HRP20191949T1 - Blautia stercosis i wexlerae za upotrebu u liječenju upalnih i autoimunih bolesti - Google Patents
Blautia stercosis i wexlerae za upotrebu u liječenju upalnih i autoimunih bolesti Download PDFInfo
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- HRP20191949T1 HRP20191949T1 HRP20191949TT HRP20191949T HRP20191949T1 HR P20191949 T1 HRP20191949 T1 HR P20191949T1 HR P20191949T T HRP20191949T T HR P20191949TT HR P20191949 T HRP20191949 T HR P20191949T HR P20191949 T1 HRP20191949 T1 HR P20191949T1
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- 208000023275 Autoimmune disease Diseases 0.000 title claims 3
- 208000027866 inflammatory disease Diseases 0.000 title claims 3
- 230000002757 inflammatory effect Effects 0.000 title claims 3
- 241001202853 Blautia Species 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 9
- 208000006673 asthma Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 241000335560 Blautia stercoris Species 0.000 claims 5
- 241001038648 Blautia wexlerae Species 0.000 claims 5
- 206010046851 Uveitis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 210000000068 Th17 cell Anatomy 0.000 claims 2
- 201000009961 allergic asthma Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000008795 neuromyelitis optica Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000010266 Aggressive Periodontitis Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010023232 Joint swelling Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010029379 Neutrophilia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010057430 Retinal injury Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039705 Scleritis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 230000024949 interleukin-17 production Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 201000006727 periodontosis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K35/66—Microorganisms or materials therefrom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Claims (15)
1. Sastav koji obuhvaća soj bakterijske vrste Blautia stercoris ili Blautia wexlerae, za upotrebu u postupku liječenja ili prevencije upalne ili autoimune bolesti.
2. Sastav prema zahtjevu 1, pri čemu je sastav za upotrebu u postupku liječenja ili prevencije bolesti ili stanja koje je izabrano iz grupe koja obuhvaća astmu, kao što je alergijska astma ili neutrofilna astma; artritis, kao što je reumatoidni artritis, osteoartritis, psorijazni artritis, ili juvenilni idiopatski artritis; multipla skleroza; optički neuromijelitis (Devicova bolest); ankilozantni spondilitis; spondiloartritis; psorijaza; sistemski eritemski lupus; upalna bolest crijeva, kao što je Crohnova bolest ili ulcerozni kolitis; celijakija; kronična opstruktivna bolest pluća (COPD); uveitis; skleritis; vaskulitis; Behcetovu bolest; ateroskleroza; atopijski dermatitis; emfizem; periodontitis ili parodontoza; alergijski rinitis; i odbacivanje alografta.
3. Sastav za upotrebu prema zahtjevu 2; pri čemu
(i) sastav je za upotrebu u postupku liječenja ili prevencije astme, kao što je neutrofilna astma ili alergijska astma, i gdje je sastav za upotrebu u postupku smanjenja neutrofilije ili eozinofilije u liječenju astme; ili pri čemu
(ii) sastav je za upotrebu u postupku liječenja ili prevencije reumatoidnog artritisa, i gdje je sastav za upotrebu u postupku smanjenja oticanja zgloba u rematoidnom artritisu; ili gdje
(iii) sastav je za upotrebu u postupku liječenja ili prevencije multiple skleroze, i gdje je sastav za upotrebu u postupku smanjenja pojave bolesti ili težine bolesti; ili gdje
(iv) sastav je za upotrebu u postupku liječenja ili prevencije uveitisa, i sastav je za upotrebu u postupku smanjenja ili prevencije oštećenja mrežnice u uveitisu.
4. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, pri čemu je sastav za upotrebu u postupku smanjenja proizvodnje IL-17 ili smanjenja diferencijacije Th17 stanice u liječenju ili prevenciji upalne ili autoimune bolesti.
5. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, pri čemu je sastav za upotrebu kod pacijenta s povećanim IL-17 razinama ili Th17 stanicama.
6. Sastav za upotrebu prema bilo kojem od zahtjeva 1-5; pri čemu (a) i soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaku sa sekvencijom 16s rRNK soja bakterije Blautia stercoris; ili pri čemu (b) soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaka sa SEQ ID NO:1 ili 2; gdje prema (b), poželjno soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaka sa SEQ ID NO:2, ili soj bakterije ima sekvenciju 16s rRNK predstavljenu sa SEQ ID NO:2.
7. Sastav za upotrebu prema bilo kojem od zahtjeva 1-5; pri čemu (a) soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaka sa sekvencijom 16s rRNK soja bakterije Blautia wexlerae; ili pri čemu (b) soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaku sa SEQ ID NO:3 ili 4; gdje prema (b), poželjno soj bakterije ima sekvenciju 16s rRNK koja je bar 95%, 96%, 97%, 98%, 99%, 99.5% ili 99.9% jednaka sa SEQ ID NO:4, ili soj bakterija ima sekvenciju 16s rRNK predstavljenu sa SEQ ID NO:4.
8. Sastav za upotrebu prema bilo kojem prethodnom zahtjevu, pri čemu je sastav za oralnu primjenu; i/ili gdje sastav obuhvaća jedan ili više farmaceutski prihvatljivih pomoćnih tvari ili nosača; i/ili gdje je soj bakterije liofiliziran.
9. Prehrambeni proizvod ili sastav cjepiva koji obuhvaća sastav prema bilo kojem prethodnom zahtjevu, za upotrebu bilo kojega prethodnoga zahtjeva.
10. Stanica soja Blautia stercoris koja je deponirana pod pristupnim brojem NCIMB 42381; ili sastav koji obuhvaća spomenutu stanicu, opcionalno gdje sastav obuhvaća farmaceutski prihvatljivi nosač ili pomoćnu tvar.
11. Biološki čista kultura soja Blautia stercoris koja je deponirana pod pristupnim brojem NCIMB 42381.
12. Stanica soja Blautia stercoris koja je deponirana pod pristupnim brojem NCIMB 42381, za upotrebu u terapiji.
13. Stanica soja Blautia wexlerae a je deponirana pod pristupnim brojem NCIMB 42486; ili sastav koji obuhvaća spomenutu stanicu, opcionalno pri čemu sastav obuhvaća farmaceutski prihvatljivi nosač ili ekscipijens.
14. Biološki čista kultura soja Blautia wexlerae koja je deponirana pod pristupnim brojem NCIMB 42486.
15. Stanica soja Blautia wexlerae koja je deponirana pod pristupnim brojem NCIMB 42486, za upotrebu u terapiji, opcionalno pri čemu je stanica za upotrebu u postupku definirana prema bilo kojem od zahtjeva 1-5.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1510466.4A GB201510466D0 (en) | 2015-06-15 | 2015-06-15 | Compositions comprising bacterial strains |
GBGB1520508.1A GB201520508D0 (en) | 2015-11-20 | 2015-11-20 | Compositions comprising bacterial strains |
GB201606810 | 2016-04-19 | ||
EP16731640.5A EP3240554B1 (en) | 2015-06-15 | 2016-06-15 | Blautia stercosis and wexlerae for use in treating inflammatory and autoimmune diseases |
PCT/GB2016/051770 WO2016203218A1 (en) | 2015-06-15 | 2016-06-15 | Compositions comprising bacterial strains |
Publications (1)
Publication Number | Publication Date |
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HRP20191949T1 true HRP20191949T1 (hr) | 2020-01-24 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20191949TT HRP20191949T1 (hr) | 2015-06-15 | 2019-10-28 | Blautia stercosis i wexlerae za upotrebu u liječenju upalnih i autoimunih bolesti |
Country Status (30)
Country | Link |
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US (3) | US10322151B2 (hr) |
EP (2) | EP3240554B1 (hr) |
JP (3) | JP6426265B2 (hr) |
KR (1) | KR20180012846A (hr) |
CN (2) | CN108271354B (hr) |
AU (1) | AU2016278067B2 (hr) |
BR (1) | BR112017025005A2 (hr) |
CA (1) | CA2988661A1 (hr) |
CO (1) | CO2017013443A2 (hr) |
CY (1) | CY1122344T1 (hr) |
DK (1) | DK3240554T3 (hr) |
EA (1) | EA201890048A1 (hr) |
ES (1) | ES2753779T3 (hr) |
HK (1) | HK1244202A1 (hr) |
HR (1) | HRP20191949T1 (hr) |
HU (1) | HUE045754T2 (hr) |
IL (1) | IL255757A (hr) |
LT (1) | LT3240554T (hr) |
MA (1) | MA51639A (hr) |
MD (1) | MD3240554T2 (hr) |
MX (1) | MX2017016560A (hr) |
PE (1) | PE20180243A1 (hr) |
PL (1) | PL3240554T3 (hr) |
PT (1) | PT3240554T (hr) |
RS (1) | RS59446B1 (hr) |
SG (2) | SG10201912323VA (hr) |
SI (1) | SI3240554T1 (hr) |
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