|
GB1338235A
(en)
|
1970-12-15 |
1973-11-21 |
May & Baker Ltd |
Azapurinones
|
|
CA1317298C
(en)
|
1987-03-03 |
1993-05-04 |
Upjohn Company (The) |
Antibiotic sulfonylaminocarbonyl activated .beta.-lactams
|
|
ATE130299T1
(de)
|
1987-07-23 |
1995-12-15 |
Zeneca Pharma Sa |
Cephalosporinverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische präparate.
|
|
US4950585A
(en)
|
1987-08-18 |
1990-08-21 |
Konica Corporation |
Coupler for photographic use
|
|
GB8814352D0
(en)
|
1988-06-16 |
1988-07-20 |
Smith Kline French Lab |
Chemical compounds
|
|
DE68908786T2
(de)
|
1988-06-16 |
1994-03-17 |
Smith Kline French Lab |
Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
|
|
US4923874A
(en)
|
1988-07-21 |
1990-05-08 |
G. D. Searle & Co. |
Use of 8-azapurin-6-one derivatives for control of hypertension
|
|
GB8817651D0
(en)
|
1988-07-25 |
1988-09-01 |
Smith Kline French Lab |
Chemical compounds
|
|
US5304121A
(en)
|
1990-12-28 |
1994-04-19 |
Boston Scientific Corporation |
Drug delivery system making use of a hydrogel polymer coating
|
|
JP2952706B2
(ja)
|
1990-10-26 |
1999-09-27 |
大塚化学株式会社 |
４―キノロン誘導体の製造法
|
|
MX9200299A
(es)
|
1991-02-07 |
1992-12-01 |
Roussel Uclaf |
Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
|
|
US5710158A
(en)
|
1991-05-10 |
1998-01-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
US5316906A
(en)
|
1991-08-23 |
1994-05-31 |
Molecular Probes, Inc. |
Enzymatic analysis using substrates that yield fluorescent precipitates
|
|
US5356897A
(en)
|
1991-09-09 |
1994-10-18 |
Fujisawa Pharmaceutical Co., Ltd. |
3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
|
|
IT1254469B
(it)
|
1992-02-25 |
1995-09-25 |
Recordati Chem Pharm |
Derivati benzopiranici e benzotiopiranici
|
|
SG65570A1
(en)
|
1992-02-25 |
1999-06-22 |
Recordati Chem Pharm |
Heterobicyclic compounds
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
DE4233717A1
(de)
|
1992-10-07 |
1994-04-14 |
Bayer Ag |
Substituierte 3,4-Hetaryl-pyrazoline
|
|
TW299333B
(https=)
|
1992-12-29 |
1997-03-01 |
Takeda Pharm Industry Co Ltd |
|
|
US5886026A
(en)
|
1993-07-19 |
1999-03-23 |
Angiotech Pharmaceuticals Inc. |
Anti-angiogenic compositions and methods of use
|
|
CZ280697A3
(cs)
|
1995-03-10 |
1998-04-15 |
Sanofi Pharmaceuticals, Inc. |
6 aryl-pyrazolo(3,4-d)pyrimidin-4-ony a kompozice je obsahující, a způsob jejich použití
|
|
US5741657A
(en)
|
1995-03-20 |
1998-04-21 |
The Regents Of The University Of California |
Fluorogenic substrates for β-lactamase and methods of use
|
|
US6099562A
(en)
|
1996-06-13 |
2000-08-08 |
Schneider (Usa) Inc. |
Drug coating with topcoat
|
|
US6200980B1
(en)
|
1995-06-07 |
2001-03-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl purinone derivatives
|
|
US6060477A
(en)
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
|
AU4153496A
(en)
|
1995-10-20 |
1997-05-07 |
Flora Inc. |
Transdermal delivery of alpha adrenoceptor blocking agents
|
|
US6080757A
(en)
|
1996-06-06 |
2000-06-27 |
Pfizer Inc |
Antibiotic quinolones and derivatives
|
|
US5700821A
(en)
|
1996-07-30 |
1997-12-23 |
University Of Pittsburgh |
Phosphatase inhibitors and methods of use thereof
|
|
US5955462A
(en)
|
1996-10-31 |
1999-09-21 |
Harbor Branch Oceanographic Institution, Inc. |
Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
|
|
WO1998027080A1
(en)
|
1996-12-19 |
1998-06-25 |
Agrevo Uk Limited |
Chromones useful as fungicides
|
|
US6274592B1
(en)
|
1997-02-04 |
2001-08-14 |
Senju Pharmaceutical Co., Ltd. |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
|
|
US5942508A
(en)
|
1997-02-04 |
1999-08-24 |
Senju Pharmaceutical Co., Ltd. |
Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
|
|
US5994367A
(en)
|
1997-03-07 |
1999-11-30 |
The University Of North Carolina At Chapel Hill |
Method for treating tumors using 2-aryl-naphthyridin-4-ones
|
|
US6514977B1
(en)
|
1997-05-22 |
2003-02-04 |
G.D. Searle & Company |
Substituted pyrazoles as p38 kinase inhibitors
|
|
HRP20000712A2
(en)
|
1998-04-20 |
2001-06-30 |
Pfizer |
PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
|
|
YU76100A
(sh)
|
1998-06-02 |
2003-12-31 |
Osi Pharmaceuticals Inc. |
Pirolo(2,3-d) pirimidin preparati i njihova primena
|
|
EP1123296B1
(en)
|
1998-10-23 |
2003-09-17 |
Pfizer Limited |
PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
|
|
JP3539628B2
(ja)
|
1999-09-17 |
2004-07-07 |
富士写真フイルム株式会社 |
発光素子材料、それを使用した発光素子およびアミン化合物
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
AP2002002455A0
(en)
|
1999-10-11 |
2002-06-30 |
Pfizer |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dIhydropyrazolo[4,3-D] pyrimidin-7-ones as phosphodiesterase inhibitors.
|
|
HUP0203935A3
(en)
|
1999-12-31 |
2006-02-28 |
Encysive Pharmaceuticals Inc H |
Sulfonamides and derivatives thereof that modulate the activity of endothelin, pharmaceutical compositions containing them and their use
|
|
EP1276739A2
(en)
|
2000-04-24 |
2003-01-22 |
Bristol-Myers Squibb Company |
Heterocycles that are inhibitors of impdh enzyme
|
|
US20020028799A1
(en)
|
2000-07-06 |
2002-03-07 |
Naylor Alasdair Mark |
Treatment of male sexual dysfunction
|
|
EP1303757B1
(en)
|
2000-07-10 |
2006-10-11 |
Vertex Pharmaceuticals (San Diego) LLC |
Ion channel assay methods
|
|
EP1176147A1
(en)
|
2000-07-28 |
2002-01-30 |
Pfizer Limited |
Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
|
|
GB0023918D0
(en)
|
2000-09-29 |
2000-11-15 |
King S College London |
Antiparasitic compounds
|
|
GB0025782D0
(en)
|
2000-10-20 |
2000-12-06 |
Pfizer Ltd |
Use of inhibitors
|
|
JP2002189128A
(ja)
|
2000-12-22 |
2002-07-05 |
Fuji Photo Film Co Ltd |
光学フイルム、偏光選択素子、偏光板および液晶表示装置
|
|
NZ535574A
(en)
|
2001-01-16 |
2006-07-28 |
Astrazeneca Ab |
Therapeutic heterocyclic compounds
|
|
CA2434066A1
(en)
|
2001-01-26 |
2002-09-12 |
Pharmacia Italia S.P.A. |
Chromane derivatives, process for their preparation and their use as antitumor agents
|
|
GB0106661D0
(en)
|
2001-03-16 |
2001-05-09 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
BR0211750A
(pt)
|
2001-08-10 |
2004-10-13 |
Shionogi & Co |
Agente antiviral
|
|
SE0103648D0
(sv)
|
2001-11-01 |
2001-11-01 |
Astrazeneca Ab |
Therapeutic quinolone compounds
|
|
GB0130416D0
(en)
|
2001-12-20 |
2002-02-06 |
Eastman Kodak Co |
Photographic elements containing a de-aggregating compound dye-forming coupler and stabilizer
|
|
GB0130418D0
(en)
|
2001-12-20 |
2002-02-06 |
Eastman Kodak Co |
Photographic elements containing a deaggregating compound and dye forming coupler
|
|
US20050244718A1
(en)
|
2002-07-01 |
2005-11-03 |
Eike Poetsch |
Polymerizable, luminescent compounds and mixtures, luminescent polymer materials and their use
|
|
JP4646626B2
(ja)
|
2002-08-16 |
2011-03-09 |
アストラゼネカ アクチボラグ |
ホスホイノシチド３−キナーゼβの阻害
|
|
US7863428B2
(en)
|
2002-12-27 |
2011-01-04 |
Tibotec Bvba |
Fluorogenic enzyme substrates and methods of preparation
|
|
JP2005008789A
(ja)
|
2003-06-20 |
2005-01-13 |
Toray Ind Inc |
有機エレクトロルミネッセンス用材料、および有機エレクトロルミネッセンス用材料の製造方法、ならびに有機エレクトロルミネッセンス素子
|
|
WO2005000309A2
(en)
|
2003-06-27 |
2005-01-06 |
Ionix Pharmaceuticals Limited |
Chemical compounds
|
|
JP2007500128A
(ja)
|
2003-07-25 |
2007-01-11 |
アムジエン・インコーポレーテツド |
置換複素環式化合物及び使用方法
|
|
JP4795634B2
(ja)
|
2003-10-31 |
2011-10-19 |
出光興産株式会社 |
有機薄膜トランジスタ
|
|
EP1685124A1
(en)
|
2003-11-10 |
2006-08-02 |
MERCK SHARP & DOHME LTD. |
Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain
|
|
JP4521182B2
(ja)
|
2003-12-26 |
2010-08-11 |
富士フイルム株式会社 |
有機電界発光素子
|
|
US20050227309A1
(en)
|
2004-01-21 |
2005-10-13 |
Corry Schuyler B |
Optically-detectable enzyme substrates and their method of use
|
|
US7119214B2
(en)
|
2004-04-13 |
2006-10-10 |
Cephalon France |
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
|
|
ES2241496B1
(es)
|
2004-04-15 |
2006-12-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de piridina.
|
|
WO2005103052A1
(en)
|
2004-04-21 |
2005-11-03 |
Pfizer Products Inc. |
Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
|
|
AU2005266090A1
(en)
|
2004-07-23 |
2006-02-02 |
Pfizer Inc. |
Pyridine derivatives
|
|
CN101014572B
(zh)
|
2004-09-15 |
2011-07-06 |
盐野义制药株式会社 |
具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物
|
|
GB0421911D0
(en)
|
2004-10-01 |
2004-11-03 |
Univ Cambridge Tech |
Methods and means
|
|
WO2006038041A1
(en)
|
2004-10-08 |
2006-04-13 |
Merck Sharp & Dohme Limited |
Besylate salts of six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain
|
|
US8697674B2
(en)
|
2004-12-29 |
2014-04-15 |
Naturon, Inc. |
Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
|
|
US20070135437A1
(en)
|
2005-03-04 |
2007-06-14 |
Alsgen, Inc. |
Modulation of neurodegenerative diseases
|
|
WO2006094604A1
(en)
|
2005-03-11 |
2006-09-14 |
Merck Patent Gmbh |
Tetrahydro- and dihydroquinazolinones
|
|
PE20061110A1
(es)
|
2005-03-24 |
2006-10-20 |
Glaxo Group Ltd |
Derivados de imidazopiridina como antagonistas de la bomba de acido (apa)
|
|
AR056347A1
(es)
|
2005-05-12 |
2007-10-03 |
Tibotec Pharm Ltd |
Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
|
|
WO2006138418A2
(en)
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
CA2612585A1
(en)
|
2005-06-27 |
2007-01-04 |
Amgen Inc. |
Anti-inflammatory aryl nitrile compounds
|
|
CA2624772C
(en)
|
2005-10-11 |
2011-11-29 |
Centre National De La Recherche Scientifique (Cnrs) |
Compounds and kits for the detection and the quantification of cell apoptosis
|
|
US20090306102A1
(en)
|
2005-12-20 |
2009-12-10 |
Eriksen Birgitte L |
2-pyridin-2-yl-quinazoline derivatives as potassium channel modulating agents for the treatment of respiratory diseases
|
|
WO2007079180A2
(en)
|
2005-12-29 |
2007-07-12 |
N.V. Organon |
Inhibitors of fatty acid amide hydrolase
|
|
US20070203236A1
(en)
|
2006-01-11 |
2007-08-30 |
Smith Jeffrey W |
Novel antagonists of the human fatty acid synthase thioesterase
|
|
CA2642754A1
(en)
|
2006-02-13 |
2007-08-23 |
Trustees Of Boston University |
Compositions and methods for antibiotic potentiation and drug discovery
|
|
JP2007230145A
(ja)
|
2006-03-02 |
2007-09-13 |
Mitsubishi Chemicals Corp |
光学記録媒体の記録層形成用色素、及びそれを用いた光学記録媒体、その光学記録媒体の記録方法
|
|
LT2656842T
(lt)
|
2006-03-27 |
2016-09-26 |
The Regents Of The University Of California |
Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui
|
|
CA2648202A1
(en)
|
2006-04-11 |
2007-10-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of voltage-gated sodium channels
|
|
EP1849781A1
(en)
|
2006-04-28 |
2007-10-31 |
Laboratorios del Dr. Esteve S.A. |
Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
|
|
WO2008024139A2
(en)
|
2006-08-18 |
2008-02-28 |
N.V. Organon |
Inhibitors of fatty acid amide hydrolase
|
|
US20100173332A1
(en)
|
2006-09-07 |
2010-07-08 |
Auckland Uniservices Limited |
Method for the Fluorescent Detection of Nitroreductase Activity Using Nitro-Substituted Aromatic Compounds
|
|
WO2008033744A2
(en)
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Dna methyl transferase inhibitors containing a zinc binding moiety
|
|
AU2007296743B2
(en)
|
2006-09-11 |
2012-02-16 |
Curis, Inc. |
Tyrosine kinase inhibitors containing a zinc binding moiety
|
|
CA2663147A1
(en)
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Substituted 2-indolinone as ptk inhibitors containing a zinc binding moiety
|
|
CN101535279B
(zh)
|
2006-09-11 |
2015-05-20 |
柯瑞斯公司 |
含锌结合基的喹唑啉基egfr抑制剂
|
|
US20080161320A1
(en)
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
|
WO2008037607A1
(de)
|
2006-09-25 |
2008-04-03 |
Basf Se |
Carbonylgruppen-enthaltende heterocyclische verbindungen und deren verwendung zur bekämpfung von phytopathogenen pilzen
|
|
AR063280A1
(es)
|
2006-10-12 |
2009-01-21 |
Xenon Pharmaceuticals Inc |
Uso de compuestos de espiro-oxindol como agentes terapeuticos
|
|
ATE507225T1
(de)
|
2006-12-04 |
2011-05-15 |
Astrazeneca Ab |
Antibakterielle polycyclische harnstoffverbindungen
|
|
DE102006059710A1
(de)
|
2006-12-18 |
2008-06-19 |
Freie Universität Berlin |
Substituierte 4-Hydroxypyridine
|
|
JP2010528256A
(ja)
|
2007-01-04 |
2010-08-19 |
ドゥ−コープ テクノロジーズ リミテッド |
分析物の検出
|
|
US20080176225A1
(en)
|
2007-01-18 |
2008-07-24 |
Steve Roffler |
Membrane bound reporter gene system
|
|
WO2008094507A2
(en)
|
2007-01-26 |
2008-08-07 |
Cellicon Biotechnologies, Inc. |
Novel fusion compounds
|
|
WO2008092231A1
(en)
|
2007-02-01 |
2008-08-07 |
Resverlogix Corp. |
Compounds for the prevention and treatment of cardiovascular diseases
|
|
US20080234297A1
(en)
|
2007-03-20 |
2008-09-25 |
Changgeng Qian |
HSP90 Inhibitors Containing a Zinc Binding Moiety
|
|
EP2136809A4
(en)
|
2007-03-20 |
2012-01-04 |
Curis Inc |
INHIBITORS OF RAF KINASE CONTAINING A ZINC BINDING FRAGMENT
|
|
GEP20125379B
(en)
|
2007-05-03 |
2012-01-10 |
Pfizer Ltd |
2 -pyridine carboxamide derivatives as sodium channel modulators
|
|
PL2182950T3
(pl)
|
2007-05-17 |
2018-01-31 |
Helperby Therapeutics Ltd |
Zastosowanie związków 4-(pirolidyn-1-ylo)chinolinowych do zabijania klinicznie latentnych drobnoustrojów
|
|
TW200922590A
(en)
|
2007-09-10 |
2009-06-01 |
Curis Inc |
VEGFR inhibitors containing a zinc binding moiety
|
|
TW200922564A
(en)
|
2007-09-10 |
2009-06-01 |
Curis Inc |
CDK inhibitors containing a zinc binding moiety
|
|
TW200920357A
(en)
|
2007-09-10 |
2009-05-16 |
Curis Inc |
HSP90 inhibitors containing a zinc binding moiety
|
|
WO2009036066A1
(en)
|
2007-09-10 |
2009-03-19 |
Curis, Inc. |
Vegfr inhibitors containing a zinc binding moiety
|
|
CN101883760A
(zh)
|
2007-10-11 |
2010-11-10 |
沃泰克斯药物股份有限公司 |
用作电压-门控钠通道抑制剂的杂芳基酰胺类
|
|
AU2008310661A1
(en)
|
2007-10-11 |
2009-04-16 |
Vertex Pharmaceuticals Incorporated |
Amides useful as inhibitors of voltage-gated sodium channels
|
|
CA2702101A1
(en)
|
2007-10-11 |
2009-04-16 |
Vertex Pharmaceuticals Incorporated |
Aryl amides useful as inhibitors of voltage-gated sodium channels
|
|
WO2009086012A1
(en)
|
2007-12-20 |
2009-07-09 |
Curis, Inc. |
Aurora inhibitors containing a zinc binding moiety
|
|
US20110046378A1
(en)
|
2008-02-14 |
2011-02-24 |
Siemens Medical Solutions Usa, Inc. |
Novel Imaging Agents for Detecting Neurological Dysfunction
|
|
JP5530599B2
(ja)
|
2008-02-28 |
2014-06-25 |
富士フイルム株式会社 |
フォトレジスト液、およびこれを用いるエッチング方法
|
|
WO2009114470A2
(en)
|
2008-03-10 |
2009-09-17 |
Curis, Inc. |
Tetrahydroindole and tetrahdyroindazole as hsp90 inhibitors containing a zinc binding moiety
|
|
EP2262366A4
(en)
|
2008-04-18 |
2012-02-22 |
Shenogen Pharma Group Ltd |
COMPOUNDS AND METHODS FOR TREATING STROGEN RECEPTOR-RELATED DISEASES
|
|
CA2725689A1
(en)
|
2008-06-04 |
2009-12-10 |
Astrazeneca Ab |
Thiazolo [5,4-b] pyridine and oxazolo [5,4-b] pyridine derivatives as antibacterial agents
|
|
AU2009330686B2
(en)
|
2008-06-16 |
2014-07-03 |
The Ohio State University Research Foundation |
Compounds for the treatment of cancer
|
|
US8822513B2
(en)
|
2010-03-01 |
2014-09-02 |
Gtx, Inc. |
Compounds for treatment of cancer
|
|
GB0815962D0
(en)
|
2008-09-02 |
2008-10-08 |
Merlion Pharmaceuticals Pte Ltd |
Hybrid antibacterial compounds and their use
|
|
US9326986B2
(en)
|
2008-09-29 |
2016-05-03 |
Glaxosmithkline Llc |
Quinazolinone, quinolone and related analogs as sirtuin modulators
|
|
TW201016676A
(en)
|
2008-10-03 |
2010-05-01 |
Astrazeneca Ab |
Heterocyclic derivatives and methods of use thereof
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
US8491891B2
(en)
|
2008-11-26 |
2013-07-23 |
Academia Sinica |
Human beta-glucuronidase mutants with elevated enzymatic activity under physiological conditions and method for identifying such
|
|
AU2009329169B2
(en)
|
2008-12-19 |
2012-06-28 |
Pfizer Inc. |
Monocarbams
|
|
CA2748251C
(en)
|
2008-12-26 |
2016-08-02 |
Dainippon Sumitomo Pharma Co., Ltd. |
Bicyclic heterocyclic compound for use as a sensory neuron specific sodium channel inhibitor
|
|
AU2010203512C1
(en)
|
2009-01-08 |
2013-10-17 |
Curis, Inc. |
Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
|
|
CA2760946C
(en)
|
2009-05-07 |
2019-06-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for studying, imaging, and treating pain
|
|
EP2264035A1
(en)
|
2009-06-04 |
2010-12-22 |
Merz Pharma GmbH & Co. KGaA |
Glycine B antagonists
|
|
CN101906105B
(zh)
|
2009-06-08 |
2013-01-16 |
河北医科大学 |
吡唑并[1，5-a]嘧啶酮衍生物及其药物组合物以及其用途
|
|
AR077252A1
(es)
|
2009-06-29 |
2011-08-10 |
Xenon Pharmaceuticals Inc |
Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
|
|
WO2011026240A1
(en)
|
2009-09-04 |
2011-03-10 |
Zalicus Pharmaceuticals Ltd. |
Oxopiperazine derivatives for the treatment of pain and epilepsy
|
|
US20110124597A1
(en)
|
2009-09-25 |
2011-05-26 |
Anacor Pharmaceuticals, Inc. |
Boron containing small molecules
|
|
MX2012004341A
(es)
|
2009-10-16 |
2012-10-05 |
Rib X Pharmaceuticals Inc |
Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
|
|
MX2012010115A
(es)
|
2010-03-01 |
2013-02-26 |
Gtx Inc |
Compuestos para el tratamiento de cancer.
|
|
AU2011239537A1
(en)
|
2010-04-16 |
2012-11-15 |
Curis, Inc. |
Treatment of cancers having K-ras mutations
|
|
US8598164B2
(en)
|
2010-05-06 |
2013-12-03 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
|
|
US8933075B2
(en)
|
2010-06-17 |
2015-01-13 |
Fuzians Biomedicals, Inc. |
Compounds useful as antiviral agents, compositions, and methods of use
|
|
US8889638B2
(en)
|
2010-06-22 |
2014-11-18 |
The Regents Of The University Of California |
Stimulus-triggered prodrugs
|
|
US8524740B2
(en)
|
2010-07-15 |
2013-09-03 |
Tairx, Inc. |
Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
|
|
BR112013002079B1
(pt)
|
2010-07-27 |
2021-09-14 |
Trustees Of Boston University |
Modificadores do receptor de aril hidrocarboneto (ahr) como novos terapêuticos contra o câncer
|
|
WO2012016133A2
(en)
|
2010-07-29 |
2012-02-02 |
President And Fellows Of Harvard College |
Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
|
|
GB201017315D0
(en)
|
2010-10-13 |
2010-11-24 |
Antoxis Ltd |
Compound
|
|
GB201020076D0
(en)
|
2010-11-26 |
2011-01-12 |
Liverpool School Tropical Medicine |
Antimalarial compounds
|
|
AU2011336209B2
(en)
|
2010-11-29 |
2015-03-19 |
Pfizer Inc. |
Monobactams
|
|
EP2651405A2
(en)
|
2010-12-14 |
2013-10-23 |
Electrophoretics Limited |
Casein kinase 1 (ck1 ) inhibitors
|
|
TWI574687B
(zh)
|
2011-01-03 |
2017-03-21 |
古利斯股份有限公司 |
具有鋅結合部份之刺蝟拮抗劑
|
|
MX355907B
(es)
|
2011-02-02 |
2018-05-04 |
Vertex Pharma |
Pirrolopirazina-piperidina espirociclica-amidas como moduladores de canales de ionicos.
|
|
WO2012106534A2
(en)
|
2011-02-02 |
2012-08-09 |
The Regents Of The University Of California |
Hiv integrase inhibitors
|
|
JP5940562B2
(ja)
|
2011-02-18 |
2016-06-29 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド
|
|
EP2681200A4
(en)
|
2011-03-03 |
2015-05-27 |
Zalicus Pharmaceuticals Ltd |
INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
|
|
MX347982B
(es)
|
2011-03-14 |
2017-05-22 |
Vertex Pharma |
Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.
|
|
CA2830065A1
(en)
|
2011-03-16 |
2012-09-20 |
Amgen Inc. |
Potent and selective inhibitors of nav1.3 and nav1.7
|
|
WO2012149157A2
(en)
|
2011-04-26 |
2012-11-01 |
Bioenergenix |
Heterocyclic compounds for the inhibition of pask
|
|
CA2832996C
(en)
|
2011-04-26 |
2019-05-07 |
Merck Sharp & Dohme Corp. |
Tricyclic triazole compounds and their use as aldosterone synthase inhibitors
|
|
WO2012151512A2
(en)
|
2011-05-04 |
2012-11-08 |
Constellation Pharmaceuticals, Inc. |
Bromodomain inhibitors and uses thereof
|
|
EP2524918A1
(en)
|
2011-05-19 |
2012-11-21 |
Centro Nacional de Investigaciones Oncológicas (CNIO) |
Imidazopyrazines derivates as kinase inhibitors
|
|
US20140094465A1
(en)
|
2011-06-10 |
2014-04-03 |
N30 Pharmaceuticals, Inc. |
Compounds as S-Nitrosoglutathione Reductase Inhibitors
|
|
EP2736904B1
(en)
|
2011-07-27 |
2016-03-16 |
AB Science |
Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit)
|
|
WO2013022740A2
(en)
|
2011-08-05 |
2013-02-14 |
Corning Incorporated |
Gpr35 ligands and the uses thereof
|
|
WO2013045854A1
(fr)
|
2011-09-29 |
2013-04-04 |
Ecole Normale Superieure De Lyon |
Substrat de peptidase fluorogene
|
|
WO2013049559A1
(en)
|
2011-09-30 |
2013-04-04 |
Endo Pharmaceuticals Inc. |
Pyridine derivatives
|
|
EA023375B1
(ru)
|
2011-10-26 |
2016-05-31 |
Пфайзер Лимитед |
Производные (4-фенилимидазол-2-ил)этиламина в качестве модуляторов натриевых каналов
|
|
EP2788332A1
(en)
|
2011-12-07 |
2014-10-15 |
Amgen, Inc. |
Bicyclic aryl and heteroaryl sodium channel inhibitors
|
|
CN103159738B
(zh)
|
2011-12-19 |
2016-09-07 |
上海泓博智源医药股份有限公司 |
炔基桥连的杂芳香化合物及其应用
|
|
RU2630677C2
(ru)
|
2011-12-21 |
2017-09-12 |
Оно Фармасьютикал Ко., Лтд. |
Соединения
|
|
JP6215230B2
(ja)
|
2012-01-16 |
2017-10-18 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド
|
|
WO2013114250A1
(en)
|
2012-02-03 |
2013-08-08 |
Pfizer Inc. |
Benziimidazole and imidazopyridine derivatives as sodium channel modulators
|
|
WO2013131018A1
(en)
|
2012-03-02 |
2013-09-06 |
Zalicus Pharmaceuticals Ltd. |
Biaryl inhibitors of the sodium channel
|
|
US9051311B2
(en)
|
2012-03-09 |
2015-06-09 |
Amgen Inc. |
Sulfamide sodium channel inhibitors
|
|
US20130281397A1
(en)
|
2012-04-19 |
2013-10-24 |
Rvx Therapeutics Inc. |
Treatment of diseases by epigenetic regulation
|
|
US20140005181A1
(en)
|
2012-06-21 |
2014-01-02 |
Sanford-Burnham Medical Research Institute |
Small molecule antagonists of the apelin receptor for the treatment of disease
|
|
TWI520962B
(zh)
|
2012-06-29 |
2016-02-11 |
|
As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
|
|
EP2877461B1
(en)
|
2012-07-27 |
2018-05-09 |
Emory University |
Heterocyclic flavone derivatives, compositions, and methods related thereto
|
|
FR2994180B1
(fr)
|
2012-08-02 |
2014-08-22 |
Ecole Norm Superieure Lyon |
Substrat de glycosidase fluorogene et procede de detection associe
|
|
EP2885287B1
(en)
|
2012-08-20 |
2017-09-20 |
Syngenta Participations AG |
Pesticidally active pyridyl- and pyrimidyl- substituted pyrazole derivatives
|
|
GB201215357D0
(en)
|
2012-08-29 |
2012-10-10 |
Respivert Ltd |
Compounds
|
|
WO2014066795A1
(en)
|
2012-10-25 |
2014-05-01 |
Bioenergenix |
Heterocyclic compounds for the inhibition of pask
|
|
US9284310B2
(en)
|
2012-11-03 |
2016-03-15 |
Boehringer Ingelheim International Gmbh |
Inhibitors of cytomegalovirus
|
|
US9757379B2
(en)
|
2012-11-14 |
2017-09-12 |
The Board Of Regents Of The University Of Texas System |
Inhibition of HIF-2α heterodimerization with HIF1β (ARNT)
|
|
US9416139B2
(en)
|
2012-11-29 |
2016-08-16 |
Sunshine Lake Pharma Co., Ltd. |
Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof
|
|
US9802949B2
(en)
|
2012-11-29 |
2017-10-31 |
Sunshine Lake Pharma Co., Ltd. |
Fused ring compounds as hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof
|
|
RU2015125570A
(ru)
|
2013-01-08 |
2017-02-10 |
Савира Фармасьютикалз Гмбх |
Пиридоновые производные и их применение в лечении, уменьшении интенсивности симптомов или предотвращении вирусного заболевания
|
|
AU2014212431B2
(en)
|
2013-01-31 |
2018-04-05 |
Vertex Pharmaceuticals Incorporated |
Amides as modulators of sodium channels
|
|
CN105073738B
(zh)
|
2013-01-31 |
2018-01-05 |
沃泰克斯药物股份有限公司 |
作为钠通道调节剂的喹啉及喹喔啉酰胺类
|
|
KR102295748B1
(ko)
|
2013-01-31 |
2021-09-01 |
버텍스 파마슈티칼스 인코포레이티드 |
나트륨 채널의 조절제로서의 피리돈 아미드
|
|
US9765052B2
(en)
|
2013-02-20 |
2017-09-19 |
Basf Se |
Anthranilamide compounds, their mixtures and the use thereof as pesticides
|
|
WO2014139326A1
(en)
|
2013-03-13 |
2014-09-18 |
Genentech, Inc. |
Pyrazolo compounds and uses thereof
|
|
WO2014179496A1
(en)
|
2013-04-30 |
2014-11-06 |
Afraxis Holdings, Inc. |
Serine/threonine kinase inhibitors
|
|
US20140323477A1
(en)
|
2013-04-30 |
2014-10-30 |
Genentech, Inc. |
Serine/threonine kinase inhibitors
|
|
WO2014201173A1
(en)
|
2013-06-12 |
2014-12-18 |
Amgen Inc. |
Bicyclic sulfonamide compounds as sodium channel inhibitors
|
|
ES2654393T3
(es)
|
2013-07-19 |
2018-02-13 |
Vertex Pharmaceuticals Incorporated |
Sulfonamidas como moduladores de los canales de sodio
|
|
JP6542212B2
(ja)
|
2013-07-31 |
2019-07-10 |
ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． |
ブロモドメイン阻害剤としての新規キナゾリノン
|
|
JP2016528276A
(ja)
|
2013-08-21 |
2016-09-15 |
レスバーロジックス コーポレイション |
プラーク退縮を促進するための組成物及び治療法
|
|
US9789096B2
(en)
|
2013-09-04 |
2017-10-17 |
Board Of Regents Of The University Of Texas System |
Methods and compositions for selective and targeted cancer therapy
|
|
MX2016002794A
(es)
|
2013-09-05 |
2016-09-13 |
Genentech Inc |
Compuestos antiproliferativos.
|
|
WO2015085238A1
(en)
|
2013-12-05 |
2015-06-11 |
The Regents Of The University Of California, A California Corporation |
Inhibitors of lpxc
|
|
LT3080134T
(lt)
|
2013-12-13 |
2018-11-12 |
Vertex Pharmaceuticals Incorporated |
Piridono amidų provaistai, naudotini kaip natrio kanalų moduliatoriai
|
|
CN104761524A
(zh)
|
2014-01-07 |
2015-07-08 |
清华大学 |
一种化合物及其在制备抗寄生虫病药物中的应用
|
|
CN105829298B
(zh)
|
2014-02-14 |
2019-02-01 |
四川海思科制药有限公司 |
一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用
|
|
WO2015135094A1
(en)
|
2014-03-13 |
2015-09-17 |
Genentech, Inc. |
Therapeutic compounds and uses thereof
|
|
EP3129381B1
(en)
|
2014-04-09 |
2020-11-04 |
Siteone Therapeutics Inc. |
10',11'-modified saxitoxins useful for the treatment of pain
|
|
FR3022784B1
(fr)
|
2014-06-26 |
2017-09-08 |
Ecole Normale Superieure Lyon |
Sondes moleculaires activables hydrosolubles, intermediaires pour leur synthese et procedes de detection associes
|
|
US9818959B2
(en)
|
2014-07-29 |
2017-11-14 |
Arizona Board of Regents on behlaf of Arizona State University |
Metal-assisted delayed fluorescent emitters containing tridentate ligands
|
|
JP2016079098A
(ja)
|
2014-10-10 |
2016-05-16 |
塩野義製薬株式会社 |
セフェム化合物
|
|
MX385021B
(es)
|
2014-12-10 |
2025-03-14 |
Ono Pharmaceutical Co |
Derivado de dihidroindolizinona.
|
|
HK1248687B
(en)
|
2015-03-02 |
2020-01-10 |
Amgen Inc. |
Bicyclic ketone sulfonamide compounds
|
|
CN105936635B
(zh)
|
2015-03-06 |
2019-06-21 |
南京圣和药业股份有限公司 |
作为磷脂酰肌醇3-激酶δ抑制剂的化合物及其应用
|
|
CN106008479B
(zh)
|
2015-03-06 |
2020-01-10 |
南京圣和药业股份有限公司 |
作为磷脂酰肌醇3-激酶δ抑制剂的取代嘧啶类化合物及其应用
|
|
GB201507463D0
(en)
|
2015-04-30 |
2015-06-17 |
Syngenta Participations Ag |
Herbicidal compounds
|
|
GB201507464D0
(en)
|
2015-04-30 |
2015-06-17 |
Syngenta Participations Ag |
Herbicidal compounds
|
|
WO2017017631A2
(en)
|
2015-07-28 |
2017-02-02 |
Vyome Biosciences Pvt. Ltd. |
Antibacterial therapeutics and prophylactics
|
|
US10112953B2
(en)
|
2015-09-30 |
2018-10-30 |
Siteone Therapeutics, Inc. |
11,13-modified saxitoxins for the treatment of pain
|
|
DE102015121035A1
(de)
|
2015-12-03 |
2017-06-08 |
Airbus Defence and Space GmbH |
Verfahren zur Detektion coliformer Keime
|
|
GB201522232D0
(en)
|
2015-12-16 |
2016-01-27 |
Liverpool School Tropical Medicine |
Combination product
|
|
CN106946775B
(zh)
|
2016-01-07 |
2020-04-10 |
清华大学 |
一种化合物及其在制备抗丙肝病毒药物中的应用
|
|
US10889556B2
(en)
|
2016-03-08 |
2021-01-12 |
The Regents Of The University Of California |
Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
|
|
WO2017156194A1
(en)
|
2016-03-08 |
2017-09-14 |
The Regents Of The University Of California |
Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
|
|
JP6992284B2
(ja)
|
2016-06-06 |
2022-01-13 |
小野薬品工業株式会社 |
ジヒドロインドリジノン誘導体を含有する医薬組成物
|
|
EP3260445A1
(en)
|
2016-06-24 |
2017-12-27 |
Universität Konstanz |
Compounds for use as an anti-bacterial or anti-fungal agent and as a zinc sensor
|
|
GB201612938D0
(en)
|
2016-07-26 |
2016-09-07 |
Almac Discovery Ltd |
Pharmaceutical compounds
|
|
CN107661333B
(zh)
|
2016-07-27 |
2020-12-29 |
清华大学 |
化合物在治疗肺癌中的应用
|
|
HRP20221497T1
(hr)
|
2016-08-19 |
2023-02-17 |
The University Of Bristol |
Derivati citizina za liječenje ovisnosti
|
|
CN107773562B
(zh)
|
2016-08-25 |
2020-04-07 |
清华大学 |
化合物在抗登革和寨卡病毒感染中的应用
|
|
US10975084B2
(en)
|
2016-10-12 |
2021-04-13 |
Merck Sharp & Dohme Corp. |
KDM5 inhibitors
|
|
EP3309154A1
(en)
|
2016-10-13 |
2018-04-18 |
Universite De Geneve |
New compounds and uses thereof for detection of target molecules in a sample
|
|
FR3060567B1
(fr)
|
2016-12-19 |
2019-05-24 |
Ecole Normale Superieure De Lyon |
Substrat de glycosidase fluorogene et procede de detection associe
|
|
CN106810548B
(zh)
|
2017-01-13 |
2019-02-15 |
苏州爱科百发生物医药技术有限公司 |
一种二氢异喹啉类化合物
|
|
WO2018161033A1
(en)
|
2017-03-02 |
2018-09-07 |
Wright, Adrian |
Small molecule ire1-alpha inhibitors
|
|
CN108623562A
(zh)
|
2017-03-24 |
2018-10-09 |
中国海洋大学 |
一种喹啉酮生物碱类化合物及其制备方法和应用
|
|
CN108623587A
(zh)
|
2017-03-24 |
2018-10-09 |
中国海洋大学 |
一种含羰基的胺类化合物及其制备方法和用途
|
|
CN108623588A
(zh)
|
2017-03-24 |
2018-10-09 |
中国海洋大学 |
一种含内酰胺的四环衍生物及其制备方法和应用
|
|
CA3058214A1
(en)
|
2017-03-29 |
2018-10-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
11,13-modified saxitoxins for the treatment of pain
|
|
US11279706B2
(en)
|
2017-03-29 |
2022-03-22 |
Siteone Therapeutics, Inc. |
11,13-modified saxitoxins for the treatment of pain
|
|
JP2020100564A
(ja)
|
2017-04-03 |
2020-07-02 |
京都薬品工業株式会社 |
リードスルー誘導剤およびその医薬用途
|
|
WO2018204765A1
(en)
|
2017-05-05 |
2018-11-08 |
Pairnomix, Llc |
Methods of treating epilepsy and kcnq2 related conditions
|
|
US11358977B2
(en)
|
2017-05-16 |
2022-06-14 |
Vertex Pharmaceuticals Incorporated |
Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
|
|
CN106977486B
(zh)
|
2017-05-25 |
2019-09-24 |
南方科技大学 |
一种手性二氢黄酮类化合物及其衍生物的制备方法和应用
|
|
US11542248B2
(en)
|
2017-06-08 |
2023-01-03 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with MLL proteins
|
|
SG11202000230VA
(en)
|
2017-07-11 |
2020-02-27 |
Vertex Pharma |
Carboxamides as modulators of sodium channels
|
|
WO2019018119A1
(en)
|
2017-07-18 |
2019-01-24 |
Pairnomix, Llc |
METHODS FOR TREATING EPILEPSY AND DISORDERS ASSOCIATED WITH KCNTI
|
|
CN107365326B
(zh)
|
2017-07-24 |
2019-08-20 |
湖北大学 |
一种用于检测活细胞内氟离子的荧光探针及其制备方法
|
|
US11505528B2
(en)
|
2017-08-04 |
2022-11-22 |
Axial Therapeutics, Inc. |
Inhibitors of microbially induced amyloid
|
|
EP3502095A1
(en)
|
2017-12-22 |
2019-06-26 |
Universität Konstanz |
Compound for use against pathogenic neisseria and haemophilus species and moraxella catarrhalis
|
|
CN111315744B
(zh)
|
2018-01-09 |
2023-07-14 |
四川科伦博泰生物医药股份有限公司 |
杂芳基并四氢吡啶类化合物、其制备方法、药物组合物及应用
|
|
WO2019157505A1
(en)
|
2018-02-12 |
2019-08-15 |
Vertex Pharmaceuticals Incorporated |
A method of treating pain
|
|
CN108329366A
(zh)
|
2018-03-07 |
2018-07-27 |
南京工业大学 |
一种用于检测β-半乳糖苷酶的荧光探针化合物及其制备方法
|
|
WO2019213006A1
(en)
|
2018-05-01 |
2019-11-07 |
Amgen Inc. |
Substituted pyrimidinones as agonists of the apj receptor
|
|
TWI815887B
(zh)
|
2018-05-15 |
2023-09-21 |
美商愛彼特生物製藥股份有限公司 |
經取代的2,2'-雙嘧啶基化合物、其類似物及其使用方法
|
|
WO2019236631A1
(en)
|
2018-06-05 |
2019-12-12 |
Rapt Therapeutics, Inc. |
Pyrazolo-pyrimidin-amino-cycloalkyl compounds and their therapeutic uses
|
|
WO2019238057A1
(zh)
|
2018-06-13 |
2019-12-19 |
中国科学院上海有机化学研究所 |
Fso 2n 3在制备叠氮化合物中的应用
|
|
TWI812739B
(zh)
|
2018-06-21 |
2023-08-21 |
景凱生物科技股份有限公司 |
Nadph氧化酶抑制劑、含其的醫藥組合物、及其應用
|
|
WO2020003219A1
(en)
|
2018-06-29 |
2020-01-02 |
Oat & Iil India Laboratories Private Limited |
Substituted pyrazole derivatives as insecticides and fungicides
|
|
AU2019301628C1
(en)
|
2018-07-09 |
2025-02-06 |
Lieber Institute, Inc. |
Pyridine carboxamide compounds for inhibiting NaV1.8
|
|
AU2019302534B2
(en)
|
2018-07-09 |
2024-10-03 |
Lieber Institute, Inc. |
Pyridazine compounds for inhibiting NaV1.8
|
|
KR20210066820A
(ko)
|
2018-08-27 |
2021-06-07 |
베이징 위에즈캉타이 바이오메디슨스 컴퍼니, 리미티드 |
다중-치환된 피리돈 유도체 및 이의 의학적 용도
|
|
EP3847159A2
(en)
|
2018-09-04 |
2021-07-14 |
Magenta Therapeutics, Inc. |
Aryl hydrocarbon receptor antagonists and methods of use
|
|
US12162886B2
(en)
|
2018-10-03 |
2024-12-10 |
Siteone Therapeutics, Inc. |
11,13-modified saxitoxins for the treatment of pain
|
|
CR20210281A
(es)
|
2018-10-30 |
2021-10-25 |
Repare Therapeutics Inc |
Compuestos, composiciones farmacéuticas y métodos de preparación de compuestos y de uso como inhibidores de la cinasa atr
|
|
EP3873893A1
(en)
|
2018-11-02 |
2021-09-08 |
Merck Sharp & Dohme Corp. |
2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors
|
|
WO2020092187A1
(en)
|
2018-11-02 |
2020-05-07 |
Merck Sharp & Dohme Corp. |
2-amino-n-phenyl-nicotinamides as nav1.8 inhibitors
|
|
CN111153899B
(zh)
|
2018-11-08 |
2023-12-01 |
四川科伦博泰生物医药股份有限公司 |
一种取代吡啶化合物、其制备方法和用途
|
|
CN111727186B
(zh)
|
2018-11-11 |
2022-11-08 |
上海海雁医药科技有限公司 |
双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途
|
|
ES2975968T3
(es)
|
2018-12-03 |
2024-07-18 |
Smilebiotek Zhuhai Ltd |
Galato de octilo y ésteres del mismo para uso en el tratamiento y prevención de la degeneración macular asociada a la edad causada por Bacillus Megaterium
|
|
EP3891157A4
(en)
|
2018-12-05 |
2022-08-31 |
Merck Sharp & Dohme Corp. |
4-AMINO- OR 4-ALKOXY-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATE SODIUM CHANNELS
|
|
WO2020118036A1
(en)
|
2018-12-06 |
2020-06-11 |
The Children's Medical Center Corporation |
Antibacterial compounds and uses thereof
|
|
CA3125244A1
(en)
|
2019-01-04 |
2020-07-09 |
Jiangsu Hengrui Medicine Co., Ltd. |
6-oxo-1,6-dihydropyridazine derivative, preparation method therefor and medical use thereof
|
|
WO2020146612A1
(en)
|
2019-01-10 |
2020-07-16 |
Vertex Pharmaceuticals Incorporated |
Esters and carbamates as modulators of sodium channels
|
|
US12441703B2
(en)
|
2019-01-10 |
2025-10-14 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
JP7446316B2
(ja)
|
2019-01-11 |
2024-03-08 |
グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング |
置換ピロリジンアミドｉｉｉ
|
|
TWI845600B
(zh)
|
2019-01-24 |
2024-06-21 |
美商普羅米修斯生物科學股份有限公司 |
Gpr35調節劑
|
|
CN112996774B
(zh)
|
2019-01-25 |
2022-11-22 |
江苏恒瑞医药股份有限公司 |
2-氧代-1,2-二氢吡啶类衍生物、其制备方法及其在医药上的应用
|
|
CN111848731B
(zh)
|
2019-04-19 |
2022-11-29 |
国家纳米科学中心 |
一种原位自组装的抗菌分子及其制备方法和应用
|
|
CN110498784B
(zh)
|
2019-05-20 |
2022-06-14 |
广东克冠达医药科技有限公司 |
一类川陈皮素衍生物或其药学上可接受的盐及其制备方法和应用
|
|
WO2020261114A1
(en)
|
2019-06-27 |
2020-12-30 |
Glaxosmithkline Intellectual Property Development Limited |
2,3-dihydroquinazolin compounds as nav1.8 inhibitors
|
|
CN114127075B
(zh)
|
2019-07-18 |
2024-05-14 |
百时美施贵宝公司 |
可用作IRAK4抑制剂的吡唑并[3,4-d]吡咯并[1,2-b]哒嗪基化合物
|
|
CN112300051A
(zh)
|
2019-07-31 |
2021-02-02 |
明慧医药（上海）有限公司 |
一种选择性钠通道调节剂及其制备和应用
|
|
CN112300069A
(zh)
|
2019-07-31 |
2021-02-02 |
明慧医药（上海）有限公司 |
一种选择性钠通道调节剂及其制备和应用
|
|
CN112390745B
(zh)
*
|
2019-08-19 |
2022-10-21 |
江苏恒瑞医药股份有限公司 |
吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用
|
|
WO2021032074A1
(zh)
|
2019-08-19 |
2021-02-25 |
江苏恒瑞医药股份有限公司 |
苯甲酰胺稠芳环类衍生物、其制备方法及其在医药上的应用
|
|
CN112409331B
(zh)
|
2019-08-21 |
2024-02-20 |
上海翰森生物医药科技有限公司 |
杂环类衍生物抑制剂、其制备方法和应用
|
|
CN112441969A
(zh)
|
2019-08-30 |
2021-03-05 |
明慧医药（上海）有限公司 |
一种选择性钠通道调节剂及其制备和应用
|
|
GEP20247688B
(en)
|
2019-09-12 |
2024-11-11 |
Orion Corp |
Pyridine oxynitride, preparation method therefor and use thereof
|
|
CN112812014B
(zh)
|
2019-11-15 |
2024-05-10 |
石家庄诚志永华显示材料有限公司 |
化合物、液晶组合物、液晶显示器
|
|
CN115003762A
(zh)
|
2019-11-29 |
2022-09-02 |
摩尔西德公司 |
荧光β-内酰胺酶底物及相关检测方法
|
|
CA3164134A1
(en)
|
2019-12-06 |
2021-06-10 |
Vertex Pharmaceuticals Incorporated |
Substituted tetrahydrofurans as modulators of sodium channels
|
|
JP2023507816A
(ja)
|
2019-12-20 |
2023-02-27 |
エンジン バイオサイエンシズ プライベート リミテッド |
がんを治療するための方法及び組成物
|
|
WO2021133917A1
(en)
|
2019-12-23 |
2021-07-01 |
Kymera Therapeutics, Inc. |
Smarca inhibitors and uses thereof
|
|
CN111217776A
(zh)
|
2020-01-19 |
2020-06-02 |
中国人民解放军军事科学院军事医学研究院 |
含苯并杂环结构的酰胺衍生物、组合物和应用
|
|
US20230128972A1
(en)
|
2020-01-31 |
2023-04-27 |
Atomwise Inc. |
Anat Inhibitors and Methods of Use Thereof
|
|
JP7739051B2
(ja)
|
2020-06-10 |
2025-09-16 |
アムジエン・インコーポレーテツド |
シクロブチルジヒドロキノリンスルホンアミド化合物
|
|
JP2021195367A
(ja)
|
2020-06-10 |
2021-12-27 |
アムジエン・インコーポレーテツド |
シクロプロピルジヒドロキノリンスルホンアミド化合物
|
|
MX2022015857A
(es)
|
2020-06-10 |
2023-01-24 |
Amgen Inc |
Compuestos de dihidroquinolin sulfonamida de heteroalquilo.
|
|
JP2023530319A
(ja)
|
2020-06-17 |
2023-07-14 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Ｎａｖ１．８阻害剤としての２－オキソ－オキサゾリジン－５－カルボキサミド
|
|
GEP20257750B
(en)
|
2020-06-17 |
2025-03-25 |
Merck Sharp & Dohme Llc |
2-oxoimidazolidine-4-carboxamides as nav1.8 inhibitors
|
|
BR112022024476A2
(pt)
|
2020-06-17 |
2022-12-27 |
Merck Sharp & Dohme Llc |
5-oxopirrolidino-3-carboxamidas como inibidores de nav1.8
|
|
JP2023537632A
(ja)
|
2020-08-14 |
2023-09-04 |
サイトワン セラピューティクス インコーポレイテッド |
疼痛の処置のためのＮａＶ１．７の非水和ケトン阻害剤
|
|
CN111808019B
(zh)
|
2020-09-08 |
2020-11-27 |
上海济煜医药科技有限公司 |
一种并环化合物及其应用
|
|
CN112047880B
(zh)
|
2020-10-15 |
2022-11-01 |
天津科技大学 |
一类氮杂黄酮衍生物及其作为抗肿瘤药物的应用
|
|
WO2022121805A1
(zh)
|
2020-12-07 |
2022-06-16 |
成都康弘药业集团股份有限公司 |
作为Nav1.8抑制剂的并环化合物及其用途
|
|
CN112225695B
(zh)
|
2020-12-15 |
2021-03-02 |
上海济煜医药科技有限公司 |
一种氮氧化合物及其制备方法和用途
|
|
CN112778288B
(zh)
|
2021-01-22 |
2022-08-09 |
湖南大学 |
一种近红外固态发光的荧光探针及其制备方法与应用
|
|
CN112457294B
(zh)
|
2021-01-27 |
2021-06-04 |
上海济煜医药科技有限公司 |
一种作为NaV1.8阻滞剂的化合物及其制备方法和用途
|
|
EP4334293A1
(en)
|
2021-05-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Cycloalkyl 3-oxopiperazine carboxamides and cycloheteroalkyl 3-oxopiperazine carboxamides as nav1.8 inhibitors
|
|
MX2023013147A
(es)
|
2021-05-07 |
2023-11-28 |
Merck Sharp & Dohme Llc |
Aril 3-oxopiperazin carboxamidas y heteroaril 3-oxopiperazin carboxamidas como inhibidores de nav1.8.
|
|
CN113200926B
(zh)
|
2021-05-10 |
2022-09-23 |
四川大学 |
一种修饰2-芳基喹唑啉-4(3h)-酮类化合物的方法
|
|
JP2024520646A
(ja)
|
2021-06-04 |
2024-05-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体
|
|
CA3221788A1
(en)
|
2021-06-04 |
2022-12-08 |
Vertex Pharmaceuticals Incorporated |
Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
|
|
SI4347031T1
(sl)
|
2021-06-04 |
2026-01-30 |
Vertex Pharmaceuticals Incorporated |
N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
|
|
MA64856B1
(fr)
|
2021-06-04 |
2026-02-27 |
Vertex Pharmaceuticals Incorporated |
Formes de dosage solides et regimens de dosage comprenant le [[3-(3,4-difluoro-2-méthoxy-phényl)-4,5-diméthyl-5-(trifluorométhyl) tétrahydrofuranne-2-carbonyl]amino]pyridine-2-carboxamide
|
|
JP2024520643A
(ja)
|
2021-06-04 |
2024-05-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ナトリウムチャネルの調節因子としてのヒドロキシ及び（ハロ）アルコキシ置換テトラヒドロフラン
|
|
TW202317520A
(zh)
|
2021-06-15 |
2023-05-01 |
德商歌林達有限公司 |
經取代之吡唑醯胺
|
|
CN113754594B
(zh)
|
2021-09-16 |
2025-01-21 |
中国药科大学 |
喹唑啉酮类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途
|
|
UY40234A
(es)
|
2022-04-22 |
2023-11-15 |
Vertex Pharma |
Compuestos heteroarilo para el tratamiento del dolor
|
|
GEAP202516634A
(en)
*
|
2022-04-22 |
2025-02-25 |
Vertex Pharma |
Heteroaryl compounds for the treatment of pain
|