JP4855680B2 - 圧力駆動プラグによる輸送と反応のための装置および方法 - Google Patents

圧力駆動プラグによる輸送と反応のための装置および方法 Download PDF

Info

Publication number
JP4855680B2
JP4855680B2 JP2004546666A JP2004546666A JP4855680B2 JP 4855680 B2 JP4855680 B2 JP 4855680B2 JP 2004546666 A JP2004546666 A JP 2004546666A JP 2004546666 A JP2004546666 A JP 2004546666A JP 4855680 B2 JP4855680 B2 JP 4855680B2
Authority
JP
Japan
Prior art keywords
plug
flow path
fluid
reaction
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2004546666A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006504512A (ja
JP2006504512A5 (https=
Inventor
ルステム エフ． イスマジロブ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32179583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4855680(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Chicago filed Critical University of Chicago
Publication of JP2006504512A publication Critical patent/JP2006504512A/ja
Publication of JP2006504512A5 publication Critical patent/JP2006504512A5/ja
Application granted granted Critical
Publication of JP4855680B2 publication Critical patent/JP4855680B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00736—Non-biologic macromolecules, e.g. polymeric compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00975—Ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00977—Infrared light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B01L2400/0448—Marangoni flow; Thermocapillary effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/12—Condition responsive control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micromachines (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Refuse Collection And Transfer (AREA)
  • Control Of Fluid Pressure (AREA)
JP2004546666A 2002-05-09 2003-05-09 圧力駆動プラグによる輸送と反応のための装置および方法 Expired - Lifetime JP4855680B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37992702P 2002-05-09 2002-05-09
US60/379,927 2002-05-09
US39454402P 2002-07-08 2002-07-08
US60/394,544 2002-07-08
PCT/US2003/014794 WO2004038363A2 (en) 2002-05-09 2003-05-09 Microfluidic device and method for pressure-driven plug transport and reaction

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009194875A Division JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Division JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法

Publications (3)

Publication Number Publication Date
JP2006504512A JP2006504512A (ja) 2006-02-09
JP2006504512A5 JP2006504512A5 (https=) 2010-10-07
JP4855680B2 true JP4855680B2 (ja) 2012-01-18

Family

ID=32179583

Family Applications (9)

Application Number Title Priority Date Filing Date
JP2004546666A Expired - Lifetime JP4855680B2 (ja) 2002-05-09 2003-05-09 圧力駆動プラグによる輸送と反応のための装置および方法
JP2009194875A Expired - Lifetime JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Pending JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法
JP2012151353A Expired - Lifetime JP5859393B2 (ja) 2002-05-09 2012-07-05 圧力駆動プラグによる輸送と反応のための装置および方法
JP2014172271A Expired - Lifetime JP6270278B2 (ja) 2002-05-09 2014-08-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2016245154A Pending JP2017104863A (ja) 2002-05-09 2016-12-19 圧力駆動プラグによる輸送と反応のための装置および方法
JP2017063059A Withdrawn JP2017159297A (ja) 2002-05-09 2017-03-28 圧力駆動プラグによる輸送と反応のための装置および方法
JP2019033902A Withdrawn JP2019141841A (ja) 2002-05-09 2019-02-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2021067056A Pending JP2021119004A (ja) 2002-05-09 2021-04-12 圧力駆動プラグによる輸送と反応のための装置および方法

Family Applications After (8)

Application Number Title Priority Date Filing Date
JP2009194875A Expired - Lifetime JP5519975B2 (ja) 2002-05-09 2009-08-25 圧力駆動プラグによる輸送と反応のための装置および方法
JP2011151228A Pending JP2011212679A (ja) 2002-05-09 2011-07-07 圧力駆動プラグによる輸送と反応のための装置および方法
JP2012151353A Expired - Lifetime JP5859393B2 (ja) 2002-05-09 2012-07-05 圧力駆動プラグによる輸送と反応のための装置および方法
JP2014172271A Expired - Lifetime JP6270278B2 (ja) 2002-05-09 2014-08-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2016245154A Pending JP2017104863A (ja) 2002-05-09 2016-12-19 圧力駆動プラグによる輸送と反応のための装置および方法
JP2017063059A Withdrawn JP2017159297A (ja) 2002-05-09 2017-03-28 圧力駆動プラグによる輸送と反応のための装置および方法
JP2019033902A Withdrawn JP2019141841A (ja) 2002-05-09 2019-02-27 圧力駆動プラグによる輸送と反応のための装置および方法
JP2021067056A Pending JP2021119004A (ja) 2002-05-09 2021-04-12 圧力駆動プラグによる輸送と反応のための装置および方法

Country Status (7)

Country Link
US (11) US7129091B2 (https=)
EP (8) EP2283917B1 (https=)
JP (9) JP4855680B2 (https=)
AT (1) ATE479899T1 (https=)
AU (1) AU2003290508A1 (https=)
DE (1) DE60333995D1 (https=)
WO (1) WO2004038363A2 (https=)

Families Citing this family (395)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2283917B1 (en) 2002-05-09 2021-12-15 The University of Chicago Device for pressure-driven plug transport and reaction
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
JP4346893B2 (ja) * 2002-11-01 2009-10-21 株式会社日立製作所 化学反応装置
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US20230366125A1 (en) * 2003-03-31 2023-11-16 President And Fellows Of Harvard College Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
AU2004229440B2 (en) 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
US20050031657A1 (en) * 2003-07-18 2005-02-10 Gilson Michael K. Hydrosomes; chemical vessels for laser-guided microfluidics
WO2005021151A1 (en) 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
EP1668355A4 (en) 2003-08-28 2011-11-09 Celula Inc METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK
WO2005023427A1 (en) 2003-09-05 2005-03-17 Stokes Bio Limited A microfluidic analysis system
US9597644B2 (en) * 2003-09-05 2017-03-21 Stokes Bio Limited Methods for culturing and analyzing cells
US8968659B2 (en) * 2003-09-05 2015-03-03 Stokes Bio Limited Sample dispensing
US20060057597A1 (en) * 2003-11-12 2006-03-16 California Institute Of Technology Method and system for processing nanoparticles using a self assembly mechanism to form combined species
US7329391B2 (en) * 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1711263A2 (en) * 2003-12-10 2006-10-18 Northeastern University Method for efficient transport of small liquid volumes to, from or within microfluidic devices
US7416370B2 (en) * 2005-06-15 2008-08-26 Lam Research Corporation Method and apparatus for transporting a substrate using non-Newtonian fluid
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
US7389879B2 (en) * 2004-01-21 2008-06-24 Hewlett-Packard Development Company, L.P. Sorting particles
EP2523004B1 (en) * 2004-01-26 2020-05-20 President and Fellows of Harvard College Method of determining a sample component and immunoassay
US7927797B2 (en) * 2004-01-28 2011-04-19 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
GB0410579D0 (en) * 2004-05-12 2004-06-16 Univ St Andrews Optoelectronic tweezers
US8075863B2 (en) * 2004-05-26 2011-12-13 Massachusetts Institute Of Technology Methods and devices for growth and/or assembly of nanostructures
GB0502398D0 (en) 2005-02-04 2005-03-16 Q Chip Ltd Device and method for producing spherical segmented flow
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
EP1802395B1 (en) 2004-09-09 2020-01-22 Institut Curie Microfluidic device using a collinear electric field
CN101073002B (zh) 2004-09-15 2012-08-08 英特基因有限公司 微流体装置
US7316967B2 (en) * 2004-09-24 2008-01-08 Massachusetts Institute Of Technology Flow method and reactor for manufacturing noncrystals
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006051153A2 (en) * 2004-11-09 2006-05-18 Nanolab Systems Oy Methods and devices for facile fabrication of nanoparticles and their applications
AU2006208124B2 (en) 2005-01-25 2011-09-15 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
DK1859330T3 (da) 2005-01-28 2012-10-15 Univ Duke Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
JP2008538077A (ja) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ マイクロフルイディックシステム
KR101637140B1 (ko) 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US8718437B2 (en) 2006-03-07 2014-05-06 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
FR2890578B3 (fr) 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
EP1915214A4 (en) * 2005-08-11 2017-11-08 GlaxoSmithKline LLC Flow reactor method and apparatus
WO2007024798A2 (en) 2005-08-22 2007-03-01 Applera Corporation Apparatus, system, and method using immiscible-fluid-discrete-volumes
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
US7704457B2 (en) * 2005-11-18 2010-04-27 Patton Charles J Automatic, field portable analyzer using discrete sample aliquots
JP4753367B2 (ja) * 2005-11-25 2011-08-24 日本電子株式会社 有機合成反応装置
GB2433448B (en) * 2005-12-20 2011-03-02 Q Chip Ltd Method for the control of chemical processes
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
CN101410049A (zh) * 2006-01-31 2009-04-15 芝加哥大学 用于检验凝血的方法和设备
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
US8298833B2 (en) 2006-02-07 2012-10-30 Stokes Bio Limited Liquid bridge and system
US9874674B2 (en) 2006-03-07 2018-01-23 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US8849087B2 (en) 2006-03-07 2014-09-30 Qd Vision, Inc. Compositions, optical component, system including an optical component, devices, and other products
US9951438B2 (en) 2006-03-07 2018-04-24 Samsung Electronics Co., Ltd. Compositions, optical component, system including an optical component, devices, and other products
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US9562837B2 (en) * 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (en) * 2006-05-11 2012-12-05 Raindance Technologies, Inc. Microfluidic Devices
US20070298486A1 (en) * 2006-06-16 2007-12-27 Velocys Inc. Microchannel Apparatus and Methods Of Conducting Unit Operations With Disrupted Flow
WO2008105792A2 (en) 2006-06-24 2008-09-04 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, methods for fabricating an array of devices and compositions
WO2008108798A2 (en) 2006-06-24 2008-09-12 Qd Vision, Inc. Methods for depositing nanomaterial, methods for fabricating a device, and methods for fabricating an array of devices
WO2008111947A1 (en) 2006-06-24 2008-09-18 Qd Vision, Inc. Methods and articles including nanomaterial
JP4651715B2 (ja) * 2006-07-05 2011-03-16 株式会社日立ハイテクノロジーズ 液体分析装置
JP4933352B2 (ja) * 2006-07-24 2012-05-16 株式会社 Ｊｅｏｌ Ｒｅｓｏｎａｎｃｅ Ｎｍｒ装置
EP2077912B1 (en) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
JP4943287B2 (ja) * 2006-09-29 2012-05-30 富士フイルム株式会社 液滴混合方法及び装置
FR2907030B1 (fr) * 2006-10-13 2014-06-06 Rhodia Recherches & Tech Procede et dispositif de gestion de bouchons dans un ecoulement fluidique
US7824736B2 (en) * 2006-12-15 2010-11-02 National Taiwan University Micro patch coating device and method
US20100078077A1 (en) * 2006-12-19 2010-04-01 Ismagilov Rustem F Spacers for Microfluidic Channels
JP4627302B2 (ja) * 2007-01-09 2011-02-09 株式会社神戸製鋼所 微粒子の製造方法及び装置
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
CA2716603A1 (en) * 2007-03-05 2009-09-12 Advanced Liquid Logic, Inc. Hydrogen peroxide droplet-based assays
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
GB2447412A (en) * 2007-03-13 2008-09-17 Shaw Stewart P D Versatile micro-mixing system with chemical and biological applications
EP2136786B8 (en) 2007-03-28 2012-11-14 President and Fellows of Harvard College Apparatus for forming droplets
EP2142314A4 (en) * 2007-03-30 2012-04-25 Fujifilm Corp METHOD FOR CLEANING MICROFLOW PATHS
US20090034359A1 (en) * 2007-04-04 2009-02-05 The Regents Of The University Of California Stopped flow, quenched flow and continuous flow reaction method and apparatus
US8186913B2 (en) * 2007-04-16 2012-05-29 The General Hospital Corporation Systems and methods for particle focusing in microchannels
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
KR101672553B1 (ko) 2007-06-25 2016-11-03 큐디 비젼, 인크. 조성물 및 나노물질의 침착을 포함하는 방법
WO2009008236A1 (ja) * 2007-07-10 2009-01-15 Konica Minolta Medical & Graphic, Inc. マイクロ検査チップの液体混合方法および検査装置
WO2009014707A2 (en) 2007-07-23 2009-01-29 Qd Vision, Inc. Quantum dot light enhancement substrate and lighting device including same
US9090885B2 (en) * 2007-07-26 2015-07-28 The University Of Chicago Co-incubating confined microbial communities
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
CN101842159B (zh) * 2007-08-09 2014-09-24 赛路拉公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
US8128249B2 (en) 2007-08-28 2012-03-06 Qd Vision, Inc. Apparatus for selectively backlighting a material
JP5738597B2 (ja) 2007-12-21 2015-06-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸の配列決定のためのシステムおよび方法
KR20110030415A (ko) 2008-01-22 2011-03-23 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 용도
JP5248140B2 (ja) * 2008-02-27 2013-07-31 旭サナック株式会社 混合塗料の供給装置
GB2459085A (en) * 2008-04-07 2009-10-14 Shaw Stewart P D Air-segmented micro-mixing system for chemical and biological applications
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US9207385B2 (en) 2008-05-06 2015-12-08 Qd Vision, Inc. Lighting systems and devices including same
WO2009137053A1 (en) 2008-05-06 2009-11-12 Qd Vision, Inc. Optical components, systems including an optical component, and devices
WO2009151515A1 (en) 2008-05-06 2009-12-17 Qd Vision, Inc. Solid state lighting devices including quantum confined semiconductor nanoparticles
EP2291509B1 (en) * 2008-05-16 2023-11-15 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids
WO2009149257A1 (en) * 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
JP2011525166A (ja) * 2008-06-13 2011-09-15 エメラルド バイオストラクチャーズ， インコーポレイテッド ナノ体積マイクロキャピラリー結晶化システム
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
EP4512526A3 (en) 2008-09-23 2025-06-04 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8546128B2 (en) * 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US8435387B2 (en) * 2008-11-14 2013-05-07 Massachusetts Institute Of Technology Small-scale method and apparatus for separating mixtures
EP3150724A1 (en) 2008-12-19 2017-04-05 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
US9713802B2 (en) * 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
US9056299B2 (en) * 2009-03-13 2015-06-16 President And Fellows Of Harvard College Scale-up of flow-focusing microfluidic devices
JP4706883B2 (ja) * 2009-03-17 2011-06-22 セイコーエプソン株式会社 生体試料定量方法
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
JP5766178B2 (ja) 2009-03-24 2015-08-19 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ＳｌｉｐＣｈｉｐ装置および方法
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
KR101893613B1 (ko) 2009-04-13 2018-08-30 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 앙상블 결정 부분 표본 순위화
JP5710597B2 (ja) 2009-04-28 2015-04-30 キユーデイー・ビジヨン・インコーポレーテツド 光学材料、光学部品および方法
US20100300869A1 (en) * 2009-05-29 2010-12-02 Siemens Aktiengesellschaft Micro-fluidic separating device for liquid mixtures
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
DE102009025007A1 (de) 2009-06-11 2011-01-05 Technische Universität Ilmenau Vorrichtung und Verfahren zur Überführung von Fluidproben in regelmäßige Probensequenzen, sowie Verfahren zur Manipulation letzterer
EP2443432B1 (en) * 2009-06-19 2018-09-05 The Regents of The University of Michigan Electrospray and nanospray ionization of discrete samples in droplet format
KR101097357B1 (ko) * 2009-07-09 2011-12-23 한국과학기술원 다기능 미세유체 유동 제어 장치 및 다기능 미세유체 유동 제어 방법
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
JP5744033B2 (ja) 2009-09-09 2015-07-01 キユーデイー・ビジヨン・インコーポレーテツド ナノ粒子を含む粒子、それの使用および方法
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
US8207651B2 (en) 2009-09-16 2012-06-26 Tyco Healthcare Group Lp Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US20110091560A1 (en) * 2009-10-21 2011-04-21 The Burnham Institute For Medical Research Compositions of nanoparticles and methods of making the same
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
JP4973721B2 (ja) * 2009-12-07 2012-07-11 東ソー株式会社 微小粒子構造体およびそれを用いた微小粒子の製造方法
BR112012015428A2 (pt) * 2009-12-21 2016-03-15 Colgate Palmolive Co composições de cuidado oral para uso com um dispositivo de luz oral
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US20110165037A1 (en) * 2010-01-07 2011-07-07 Ismagilov Rustem F Interfaces that eliminate non-specific adsorption, and introduce specific interactions
WO2011088247A1 (en) * 2010-01-13 2011-07-21 Nomadics, Inc. In situ-dilution method and system for measuring molecular and chemical interactions
RU2583068C2 (ru) * 2010-01-24 2016-05-10 Институт Хеми Физичней Польской Академии Наук Система и способ автоматического образования жидких смесей и работы с ними
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5691195B2 (ja) * 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP5550014B2 (ja) * 2010-04-19 2014-07-16 国立大学法人 筑波大学 マイクロポンプおよび送液制御装置
US9228785B2 (en) 2010-05-04 2016-01-05 Alexander Poltorak Fractal heat transfer device
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
GB201011019D0 (en) 2010-07-01 2010-08-18 Weston Richard Ionisation mass spectrometry
US8465707B2 (en) 2010-07-22 2013-06-18 Gencell Biosystems Ltd. Composite liquid cells
US8748191B2 (en) * 2010-08-02 2014-06-10 Ecolab Usa Inc. Stop-flow analytical systems and methods
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2606154B1 (en) 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3574990B1 (en) 2010-11-01 2022-04-06 Bio-Rad Laboratories, Inc. System for forming emulsions
EP3412778A1 (en) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
CN103534360A (zh) 2011-03-18 2014-01-22 伯乐生命医学产品有限公司 借助对信号的组合使用进行的多重数字分析
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2012134629A1 (en) 2011-04-01 2012-10-04 Qd Vision, Inc. Quantum dots, method, and devices
WO2012139038A1 (en) * 2011-04-08 2012-10-11 Stokes Bio Limited Systems and methods for continuous flow pcr systems
EP3395957B1 (en) 2011-04-25 2020-08-12 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
BR112013029729A2 (pt) * 2011-05-23 2017-01-24 Basf Se controle de emulsões, incluindo emulsões múltiplas
GB201109203D0 (en) * 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
JP5749987B2 (ja) * 2011-06-22 2015-07-15 株式会社神戸製鋼所 液体混合方法及び装置
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US8932543B2 (en) * 2011-09-21 2015-01-13 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
EP2760578B1 (en) * 2011-09-28 2020-08-26 President and Fellows of Harvard College Systems and methods for droplet production and/or fluidic manipulation
JP5908244B2 (ja) * 2011-09-29 2016-04-26 デクセリアルズ株式会社 マイクロリアクタ及び反応生成物の製造方法
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
JP5800195B2 (ja) * 2011-11-25 2015-10-28 国立研究開発法人産業技術総合研究所 結晶成長用容器、液滴調製器具および結晶取得方法
WO2013101741A1 (en) 2011-12-30 2013-07-04 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
EP2807255B1 (en) 2012-01-25 2017-08-02 Gencell Biosystems Limited Biomolecule isolation
EP2826575B1 (en) 2012-03-16 2024-08-07 M Technique Co., Ltd. Production method of solid gold-nickel alloy nanoparticles
WO2013159116A1 (en) 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
WO2013159117A1 (en) 2012-04-20 2013-10-24 SlipChip, LLC Fluidic devices and systems for sample preparation or autonomous analysis
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
US9929325B2 (en) 2012-06-05 2018-03-27 Samsung Electronics Co., Ltd. Lighting device including quantum dots
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
FR2996545B1 (fr) 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
US9990464B1 (en) 2012-10-09 2018-06-05 Pall Corporation Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method
CA2888042A1 (en) 2012-11-27 2014-06-05 Gencell Biosystems Ltd. Handling liquid samples
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014108323A1 (en) * 2013-01-10 2014-07-17 Eth Zurich Method and apparatus for depositing droplets onto a substrate
KR20200140929A (ko) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
EP2969156B1 (en) 2013-03-13 2019-04-10 Opko Diagnostics, LLC Mixing of fluids in fluidic systems
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
US10527626B2 (en) 2013-07-05 2020-01-07 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
GB201313583D0 (en) 2013-07-30 2013-09-11 Sphere Fluidics Ltd Emulsion
GB2516684A (en) 2013-07-30 2015-02-04 Sphere Fluidics Ltd Microfluidic devices and systems
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
EP3058367B1 (en) * 2013-10-16 2019-01-09 President and Fellows of Harvard College A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
CN114471756B (zh) 2013-11-18 2024-04-16 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
GB201321433D0 (en) * 2013-12-04 2014-01-15 Isis Innovation Controling fluid micro compartments
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
EP3100045A4 (en) * 2014-01-31 2017-10-25 Carnegie Mellon University Device and method for clinical data sampling and specimen banking
US10384187B2 (en) 2014-02-10 2019-08-20 Gencell Biosystems Ltd Composite liquid cell (CLC) mediated nucleic acid library preparation device, and methods for using the same
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
JP6366988B2 (ja) * 2014-04-25 2018-08-01 国立研究開発法人産業技術総合研究所 長さの揃った金又は銀ナノロッドの製造方法
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
US9757727B2 (en) * 2014-05-29 2017-09-12 Massachusetts Institute Of Technology Hydrodynamic trap array
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
KR20170023979A (ko) 2014-06-26 2017-03-06 10엑스 제노믹스, 인크. 핵산 서열 조립을 위한 프로세스 및 시스템
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
GB201414177D0 (en) 2014-08-11 2014-09-24 Sphere Fluidics Ltd Droplet Sorting
CN107873054B (zh) 2014-09-09 2022-07-12 博德研究所 用于复合单细胞核酸分析的基于微滴的方法和设备
CN104237186B (zh) * 2014-09-15 2017-01-25 华中科技大学 一种荧光成像装置及方法
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
BR112017008877A2 (pt) 2014-10-29 2018-07-03 10X Genomics Inc métodos e composições para sequenciamento de ácido nucleico-alvo
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10258986B2 (en) 2014-11-12 2019-04-16 University Of New Hampshire Viscoelastic fluid drop production
KR102587637B1 (ko) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템
JP6769969B2 (ja) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
US12290811B2 (en) 2015-01-23 2025-05-06 Unchained Labs Microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors
US20160238506A1 (en) * 2015-02-02 2016-08-18 Derek Oberreit Ice nucleii counter technology
WO2016127073A1 (en) * 2015-02-06 2016-08-11 The Regents Of The University Of Michigan Controlled coalescence of gas phase segmented droplets
WO2016130578A1 (en) 2015-02-09 2016-08-18 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
US10639631B2 (en) 2015-02-13 2020-05-05 International Business Machines Corporation Microfluidic probe head for processing a sequence of liquid volumes separated by spacers
US10391488B2 (en) * 2015-02-13 2019-08-27 International Business Machines Corporation Microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
MX2017010857A (es) 2015-02-24 2017-12-11 10X Genomics Inc Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana.
US11873483B2 (en) 2015-03-11 2024-01-16 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
EP3285928B1 (en) 2015-04-22 2020-04-08 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system
US11123740B2 (en) 2015-06-29 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
EP3112869A1 (en) * 2015-06-30 2017-01-04 IMEC vzw Sensor device
WO2017033224A1 (ja) * 2015-08-21 2017-03-02 株式会社日立製作所 光検出装置
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN108472647B (zh) 2015-10-16 2021-06-29 牛津大学科技创新有限公司 微流体布置
GB201614150D0 (en) * 2016-08-18 2016-10-05 Univ Oxford Innovation Ltd Microfluidic arrangements
CN105289385A (zh) * 2015-10-22 2016-02-03 上海交通大学 基于增强弯道二次流效应的扭曲弧形微混合器
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
US12071663B2 (en) 2016-01-15 2024-08-27 Massachusetts Institute Of Technology Semi-permeable arrays for analyzing biological systems and methods of using same
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
US10688493B2 (en) * 2016-03-09 2020-06-23 Texas Tech University System Integrated microfluidic rectifier for various bioanalytical applications
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10830545B2 (en) 2016-07-12 2020-11-10 Fractal Heatsink Technologies, LLC System and method for maintaining efficiency of a heat sink
JP2019521709A (ja) 2016-07-12 2019-08-08 マイクロ グリーン テクノロジーズ エルティーディーＭｉｃｒｏ Ｇｒｅｅｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｔｄ． 微細藻類を含む組成物及びこの組成物を製造し使用する方法
US11029293B2 (en) 2016-10-18 2021-06-08 Institut National D'optique Method and system for the detection of a chemical species in solution
EP3544737B1 (en) 2016-11-28 2025-04-23 Arizona Board of Regents on behalf of Arizona State University Methods related to continuous flow droplet reaction
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
EP3838268B1 (en) 2017-02-24 2023-05-10 The Regents of the University of California Particle-drop structures and methods for making and using the same
CN110520214B (zh) * 2017-04-13 2023-03-21 国立大学法人北海道大学 使用流路构造体的脂质粒子或微胞的形成方法
WO2018200896A1 (en) 2017-04-28 2018-11-01 Neofluidics, Llc Fluidic devices with reaction wells and uses thereof
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
EP3625715A4 (en) 2017-05-19 2021-03-17 10X Genomics, Inc. DATA SET ANALYSIS SYSTEMS AND METHODS
EP3445876B1 (en) 2017-05-26 2023-07-05 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CA3072328A1 (en) 2017-08-09 2019-02-14 Neofluidics, Llc Devices and methods for bioassay
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
EP3700672B1 (en) 2017-10-27 2022-12-28 10X Genomics, Inc. Methods for sample preparation and analysis
EP3706905A4 (en) * 2017-11-10 2021-11-03 Neofluidics, LLC INTEGRATED FLUID CIRCUIT AND DEVICE FOR DROPLET MANIPULATION AND PROCEDURE FOR THIS
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
EP3724658A1 (en) 2017-12-12 2020-10-21 10X Genomics, Inc. Systems and methods for single cell processing
JP7218558B2 (ja) * 2017-12-19 2023-02-07 東ソー株式会社 核酸増幅法および核酸増幅試薬
CN111712579B (zh) 2017-12-22 2024-10-15 10X基因组学有限公司 用于处理来自一个或多个细胞的核酸分子的系统和方法
CN111699255B (zh) * 2018-02-09 2024-03-08 首尔大学校产学协力团 基于生物反应器的生物样品分析方法、分析芯片及分析系统
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
WO2019169028A1 (en) 2018-02-28 2019-09-06 10X Genomics, Inc. Transcriptome sequencing through random ligation
EP3533519B1 (en) * 2018-02-28 2020-09-30 Paris Sciences et Lettres - Quartier Latin Biphasic plasma microreactor and method of using the same
EP3774005B1 (en) 2018-04-02 2025-01-29 Dropworks, Inc. Systems and methods for serial flow emulsion processes
WO2019194799A1 (en) * 2018-04-04 2019-10-10 Hewlett-Packard Development Company, L.P. Microfluidic cellular membrane modification devices
CN112262218B (zh) 2018-04-06 2024-11-08 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
US20210031201A1 (en) * 2018-04-15 2021-02-04 Optofluidic Bioassay, Llc Differential pressure assisted drainage system
CN112399882B (zh) 2018-04-16 2023-08-01 派特恩生物技术有限公司 用于形成二维微滴阵列的方法和设备
US11673107B2 (en) * 2018-05-01 2023-06-13 Hewlett-Packard Development Company, L.P. Sequential encapsulation of reagents
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
WO2019235542A1 (ja) 2018-06-07 2019-12-12 横河電機株式会社 光学分析システム及び光学分析方法
FR3082440B1 (fr) * 2018-06-14 2020-12-11 Paris Sciences Lettres Quartier Latin Methode de transfert de matiere dans un dispositif microfluidique ou millifluidique
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US12188014B1 (en) 2018-07-25 2025-01-07 10X Genomics, Inc. Compositions and methods for nucleic acid processing using blocking agents
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
SG11202101164TA (en) 2018-08-03 2021-03-30 10X Genomics Inc Methods and systems to minimize barcode exchange
WO2020041148A1 (en) 2018-08-20 2020-02-27 10X Genomics, Inc. Methods and systems for detection of protein-dna interactions using proximity ligation
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
AU2019343188A1 (en) 2018-09-21 2021-05-20 Aufbau Medical Innovations Limited Compositions and methods for glaucoma
US11137493B2 (en) * 2018-10-15 2021-10-05 GM Global Technology Operations LLC System and method for detecting precipitation using radar
US10486155B1 (en) 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
EP3870369A4 (en) 2018-10-26 2022-11-09 Neofluidics, LLC FLUID DEVICES HAVING REACTION WELLS AND THROAT CHANNEL AND USES THEREOF
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US12169198B2 (en) 2019-01-08 2024-12-17 10X Genomics, Inc. Systems and methods for sample analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
WO2020167862A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transfer of reagents between droplets
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US12305239B2 (en) 2019-02-12 2025-05-20 10X Genomics, Inc. Analysis of nucleic acid sequences
EP3924505B1 (en) 2019-02-12 2025-12-17 10X Genomics, Inc. Methods for processing nucleic acid molecules
US12275993B2 (en) 2019-02-12 2025-04-15 10X Genomics, Inc. Analysis of nucleic acid sequences
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
WO2020167866A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transposon loading
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
SG11202111242PA (en) 2019-03-11 2021-11-29 10X Genomics Inc Systems and methods for processing optically tagged beads
EP3947722A1 (en) 2019-03-27 2022-02-09 10X Genomics, Inc. Systems and methods for processing rna from cells
EP3747541B1 (en) * 2019-06-03 2024-02-07 Cellular Highways Ltd. Apparatus for sorting microfluidic particles
US12235262B1 (en) 2019-09-09 2025-02-25 10X Genomics, Inc. Methods and systems for single cell protein analysis
CN110560188B (zh) * 2019-09-19 2021-09-28 济南大学 一种合成Ag/Ag2S/CdS异质结的多级进样微流控芯片的制备方法
JP7267442B2 (ja) * 2019-09-24 2023-05-01 富士フイルム株式会社 スラグ流の形成方法、有機化合物の製造方法、粒子の製造方法、及び抽出方法
WO2021072306A1 (en) 2019-10-10 2021-04-15 1859, Inc. Methods and systems for microfluidic screening
WO2021119201A1 (en) 2019-12-10 2021-06-17 Enumerix, Inc. Methods and systems for three-dimensional lightsheet imaging
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
CN115428088A (zh) 2020-02-13 2022-12-02 10X基因组学有限公司 用于基因表达和dna染色质可及性的联合交互式可视化的系统和方法
CN111289469B (zh) * 2020-02-28 2021-03-23 浙江大学 一种icf靶丸内冰层折射率分布的测量装置和方法
CN115697561A (zh) 2020-04-15 2023-02-03 伊努梅里斯公司 用于产生具有合适澄清度的乳剂的系统和方法及其应用
WO2021216036A1 (en) * 2020-04-20 2021-10-28 Hewlett-Packard Development Company, L.P. Fluid dispenser frequencies
US10953404B1 (en) 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
US11686730B2 (en) 2020-04-30 2023-06-27 Quanterix Corporation Quantitative antibody test
GB202006525D0 (en) 2020-05-04 2020-06-17 Sphere Fluidics Ltd Surfactant
US12330160B2 (en) * 2020-05-12 2025-06-17 The Texas A&M University System Microfluidic platform for evaluation of liquid interfaces
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
GB2595519A (en) * 2020-05-29 2021-12-01 Univ Leiden Assemblies and methods
JP7522444B2 (ja) * 2020-09-09 2024-07-25 株式会社チップトン テイラー反応装置
EP4228796A1 (en) * 2020-10-19 2023-08-23 Sartorius Chromatography Equipment Apparatus and method for the purification of biomolecules
CN112354573B (zh) 2020-10-26 2022-01-04 深圳亘流科技有限公司 阶跃式惯性聚焦微流控芯片
US12084715B1 (en) 2020-11-05 2024-09-10 10X Genomics, Inc. Methods and systems for reducing artifactual antisense products
US12480158B1 (en) 2020-11-05 2025-11-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP7804929B2 (ja) * 2020-11-30 2026-01-23 国立大学法人茨城大学 マイクロ流路デバイスを用いた結晶製造方法及び装置
US12398262B1 (en) 2021-01-22 2025-08-26 10X Genomics, Inc. Triblock copolymer-based cell stabilization and fixation system and methods of use thereof
CN117015617B (zh) 2021-02-23 2025-04-04 10X基因组学有限公司 基于探针的核酸和蛋白质分析
EP4301499A4 (en) 2021-03-05 2025-01-22 Enumerix, Inc. SYSTEMS AND METHODS FOR GENERATING DROPLETS AND PERFORMING DIGITAL ANALYSES
WO2022221391A1 (en) 2021-04-14 2022-10-20 Partillion Bioscience Corporation Nanoscale reaction chambers and methods of using the same
US20240200005A1 (en) 2021-04-15 2024-06-20 Screensys Gmbh Method for developing and/or reprogramming plant cellular objects
US12252745B2 (en) 2021-09-02 2025-03-18 Enumerix, Inc. Detection and digital quantitation of multiple targets
EP4453246A4 (en) 2021-12-20 2025-12-24 Countable Labs Inc DIGITAL DETECTION AND QUANTIFICATION OF MULTIPLE TARGETS
CN114534652B (zh) 2022-02-08 2024-07-19 上海天泽云泰生物医药有限公司 波形微结构混合单元及其用途
KR102506675B1 (ko) * 2022-03-14 2023-03-08 서강대학교산학협력단 IoT 기반 휴대용 dPCR 시스템
CN114398378B (zh) * 2022-03-25 2022-11-01 北京奥星贝斯科技有限公司 确定索引代价的方法和装置
EP4253965B1 (en) * 2022-04-01 2025-09-10 F. Hoffmann-La Roche AG Method for sensor calibration and in-vitro diagnostic analyzer
JP7850933B2 (ja) * 2022-04-27 2026-04-24 パナソニックＩｐマネジメント株式会社 液体混合装置及び液体混合方法
JP7796324B2 (ja) * 2022-04-27 2026-01-09 パナソニックＩｐマネジメント株式会社 マイクロリアクタ装置
CN115069134B (zh) * 2022-07-07 2023-09-05 山东省科学院能源研究所 一种基于迪恩涡流的微流体高效混合器
DE102022124200A1 (de) * 2022-09-21 2024-03-21 Asepto GmbH Aseptische Verfahrenstechnik und Automation Verfahren zum Herstellen zumindest eines pflanzenbasierten Getränkes und Vorrichtung zum Herstellen zumindest eines pflanzenbasierten Getränkes
WO2024091930A1 (en) * 2022-10-24 2024-05-02 1859, Inc. Miniaturized methods and systems for sample screening
US20240198336A1 (en) * 2022-12-19 2024-06-20 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
AU2024282145A1 (en) 2023-05-27 2025-12-18 Droplet Genomics, Uab Direct loading
GB2636109A (en) 2023-11-29 2025-06-11 Sphere Fluidics Ltd Dendronized surfactants
EP4640316A1 (en) 2024-04-28 2025-10-29 Inorevia Method for individual droplet separation from a carrier fluid
CN120115206B (zh) * 2025-03-19 2025-12-05 重庆大学 一种无源离散型浓度梯度芯片及无源离散型浓度梯度的建立方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59102163A (ja) * 1982-11-15 1984-06-13 テクニコン，インストルメンツ，コ−ポレ−シヨン 液体区分反応方法、液体区分反応分析方法、単一流路分析装置及び連続流れ装置
WO1998002237A1 (en) * 1996-07-15 1998-01-22 Kemgas Limited Production of powders

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479141A (en) * 1967-05-17 1969-11-18 Technicon Corp Method and apparatus for analysis
US3960187A (en) * 1974-07-23 1976-06-01 Usm Corporation Method and device for metering and dispersing fluid materials
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4853336A (en) * 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
JPS61238330A (ja) * 1985-04-12 1986-10-23 Mitsui Petrochem Ind Ltd 乳化装置
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5185099A (en) * 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
DE69413012T2 (de) * 1993-03-19 1999-03-25 Du Pont Integrierte vorrichtung für chemische verfahrensschritte und herstellungsverfahren dafür
MY110990A (en) * 1993-06-03 1999-07-31 Atomaer Pty Ltd Multiphase staged passive reactor
DE69429038T2 (de) * 1993-07-28 2002-03-21 Pe Corporation (Ny), Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5595712A (en) * 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
EP0957772A2 (en) * 1995-06-06 1999-11-24 Quantic Biomedical Partners Wound sealant preparation and application device and method
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6130098A (en) * 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
WO1997029508A2 (en) * 1996-02-08 1997-08-14 Perseptive Biosystems, Inc. Interface between liquid flow and mass spectrometer
US5948684A (en) * 1997-03-31 1999-09-07 University Of Washington Simultaneous analyte determination and reference balancing in reference T-sensor devices
EP0832436A1 (en) * 1996-04-15 1998-04-01 Dade Behring Inc. Apparatus and method for analysis
CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
CN1329729C (zh) * 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5993750A (en) * 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DE19717085C2 (de) * 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
WO1998049548A1 (en) * 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
DE69823347T2 (de) * 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
JP2843319B1 (ja) 1997-06-27 1999-01-06 科学技術振興事業団 マイクロストリップガスチャンバー高速データ収集システム及びそれを用いた試料の測定方法
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
FR2769215B1 (fr) * 1997-10-03 1999-12-24 Oreal Composition de teinture des fibres keratiniques et procede de teinture mettant en oeuvre cette composition
US5997636A (en) * 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6569631B1 (en) * 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
JP2001088098A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 減圧送液機構を有する微小ケミカルデバイス
JP2001088096A (ja) * 1999-09-14 2001-04-03 Kawamura Inst Of Chem Res 吸収式送液機構を有する微小ケミカルデバイス
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
JP2001145486A (ja) * 1999-11-19 2001-05-29 Natl Inst Of Advanced Industrial Science & Technology Meti 多試料用の微小容量化学反応装置
US6432290B1 (en) * 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
US6790328B2 (en) * 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
AU2001234997B2 (en) * 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
US6454924B2 (en) * 2000-02-23 2002-09-24 Zyomyx, Inc. Microfluidic devices and methods
GB2359765B (en) 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
WO2001075415A2 (en) * 2000-03-31 2001-10-11 Micronics, Inc. Protein crystallization in microfluidic structures
WO2001077683A1 (en) * 2000-04-06 2001-10-18 Caliper Technologies Corp. Methods and devices for achieving long incubation times in high-throughput systems
CA2408574A1 (en) * 2000-05-24 2001-11-29 Micronics, Inc. Microfluidic concentration gradient loop
US20010048637A1 (en) * 2000-05-24 2001-12-06 Weigl Bernhard H. Microfluidic system and method
JP2002031638A (ja) * 2000-07-17 2002-01-31 Mitsubishi Chemicals Corp 生体試料検出用チップ及び生体試料検出方法
US7004184B2 (en) * 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
WO2002012856A1 (en) * 2000-08-04 2002-02-14 Caliper Technologies Corp. Control of operation conditions within fluidic systems
US20040005582A1 (en) * 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
WO2002023163A1 (en) * 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
EP1327132A4 (en) * 2000-09-21 2004-03-31 Dna Sciences Inc METHOD AND SYSTEM FOR INJECTING A SPECIMEN
JP4361271B2 (ja) * 2000-10-10 2009-11-11 バイオトローブ・インコーポレイテツド アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法
US20020067800A1 (en) 2000-10-19 2002-06-06 Janet Newman Apparatus and method for identification of crystals by in-situ X-ray diffraction
CN2482070Y (zh) 2001-01-02 2002-03-13 大连市临床检验中心 血液促凝球
JP4148778B2 (ja) * 2001-03-09 2008-09-10 バイオミクロ システムズ インコーポレイティッド アレイとのミクロ流体的インターフェース機器
US20030064414A1 (en) * 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
WO2002081934A2 (en) * 2001-04-03 2002-10-17 Micronics, Inc. Pneumatic valve interface for use in microfluidic structures
US6797056B2 (en) * 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6719840B2 (en) * 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6656267B2 (en) 2001-07-10 2003-12-02 Structural Genomix, Inc. Tray for macromolecule crystallization and method of using the same
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
JP2005509872A (ja) * 2001-10-19 2005-04-14 ウエスト バージニア ユニバーシティ リサーチ コーポレーション プロテオーム解析のための微小流体システム
EP1485191B1 (en) * 2002-03-05 2012-08-01 Caliper Life Sciences, Inc. Mixed mode microfluidic system and method
US7101467B2 (en) * 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
EP2283917B1 (en) 2002-05-09 2021-12-15 The University of Chicago Device for pressure-driven plug transport and reaction
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP3883060B2 (ja) 2002-06-17 2007-02-21 株式会社リガク 結晶評価装置
JP2004016925A (ja) * 2002-06-17 2004-01-22 Taisei Corp 管内面ライニング装置
US20040136497A1 (en) 2002-10-30 2004-07-15 Meldrum Deirdre R Preparation of samples and sample evaluation
US7445926B2 (en) * 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
WO2004075734A2 (en) * 2003-02-25 2004-09-10 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7262059B2 (en) * 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
JP4466991B2 (ja) 2003-05-22 2010-05-26 英明 森山 結晶成長装置及び方法
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
AU2006214085A1 (en) 2005-02-18 2006-08-24 Canon U.S. Life Sciences, Inc. Devices and methods for identifying genomic DNA of organisms
CN101223268A (zh) 2005-05-18 2008-07-16 康奈尔研究基金会（有限公司） 具有生物屏障的基于药代动力学的培养系统
CN101351542A (zh) * 2005-07-15 2009-01-21 阿普尔拉公司 液体加工装置和方法
US9458451B2 (en) * 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
WO2009149257A1 (en) 2008-06-04 2009-12-10 The University Of Chicago The chemistrode: a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
EP4047367A1 (en) * 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59102163A (ja) * 1982-11-15 1984-06-13 テクニコン，インストルメンツ，コ−ポレ−シヨン 液体区分反応方法、液体区分反応分析方法、単一流路分析装置及び連続流れ装置
WO1998002237A1 (en) * 1996-07-15 1998-01-22 Kemgas Limited Production of powders

Also Published As

Publication number Publication date
JP2006504512A (ja) 2006-02-09
JP2015024406A (ja) 2015-02-05
US20170361321A1 (en) 2017-12-21
JP2021119004A (ja) 2021-08-12
JP2017159297A (ja) 2017-09-14
US20200360928A1 (en) 2020-11-19
WO2004038363A2 (en) 2004-05-06
US10668471B2 (en) 2020-06-02
EP2282214A3 (en) 2012-08-01
EP3290921A1 (en) 2018-03-07
US9889446B2 (en) 2018-02-13
US20160051960A1 (en) 2016-02-25
US8889083B2 (en) 2014-11-18
EP2283917B1 (en) 2021-12-15
JP2017104863A (ja) 2017-06-15
EP2282214B1 (en) 2022-10-05
EP2282214A2 (en) 2011-02-09
JP2011212679A (ja) 2011-10-27
EP2278337A2 (en) 2011-01-26
EP1508044A4 (en) 2008-09-10
EP2278337B1 (en) 2019-06-26
AU2003290508A8 (en) 2004-05-13
EP1508044B1 (en) 2010-09-01
US20170368551A1 (en) 2017-12-28
EP2283918A3 (en) 2012-08-01
EP2278338A2 (en) 2011-01-26
US20050272159A1 (en) 2005-12-08
EP1508044A2 (en) 2005-02-23
JP5519975B2 (ja) 2014-06-11
US20150099264A1 (en) 2015-04-09
DE60333995D1 (de) 2010-10-14
US20170232440A1 (en) 2017-08-17
US20180154362A1 (en) 2018-06-07
AU2003290508A1 (en) 2004-05-13
US9968933B2 (en) 2018-05-15
EP2283918B1 (en) 2022-10-05
JP2019141841A (ja) 2019-08-29
JP2012254452A (ja) 2012-12-27
US20180193837A1 (en) 2018-07-12
US20070172954A1 (en) 2007-07-26
US10118174B2 (en) 2018-11-06
EP2283918A2 (en) 2011-02-16
US10562028B2 (en) 2020-02-18
EP2278338A3 (en) 2012-09-26
JP5859393B2 (ja) 2016-02-10
US7129091B2 (en) 2006-10-31
EP3290921B1 (en) 2022-06-15
US20180193838A1 (en) 2018-07-12
EP2278338B1 (en) 2020-08-26
US9839893B2 (en) 2017-12-12
EP2283917A2 (en) 2011-02-16
ATE479899T1 (de) 2010-09-15
US9579622B2 (en) 2017-02-28
JP6270278B2 (ja) 2018-01-31
EP2302389B1 (en) 2018-01-24
EP2302389A1 (en) 2011-03-30
EP2278337A3 (en) 2012-09-26
WO2004038363A3 (en) 2004-12-09
JP2009291788A (ja) 2009-12-17
US10105703B2 (en) 2018-10-23
EP2283917A3 (en) 2012-08-01

Similar Documents

Publication Publication Date Title
JP4855680B2 (ja) 圧力駆動プラグによる輸送と反応のための装置および方法
US10532358B2 (en) Device and method for pressure-driven plug transport and reaction

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20060120

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060508

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090525

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090825

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100518

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20100818

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110307

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110707

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20110829

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20111011

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20111027

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20141104

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4855680

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term