JP4332314B2 - 血糖値を降下させるペプチド - Google Patents

血糖値を降下させるペプチド Download PDF

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Publication number
JP4332314B2
JP4332314B2 JP2001509765A JP2001509765A JP4332314B2 JP 4332314 B2 JP4332314 B2 JP 4332314B2 JP 2001509765 A JP2001509765 A JP 2001509765A JP 2001509765 A JP2001509765 A JP 2001509765A JP 4332314 B2 JP4332314 B2 JP 4332314B2
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Prior art keywords
lys
peptide
exendin
gly
glu
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Expired - Lifetime
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JP2001509765A
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Japanese (ja)
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JP2003505347A5 (enExample
JP2003505347A (ja
Inventor
ラーセン，ブジャーン，デュウ
ミッケルセン，ジェンス，ダムスガード
ネヴェ，ソーレン
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ジーランド ファーマ エー／エス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2001509765A 1999-07-12 2000-07-12 血糖値を降下させるペプチド Expired - Lifetime JP4332314B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14359199P 1999-07-12 1999-07-12
US60/143,591 1999-07-12
EP99610043A EP1076066A1 (en) 1999-07-12 1999-08-09 Peptides for lowering blood glucose levels
EP99610043.4 1999-08-09
PCT/DK2000/000393 WO2001004156A1 (en) 1999-07-12 2000-07-12 Peptides that lower blood glucose levels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006243389A Division JP5414144B2 (ja) 1999-07-12 2006-09-07 血糖値を降下させるペプチド

Publications (3)

Publication Number Publication Date
JP2003505347A JP2003505347A (ja) 2003-02-12
JP2003505347A5 JP2003505347A5 (enExample) 2006-08-10
JP4332314B2 true JP4332314B2 (ja) 2009-09-16

Family

ID=26153727

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2001509765A Expired - Lifetime JP4332314B2 (ja) 1999-07-12 2000-07-12 血糖値を降下させるペプチド
JP2006243389A Expired - Lifetime JP5414144B2 (ja) 1999-07-12 2006-09-07 血糖値を降下させるペプチド
JP2010286968A Expired - Lifetime JP5553742B2 (ja) 1999-07-12 2010-12-24 血糖値を降下させるペプチド
JP2014079124A Pending JP2014169296A (ja) 1999-07-12 2014-04-08 血糖値を降下させるペプチド

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2006243389A Expired - Lifetime JP5414144B2 (ja) 1999-07-12 2006-09-07 血糖値を降下させるペプチド
JP2010286968A Expired - Lifetime JP5553742B2 (ja) 1999-07-12 2010-12-24 血糖値を降下させるペプチド
JP2014079124A Pending JP2014169296A (ja) 1999-07-12 2014-04-08 血糖値を降下させるペプチド

Country Status (19)

Country Link
US (1) US20070111940A1 (enExample)
EP (4) EP1076066A1 (enExample)
JP (4) JP4332314B2 (enExample)
CN (1) CN1229390C (enExample)
AT (2) ATE551362T1 (enExample)
AU (2) AU781338B2 (enExample)
BE (1) BE2013C033I2 (enExample)
CA (2) CA2680437A1 (enExample)
CY (2) CY1113347T1 (enExample)
DE (1) DE60003182T2 (enExample)
DK (3) DK2112161T3 (enExample)
ES (3) ES2200892T3 (enExample)
FR (1) FR13C0021I2 (enExample)
IL (4) IL147293A0 (enExample)
LU (1) LU92175I2 (enExample)
NZ (1) NZ517012A (enExample)
PT (3) PT2112161E (enExample)
SI (2) SI2112161T1 (enExample)
WO (1) WO2001004156A1 (enExample)

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