YU51701A - Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata - Google Patents

Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata

Info

Publication number
YU51701A
YU51701A YU51701A YUP51701A YU51701A YU 51701 A YU51701 A YU 51701A YU 51701 A YU51701 A YU 51701A YU P51701 A YUP51701 A YU P51701A YU 51701 A YU51701 A YU 51701A
Authority
YU
Yugoslavia
Prior art keywords
compounds
pyrazolo
pyrimidin
intermediates
preparation
Prior art date
Application number
YU51701A
Other languages
English (en)
Inventor
Charlotte Moira N. Allerton
Christopher Gordon Barber
Keith Michael Devries
Laurence James Harris
Philip Charles Levett
Joanna Teresa Negri
David James Rawson
Albert Shaw Wood
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018660A external-priority patent/GB0018660D0/en
Priority claimed from GB0107526A external-priority patent/GB0107526D0/en
Priority claimed from GB0110251A external-priority patent/GB0110251D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU51701A publication Critical patent/YU51701A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Daje se postupak za dobijanje jedinjenja formule (I), koji se sastoji u reagovanju jedinjenja formule (II), (III), (IV) ili (V), u prisustvu -OR3 i sredstva za hvatanje hidroksida, ili u slučaju jedinjenja formule (IV), reagovanju u prisustvu pomoćne baze i sredstva za hvatanje hidroksida (tj. -OR-3 je zamenjen pomoćnom bazom), gde X predstavlja odlazeću grupu, a R1 do R4 su ranije definisani.[The procedure is given for the obtaining of formula (I), that consists in the reaction of compounds of formula (II), (III), (IV) or (V), in the presence of - OR3 and means for capture of hydroxide, or in the case of compounds of the formula (IV), in the reaction in the presence of auxilliary base and means for the capture of hydroxides (i.e. -OR3 has been replaced with auxilliary base), where x represents the exit group, and R1 to R4 have been previously defined.
YU51701A 2000-07-28 2001-07-17 Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata YU51701A (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018660A GB0018660D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
GB0107526A GB0107526D0 (en) 2001-03-26 2001-03-26 Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
GB0110251A GB0110251D0 (en) 2001-04-26 2001-04-26 Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
YU51701A true YU51701A (sh) 2003-12-31

Family

ID=27255823

Family Applications (1)

Application Number Title Priority Date Filing Date
YU51701A YU51701A (sh) 2000-07-28 2001-07-17 Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata

Country Status (17)

Country Link
EP (1) EP1176147A1 (sh)
JP (1) JP2002105076A (sh)
KR (1) KR20020010102A (sh)
CN (1) CN1335317A (sh)
AR (1) AR035650A1 (sh)
AU (1) AU754962B2 (sh)
BR (1) BR0103072A (sh)
CA (1) CA2354175A1 (sh)
CZ (1) CZ20012713A3 (sh)
HK (1) HK1040715A1 (sh)
HU (1) HUP0103075A3 (sh)
IL (1) IL144516A0 (sh)
IN (1) IN191315B (sh)
MX (1) MXPA01007676A (sh)
PL (1) PL348935A1 (sh)
RU (1) RU2224759C2 (sh)
YU (1) YU51701A (sh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
OA13050A (en) 2003-04-29 2006-11-10 Pfizer Ltd 5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1742950B1 (en) 2004-04-07 2008-12-17 Pfizer Limited Pyrazolo[4,3-d] pyrimidines
CN101309903B (zh) * 2005-11-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 制备thoc的新方法
CA2645893A1 (en) * 2006-03-17 2007-09-27 Cipla Limited Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-tr1azol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
BRPI0814294A2 (pt) 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.
WO2011041154A1 (en) 2009-10-01 2011-04-07 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
CN109674753A (zh) 2010-06-23 2019-04-26 希玛贝治疗股份有限公司 固态分散体
CA3032432A1 (en) 2016-08-03 2018-02-08 Charles A. Mcwherter Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2089971A (en) * 1937-08-17 Condensation products of
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds

Also Published As

Publication number Publication date
IN191315B (sh) 2003-11-22
CZ20012713A3 (cs) 2002-04-17
HU0103075D0 (en) 2001-10-28
AR035650A1 (es) 2004-06-23
AU754962B2 (en) 2002-11-28
CN1335317A (zh) 2002-02-13
PL348935A1 (en) 2002-02-11
HK1040715A1 (zh) 2002-06-21
JP2002105076A (ja) 2002-04-10
RU2224759C2 (ru) 2004-02-27
CA2354175A1 (en) 2002-01-28
EP1176147A1 (en) 2002-01-30
IL144516A0 (en) 2002-05-23
AU5767201A (en) 2002-01-31
HUP0103075A2 (hu) 2002-07-29
MXPA01007676A (es) 2002-10-23
BR0103072A (pt) 2002-04-09
KR20020010102A (ko) 2002-02-02
HUP0103075A3 (en) 2003-04-28

Similar Documents

Publication Publication Date Title
YU51701A (sh) Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
GR3018947T3 (en) 2-Thienylglycidic acid derivative, process for its preparation and its use as synthetic intermediate
GEP20053541B (en) Pyrrolo[2,3-d]Pyrimidine Compounds
MX9704433A (es) Procedimiento para la preparacion de sildenafil.
MX336939B (es) Novedosos compuestos de triazolo pirimidina.
YU48999A (sh) Postupak za dobijanje pirazolo(4,3-d)pirimidin-7-ona i njihovih intermedijera
GR3007391T3 (sh)
YU59100A (sh) Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera
TW238304B (en) A process for the preparation of 1-substituted-5(4H)-tetrazolinones
GB9807114D0 (en) Novel process
SI1172364T1 (en) A process for the preparation of 2-phenyl-imidazo(1,2-A)pyridine-3-acetamides
AU3259997A (en) Ring-fused dihydropyranes, process for the preparation and use thereof
IL138638A0 (en) Processes for preparing intermediates
GB2425309A (en) C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers
GB9920959D0 (en) Novel process
IL154165A0 (en) Method for the production of imidazo-(1,2-c) (2,3)-benzodiazepines and intermediates in the production thereof
MXPA03002363A (es) Delta-1-pirrolinas.
YU125083A (en) Process for obtaining pyrido (1,4)benzodiazepine
HK1079198A1 (en) Nobel process for the preparation of pyrazolopyrimidiones
IL141010A (en) Method for producing atropic acid ethyl ester
BG103737A (en) Method for the preparation of derivatives of 4h-4-oxo-quinolysine-3-carboxylic acid
IL147767A0 (en) Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds
JPS52153915A (en) Preparation of alpha-amino-delta-hydroxyvaleric acid
AP2000001960A0 (en) Process for the preparation of pyrazole(4,3-d)pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof.
MXPA04004708A (es) Proceso para preparacion de 2- o 9-oxa-3,7-diazabiciclo (3.3.1)nonanos a partir de 2-aminometil-2,3-dihidrooxazinas, compuestos intermedios para los mismos y proceso para preparar tales compuestos intermedios.