EP2844756A4 - Modulating immune responses - Google Patents
Modulating immune responsesInfo
- Publication number
- EP2844756A4 EP2844756A4 EP13784572.3A EP13784572A EP2844756A4 EP 2844756 A4 EP2844756 A4 EP 2844756A4 EP 13784572 A EP13784572 A EP 13784572A EP 2844756 A4 EP2844756 A4 EP 2844756A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- immune responses
- modulating immune
- modulating
- responses
- immune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/460,408 US20130039933A1 (en) | 2008-08-04 | 2012-04-30 | Sting (stimulator of interferon genes), a regulator of innate immune responses |
PCT/US2013/038840 WO2013166000A1 (en) | 2012-04-30 | 2013-04-30 | Modulating immune responses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2844756A1 EP2844756A1 (en) | 2015-03-11 |
EP2844756A4 true EP2844756A4 (en) | 2016-02-24 |
Family
ID=49514802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13784572.3A Ceased EP2844756A4 (en) | 2012-04-30 | 2013-04-30 | Modulating immune responses |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2844756A4 (en) |
JP (1) | JP2015516989A (en) |
KR (1) | KR20150004416A (en) |
CN (1) | CN104540945A (en) |
AU (1) | AU2013256468A1 (en) |
CA (1) | CA2907616A1 (en) |
WO (1) | WO2013166000A1 (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201610251PA (en) | 2012-06-08 | 2017-01-27 | Aduro Biotech | Compositions and methods for cancer immunotherapy |
SG10201704611WA (en) | 2012-12-13 | 2017-07-28 | Aduro Biotech Inc | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
RU2015129030A (en) | 2012-12-19 | 2017-01-26 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | PHARMACEUTICAL DIRECTED IMPACT ON THE WAY OF TRANSMISSION OF THE SIGNAL OF CYCLIC MAMMAL DYNUCLEOTIDES |
BR112015027327B1 (en) | 2013-04-29 | 2022-08-02 | Rutgers, The State University Of New Jersey | COMPOUND, CGA MODULATOR, PHARMACEUTICAL COMPOSITION INCLUDING SUCH COMPOUND OR MODULATOR |
CN105377867B (en) | 2013-05-03 | 2019-11-12 | 加利福尼亚大学董事会 | The cyclic annular dinucleotides of I type interferon induces |
AU2014268836B2 (en) | 2013-05-18 | 2018-08-02 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
WO2015017652A1 (en) | 2013-07-31 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Sting crystals and modulators |
KR20170015353A (en) | 2014-06-04 | 2017-02-08 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Cyclic di-nucleotides as modulators of sting |
GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
MY190404A (en) | 2015-03-10 | 2022-04-21 | Aduro Biotech Inc | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling |
MX363780B (en) | 2015-12-03 | 2019-04-03 | Glaxosmithkline Ip Dev Ltd | Cyclic purine dinucleotides as modulators of sting. |
CN106540260A (en) * | 2015-12-09 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | Interferon gene stimulatory protein(SP)(STING)Application of the agonist in anti-alzheimer's disease |
HRP20221263T1 (en) | 2016-03-18 | 2023-03-03 | Immune Sensor, Llc | Cyclic di-nucleotide compounds and methods of use |
CN106539757A (en) * | 2016-03-20 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | Application of the ring dinucleotide cGAMP- liposomees in antitumor |
EP3440072B1 (en) | 2016-04-07 | 2020-01-29 | GlaxoSmithKline Intellectual Property Development Ltd | Heterocyclic amides useful as protein modulators |
US10981901B1 (en) | 2016-04-07 | 2021-04-20 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
KR20190110612A (en) | 2017-02-01 | 2019-09-30 | 모더나티엑스, 인크. | Immunomodulatory Therapeutic MRNA Compositions Encoding Activating Oncogene Mutant Peptides |
CN106667914B (en) * | 2017-03-13 | 2022-02-01 | 杭州星鳌生物科技有限公司 | Composition of targeted liposome-cyclic dinucleotide, preparation method and application of targeted liposome-cyclic dinucleotide in resisting tumors |
TW201927771A (en) | 2017-10-05 | 2019-07-16 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | Heterocyclic amides useful as protein modulators and methods of using the same |
JP7291130B2 (en) | 2017-10-05 | 2023-06-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | A modulator of the stimulator of the interferon gene (STING) |
JP7262451B2 (en) | 2017-10-05 | 2023-04-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Administration method of STING agonist |
GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
WO2020006432A1 (en) | 2018-06-28 | 2020-01-02 | Eternity Bioscience Inc. | Fused tricyclic heterocycle compounds and therapeutic uses thereof |
TW202104214A (en) | 2019-04-05 | 2021-02-01 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | Chemical compounds |
GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
US11897888B1 (en) | 2020-04-30 | 2024-02-13 | Stinginn Llc | Small molecular inhibitors of sting signaling compositions and methods of use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110262485A1 (en) * | 2008-08-04 | 2011-10-27 | University Of Miami | Sting (stimulator of interferon genes), a regulator of innate immune responses |
-
2013
- 2013-04-30 EP EP13784572.3A patent/EP2844756A4/en not_active Ceased
- 2013-04-30 CA CA2907616A patent/CA2907616A1/en not_active Abandoned
- 2013-04-30 KR KR20147033632A patent/KR20150004416A/en not_active Application Discontinuation
- 2013-04-30 CN CN201380029115.7A patent/CN104540945A/en active Pending
- 2013-04-30 JP JP2015510379A patent/JP2015516989A/en active Pending
- 2013-04-30 WO PCT/US2013/038840 patent/WO2013166000A1/en active Application Filing
- 2013-04-30 AU AU2013256468A patent/AU2013256468A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110262485A1 (en) * | 2008-08-04 | 2011-10-27 | University Of Miami | Sting (stimulator of interferon genes), a regulator of innate immune responses |
Non-Patent Citations (3)
Title |
---|
ABE TAKAYUKI ET AL: "STING Recognition of Cytoplasmic DNA Instigates Cellular Defense", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 50, no. 1, 7 March 2013 (2013-03-07), pages 5 - 15, XP028547914, ISSN: 1097-2765, DOI: 10.1016/J.MOLCEL.2013.01.039 * |
MARCO PRINZ ET AL: "Type I Interferons as Ambiguous Modulators of Chronic Inflammation in the Central Nervous System", FRONTIERS IN IMMUNOLOGY, vol. 3, 1 January 2012 (2012-01-01), XP055211634, DOI: 10.3389/fimmu.2012.00067 * |
See also references of WO2013166000A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2015516989A (en) | 2015-06-18 |
KR20150004416A (en) | 2015-01-12 |
CN104540945A (en) | 2015-04-22 |
EP2844756A1 (en) | 2015-03-11 |
AU2013256468A1 (en) | 2014-12-04 |
CA2907616A1 (en) | 2013-11-07 |
WO2013166000A1 (en) | 2013-11-07 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/11 20060101AFI20150914BHEP Ipc: A61K 31/711 20060101ALI20150914BHEP Ipc: A61P 35/00 20060101ALI20150914BHEP Ipc: A61K 31/713 20060101ALI20150914BHEP |
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RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20160126 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20160120BHEP Ipc: A61K 31/711 20060101ALI20160120BHEP Ipc: C12N 15/11 20060101AFI20160120BHEP Ipc: A61K 31/713 20060101ALI20160120BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
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17Q | First examination report despatched |
Effective date: 20170131 |
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REG | Reference to a national code |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
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18R | Application refused |
Effective date: 20180625 |