HRP20220747T1 - Pripravci koji sadrže bakterijske sojeve - Google Patents
Pripravci koji sadrže bakterijske sojeve Download PDFInfo
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- HRP20220747T1 HRP20220747T1 HRP20220747TT HRP20220747T HRP20220747T1 HR P20220747 T1 HRP20220747 T1 HR P20220747T1 HR P20220747T T HRP20220747T T HR P20220747TT HR P20220747 T HRP20220747 T HR P20220747T HR P20220747 T1 HRP20220747 T1 HR P20220747T1
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- Prior art keywords
- preparation
- disease
- use according
- treatment
- bacterial strain
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- 230000001580 bacterial effect Effects 0.000 title claims 8
- 239000000203 mixture Substances 0.000 title claims 2
- 230000002265 prevention Effects 0.000 claims 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 3
- CFFZDZCDUFSOFZ-UHFFFAOYSA-N 3,4-Dihydroxy-phenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C(O)=C1 CFFZDZCDUFSOFZ-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 241000352296 Megasphaera massiliensis Species 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000027089 Parkinsonian disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014461 Ataxins Human genes 0.000 claims 1
- 108010078286 Ataxins Proteins 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 1
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 208000003906 hydrocephalus Diseases 0.000 claims 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
- 210000004558 lewy body Anatomy 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000016273 neuron death Effects 0.000 claims 1
- 208000014670 posterior cortical atrophy Diseases 0.000 claims 1
- 208000001282 primary progressive aphasia Diseases 0.000 claims 1
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (12)
1. Pripravak, naznačen time, da sadrži bakterijski soj Megasphaera massiliensis, za uporabu u liječenju.
2. Pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, da je za uporabu u postupku liječenja ili prevencije neurodegenerativnog poremećaja.
3. Pripravak za uporabu prema patentnom zahtjevu 1 ili 2, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije bolesti ili stanja odabranog iz skupine koju čine Parkinsonova bolest, uključujući progresivnu supranuklearnu palsiju, sindrom Steele-Richardson-Olszewski, hidrocefalus normalnog tlaka, vaskularni ili arteriosklerotični parkinsonizam i parkinsonizam induciran supstancom; Alzheimerova bolest, uključujući Bensonov sindrom; multipla skleroza; Huntingtonova bolest; amiotrofična lateralna skleroza; Lou Gehrigova bolest; bolest motornih neurona; prionska bolest; spinocerebelarna ataksija; spinalna muskularna atrofija; demencija, uključujući Lewyjeva tijela, vaskularna i frontotemporalna demencija; primarna progresivna afazija; blago kognitivno oštećenje; HTV-povezano kognitivno oštećenje i kortikobazalna degeneracija.
4. Pripravak za uporabu prema patentnom zahtjevu 3, naznačen time, da je pripravak za uporabu u postupku liječenja ili prevencije Parkinsonove bolesti.
5. Pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-4, naznačen time, da pripravak je za uporabu u:
(a) postupku liječenja ili prevencije ranog početka neurodegenerativne bolesti,
(b) smanjivanju smrti neurona ili zaštiti neurona,
(c) postupku prevencije ili odgađanja početka ili progresije neurodegenerativne bolesti,
(d) postupku smanjivanja IL-6 razina i/ili NFκB razina u liječenju ili prevenciji neurodegenerativne bolesti, i/ili
(e) postupku povećanja razine dopamina i/ili DOPAC razina u liječenju ili prevenciji neurodegenerativne bolesti.
6. Pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, da je za uporabu u liječenju ozljede mozga.
7. Pripravak za uporabu prema patentnom zahtjevu 6, naznačen time, da ozljeda mozga je moždani udar, kao što je cerebralna ishemija, fokalna cerebralna ishemija, ishemijski moždani udar ili hemoragijski moždani udar.
8. Pripravak za uporabu prema bilo kojem od patentnih zahtjeva 1-7, naznačen time, da bakterijski soj ima 16s rRNA slijed koji je najmanje 95%, 96%, 97%, 98%, 99%, 99,5% ili 99,9% istovjetan slijedu SEQ ID NO: 1 ili 2, opcionalno pritom bakterijski soj ima 16s rRNA slijed koji je najmanje 95%, 96%, 97%, 98%, 99%, 99,5% ili 99,9% istovjetan slijedu SEQ ID NO: 2, ili time, da bakterijski soj ima 16s rRNA slijed koji je predstavljen slijedom SEQ ID NO: 2.
9. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je pripravak za oralnu primjenu, i/ili time, da pripravak sadrži jedno ili više farmaceutski prihvatljivih pomoćnih sredstava ili nosača.
10. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da se bakterijski soj liofilizira.
11. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj jest Megasphaera massiliensis bakterijski soj koji je deponiran pod pristupnim brojem NCIMB 42787.
12. Prehrambeni proizvod ili pripravak cjepiva, naznačen time, da sadrži pripravak prema bilo kojem prethodnom patentnom zahtjevu, za uporabu prema bilo kojem prethodnom patentnom zahtjevu.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1709468.1A GB201709468D0 (en) | 2017-06-14 | 2017-06-14 | Compositions comprising bacterial strains |
GBGB1709534.0A GB201709534D0 (en) | 2017-06-15 | 2017-06-15 | Compositions comprising bacterial strains |
GBGB1712851.3A GB201712851D0 (en) | 2017-08-10 | 2017-08-10 | Compositions comprising bacterial strains |
GBGB1803826.5A GB201803826D0 (en) | 2018-03-09 | 2018-03-09 | Compositions comprising bacterial strains |
GBGB1805989.9A GB201805989D0 (en) | 2018-04-11 | 2018-04-11 | Compositions comprising bacterial strains |
GBGB1805990.7A GB201805990D0 (en) | 2018-04-11 | 2018-04-11 | Compostions comprising bacterial strains |
GBGB1805991.5A GB201805991D0 (en) | 2018-04-11 | 2018-04-11 | Compositions comprising bacterial strains |
GBGB1806780.1A GB201806780D0 (en) | 2018-04-25 | 2018-04-25 | Compositions comprising bacterial strains |
GBGB1806779.3A GB201806779D0 (en) | 2018-04-25 | 2018-04-25 | Compositions comprising bacterial strains |
EP20189452.4A EP3804737B1 (en) | 2017-06-14 | 2018-06-14 | Compositions comprising bacterial strains |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20220747T1 true HRP20220747T1 (hr) | 2022-10-14 |
Family
ID=62784100
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220747TT HRP20220747T1 (hr) | 2017-06-14 | 2018-06-14 | Pripravci koji sadrže bakterijske sojeve |
HRP20201629TT HRP20201629T1 (hr) | 2017-06-14 | 2020-10-09 | Sastavi koji sadrže bakterijski soj roda megasphaera i njihove upotrebe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201629TT HRP20201629T1 (hr) | 2017-06-14 | 2020-10-09 | Sastavi koji sadrže bakterijski soj roda megasphaera i njihove upotrebe |
Country Status (25)
Country | Link |
---|---|
US (3) | US11660319B2 (hr) |
EP (4) | EP3638273A2 (hr) |
JP (4) | JP2020523326A (hr) |
KR (2) | KR20200015575A (hr) |
CN (2) | CN111032061A (hr) |
AU (4) | AU2018285453B2 (hr) |
BR (2) | BR112019026677A2 (hr) |
CA (3) | CA3066561C (hr) |
CY (2) | CY1123565T1 (hr) |
DK (2) | DK3804737T3 (hr) |
ES (2) | ES2823053T3 (hr) |
HR (2) | HRP20220747T1 (hr) |
HU (2) | HUE052258T2 (hr) |
IL (3) | IL292373A (hr) |
LT (2) | LT3804737T (hr) |
MA (3) | MA49425A (hr) |
MD (2) | MD3600364T2 (hr) |
MX (1) | MX2021006456A (hr) |
PL (2) | PL3804737T3 (hr) |
PT (2) | PT3600364T (hr) |
RS (2) | RS60910B1 (hr) |
SG (2) | SG11201912153VA (hr) |
SI (2) | SI3804737T1 (hr) |
TW (2) | TWI812624B (hr) |
WO (2) | WO2018229236A2 (hr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA49425A (fr) * | 2017-06-14 | 2020-04-22 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
MD3743086T2 (ro) | 2018-05-11 | 2022-12-31 | 4D Pharma Res Limited | Compoziții cuprizând tulpini bacteriene |
SG11202106230XA (en) * | 2018-12-12 | 2021-07-29 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
KR20220016481A (ko) * | 2019-06-03 | 2022-02-09 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 패혈증 및 괴사성 장염 유도된 신경발달 결핍의 예방을 위한 프리바이오틱 제형 |
EP3993815A2 (en) | 2019-07-05 | 2022-05-11 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
CN110420228A (zh) * | 2019-09-16 | 2019-11-08 | 山东大学齐鲁医院 | 脆弱拟杆菌ych46在制备治疗或辅助治疗高血压的药物中的应用 |
US20220364056A1 (en) * | 2019-09-25 | 2022-11-17 | Philipps-Universität Marburg | Short-chain fatty acid pentanoate as enhancer for cellular therapy and anti-tumor therapy |
WO2022061094A1 (en) | 2020-09-18 | 2022-03-24 | Evelo Biosciences, Inc. | Solid dosage forms of bacteria |
CN112239741B (zh) * | 2020-12-10 | 2022-05-27 | 慕恩(广州)生物科技有限公司 | 一种Megasphaera属的细菌MNC-992及其培养方法和应用 |
KR20230145050A (ko) | 2020-12-14 | 2023-10-17 | 에벨로 바이오사이언시즈, 인크. | 세포외 소포체 제제 |
WO2022187578A1 (en) | 2021-03-05 | 2022-09-09 | Evelo Biosciences, Inc. | Solid dosage forms |
WO2022217030A1 (en) | 2021-04-08 | 2022-10-13 | Evelo Biosciences, Inc. | Pharmaceutical composition containing bacteria |
IL308247A (en) * | 2021-05-12 | 2024-01-01 | Biomica Ltd | Bacteria from the microbiota and their uses |
WO2023049268A1 (en) | 2021-09-24 | 2023-03-30 | Evelo Biosciences, Inc. | Solid dosage forms containing bacteria and microbial extracellular vesicles |
CN114276948B (zh) * | 2021-11-08 | 2023-06-20 | 泸州老窖股份有限公司 | 产己酸的赖氨酸芽孢杆菌及其用途 |
WO2023107537A1 (en) | 2021-12-07 | 2023-06-15 | Evelo Biosciences, Inc. | Antibody compositions and methods for utilizing with extracellular vesicles and microbes |
WO2023114293A1 (en) | 2021-12-14 | 2023-06-22 | Evelo Biosciences, Inc. | Extracellular vesicle assays |
WO2024015522A1 (en) | 2022-07-13 | 2024-01-18 | Evelo Biosciences, Inc. | Methods for analyzing extracellular vesicles and microbes |
WO2024076723A1 (en) | 2022-10-07 | 2024-04-11 | Evelo Biosciences, Inc. | Processing extracellular vesicles |
WO2024102226A1 (en) | 2022-10-14 | 2024-05-16 | Evelo Biosciences, Inc. | Methods for assaying drug substances and drug products by using cell lines with nf-kb- inducible reporter genes |
Family Cites Families (405)
Publication number | Priority date | Publication date | Assignee | Title |
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NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
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