JP2021105013A5 - - Google Patents
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- JP2021105013A5 JP2021105013A5 JP2021054203A JP2021054203A JP2021105013A5 JP 2021105013 A5 JP2021105013 A5 JP 2021105013A5 JP 2021054203 A JP2021054203 A JP 2021054203A JP 2021054203 A JP2021054203 A JP 2021054203A JP 2021105013 A5 JP2021105013 A5 JP 2021105013A5
- Authority
- JP
- Japan
- Prior art keywords
- benzo
- ethyl
- methyl
- pyrazole
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- -1 1H-benzo [d] imidazole-1-yl Chemical group 0.000 claims 12
- BAPVOVWXTHCGHX-UHFFFAOYSA-N 2-ethyl-5-methylpyrazole-3-carboxamide Chemical compound CCN1N=C(C)C=C1C(N)=O BAPVOVWXTHCGHX-UHFFFAOYSA-N 0.000 claims 11
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 9
- MHZDONKZSXBOGL-UHFFFAOYSA-N propyl dihydrogen phosphate Chemical compound CCCOP(O)(O)=O MHZDONKZSXBOGL-UHFFFAOYSA-N 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 5
- ZBNZAJFNDPPMDT-UHFFFAOYSA-N 1h-imidazole-5-carboxamide Chemical compound NC(=O)C1=CNC=N1 ZBNZAJFNDPPMDT-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000003857 carboxamides Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- FSWUGFSHWYDKTO-UHFFFAOYSA-N 1-ethyl-3-methylpyrazole Chemical compound CCN1C=CC(C)=N1 FSWUGFSHWYDKTO-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
- NWLOFUCMYZWTOK-CMDGGOBGSA-N CC[n]1nc(C)cc1C(Nc1nc2cc(C(N)=O)cc(OC)c2[n]1C/C=C/C[n]1c(NC(c2cc(C)n[n]2CC)=O)nc2cc(C(N)=O)cc(OCCCO)c12)=O Chemical compound CC[n]1nc(C)cc1C(Nc1nc2cc(C(N)=O)cc(OC)c2[n]1C/C=C/C[n]1c(NC(c2cc(C)n[n]2CC)=O)nc2cc(C(N)=O)cc(OCCCO)c12)=O NWLOFUCMYZWTOK-CMDGGOBGSA-N 0.000 description 4
- CRCBFMQMRSVNEU-CMDGGOBGSA-N CC[n]1nc(C)cc1C(Nc1nc2cc(C(N)=O)cc(OC)c2[n]1C/C=C/C[n]1c(NC(c2cc(C)n[n]2CC)=O)nc2cc(C(N)=O)cc(OCCCOP(O)(O)=O)c12)=O Chemical compound CC[n]1nc(C)cc1C(Nc1nc2cc(C(N)=O)cc(OC)c2[n]1C/C=C/C[n]1c(NC(c2cc(C)n[n]2CC)=O)nc2cc(C(N)=O)cc(OCCCOP(O)(O)=O)c12)=O CRCBFMQMRSVNEU-CMDGGOBGSA-N 0.000 description 2
- FOMDHVGKQFWUIC-MDZDMXLPSA-N CC[n]1nc(C)cc1C(/N=C(\Nc1cc(C(N)=O)c2)/N(C/C=C/CN(c(c(N3)cc(C(NC)=O)c4)c4OCCCOC(C(O)O)=O)/C3=N/C(c3cc(C)n[n]3CC)=O)c1c2OC)=O Chemical compound CC[n]1nc(C)cc1C(/N=C(\Nc1cc(C(N)=O)c2)/N(C/C=C/CN(c(c(N3)cc(C(NC)=O)c4)c4OCCCOC(C(O)O)=O)/C3=N/C(c3cc(C)n[n]3CC)=O)c1c2OC)=O FOMDHVGKQFWUIC-MDZDMXLPSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022122895A JP7466596B2 (ja) | 2016-04-07 | 2022-08-01 | タンパク質調節因子として有用な複素環式アミド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319358P | 2016-04-07 | 2016-04-07 | |
| US62/319,358 | 2016-04-07 | ||
| US201762461301P | 2017-02-21 | 2017-02-21 | |
| US62/461,301 | 2017-02-21 | ||
| US201762461975P | 2017-02-22 | 2017-02-22 | |
| US62/461,975 | 2017-02-22 | ||
| JP2020030908A JP6861307B2 (ja) | 2016-04-07 | 2020-02-26 | タンパク質調節因子として有用な複素環式アミド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020030908A Division JP6861307B2 (ja) | 2016-04-07 | 2020-02-26 | タンパク質調節因子として有用な複素環式アミド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122895A Division JP7466596B2 (ja) | 2016-04-07 | 2022-08-01 | タンパク質調節因子として有用な複素環式アミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021105013A JP2021105013A (ja) | 2021-07-26 |
| JP2021105013A5 true JP2021105013A5 (enExample) | 2021-09-16 |
| JP7119158B2 JP7119158B2 (ja) | 2022-08-16 |
Family
ID=58503675
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552758A Active JP6746712B2 (ja) | 2016-04-07 | 2017-04-05 | タンパク質調節因子として有用な複素環式アミド |
| JP2020030908A Active JP6861307B2 (ja) | 2016-04-07 | 2020-02-26 | タンパク質調節因子として有用な複素環式アミド |
| JP2021054203A Active JP7119158B2 (ja) | 2016-04-07 | 2021-03-26 | タンパク質調節因子として有用な複素環式アミド |
| JP2022122895A Active JP7466596B2 (ja) | 2016-04-07 | 2022-08-01 | タンパク質調節因子として有用な複素環式アミド |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552758A Active JP6746712B2 (ja) | 2016-04-07 | 2017-04-05 | タンパク質調節因子として有用な複素環式アミド |
| JP2020030908A Active JP6861307B2 (ja) | 2016-04-07 | 2020-02-26 | タンパク質調節因子として有用な複素環式アミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122895A Active JP7466596B2 (ja) | 2016-04-07 | 2022-08-01 | タンパク質調節因子として有用な複素環式アミド |
Country Status (33)
Families Citing this family (124)
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| JP6411676B2 (ja) | 2015-12-03 | 2018-10-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド |
| ES2921855T3 (es) | 2016-04-07 | 2022-09-01 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas útiles como moduladores de proteínas |
| RU2018137389A (ru) | 2016-04-07 | 2020-05-12 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Гетероциклические амиды, полезные в качестве модуляторов |
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