JP4758608B2 - 分枝ポリマーおよびそれらの結合体 - Google Patents
分枝ポリマーおよびそれらの結合体 Download PDFInfo
- Publication number
- JP4758608B2 JP4758608B2 JP2003542253A JP2003542253A JP4758608B2 JP 4758608 B2 JP4758608 B2 JP 4758608B2 JP 2003542253 A JP2003542253 A JP 2003542253A JP 2003542253 A JP2003542253 A JP 2003542253A JP 4758608 B2 JP4758608 B2 JP 4758608B2
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- poly
- branched
- group
- aliphatic hydrocarbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33761301P | 2001-11-07 | 2001-11-07 | |
US60/337,613 | 2001-11-07 | ||
PCT/US2002/035759 WO2003040211A2 (en) | 2001-11-07 | 2002-11-07 | Branched polymers and their conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005508421A JP2005508421A (ja) | 2005-03-31 |
JP4758608B2 true JP4758608B2 (ja) | 2011-08-31 |
Family
ID=23321254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003542253A Expired - Lifetime JP4758608B2 (ja) | 2001-11-07 | 2002-11-07 | 分枝ポリマーおよびそれらの結合体 |
Country Status (8)
Families Citing this family (221)
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ES2315526T3 (es) * | 2002-09-09 | 2009-04-01 | Nektar Therapeutics Al, Corporation | Metodo para preparar derivados polimericos solubles en agua que llevan un acido carboxilico terminal. |
JP4764630B2 (ja) * | 2002-09-09 | 2011-09-07 | ネクター セラピューティックス | 水溶性ポリマーアルカナール |
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Patent Citations (8)
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JPH08510255A (ja) * | 1993-05-10 | 1996-10-29 | プロティン.デリバリー.インコーポレイテッド | 接合−安定化ポリペプチド組成物 |
US5684096A (en) * | 1993-08-16 | 1997-11-04 | Nalco/Exxon Energy Chemicals, L.P. | Adducts of polyalkylene glycol and diglycidyl ether |
JPH09504299A (ja) * | 1993-10-27 | 1997-04-28 | エンゾン,インコーポレーテッド | 非抗原性分枝ポリマー複合体 |
WO1998025990A1 (fr) * | 1996-12-09 | 1998-06-18 | Daiso Co., Ltd. | Electrolyte polymere solide comprenant du copolyether |
JP2001519784A (ja) * | 1997-03-20 | 2001-10-23 | エンゾン,インコーポレーテッド | 非抗原性分枝ポリマーコンジュゲート |
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Also Published As
Publication number | Publication date |
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US20200048412A1 (en) | 2020-02-13 |
KR20050044364A (ko) | 2005-05-12 |
US7026440B2 (en) | 2006-04-11 |
US9187569B2 (en) | 2015-11-17 |
US7872072B2 (en) | 2011-01-18 |
WO2003040211A3 (en) | 2003-07-03 |
MXPA04004336A (es) | 2005-05-16 |
US8809453B2 (en) | 2014-08-19 |
EP1446438A2 (en) | 2004-08-18 |
CA2466027A1 (en) | 2003-05-15 |
US8440816B2 (en) | 2013-05-14 |
CA2466027C (en) | 2013-01-08 |
US20120322134A1 (en) | 2012-12-20 |
US20140329994A1 (en) | 2014-11-06 |
JP2005508421A (ja) | 2005-03-31 |
US20030143596A1 (en) | 2003-07-31 |
US20060178475A1 (en) | 2006-08-10 |
US20130295639A1 (en) | 2013-11-07 |
KR100948532B1 (ko) | 2010-03-23 |
AU2002352524B2 (en) | 2007-10-04 |
US20110077362A1 (en) | 2011-03-31 |
US8273833B2 (en) | 2012-09-25 |
US20160032049A1 (en) | 2016-02-04 |
WO2003040211A2 (en) | 2003-05-15 |
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