBKDUMLB-UHFFFAOYSA-N 2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxo-n-quinolin-3-ylacetamide Chemical compound C=1N=C2C=CC=CC2=CC=1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 BSSSIIUBKDUMLB-UHFFFAOYSA-N 0.000 claims 1
SAWFAYWCDKYSMF-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxoacetamide Chemical compound C1CN(C(=O)C)CCN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 SAWFAYWCDKYSMF-UHFFFAOYSA-N 0.000 claims 1
OTHGSPDUEPBQAC-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCN(C(C)=O)CC1 OTHGSPDUEPBQAC-UHFFFAOYSA-N 0.000 claims 1
SQGFXTIHAWNAEZ-UHFFFAOYSA-N 2-[4-[2-(4-acetylpiperazin-1-yl)ethyl]naphthalen-1-yl]-n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxoacetamide Chemical compound C1CN(C(=O)C)CCN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 SQGFXTIHAWNAEZ-UHFFFAOYSA-N 0.000 claims 1
125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
XBTBLTVRRSBIDI-UHFFFAOYSA-N 3-[[2-(4-bromonaphthalen-1-yl)-2-oxoacetyl]amino]-5-tert-butyl-n-cyclopropyl-2-methoxybenzamide Chemical compound COC1=C(NC(=O)C(=O)C=2C3=CC=CC=C3C(Br)=CC=2)C=C(C(C)(C)C)C=C1C(=O)NC1CC1 XBTBLTVRRSBIDI-UHFFFAOYSA-N 0.000 claims 1
UEUMWGIUABGHOM-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-phenylpyrazole-1-carboxamide Chemical compound C=1C=CC=CC=1NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UEUMWGIUABGHOM-UHFFFAOYSA-N 0.000 claims 1
ONLRXOKCFLRNGX-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propan-2-ylpyrazole-1-carboxamide Chemical compound CC(C)NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ONLRXOKCFLRNGX-UHFFFAOYSA-N 0.000 claims 1
OZAFLFDMHUWUOS-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propylpyrazole-1-carboxamide Chemical compound CCCNC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OZAFLFDMHUWUOS-UHFFFAOYSA-N 0.000 claims 1
BLATWTPTWPGVIM-UHFFFAOYSA-N 3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 BLATWTPTWPGVIM-UHFFFAOYSA-N 0.000 claims 1
XMZAQKDAWRWRTF-UHFFFAOYSA-N 3-tert-butyl-n-cyclohexyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound C1CCCCC1NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XMZAQKDAWRWRTF-UHFFFAOYSA-N 0.000 claims 1
SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 1
YWBYYTWBEXASOQ-UHFFFAOYSA-N 5-tert-butyl-2-hydroxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzamide Chemical compound NC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O YWBYYTWBEXASOQ-UHFFFAOYSA-N 0.000 claims 1
PMPFELVJEDKLCP-UHFFFAOYSA-N 5-tert-butyl-2-hydroxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]benzoic acid Chemical compound OC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O PMPFELVJEDKLCP-UHFFFAOYSA-N 0.000 claims 1
PWVNYDITVNDPFH-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-(4-methoxynaphthalen-1-yl)-2-oxoacetyl]amino]benzamide Chemical compound C12=CC=CC=C2C(OC)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=CC(C(N)=O)=C1OC PWVNYDITVNDPFH-UHFFFAOYSA-N 0.000 claims 1
NXNPXBJSTOYMNB-UHFFFAOYSA-N 5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]-n-propan-2-ylbenzamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)NC(C)C)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NXNPXBJSTOYMNB-UHFFFAOYSA-N 0.000 claims 1
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125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
208000019664 bone resorption disease Diseases 0.000 claims 1
206010006451 bronchitis Diseases 0.000 claims 1
125000004452 carbocyclyl group Chemical group 0.000 claims 1
210000004027 cell Anatomy 0.000 claims 1
210000003169 central nervous system Anatomy 0.000 claims 1
230000001684 chronic effect Effects 0.000 claims 1
230000036461 convulsion Effects 0.000 claims 1
210000004351 coronary vessel Anatomy 0.000 claims 1
125000000392 cycloalkenyl group Chemical group 0.000 claims 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims 1
206010012601 diabetes mellitus Diseases 0.000 claims 1
125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
125000004611 dihydroisoindolyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
125000005046 dihydronaphthyl group Chemical group 0.000 claims 1
QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
208000028329 epileptic seizure Diseases 0.000 claims 1
VVIMUDKYLDLAJU-UHFFFAOYSA-N ethyl 2-[5-tert-butyl-2-methoxy-n-methylsulfonyl-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]anilino]acetate Chemical compound CCOC(=O)CN(S(C)(=O)=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC VVIMUDKYLDLAJU-UHFFFAOYSA-N 0.000 claims 1
HKJXQIQJXGZVAZ-GKPLWNPISA-N ethyl n-[(e)-[2-[(5-tert-butyl-2-methylpyrazol-3-yl)amino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/NC(=O)OCC)\C(=O)NC1=CC(C(C)(C)C)=NN1C HKJXQIQJXGZVAZ-GKPLWNPISA-N 0.000 claims 1
HCZRULBBXMAYLZ-KGHBKMJJSA-N ethyl n-[(e)-[2-[5-tert-butyl-3-(cyclopropylcarbamoyl)-2-methoxyanilino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/NC(=O)OCC)\C(=O)NC(C=1OC)=CC(C(C)(C)C)=CC=1C(=O)NC1CC1 HCZRULBBXMAYLZ-KGHBKMJJSA-N 0.000 claims 1
QAXNNYZIYUNJPQ-BIXQXLNPSA-N ethyl n-[(e)-[2-[5-tert-butyl-3-(ethylcarbamoyl)-2-methoxyanilino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound CCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=N\NC(=O)OCC)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC QAXNNYZIYUNJPQ-BIXQXLNPSA-N 0.000 claims 1
MVRAUTPJEMMGDO-OZMGXUMRSA-N ethyl n-[(e)-[2-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyanilino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/NC(=O)OCC)\C(=O)NC1=CC(C(C)(C)C)=CC(NS(C)(=O)=O)=C1OC MVRAUTPJEMMGDO-OZMGXUMRSA-N 0.000 claims 1
OUNMOOQPBVSPFU-DKJXEYTPSA-N ethyl n-[(z)-[2-(5-tert-butyl-3-carbamoyl-2-methoxyanilino)-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/NC(=O)OCC)/C(=O)NC1=CC(C(C)(C)C)=CC(C(N)=O)=C1OC OUNMOOQPBVSPFU-DKJXEYTPSA-N 0.000 claims 1
HKJXQIQJXGZVAZ-ZXPTYKNPSA-N ethyl n-[(z)-[2-[(5-tert-butyl-2-methylpyrazol-3-yl)amino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound C=1C=C(OCCN2CCOCC2)C2=CC=CC=C2C=1C(=N/NC(=O)OCC)/C(=O)NC1=CC(C(C)(C)C)=NN1C HKJXQIQJXGZVAZ-ZXPTYKNPSA-N 0.000 claims 1
QAXNNYZIYUNJPQ-ZREQDNEKSA-N ethyl n-[(z)-[2-[5-tert-butyl-3-(ethylcarbamoyl)-2-methoxyanilino]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoethylidene]amino]carbamate Chemical compound CCNC(=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=N/NC(=O)OCC)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC QAXNNYZIYUNJPQ-ZREQDNEKSA-N 0.000 claims 1
201000011205 glycine encephalopathy Diseases 0.000 claims 1
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208000024908 graft versus host disease Diseases 0.000 claims 1
125000005843 halogen group Chemical group 0.000 claims 1
208000007386 hepatic encephalopathy Diseases 0.000 claims 1
125000001072 heteroaryl group Chemical group 0.000 claims 1
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125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 1
230000001939 inductive effect Effects 0.000 claims 1
125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
125000001786 isothiazolyl group Chemical group 0.000 claims 1
201000004792 malaria Diseases 0.000 claims 1
230000036210 malignancy Effects 0.000 claims 1
OBTPMQFPBYQLFP-KRUMMXJUSA-N methyl 5-tert-butyl-3-[[(2z)-2-hydroxyimino-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetyl]amino]thiophene-2-carboxylate Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=N/O)\C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C(=O)OC OBTPMQFPBYQLFP-KRUMMXJUSA-N 0.000 claims 1
150000004702 methyl esters Chemical class 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
125000002950 monocyclic group Chemical group 0.000 claims 1
210000003097 mucus Anatomy 0.000 claims 1
IJSQZZCKDHTPSD-UHFFFAOYSA-N n,3-ditert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound CC(C)(C)NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IJSQZZCKDHTPSD-UHFFFAOYSA-N 0.000 claims 1
GOTPZIQCGDCWPL-UHFFFAOYSA-N n-(1-adamantyl)-3-tert-butyl-5-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]pyrazole-1-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13NC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GOTPZIQCGDCWPL-UHFFFAOYSA-N 0.000 claims 1
RNHCBGVSDIGRRK-UHFFFAOYSA-N n-(2,3-dihydro-1h-inden-5-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C2CCCC2=CC=1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 RNHCBGVSDIGRRK-UHFFFAOYSA-N 0.000 claims 1
FOXINTKAGJUDEG-UHFFFAOYSA-N n-(2,5-dimethylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=C(C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 FOXINTKAGJUDEG-UHFFFAOYSA-N 0.000 claims 1
GMWFGTCYWDXLPB-UHFFFAOYSA-N n-(2,5-ditert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC=C(C(C)(C)C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 GMWFGTCYWDXLPB-UHFFFAOYSA-N 0.000 claims 1
YOKZLHUWWAZSFB-UHFFFAOYSA-N n-(2,5-ditert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YOKZLHUWWAZSFB-UHFFFAOYSA-N 0.000 claims 1
ZBCUSLWZRHATJO-UHFFFAOYSA-N n-(2-acetyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ZBCUSLWZRHATJO-UHFFFAOYSA-N 0.000 claims 1
YZOXCRKQGXDHRT-UHFFFAOYSA-N n-(2-benzoyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YZOXCRKQGXDHRT-UHFFFAOYSA-N 0.000 claims 1
NYGPUSMTNRKKLZ-UHFFFAOYSA-N n-(2-benzyl-5-tert-butylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NYGPUSMTNRKKLZ-UHFFFAOYSA-N 0.000 claims 1
CKLVKADHWAYJPU-UHFFFAOYSA-N n-(2-methyl-5-propan-2-ylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)C1=CC=C(C)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 CKLVKADHWAYJPU-UHFFFAOYSA-N 0.000 claims 1
SUKFMRZDXZFTPQ-UHFFFAOYSA-N n-(3,4-dimethylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C(C)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 SUKFMRZDXZFTPQ-UHFFFAOYSA-N 0.000 claims 1
BDNSDNJMAVRZIH-UHFFFAOYSA-N n-(3,5-ditert-butyl-2-hydroxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O BDNSDNJMAVRZIH-UHFFFAOYSA-N 0.000 claims 1
JDRFUOFUBPUXNG-UHFFFAOYSA-N n-(3,5-ditert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(C)(C)C)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JDRFUOFUBPUXNG-UHFFFAOYSA-N 0.000 claims 1
JNZWQDZJEZVRCK-UHFFFAOYSA-N n-(3,5-ditert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 JNZWQDZJEZVRCK-UHFFFAOYSA-N 0.000 claims 1
HGUYGDJAEGPRGM-UHFFFAOYSA-N n-(3-acetamido-5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(NC(C)=O)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HGUYGDJAEGPRGM-UHFFFAOYSA-N 0.000 claims 1
AZMVNQYKELLYRE-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 AZMVNQYKELLYRE-UHFFFAOYSA-N 0.000 claims 1
GPVLOHZKQURHEO-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 GPVLOHZKQURHEO-UHFFFAOYSA-N 0.000 claims 1
VNHDQFUAVMMOQO-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 VNHDQFUAVMMOQO-UHFFFAOYSA-N 0.000 claims 1
OSOYZOXNDHHKNK-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N(C)C)=N1 OSOYZOXNDHHKNK-UHFFFAOYSA-N 0.000 claims 1
KEEOETLICJGWPP-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(methylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CNC1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC=3C(=C(N)C=C(C=3)C(C)(C)C)OC)=CC=2)=N1 KEEOETLICJGWPP-UHFFFAOYSA-N 0.000 claims 1
DMJNCMHJMLEJSQ-UHFFFAOYSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-naphthalen-1-yl-2-oxoacetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C1=CC=CC2=CC=CC=C12 DMJNCMHJMLEJSQ-UHFFFAOYSA-N 0.000 claims 1
WPADCIKZURWWQM-NRFANRHFSA-N n-(3-amino-5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-[[2-[[(1s)-1-phenylethyl]amino]pyrimidin-4-yl]amino]naphthalen-1-yl]acetamide Chemical compound COC1=C(N)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N[C@@H](C)C=2C=CC=CC=2)=N1 WPADCIKZURWWQM-NRFANRHFSA-N 0.000 claims 1
NPERSMPHQQPDDJ-UHFFFAOYSA-O n-(3-amino-5-tert-butyl-2-pyridin-1-ium-1-ylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(C(C)(C)C)=CC(N)=C([N+]=2C=CC=CC=2)C=1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NPERSMPHQQPDDJ-UHFFFAOYSA-O 0.000 claims 1
QNKWNESTSOPQLJ-UHFFFAOYSA-N n-(3-tert-butyl-1,2-oxazol-5-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QNKWNESTSOPQLJ-UHFFFAOYSA-N 0.000 claims 1
NPNGKGSEIGDQQB-UHFFFAOYSA-N n-(3-tert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NPNGKGSEIGDQQB-UHFFFAOYSA-N 0.000 claims 1
NDCOXQWOLXUZAP-UHFFFAOYSA-N n-(4-tert-butylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C(C)(C)C)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NDCOXQWOLXUZAP-UHFFFAOYSA-N 0.000 claims 1
CPNIJWYLPBVBKB-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-(4-methoxynaphthalen-1-yl)-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OC)=CC=C1C(=O)C(=O)NC=1C=C(C(C)(C)C)ON=1 CPNIJWYLPBVBKB-UHFFFAOYSA-N 0.000 claims 1
YICSUCNKTZMZRN-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=N1 YICSUCNKTZMZRN-UHFFFAOYSA-N 0.000 claims 1
IWEVMKIIKJWIQT-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=N1 IWEVMKIIKJWIQT-UHFFFAOYSA-N 0.000 claims 1
NVGAQTKWVSNMEE-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-(3-hydroxypropoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCCO)=CC=2)=N1 NVGAQTKWVSNMEE-UHFFFAOYSA-N 0.000 claims 1
VKCVBNNIZZZTNA-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=N1 VKCVBNNIZZZTNA-UHFFFAOYSA-N 0.000 claims 1
BIUSIFGDFPPEKM-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=N1 BIUSIFGDFPPEKM-UHFFFAOYSA-N 0.000 claims 1
KYYDMLLJHLPDES-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound O1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=N1 KYYDMLLJHLPDES-UHFFFAOYSA-N 0.000 claims 1
SFCGZIMIBDUXAY-UHFFFAOYSA-N n-(5-tert-butyl-1,2-oxazol-3-yl)-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN(C)C1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC3=NOC(=C3)C(C)(C)C)=CC=2)=N1 SFCGZIMIBDUXAY-UHFFFAOYSA-N 0.000 claims 1
GWMGXSUTAKUCQO-UHFFFAOYSA-N n-(5-tert-butyl-1h-pyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GWMGXSUTAKUCQO-UHFFFAOYSA-N 0.000 claims 1
YCXWMIKLLQMSAR-UHFFFAOYSA-N n-(5-tert-butyl-2-cyclohexylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CCCCC1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YCXWMIKLLQMSAR-UHFFFAOYSA-N 0.000 claims 1
MBQPRQGGWOXWQA-UHFFFAOYSA-N n-(5-tert-butyl-2-ethoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCOC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MBQPRQGGWOXWQA-UHFFFAOYSA-N 0.000 claims 1
AIMKXNYNVHAHGE-UHFFFAOYSA-N n-(5-tert-butyl-2-hydroxy-3-methylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O AIMKXNYNVHAHGE-UHFFFAOYSA-N 0.000 claims 1
HRWXESULEXYMNG-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxy-3-methylphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(C)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HRWXESULEXYMNG-UHFFFAOYSA-N 0.000 claims 1
GHVRAPBHFZUHHM-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GHVRAPBHFZUHHM-UHFFFAOYSA-N 0.000 claims 1
FNHGFASCDFXJKF-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 FNHGFASCDFXJKF-UHFFFAOYSA-N 0.000 claims 1
RBLJRIREZZLBNG-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=C1 RBLJRIREZZLBNG-UHFFFAOYSA-N 0.000 claims 1
HPQWLHXNYHBCEA-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 HPQWLHXNYHBCEA-UHFFFAOYSA-N 0.000 claims 1
LLIBZCPHHJQNGM-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 LLIBZCPHHJQNGM-UHFFFAOYSA-N 0.000 claims 1
VGHGGKXNJJLKBG-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[6-(oxan-4-ylamino)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1NC1CCOCC1 VGHGGKXNJJLKBG-UHFFFAOYSA-N 0.000 claims 1
XIMXXKWKAWOWGF-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N(C)C)=N1 XIMXXKWKAWOWGF-UHFFFAOYSA-N 0.000 claims 1
ZJUMPNTYBZULBY-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-[4-[[2-(methylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CNC1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC=3C(=CC=C(C=3)C(C)(C)C)OC)=CC=2)=N1 ZJUMPNTYBZULBY-UHFFFAOYSA-N 0.000 claims 1
QEVCGUAHNFTMBY-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-naphthalen-1-yl-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C1=CC=CC2=CC=CC=C12 QEVCGUAHNFTMBY-UHFFFAOYSA-N 0.000 claims 1
MYMSGNONGAITCI-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-(4-pyridin-3-ylnaphthalen-1-yl)acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C1=CC=CN=C1 MYMSGNONGAITCI-UHFFFAOYSA-N 0.000 claims 1
BCCDBNZRUVAZPR-UHFFFAOYSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-(2-piperidin-1-ylpyrimidin-4-yl)oxynaphthalen-1-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCCCC2)=N1 BCCDBNZRUVAZPR-UHFFFAOYSA-N 0.000 claims 1
ZQQQDKRLZGKCNS-QFIPXVFZSA-N n-(5-tert-butyl-2-methoxyphenyl)-2-oxo-2-[4-[[2-[[(1s)-1-phenylethyl]amino]pyrimidin-4-yl]amino]naphthalen-1-yl]acetamide Chemical compound COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N[C@@H](C)C=2C=CC=CC=2)=N1 ZQQQDKRLZGKCNS-QFIPXVFZSA-N 0.000 claims 1
OJWCEYVLTUKVFG-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-(4-methoxynaphthalen-1-yl)-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OC)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C OJWCEYVLTUKVFG-UHFFFAOYSA-N 0.000 claims 1
ONQABYHFFGWLSD-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ONQABYHFFGWLSD-UHFFFAOYSA-N 0.000 claims 1
RYJYCJAEOMXCMT-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 RYJYCJAEOMXCMT-UHFFFAOYSA-N 0.000 claims 1
KQCSYRHCAKWBAC-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 KQCSYRHCAKWBAC-UHFFFAOYSA-N 0.000 claims 1
DUAYQVWFLWXVEU-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[(4-morpholin-4-ylpyrimidin-2-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=NC=CC(N2CCOCC2)=N1 DUAYQVWFLWXVEU-UHFFFAOYSA-N 0.000 claims 1
ZTWYEISFWJJJTC-UHFFFAOYSA-N n-(5-tert-butyl-2-methylpyrazol-3-yl)-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound CN1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1CN1CCOCC1 ZTWYEISFWJJJTC-UHFFFAOYSA-N 0.000 claims 1
VACQJQSMWKNDEF-UHFFFAOYSA-N n-(5-tert-butyl-2-naphthalen-1-ylpyrazol-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC2=CC=CC=C2C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 VACQJQSMWKNDEF-UHFFFAOYSA-N 0.000 claims 1
NIJLJZXZICPWHI-UHFFFAOYSA-N n-(5-tert-butyl-2-propan-2-yloxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)OC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NIJLJZXZICPWHI-UHFFFAOYSA-N 0.000 claims 1
JQUTUFUVQNZOGP-UHFFFAOYSA-N n-(5-tert-butyl-3-chloro-2-methoxyphenyl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(Cl)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JQUTUFUVQNZOGP-UHFFFAOYSA-N 0.000 claims 1
ZMGAZIPLMZBPFG-UHFFFAOYSA-N n-(5-tert-butylthiophen-3-yl)-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound S1C(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 ZMGAZIPLMZBPFG-UHFFFAOYSA-N 0.000 claims 1
BHTQSXPVZKCWAS-UHFFFAOYSA-N n-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 BHTQSXPVZKCWAS-UHFFFAOYSA-N 0.000 claims 1
LXFJUECJZPBGLM-UHFFFAOYSA-N n-[2-(4-acetylphenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C(=O)C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 LXFJUECJZPBGLM-UHFFFAOYSA-N 0.000 claims 1
GEOIGXFUOOWIQB-UHFFFAOYSA-N n-[2-(4-aminophenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(N)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GEOIGXFUOOWIQB-UHFFFAOYSA-N 0.000 claims 1
CTWPDJHKHQCSSD-UHFFFAOYSA-N n-[2-(4-bromophenyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Br)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CTWPDJHKHQCSSD-UHFFFAOYSA-N 0.000 claims 1
ZEXLFVYJIOIASK-UHFFFAOYSA-N n-[2-(4-methylphenyl)-5-propan-2-ylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(C(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ZEXLFVYJIOIASK-UHFFFAOYSA-N 0.000 claims 1
NXGIMXZBMNXYNE-UHFFFAOYSA-N n-[2-(benzenesulfonyl)-5-tert-butylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1S(=O)(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NXGIMXZBMNXYNE-UHFFFAOYSA-N 0.000 claims 1
KZWSLFRPOVRNHH-UHFFFAOYSA-N n-[2-bromo-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC=C(Br)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KZWSLFRPOVRNHH-UHFFFAOYSA-N 0.000 claims 1
HGADCMCJIWMZTQ-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC=C(Cl)C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 HGADCMCJIWMZTQ-UHFFFAOYSA-N 0.000 claims 1
IHNCYNCUEZUHRG-UHFFFAOYSA-N n-[2-hydroxy-3,5-bis(2-methylbutan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCC(C)(C)C1=CC(C(C)(C)CC)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O IHNCYNCUEZUHRG-UHFFFAOYSA-N 0.000 claims 1
HXDXBVWDXXFXEY-UHFFFAOYSA-N n-[2-methoxy-3,5-bis(2-methylbutan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCC(C)(C)C1=CC(C(C)(C)CC)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC HXDXBVWDXXFXEY-UHFFFAOYSA-N 0.000 claims 1
MIDKJWWNZVBXDK-UHFFFAOYSA-N n-[2-methoxy-5-(2-phenylpropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(C)(C)C=2C=CC=CC=2)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MIDKJWWNZVBXDK-UHFFFAOYSA-N 0.000 claims 1
NJEWXMSBYWCRAV-UHFFFAOYSA-N n-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=C(C(F)(F)F)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NJEWXMSBYWCRAV-UHFFFAOYSA-N 0.000 claims 1
IZWKJTXMNKXBJU-UHFFFAOYSA-N n-[3-(4-acetylpiperazine-1-carbonyl)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCN(CC2)C(C)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IZWKJTXMNKXBJU-UHFFFAOYSA-N 0.000 claims 1
DPJYLCHHHMUFNM-UHFFFAOYSA-N n-[3-(benzenesulfonamido)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)C=2C=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DPJYLCHHHMUFNM-UHFFFAOYSA-N 0.000 claims 1
TWFOYJQVKPNAHA-UHFFFAOYSA-N n-[3-(benzylsulfonylamino)-5-tert-butyl-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)CC=2C=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 TWFOYJQVKPNAHA-UHFFFAOYSA-N 0.000 claims 1
LXSKFXJXYUJSRL-UHFFFAOYSA-N n-[3-(methanesulfonamido)-2-methoxy-5-methylphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 LXSKFXJXYUJSRL-UHFFFAOYSA-N 0.000 claims 1
VKYYOAMSXWQPHF-UHFFFAOYSA-N n-[3-(methanesulfonamido)-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC(NS(=O)(=O)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 VKYYOAMSXWQPHF-UHFFFAOYSA-N 0.000 claims 1
XIXJYJPHMQKVFI-UHFFFAOYSA-N n-[3-[(2-amino-2-oxoethyl)-(benzenesulfonyl)amino]-5-tert-butyl-2-methoxyphenyl]-2-naphthalen-1-yl-2-oxoacetamide Chemical compound COC1=C(NC(=O)C(=O)C=2C3=CC=CC=C3C=CC=2)C=C(C(C)(C)C)C=C1N(CC(N)=O)S(=O)(=O)C1=CC=CC=C1 XIXJYJPHMQKVFI-UHFFFAOYSA-N 0.000 claims 1
AUJYDDPHQWCTCX-UHFFFAOYSA-N n-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5-tert-butyl-2-methoxyphenyl]-2-naphthalen-1-yl-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(N(CC(N)=O)S(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CC=CC2=CC=CC=C12 AUJYDDPHQWCTCX-UHFFFAOYSA-N 0.000 claims 1
NFMJYKDPDWCADA-UHFFFAOYSA-N n-[3-[(2-amino-2-oxoethyl)-propylsulfonylamino]-5-tert-butyl-2-methoxyphenyl]-2-naphthalen-1-yl-2-oxoacetamide Chemical compound CCCS(=O)(=O)N(CC(N)=O)C1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C=CC=2)=C1OC NFMJYKDPDWCADA-UHFFFAOYSA-N 0.000 claims 1
NWVBFFJKNGLBOI-UHFFFAOYSA-N n-[3-amino-5-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound FC(F)(F)C1=CC(N)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NWVBFFJKNGLBOI-UHFFFAOYSA-N 0.000 claims 1
KMXQHQZTCSEHMU-UHFFFAOYSA-N n-[4-bromo-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(Br)C(C(F)(F)F)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KMXQHQZTCSEHMU-UHFFFAOYSA-N 0.000 claims 1
SRFKLPOUEZUSRO-UHFFFAOYSA-N n-[4-chloro-3-(trifluoromethyl)phenyl]-2-(4-methoxynaphthalen-1-yl)-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OC)=CC=C1C(=O)C(=O)NC1=CC=C(Cl)C(C(F)(F)F)=C1 SRFKLPOUEZUSRO-UHFFFAOYSA-N 0.000 claims 1
LFBNKYGQNYBSCH-UHFFFAOYSA-N n-[4-chloro-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 LFBNKYGQNYBSCH-UHFFFAOYSA-N 0.000 claims 1
JBUZPAYYXQPNRC-UHFFFAOYSA-N n-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(F)(F)F)C(F)=CC=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JBUZPAYYXQPNRC-UHFFFAOYSA-N 0.000 claims 1
YPEIYUPJEOHVTR-UHFFFAOYSA-N n-[4-tert-butyl-6-(trifluoromethyl)pyrimidin-2-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)(C)C1=CC(C(F)(F)F)=NC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=N1 YPEIYUPJEOHVTR-UHFFFAOYSA-N 0.000 claims 1
QXLLQROHJOPELG-UHFFFAOYSA-N n-[5-(2-methylpentan-2-yl)-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C)C=CC=1N1N=C(C(C)(C)CCC)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QXLLQROHJOPELG-UHFFFAOYSA-N 0.000 claims 1
GHBKVEBOASMNCE-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,3-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GHBKVEBOASMNCE-UHFFFAOYSA-N 0.000 claims 1
OBYUUXIPVPQYMO-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,3-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1C OBYUUXIPVPQYMO-UHFFFAOYSA-N 0.000 claims 1
XIKHADGAOSJYHC-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,4-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XIKHADGAOSJYHC-UHFFFAOYSA-N 0.000 claims 1
MBVXHAXQHPGQMA-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,4-difluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(F)C=C(F)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 MBVXHAXQHPGQMA-UHFFFAOYSA-N 0.000 claims 1
JECNCEWOLYWOPG-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(Cl)=CC=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JECNCEWOLYWOPG-UHFFFAOYSA-N 0.000 claims 1
HFZRUOGIEIPCAC-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-difluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(F)=CC=C(F)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HFZRUOGIEIPCAC-UHFFFAOYSA-N 0.000 claims 1
WDJSELWMGSEBTI-UHFFFAOYSA-N n-[5-tert-butyl-2-(2,5-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=C(C)C(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 WDJSELWMGSEBTI-UHFFFAOYSA-N 0.000 claims 1
OOLGXTRXXACWEA-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=C(Cl)C=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OOLGXTRXXACWEA-UHFFFAOYSA-N 0.000 claims 1
HKNRETMMTGULKN-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 HKNRETMMTGULKN-UHFFFAOYSA-N 0.000 claims 1
ACLZWLPFORXEEN-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-methylpropoxy)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC(C)COC1=CC=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ACLZWLPFORXEEN-UHFFFAOYSA-N 0.000 claims 1
YVXHDLGWWKWCRW-UHFFFAOYSA-N n-[5-tert-butyl-2-(2-phenylacetyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC=CC=1CC(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 YVXHDLGWWKWCRW-UHFFFAOYSA-N 0.000 claims 1
UVYUUWPDALWLDI-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,4-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UVYUUWPDALWLDI-UHFFFAOYSA-N 0.000 claims 1
OHLWVBVKQCVLQB-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,4-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C)C(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 OHLWVBVKQCVLQB-UHFFFAOYSA-N 0.000 claims 1
CAUOYLPQRLMXQE-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,5-dichlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C(Cl)=CC(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CAUOYLPQRLMXQE-UHFFFAOYSA-N 0.000 claims 1
BALVHKZKXQVVDP-UHFFFAOYSA-N n-[5-tert-butyl-2-(3,5-dimethylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC(C)=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 BALVHKZKXQVVDP-UHFFFAOYSA-N 0.000 claims 1
FUSOJPSGILWHLE-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(F)C(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 FUSOJPSGILWHLE-UHFFFAOYSA-N 0.000 claims 1
GKLSQOGLWMKREW-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chloro-4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(Cl)C(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 GKLSQOGLWMKREW-UHFFFAOYSA-N 0.000 claims 1
CXIVVVQOPYUYMM-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorobenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CXIVVVQOPYUYMM-UHFFFAOYSA-N 0.000 claims 1
ICQDHRCTZUGWLT-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 ICQDHRCTZUGWLT-UHFFFAOYSA-N 0.000 claims 1
QIRFKOKMUUQCDG-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-chlorophenyl)sulfonylpyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(Cl)=CC=1S(=O)(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QIRFKOKMUUQCDG-UHFFFAOYSA-N 0.000 claims 1
PWDHTGNLCDFXCC-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-cyanophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(C#N)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 PWDHTGNLCDFXCC-UHFFFAOYSA-N 0.000 claims 1
BRDAZKBHNVQTRS-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-fluoro-4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(F)C(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 BRDAZKBHNVQTRS-UHFFFAOYSA-N 0.000 claims 1
QBOMNQTZLFCRKK-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(F)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 QBOMNQTZLFCRKK-UHFFFAOYSA-N 0.000 claims 1
KXIBNDFIIHQGLF-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 KXIBNDFIIHQGLF-UHFFFAOYSA-N 0.000 claims 1
WLHZOCKYDCYEKR-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=C1 WLHZOCKYDCYEKR-UHFFFAOYSA-N 0.000 claims 1
WLOQSZJAQOBRFE-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=C1 WLOQSZJAQOBRFE-UHFFFAOYSA-N 0.000 claims 1
LHVPJEKMQKNYJU-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3-yl]-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N(C)C)=CC=2)=C1 LHVPJEKMQKNYJU-UHFFFAOYSA-N 0.000 claims 1
IPWSPNZYVWESPU-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylbenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(C(=O)N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 IPWSPNZYVWESPU-UHFFFAOYSA-N 0.000 claims 1
NDJIGWBGLINRRI-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CC1=CC=CC(N2C(=CC(=N2)C(C)(C)C)NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1 NDJIGWBGLINRRI-UHFFFAOYSA-N 0.000 claims 1
VYCTWZSVKIKCET-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylphenyl)pyrazol-3-yl]-2-[4-[2-(dimethylamino)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OCCN(C)C)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=CC(C)=C1 VYCTWZSVKIKCET-UHFFFAOYSA-N 0.000 claims 1
FJHLYOLONUOETL-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-methylsulfonylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(S(C)(=O)=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 FJHLYOLONUOETL-UHFFFAOYSA-N 0.000 claims 1
USHSANZZMUSRKA-UHFFFAOYSA-N n-[5-tert-butyl-2-(3-nitrophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC([N+]([O-])=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 USHSANZZMUSRKA-UHFFFAOYSA-N 0.000 claims 1
GWUYPCRHNKUROU-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-chlorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GWUYPCRHNKUROU-UHFFFAOYSA-N 0.000 claims 1
UXGXXMXYEYSJOE-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-cyanophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C#N)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UXGXXMXYEYSJOE-UHFFFAOYSA-N 0.000 claims 1
DMZSWEMXIXYFDJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DMZSWEMXIXYFDJ-UHFFFAOYSA-N 0.000 claims 1
VZXNRXHWROWZCV-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methoxyphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(OC)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 VZXNRXHWROWZCV-UHFFFAOYSA-N 0.000 claims 1
LNYBFILPLMPHNN-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylbenzoyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1C(=O)N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 LNYBFILPLMPHNN-UHFFFAOYSA-N 0.000 claims 1
JDBNVWJZMZATCK-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[3-chloro-4-(2-morpholin-4-ylethoxy)phenyl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C=C(Cl)C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 JDBNVWJZMZATCK-UHFFFAOYSA-N 0.000 claims 1
IFRGORKZXUPBFK-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-imidazol-1-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3C=NC=C3)=CC=2)=CC(C(C)(C)C)=N1 IFRGORKZXUPBFK-UHFFFAOYSA-N 0.000 claims 1
KTWLENWFTNYHHC-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-imidazol-1-ylethyl)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(CCN3C=NC=C3)=CC=2)=CC(C(C)(C)C)=N1 KTWLENWFTNYHHC-UHFFFAOYSA-N 0.000 claims 1
MEVNIFZDIFKOCZ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 MEVNIFZDIFKOCZ-UHFFFAOYSA-N 0.000 claims 1
GTAMXPWLQGWMGL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 GTAMXPWLQGWMGL-UHFFFAOYSA-N 0.000 claims 1
KGIRDMICAOKILV-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 KGIRDMICAOKILV-UHFFFAOYSA-N 0.000 claims 1
GTSQQRRXPFYYRT-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 GTSQQRRXPFYYRT-UHFFFAOYSA-N 0.000 claims 1
XQFWBRUDDBDWAD-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(1,4-oxazepan-4-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCCC3)=CC=2)=CC(C(C)(C)C)=N1 XQFWBRUDDBDWAD-UHFFFAOYSA-N 0.000 claims 1
OXYPFEXCUCDTOE-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(2,6-dimethylmorpholin-4-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1C(C)OC(C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-UHFFFAOYSA-N 0.000 claims 1
BTCVSQNKIXZREL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(2,6-dimethylmorpholin-4-yl)ethyl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1C(C)OC(C)CN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 BTCVSQNKIXZREL-UHFFFAOYSA-N 0.000 claims 1
WBPZRDCPXMTWRJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(4-methylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CN(C)CCN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 WBPZRDCPXMTWRJ-UHFFFAOYSA-N 0.000 claims 1
UPGUODJRUQPNGU-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1CN(C)CCN1CCC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 UPGUODJRUQPNGU-UHFFFAOYSA-N 0.000 claims 1
OXYPFEXCUCDTOE-DNQXCXABSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-[(2r,6r)-2,6-dimethylmorpholin-4-yl]ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1[C@@H](C)O[C@H](C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-DNQXCXABSA-N 0.000 claims 1
OXYPFEXCUCDTOE-PSWAGMNNSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[2-[(2s,6r)-2,6-dimethylmorpholin-4-yl]ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1[C@@H](C)O[C@@H](C)CN1CCOC(C1=CC=CC=C11)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=NN1C1=CC=C(C)C=C1 OXYPFEXCUCDTOE-PSWAGMNNSA-N 0.000 claims 1
SZPGGSJYCLQLBL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(C=3C=NC(CN4CCOCC4)=CC=3)=CC=2)=CC(C(C)(C)C)=N1 SZPGGSJYCLQLBL-UHFFFAOYSA-N 0.000 claims 1
KMJJCZVUYDIXTL-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-[7-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC(Cl)=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 KMJJCZVUYDIXTL-UHFFFAOYSA-N 0.000 claims 1
FZVFQDSBFGYBDB-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-(2-pyridin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 FZVFQDSBFGYBDB-UHFFFAOYSA-N 0.000 claims 1
INTCILADWQVLGH-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-(2-thiomorpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCSCC3)=CC=2)=CC(C(C)(C)C)=N1 INTCILADWQVLGH-UHFFFAOYSA-N 0.000 claims 1
SYPFVYGKNNXQLN-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-(3-pyridin-4-ylpropoxy)naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCCC=3C=CN=CC=3)=CC=2)=CC(C(C)(C)C)=N1 SYPFVYGKNNXQLN-UHFFFAOYSA-N 0.000 claims 1
CVWQTWQGPQVJIW-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-[2-(3-oxopiperazin-1-yl)ethoxy]naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CC(=O)NCC3)=CC=2)=CC(C(C)(C)C)=N1 CVWQTWQGPQVJIW-UHFFFAOYSA-N 0.000 claims 1
MIVYVLSKXXQSAE-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-2-oxo-2-[4-[2-(3-oxopiperazin-1-yl)ethyl]naphthalen-1-yl]acetamide Chemical compound C1=CC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(CCN3CC(=O)NCC3)=CC=2)=CC(C(C)(C)C)=N1 MIVYVLSKXXQSAE-UHFFFAOYSA-N 0.000 claims 1
IMXGMEWHVAMODJ-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-methylsulfonylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 IMXGMEWHVAMODJ-UHFFFAOYSA-N 0.000 claims 1
XQSDOJBTJZBNEB-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-nitrophenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C([N+]([O-])=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XQSDOJBTJZBNEB-UHFFFAOYSA-N 0.000 claims 1
CKAIKGOCBIYBCC-UHFFFAOYSA-N n-[5-tert-butyl-2-(4-sulfamoylphenyl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(S(N)(=O)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CKAIKGOCBIYBCC-UHFFFAOYSA-N 0.000 claims 1
VFJOVTHKLWNEAT-UHFFFAOYSA-N n-[5-tert-butyl-2-(6-chloropyridazin-3-yl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(Cl)N=NC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 VFJOVTHKLWNEAT-UHFFFAOYSA-N 0.000 claims 1
HXLFTRKRDXWTQY-UHFFFAOYSA-N n-[5-tert-butyl-2-(6-methylpyridin-3-yl)pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=NC(C)=CC=C1N1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=N1 HXLFTRKRDXWTQY-UHFFFAOYSA-N 0.000 claims 1
OCJHBHZRYZIRKZ-UHFFFAOYSA-N n-[5-tert-butyl-2-(diethylamino)-3-(methanesulfonamido)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(N(CC)CC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OCJHBHZRYZIRKZ-UHFFFAOYSA-N 0.000 claims 1
PKZDBHMGJKXJRM-UHFFFAOYSA-N n-[5-tert-butyl-2-(morpholine-4-carbonyl)thiophen-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1COCCN1C(=O)C=1SC(C(C)(C)C)=CC=1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 PKZDBHMGJKXJRM-UHFFFAOYSA-N 0.000 claims 1
HFLUCDPQUAEACH-UHFFFAOYSA-N n-[5-tert-butyl-2-[3-(carbamoylamino)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(NC(N)=O)=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HFLUCDPQUAEACH-UHFFFAOYSA-N 0.000 claims 1
NIYVAPRPWZJTIL-UHFFFAOYSA-N n-[5-tert-butyl-2-[3-(trifluoromethyl)benzoyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1C(=O)N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NIYVAPRPWZJTIL-UHFFFAOYSA-N 0.000 claims 1
XOKGFSVQBOOJEN-UHFFFAOYSA-N n-[5-tert-butyl-2-[4-(carbamoylamino)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(NC(N)=O)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 XOKGFSVQBOOJEN-UHFFFAOYSA-N 0.000 claims 1
WHDPRYKCFNISOU-UHFFFAOYSA-N n-[5-tert-butyl-2-[4-(trifluoromethyl)phenyl]pyrazol-3-yl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C=1C=C(C(F)(F)F)C=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 WHDPRYKCFNISOU-UHFFFAOYSA-N 0.000 claims 1
SHDOEFWHXQMGRL-UHFFFAOYSA-N n-[5-tert-butyl-2-ethoxy-3-(methanesulfonamido)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OCC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 SHDOEFWHXQMGRL-UHFFFAOYSA-N 0.000 claims 1
ZSAWPPUKGUDLHI-UHFFFAOYSA-N n-[5-tert-butyl-2-hydroxy-3-(morpholin-4-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound OC=1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=CC=1CN1CCOCC1 ZSAWPPUKGUDLHI-UHFFFAOYSA-N 0.000 claims 1
PUDCQZDFNYFQNJ-UHFFFAOYSA-N n-[5-tert-butyl-2-hydroxy-3-(piperidin-1-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound OC=1C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=CC(C(C)(C)C)=CC=1CN1CCCCC1 PUDCQZDFNYFQNJ-UHFFFAOYSA-N 0.000 claims 1
KMJOCMLVKKSYNH-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(2,2,2-trifluoroethylsulfonylamino)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(=O)(=O)CC(F)(F)F)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 KMJOCMLVKKSYNH-UHFFFAOYSA-N 0.000 claims 1
CTDPKECAWWNOJF-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(3-oxopiperazine-1-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CC(=O)NCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 CTDPKECAWWNOJF-UHFFFAOYSA-N 0.000 claims 1
DPDSBDPSDYYSLY-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(morpholine-4-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCOCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DPDSBDPSDYYSLY-UHFFFAOYSA-N 0.000 claims 1
APPPYTFWOOONBT-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(piperidin-1-ylmethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)C(OC)=C1CN1CCCCC1 APPPYTFWOOONBT-UHFFFAOYSA-N 0.000 claims 1
DKGHIJQVPQVQIR-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(piperidine-1-carbonyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2CCCCC2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DKGHIJQVPQVQIR-UHFFFAOYSA-N 0.000 claims 1
GNJRIROASRRSBG-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propan-2-ylcarbamoylamino)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(NC(=O)NC(C)C)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 GNJRIROASRRSBG-UHFFFAOYSA-N 0.000 claims 1
CSPHNVFUBYJQBX-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-(4-methoxynaphthalen-1-yl)-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC)=CC=2)=C1OC CSPHNVFUBYJQBX-UHFFFAOYSA-N 0.000 claims 1
FNRYKRVTECSVKK-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC FNRYKRVTECSVKK-UHFFFAOYSA-N 0.000 claims 1
DIFCLHZHAFXKEB-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=C1OC DIFCLHZHAFXKEB-UHFFFAOYSA-N 0.000 claims 1
QCJNHASWXMRIFJ-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3C=C(N=CC=3)N3CCOCC3)=CC=2)=C1OC QCJNHASWXMRIFJ-UHFFFAOYSA-N 0.000 claims 1
QMCOFSTZMMGTKG-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N3CCOCC3)=CC=2)=C1OC QMCOFSTZMMGTKG-UHFFFAOYSA-N 0.000 claims 1
JDFRPEFIPMFGNW-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(propylsulfonylamino)phenyl]-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CCCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(NC=3N=C(N=CC=3)N(C)C)=CC=2)=C1OC JDFRPEFIPMFGNW-UHFFFAOYSA-N 0.000 claims 1
RMKMPDIYPIBFHJ-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-(trifluoromethyl)phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(F)(F)F)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 RMKMPDIYPIBFHJ-UHFFFAOYSA-N 0.000 claims 1
HPUDTMLIAVIJNH-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[(2-methoxyacetyl)amino]phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COCC(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC HPUDTMLIAVIJNH-UHFFFAOYSA-N 0.000 claims 1
HYVIXCYFEVZKFI-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[(2-phenylacetyl)amino]phenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)C(OC)=C1NC(=O)CC1=CC=CC=C1 HYVIXCYFEVZKFI-UHFFFAOYSA-N 0.000 claims 1
PWBSIKFKPQBYLW-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]phenyl]benzamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C=2C=CC=CC=2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 PWBSIKFKPQBYLW-UHFFFAOYSA-N 0.000 claims 1
UDZDWDQQUQUWME-UHFFFAOYSA-N n-[5-tert-butyl-2-methoxy-3-[[2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetyl]amino]phenyl]pyrrolidine-1-carboxamide Chemical compound C1=C(C(C)(C)C)C=C(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)C(OC)=C1NC(=O)N1CCCC1 UDZDWDQQUQUWME-UHFFFAOYSA-N 0.000 claims 1
DBCUAWINNGVGBA-UHFFFAOYSA-N n-[5-tert-butyl-3-(diethylaminomethyl)-2-hydroxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCN(CC)CC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1O DBCUAWINNGVGBA-UHFFFAOYSA-N 0.000 claims 1
FKOFMGUSPWXXRE-UHFFFAOYSA-N n-[5-tert-butyl-3-(diethylcarbamoylamino)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCN(CC)C(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC FKOFMGUSPWXXRE-UHFFFAOYSA-N 0.000 claims 1
NERXFJOSINPKTF-UHFFFAOYSA-N n-[5-tert-butyl-3-(dimethylcarbamoylamino)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(NC(=O)N(C)C)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 NERXFJOSINPKTF-UHFFFAOYSA-N 0.000 claims 1
FBESVIHALYOKMN-UHFFFAOYSA-N n-[5-tert-butyl-3-(ethylsulfonylamino)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound CCS(=O)(=O)NC1=CC(C(C)(C)C)=CC(NC(=O)C(=O)C=2C3=CC=CC=C3C(OCCN3CCOCC3)=CC=2)=C1OC FBESVIHALYOKMN-UHFFFAOYSA-N 0.000 claims 1
OINNPLJZUXRDGP-UHFFFAOYSA-N n-[5-tert-butyl-3-(imidazole-1-carbonyl)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(C(=O)N2C=NC=C2)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 OINNPLJZUXRDGP-UHFFFAOYSA-N 0.000 claims 1
NXZBMERBUYMBAP-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-(1-methylindol-3-yl)-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CN(C)C2=CC=CC=C12 NXZBMERBUYMBAP-UHFFFAOYSA-N 0.000 claims 1
KRTJXGCIBLINBX-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-(1h-indol-3-yl)-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CNC2=CC=CC=C12 KRTJXGCIBLINBX-UHFFFAOYSA-N 0.000 claims 1
VPGRAFNAIUQWPV-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-(4-methoxynaphthalen-1-yl)-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OC)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=CC(NS(C)(=O)=O)=C1OC VPGRAFNAIUQWPV-UHFFFAOYSA-N 0.000 claims 1
GHVJWPAPNOOVKX-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-chloroethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CC=C(OCCCl)C2=CC=CC=C12 GHVJWPAPNOOVKX-UHFFFAOYSA-N 0.000 claims 1
ZWWULFVLBGOXGV-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-imidazol-1-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1C=NC=C1 ZWWULFVLBGOXGV-UHFFFAOYSA-N 0.000 claims 1
IHCCPZUIAUOODE-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)-5,6,7,8-tetrahydronaphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C=1CCCCC=11)=CC=C1OCCN1CCOCC1 IHCCPZUIAUOODE-UHFFFAOYSA-N 0.000 claims 1
UUROSJLZNDSXRF-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 UUROSJLZNDSXRF-UHFFFAOYSA-N 0.000 claims 1
FQTSKVOXXUUFEJ-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylpyrimidin-4-yl)oxynaphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCOCC2)=N1 FQTSKVOXXUUFEJ-UHFFFAOYSA-N 0.000 claims 1
FEORRQJKXUYJEF-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(6-morpholin-4-ylpyridin-3-yl)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C1=CC=C(N2CCOCC2)N=C1 FEORRQJKXUYJEF-UHFFFAOYSA-N 0.000 claims 1
OYGDFBCGSIUKFB-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[(2-morpholin-4-ylpyridin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=C1 OYGDFBCGSIUKFB-UHFFFAOYSA-N 0.000 claims 1
BTEMDMBVMXBEKK-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[(2-morpholin-4-ylpyrimidin-4-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N2CCOCC2)=N1 BTEMDMBVMXBEKK-UHFFFAOYSA-N 0.000 claims 1
JWJZTQFCANVDEL-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[(4-morpholin-4-ylpyrimidin-2-yl)amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=NC=CC(N2CCOCC2)=N1 JWJZTQFCANVDEL-UHFFFAOYSA-N 0.000 claims 1
DHVHHWSVISPNMU-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(1,4-oxazepan-4-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCCC1 DHVHHWSVISPNMU-UHFFFAOYSA-N 0.000 claims 1
FWZXQFARQRXVNL-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(2,6-dimethylmorpholin-4-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CC(C)OC(C)C1 FWZXQFARQRXVNL-UHFFFAOYSA-N 0.000 claims 1
HESPPVVTFADQCC-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(4-methylpiperazin-1-yl)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCN(C)CC1 HESPPVVTFADQCC-UHFFFAOYSA-N 0.000 claims 1
WKPWLZYVMIAZEG-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(diethylamino)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OCCN(CC)CC)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=CC(NS(C)(=O)=O)=C1OC WKPWLZYVMIAZEG-UHFFFAOYSA-N 0.000 claims 1
CDSJYKCAKNCPKQ-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(dimethylamino)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C1=CC=C(OCCN(C)C)C2=CC=CC=C12 CDSJYKCAKNCPKQ-UHFFFAOYSA-N 0.000 claims 1
ZFOHLIXIWRTJOR-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[2-(ethylamino)ethoxy]naphthalen-1-yl]-2-oxoacetamide Chemical compound C12=CC=CC=C2C(OCCNCC)=CC=C1C(=O)C(=O)NC1=CC(C(C)(C)C)=CC(NS(C)(=O)=O)=C1OC ZFOHLIXIWRTJOR-UHFFFAOYSA-N 0.000 claims 1
WCVYSWIBQQTZOY-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[6-(oxan-4-ylamino)pyridin-3-yl]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C(C=N1)=CC=C1NC1CCOCC1 WCVYSWIBQQTZOY-UHFFFAOYSA-N 0.000 claims 1
CRNKNGKOWDYFHM-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[[2-(dimethylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1NC1=CC=NC(N(C)C)=N1 CRNKNGKOWDYFHM-UHFFFAOYSA-N 0.000 claims 1
KEHWOBPPUFTWHJ-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-[[2-(methylamino)pyrimidin-4-yl]amino]naphthalen-1-yl]-2-oxoacetamide Chemical compound CNC1=NC=CC(NC=2C3=CC=CC=C3C(C(=O)C(=O)NC=3C(=C(NS(C)(=O)=O)C=C(C=3)C(C)(C)C)OC)=CC=2)=N1 KEHWOBPPUFTWHJ-UHFFFAOYSA-N 0.000 claims 1
BNPABIXPVMDUKW-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[7-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC(Cl)=CC=C11)=CC=C1OCCN1CCOCC1 BNPABIXPVMDUKW-UHFFFAOYSA-N 0.000 claims 1
JUSDTNAHICLPMI-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[7-fluoro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC(F)=CC=C11)=CC=C1OCCN1CCOCC1 JUSDTNAHICLPMI-UHFFFAOYSA-N 0.000 claims 1
RUYTXOYLKUGQLK-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[8-chloro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=C(Cl)C=CC=C11)=CC=C1OCCN1CCOCC1 RUYTXOYLKUGQLK-UHFFFAOYSA-N 0.000 claims 1
XMJMAVNKIJGCQV-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[8-fluoro-4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=C(F)C=CC=C11)=CC=C1OCCN1CCOCC1 XMJMAVNKIJGCQV-UHFFFAOYSA-N 0.000 claims 1
HSKIXCAWWMJPCC-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-hydrazinylidene-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=NN)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 HSKIXCAWWMJPCC-UHFFFAOYSA-N 0.000 claims 1
SISDMUAQPXJRRZ-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxo-2-(4-pyridin-3-ylnaphthalen-1-yl)acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1C1=CC=CN=C1 SISDMUAQPXJRRZ-UHFFFAOYSA-N 0.000 claims 1
ARDMZIRXBHZWNW-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxo-2-[4-(2-piperazin-1-ylethoxy)naphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCNCC1 ARDMZIRXBHZWNW-UHFFFAOYSA-N 0.000 claims 1
WVLPPNXSNMDYFF-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxo-2-[4-(2-piperidin-1-ylpyrimidin-4-yl)oxynaphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OC1=CC=NC(N2CCCCC2)=N1 WVLPPNXSNMDYFF-UHFFFAOYSA-N 0.000 claims 1
WUPYBGVNJZKRSC-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-oxo-2-[4-[2-(3-oxopiperazin-1-yl)ethoxy]naphthalen-1-yl]acetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CC(=O)NCC1 WUPYBGVNJZKRSC-UHFFFAOYSA-N 0.000 claims 1
DAEDQVOPZXCWRX-UHFFFAOYSA-N n-[5-tert-butyl-3-(methanesulfonamido)-2-propan-2-yloxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound C1=C(C(C)(C)C)C=C(NS(C)(=O)=O)C(OC(C)C)=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 DAEDQVOPZXCWRX-UHFFFAOYSA-N 0.000 claims 1
JSILCPPLHTUDPQ-UHFFFAOYSA-N n-[5-tert-butyl-3-[[2-(dimethylamino)acetyl]amino]-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide Chemical compound COC1=C(NC(=O)CN(C)C)C=C(C(C)(C)C)C=C1NC(=O)C(=O)C(C1=CC=CC=C11)=CC=C1OCCN1CCOCC1 JSILCPPLHTUDPQ-UHFFFAOYSA-N 0.000 claims 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
208000021971 neovascular inflammatory vitreoretinopathy Diseases 0.000 claims 1
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125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 1
125000004193 piperazinyl group Chemical group 0.000 claims 1
229940002612 prodrug Drugs 0.000 claims 1
239000000651 prodrug Substances 0.000 claims 1
230000006785 proliferative vitreoretinopathy Effects 0.000 claims 1
125000003373 pyrazinyl group Chemical group 0.000 claims 1
125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
208000002574 reactive arthritis Diseases 0.000 claims 1
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239000012453 solvate Substances 0.000 claims 1
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230000009885 systemic effect Effects 0.000 claims 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
125000003831 tetrazolyl group Chemical group 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
125000000335 thiazolyl group Chemical group 0.000 claims 1
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230000003612 virological effect Effects 0.000 claims 1
208000029257 vision disease Diseases 0.000 claims 1
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JP2006526272A 2003-09-11 2004-09-10 サイトカイン阻害剤 Expired - Fee Related JP4895811B2 (ja)