JP2020523326A - 細菌株を含む組成物 - Google Patents

細菌株を含む組成物 Download PDF

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Publication number
JP2020523326A
JP2020523326A JP2019568002A JP2019568002A JP2020523326A JP 2020523326 A JP2020523326 A JP 2020523326A JP 2019568002 A JP2019568002 A JP 2019568002A JP 2019568002 A JP2019568002 A JP 2019568002A JP 2020523326 A JP2020523326 A JP 2020523326A
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JP
Japan
Prior art keywords
composition
compositions
strain
acid
disease
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Pending
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JP2019568002A
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English (en)
Japanese (ja)
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JP2020523326A5 (enExample
Inventor
イムケ エリザベス ムルダー
イムケ エリザベス ムルダー
アンナ エトール
アンナ エトール
スアード アーメッド
スアード アーメッド
パルセナ フォティアドウ
パルセナ フォティアドウ
サマンサ ユイール
サマンサ ユイール
ジョセフ ロビー イリンガン ウルシア
ジョセフ ロビー イリンガン ウルシア
ヘレン サヴィニャック
ヘレン サヴィニャック
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4D Pharma Research Ltd
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4D Pharma Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1709468.1A external-priority patent/GB201709468D0/en
Priority claimed from GBGB1709534.0A external-priority patent/GB201709534D0/en
Priority claimed from GBGB1712851.3A external-priority patent/GB201712851D0/en
Priority claimed from GBGB1803826.5A external-priority patent/GB201803826D0/en
Priority claimed from GBGB1805989.9A external-priority patent/GB201805989D0/en
Priority claimed from GBGB1805991.5A external-priority patent/GB201805991D0/en
Priority claimed from GBGB1805990.7A external-priority patent/GB201805990D0/en
Priority claimed from GBGB1806779.3A external-priority patent/GB201806779D0/en
Priority claimed from GBGB1806780.1A external-priority patent/GB201806780D0/en
Application filed by 4D Pharma Research Ltd filed Critical 4D Pharma Research Ltd
Publication of JP2020523326A publication Critical patent/JP2020523326A/ja
Publication of JP2020523326A5 publication Critical patent/JP2020523326A5/ja
Priority to JP2022063189A priority Critical patent/JP2022088641A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0208—Specific bacteria not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019568002A 2017-06-14 2018-06-14 細菌株を含む組成物 Pending JP2020523326A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022063189A JP2022088641A (ja) 2017-06-14 2022-04-06 細菌株を含む組成物

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GBGB1709468.1A GB201709468D0 (en) 2017-06-14 2017-06-14 Compositions comprising bacterial strains
GB1709468.1 2017-06-14
GB1709534.0 2017-06-15
GBGB1709534.0A GB201709534D0 (en) 2017-06-15 2017-06-15 Compositions comprising bacterial strains
GB1712851.3 2017-08-10
GBGB1712851.3A GB201712851D0 (en) 2017-08-10 2017-08-10 Compositions comprising bacterial strains
GB1803826.5 2018-03-09
GBGB1803826.5A GB201803826D0 (en) 2018-03-09 2018-03-09 Compositions comprising bacterial strains
GBGB1805991.5A GB201805991D0 (en) 2018-04-11 2018-04-11 Compositions comprising bacterial strains
GBGB1805989.9A GB201805989D0 (en) 2018-04-11 2018-04-11 Compositions comprising bacterial strains
GBGB1805990.7A GB201805990D0 (en) 2018-04-11 2018-04-11 Compostions comprising bacterial strains
GB1805990.7 2018-04-11
GB1805991.5 2018-04-11
GB1805989.9 2018-04-11
GBGB1806779.3A GB201806779D0 (en) 2018-04-25 2018-04-25 Compositions comprising bacterial strains
GB1806780.1 2018-04-25
GBGB1806780.1A GB201806780D0 (en) 2018-04-25 2018-04-25 Compositions comprising bacterial strains
GB1806779.3 2018-04-25
PCT/EP2018/065903 WO2018229236A2 (en) 2017-06-14 2018-06-14 Compositions comprising bacterial strains

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022063189A Division JP2022088641A (ja) 2017-06-14 2022-04-06 細菌株を含む組成物

Publications (2)

Publication Number Publication Date
JP2020523326A true JP2020523326A (ja) 2020-08-06
JP2020523326A5 JP2020523326A5 (enExample) 2021-08-19

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019568002A Pending JP2020523326A (ja) 2017-06-14 2018-06-14 細菌株を含む組成物
JP2019567545A Active JP6837581B2 (ja) 2017-06-14 2018-06-14 Ｍｅｇａｓｐｈａｅｒａ属の細菌株を含む組成物及びその使用
JP2021018974A Pending JP2021075556A (ja) 2017-06-14 2021-02-09 Ｍｅｇａｓｐｈａｅｒａ属の細菌株を含む組成物及びその使用
JP2022063189A Pending JP2022088641A (ja) 2017-06-14 2022-04-06 細菌株を含む組成物

Family Applications After (3)

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JP2019567545A Active JP6837581B2 (ja) 2017-06-14 2018-06-14 Ｍｅｇａｓｐｈａｅｒａ属の細菌株を含む組成物及びその使用
JP2021018974A Pending JP2021075556A (ja) 2017-06-14 2021-02-09 Ｍｅｇａｓｐｈａｅｒａ属の細菌株を含む組成物及びその使用
JP2022063189A Pending JP2022088641A (ja) 2017-06-14 2022-04-06 細菌株を含む組成物

Country Status (26)

Country Link
US (3) US11007233B2 (enExample)
EP (4) EP3638273A2 (enExample)
JP (4) JP2020523326A (enExample)
KR (2) KR102519483B1 (enExample)
CN (2) CN111032061A (enExample)
AU (4) AU2018285453B2 (enExample)
BR (2) BR112019026677A2 (enExample)
CA (3) CA3066561C (enExample)
CY (2) CY1123565T1 (enExample)
DK (2) DK3804737T3 (enExample)
ES (2) ES2917415T3 (enExample)
HR (2) HRP20220747T1 (enExample)
HU (2) HUE052258T2 (enExample)
IL (3) IL292373A (enExample)
LT (2) LT3804737T (enExample)
MA (3) MA49425A (enExample)
MD (2) MD3804737T2 (enExample)
MX (2) MX383130B (enExample)
PL (2) PL3804737T3 (enExample)
PT (2) PT3600364T (enExample)
RS (2) RS60910B1 (enExample)
SG (2) SG11201912153VA (enExample)
SI (2) SI3600364T1 (enExample)
SM (2) SMT202200272T1 (enExample)
TW (2) TWI812624B (enExample)
WO (2) WO2018229236A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022053525A (ja) * 2020-09-24 2022-04-05 森下仁丹株式会社 乳酸産生菌叢の保持剤ならびにそれを用いた経口組成物および乳酸産生菌叢の保持方法
JP2024507187A (ja) * 2021-02-10 2024-02-16 中科微智（北京）生物科技有限公司 ビフィドバクテリウム・ラクティス及びその使用

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JP2020523326A (ja) 2017-06-14 2020-08-06 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ 細菌株を含む組成物
LT3743086T (lt) * 2018-05-11 2022-06-10 4D Pharma Research Limited Kompozicijos, apimančios bakterinius kamienus
EP3870154A4 (en) 2018-10-22 2022-07-27 Research Institute at Nationwide Children's Hospital COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ANTIBIOTIC-INDUCED PATHOLOGIES USING PROBIOTICS IN BIOFILM STATE
WO2020120714A1 (en) * 2018-12-12 2020-06-18 4D Pharma Research Limited Compositions comprising bacterial strains
KR102978329B1 (ko) * 2019-06-03 2026-06-17 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 패혈증 및 괴사성 장염 유도된 신경발달 결핍의 예방을 위한 프리바이오틱 제형
EP4066844A1 (en) 2019-07-05 2022-10-05 4D Pharma Research Limited Compositions comprising anaerostipes hadrus
CN110420228A (zh) * 2019-09-16 2019-11-08 山东大学齐鲁医院 脆弱拟杆菌ych46在制备治疗或辅助治疗高血压的药物中的应用
AU2020355194B2 (en) * 2019-09-25 2026-06-18 Julius-Maximilians-Universität Würzburg Short-chain fatty acid pentanoate as enhancer for cellular therapy and anti-tumor therapy
AU2021342481A1 (en) 2020-09-18 2023-05-04 Evelo Biosciences, Inc. Solid dosage forms of bacteria
CN112239741B (zh) * 2020-12-10 2022-05-27 慕恩（广州）生物科技有限公司 一种Megasphaera属的细菌MNC-992及其培养方法和应用
JP2024501481A (ja) 2020-12-14 2024-01-12 エヴェロ バイオサイエンシズ，インコーポレーテッド 細胞外小胞調製物
WO2022187578A1 (en) 2021-03-05 2022-09-09 Evelo Biosciences, Inc. Solid dosage forms
TW202304415A (zh) 2021-04-08 2023-02-01 美商艾弗洛生物科技股份有限公司 含有細菌的藥物製劑
IL308253A (en) * 2021-05-12 2024-01-01 Biomica Ltd A microbial consortium and its uses
WO2023049268A1 (en) 2021-09-24 2023-03-30 Evelo Biosciences, Inc. Solid dosage forms containing bacteria and microbial extracellular vesicles
CA3237172A1 (en) * 2021-11-02 2023-05-11 Mach32 Inc. Devices, systems and methods for medicament delivery
CN114276948B (zh) * 2021-11-08 2023-06-20 泸州老窖股份有限公司 产己酸的赖氨酸芽孢杆菌及其用途
WO2023107537A1 (en) 2021-12-07 2023-06-15 Evelo Biosciences, Inc. Antibody compositions and methods for utilizing with extracellular vesicles and microbes
WO2023114293A1 (en) 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Extracellular vesicle assays
CN116731894B (zh) * 2021-12-31 2025-05-20 深圳未知君生物科技有限公司 一种巨球形菌菌株及其应用
WO2024015522A1 (en) 2022-07-13 2024-01-18 Evelo Biosciences, Inc. Methods for analyzing extracellular vesicles and microbes
WO2024076723A1 (en) 2022-10-07 2024-04-11 Evelo Biosciences, Inc. Processing extracellular vesicles
WO2024102226A1 (en) 2022-10-14 2024-05-16 Evelo Biosciences, Inc. Methods for assaying drug substances and drug products by using cell lines with nf-kb- inducible reporter genes
WO2024229110A1 (en) * 2023-05-01 2024-11-07 The Johns Hopkins University Indole lactate for the treatment of multiple sclerosis
CN117821621B (zh) * 2023-12-15 2024-08-13 深圳未知君生物科技有限公司 一种马氏巨球菌的分子标记及其应用
WO2025264544A1 (en) * 2024-06-20 2025-12-26 The Regents Of The University Of California Compositions and methods for treating neurological disorders
CN118526523B (zh) * 2024-07-26 2025-01-28 山东大学齐鲁医院 一种治疗脑胶质母细胞瘤的药物组合物

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JP6837581B2 (ja) * 2017-06-14 2021-03-03 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ Ｍｅｇａｓｐｈａｅｒａ属の細菌株を含む組成物及びその使用

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