|
ES521370A0
(es)
|
1982-04-12 |
1985-04-16 |
Hybritech Inc |
Un procedimiento para obtener un polidoma.
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
DE3689123T2
(de)
|
1985-11-01 |
1994-03-03 |
Xoma Corp |
Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4880935A
(en)
|
1986-07-11 |
1989-11-14 |
Icrf (Patents) Limited |
Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
IL106992A
(en)
|
1988-02-11 |
1994-06-24 |
Bristol Myers Squibb Co |
Acylhydrazone derivatives of anthracycline and methods for their preparation
|
|
US5851527A
(en)
|
1988-04-18 |
1998-12-22 |
Immunomedics, Inc. |
Method for antibody targeting of therapeutic agents
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US5166322A
(en)
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5278299A
(en)
|
1991-03-18 |
1994-01-11 |
Scripps Clinic And Research Foundation |
Method and composition for synthesizing sialylated glycosyl compounds
|
|
FR2676058B1
(fr)
|
1991-04-30 |
1994-02-25 |
Hoechst Lab |
Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
WO1993010260A1
(en)
|
1991-11-21 |
1993-05-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases
|
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6569834B1
(en)
|
1992-12-03 |
2003-05-27 |
George R. Pettit |
Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
CA2172983A1
(en)
*
|
1993-09-29 |
1995-04-06 |
Kei Sugai |
21-substituted steroid compound
|
|
EP0731106B1
(en)
|
1993-10-01 |
2004-11-17 |
Teikoku Hormone Mfg. Co., Ltd. |
Dolastatin derivatives
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
JP2763020B2
(ja)
|
1995-04-27 |
1998-06-11 |
日本電気株式会社 |
半導体パッケージ及び半導体装置
|
|
DE19516717A1
(de)
|
1995-05-06 |
1996-11-07 |
Basf Ag |
Verfahren zur Herstellung von Diarylethanen
|
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
DK0871490T3
(da)
|
1995-12-22 |
2003-07-07 |
Bristol Myers Squibb Co |
Forgrenede hydrazonlinkere
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US7011812B1
(en)
|
1996-05-03 |
2006-03-14 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer and infectious diseases
|
|
EP0954340B1
(en)
|
1996-05-03 |
2007-06-27 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer
|
|
EP0964702B1
(en)
|
1996-08-02 |
2006-10-04 |
Ortho-McNeil Pharmaceutical, Inc. |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US6130237A
(en)
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
US6261537B1
(en)
|
1996-10-28 |
2001-07-17 |
Nycomed Imaging As |
Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
|
|
US6331289B1
(en)
|
1996-10-28 |
2001-12-18 |
Nycomed Imaging As |
Targeted diagnostic/therapeutic agents having more than one different vectors
|
|
WO1998036765A1
(en)
|
1997-02-25 |
1998-08-27 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
|
|
EP0979102A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE
|
|
US20040009166A1
(en)
|
1997-04-30 |
2004-01-15 |
Filpula David R. |
Single chain antigen-binding polypeptides for polymer conjugation
|
|
ATE472599T1
(de)
|
1997-11-21 |
2010-07-15 |
Human Genome Sciences Inc |
Chemokin alpha-5
|
|
GB2332539B
(en)
|
1997-12-17 |
2003-04-23 |
Fujitsu Ltd |
Memory access methods and devices for use with random access memories
|
|
US6624142B2
(en)
|
1997-12-30 |
2003-09-23 |
Enzon, Inc. |
Trimethyl lock based tetrapartate prodrugs
|
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
|
US7060479B2
(en)
|
1999-12-08 |
2006-06-13 |
Serono Genetics Institute, S.A. |
Full-length human cDNAs encoding potentially secreted proteins
|
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
US6214330B1
(en)
|
1998-07-13 |
2001-04-10 |
Enzon, Inc. |
Coumarin and related aromatic-based polymeric prodrugs
|
|
US6361774B1
(en)
|
1999-09-17 |
2002-03-26 |
Immunomedics, Inc. |
Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
|
|
US6323135B1
(en)
|
1998-12-09 |
2001-11-27 |
Advanced Micro Devices, Inc. |
Method of forming reliable capped copper interconnects/with high etch selectivity to capping layer
|
|
JP2000230000A
(ja)
|
1999-02-08 |
2000-08-22 |
Hokkaido Univ |
一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体
|
|
US6602498B2
(en)
|
2000-02-22 |
2003-08-05 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
US6777387B2
(en)
|
2000-03-31 |
2004-08-17 |
Enzon Pharmaceuticals, Inc. |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
|
|
US7063845B2
(en)
|
2000-04-28 |
2006-06-20 |
Gemini Science, Inc. |
Human anti-CD40 antibodies
|
|
DE60129741T2
(de)
|
2000-06-20 |
2008-04-30 |
Immunomedics, Inc. |
Zielgerichtete kombinationsimmuntherapie für krebs und infektionskrankheiten
|
|
US7090843B1
(en)
|
2000-11-28 |
2006-08-15 |
Seattle Genetics, Inc. |
Recombinant anti-CD30 antibodies and uses thereof
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
JP4179771B2
(ja)
|
2001-06-25 |
2008-11-12 |
株式会社デンソー |
自動車の乗員保護装置
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
WO2003026577A2
(en)
|
2001-09-24 |
2003-04-03 |
Seattle Genetics, Inc. |
P-amidobenzylethers in drug delivery agents
|
|
EP1446438A2
(en)
|
2001-11-07 |
2004-08-18 |
Nektar Therapeutics Al, Corporation |
Branched polymers and their conjugates
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
IL162835A0
(en)
|
2002-01-09 |
2005-11-20 |
Medarex Inc |
Human monoclonal antibodies against cd30
|
|
WO2003070823A2
(en)
|
2002-02-20 |
2003-08-28 |
The General Hospital Corporation |
Conjugates comprising a biodegradable polymer and uses therefor
|
|
US7591994B2
(en)
|
2002-12-13 |
2009-09-22 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
GB0218518D0
(en)
|
2002-03-22 |
2002-09-18 |
Aventis Pharma Inc |
Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
|
|
WO2003086312A2
(en)
|
2002-04-12 |
2003-10-23 |
A & D Bioscience, Inc. |
Conjugates comprising cancer cell specific ligands, a sugar and cancer chemotherapeutic agents/boron neutron capture therapy agents, and uses thereof
|
|
US20090068178A1
(en)
|
2002-05-08 |
2009-03-12 |
Genentech, Inc. |
Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
US7413738B2
(en)
|
2002-08-13 |
2008-08-19 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on biodegradable linkers
|
|
WO2004044223A2
(en)
|
2002-11-12 |
2004-05-27 |
Enzon Pharmaceuticals, Inc. |
Prodrugs of vancomycin with hydrolysis resistant polymer linkers
|
|
WO2004044222A2
(en)
|
2002-11-12 |
2004-05-27 |
Enzon Pharmaceuticals, Inc. |
Polymeric prodrugs of vancomycin
|
|
DE10254439A1
(de)
|
2002-11-21 |
2004-06-03 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Tubulysine, Herstellungsverfahren und Tubulysin-Mittel
|
|
US7888536B2
(en)
|
2004-02-13 |
2011-02-15 |
Quanta Biodesign, Ltd. |
Selective and specific preparation of discrete PEG compounds
|
|
US7332164B2
(en)
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
NZ542687A
(en)
|
2003-04-13 |
2010-02-26 |
Enzon Pharmaceuticals Inc |
Polymeric oligonucleotide prodrugs
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
CN1816356A
(zh)
|
2003-05-14 |
2006-08-09 |
免疫原公司 |
药物缀合物组合物
|
|
EP2478912B1
(en)
*
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
US20060003412A1
(en)
|
2003-12-08 |
2006-01-05 |
Xencor, Inc. |
Protein engineering with analogous contact environments
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
CA2940803A1
(en)
|
2004-03-23 |
2005-10-27 |
Ascendis Pharma Gmbh |
Prodrug linker
|
|
JP4806680B2
(ja)
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
US8288352B2
(en)
|
2004-11-12 |
2012-10-16 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the N terminus
|
|
US20070134243A1
(en)
|
2004-12-01 |
2007-06-14 |
Gazzard Lewis J |
Antibody drug conjugates and methods
|
|
US7947839B2
(en)
|
2004-12-01 |
2011-05-24 |
Genentech, Inc. |
Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
|
|
JP2008537673A
(ja)
|
2005-01-31 |
2008-09-25 |
ジェネンテック・インコーポレーテッド |
抗ｅｐｈｂ２抗体とその使用方法
|
|
US8012488B2
(en)
|
2005-02-18 |
2011-09-06 |
Nof Corporation |
Polyoxyalkylene derivative
|
|
JP5122441B2
(ja)
|
2005-04-19 |
2013-01-16 |
シアトル ジェネティックス， インコーポレイテッド |
ヒト化抗ｃｄ７０結合剤およびその使用
|
|
US8132476B2
(en)
|
2005-06-20 |
2012-03-13 |
Hy-Energy, Llc |
Method and apparatus for handling small quantities of fluids
|
|
WO2007008848A2
(en)
|
2005-07-07 |
2007-01-18 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
|
|
DK3248613T3
(da)
|
2005-07-18 |
2022-03-14 |
Seagen Inc |
Beta-glucuronid-lægemiddel-linkerkonjugater
|
|
WO2007080114A2
(en)
|
2006-01-11 |
2007-07-19 |
Biotech Igg Ab |
Macromolecule conjugate
|
|
RS52060B
(sr)
|
2006-01-25 |
2012-04-30 |
Sanofi |
Citotoksični agensi koji sadrže nove derivate tomaimicina
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
WO2007103288A2
(en)
|
2006-03-02 |
2007-09-13 |
Seattle Genetics, Inc. |
Engineered antibody drug conjugates
|
|
US8257706B2
(en)
|
2006-08-25 |
2012-09-04 |
Seattle Genetics, Inc. |
CD30 binding agents and uses thereof
|
|
US8367065B2
(en)
|
2006-09-15 |
2013-02-05 |
Enzon Pharmaceuticals, Inc. |
Targeted polymeric prodrugs containing multifunctional linkers
|
|
BRPI0716808A2
(pt)
|
2006-09-15 |
2013-11-05 |
Enzon Pharmaceuticals Inc |
Ligantes poliméricos baseados em lisina
|
|
JP2010503708A
(ja)
|
2006-09-15 |
2010-02-04 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
多官能性リンカーを含む標的化ポリマープロドラッグ
|
|
WO2008034123A2
(en)
|
2006-09-15 |
2008-03-20 |
Enzon Pharmaceuticals, Inc. |
Polymeric conjugates containing positively-charged moieties
|
|
EP2368908A3
(en)
|
2006-11-10 |
2011-10-12 |
CovX Technologies Ireland Limited |
Anti- angiogenic compounds
|
|
PT2099823E
(pt)
|
2006-12-01 |
2014-12-22 |
Seattle Genetics Inc |
Agentes de ligação ao alvo variantes e suas utilizações
|
|
US7884869B2
(en)
|
2007-04-30 |
2011-02-08 |
Motorola Mobility, Inc. |
Assignment of pixel element exposure times in digital camera modules and mobile communication devices
|
|
CN101784565B
(zh)
|
2007-06-25 |
2014-12-10 |
恩多塞特公司 |
含有亲水性间隔区接头的共轭物
|
|
EP2176404A4
(en)
|
2007-07-11 |
2014-11-19 |
Belrose Pharma Inc |
POLYMERIC DRUG DELIVERY SYSTEMS WITH AN AROMATIC ALLYLIC ACID
|
|
JP2010533202A
(ja)
|
2007-07-11 |
2010-10-21 |
エンゾン ファーマシューティカルズ，インコーポレーテッド |
多置換芳香族部分を含むポリマー性薬剤送達システム
|
|
EP2181101A2
(en)
|
2007-07-20 |
2010-05-05 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Tubulysin d analogues
|
|
US20100203066A1
(en)
|
2007-08-20 |
2010-08-12 |
Enzon Pharmaceuticals, Inc. |
Polymeric linkers containing pyridyl disulfide moieties
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
DK2265283T3
(da)
|
2008-03-18 |
2014-10-20 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
EP2174947A1
(en)
|
2008-09-25 |
2010-04-14 |
Universität des Saarlandes |
Bioactive pre-tubulysins and use thereof
|
|
KR20110075029A
(ko)
|
2008-10-21 |
2011-07-05 |
엔즌 파마슈티칼스, 인코포레이티드 |
7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
|
|
WO2010081004A1
(en)
|
2009-01-09 |
2010-07-15 |
Seattle Genetics, Inc. |
Weekly dosing regimens for anti-cd30 vc-pab-mmae antibody drug-conjugates
|
|
US8802833B2
(en)
|
2009-01-12 |
2014-08-12 |
University Of Washington |
Method for 2-sulfation of glycosides
|
|
RU2683325C2
(ru)
|
2009-02-05 |
2019-03-28 |
Иммьюноджен, Инк. |
Новые производные бензодиазепина
|
|
FR2949469A1
(fr)
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
JP2013505944A
(ja)
|
2009-09-24 |
2013-02-21 |
シアトル ジェネティックス， インコーポレイテッド |
Ｄｒ５リガンド薬物結合体
|
|
CN102596922A
(zh)
|
2009-10-06 |
2012-07-18 |
免疫基因公司 |
有效的缀合物和亲水性连接体
|
|
EP2322537A1
(en)
|
2009-11-12 |
2011-05-18 |
R & D Biopharmaceuticals Gmbh |
Tubulin inhibitors
|
|
CN102648208B
(zh)
|
2009-11-12 |
2016-04-27 |
R&D生技药品有限责任公司 |
微管蛋白抑制剂
|
|
WO2011072240A1
(en)
|
2009-12-10 |
2011-06-16 |
Cedars-Sinai Medical Center |
Drug delivery of temozolomide for systemic based treatment of cancer
|
|
CN102844045A
(zh)
|
2010-02-08 |
2012-12-26 |
艾更斯司股份有限公司 |
结合于161p2f10b蛋白的抗体药物偶联物(adc)
|
|
PL2542576T3
(pl)
|
2010-03-02 |
2016-10-31 |
|
Sposoby badań przesiewowych przeciwciał
|
|
EP2553019A1
(en)
|
2010-03-26 |
2013-02-06 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
|
JP5875083B2
(ja)
|
2010-04-15 |
2016-03-02 |
メディミューン リミテッド |
増殖性疾患治療用ピロロベンゾジアゼピン
|
|
CA2795349C
(en)
|
2010-04-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
SI2528625T1
(sl)
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
WO2011130599A1
(en)
|
2010-04-16 |
2011-10-20 |
Enzon Pharmaceuticals, Inc. |
Polymeric conjugates of adenine nucleoside analogs
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
EP2648752B1
(en)
|
2010-12-06 |
2017-02-15 |
Seattle Genetics, Inc. |
Humanized antibodies to liv-1 and use of same to treat cancer
|
|
JP5826863B2
(ja)
|
2011-02-15 |
2015-12-02 |
イミュノジェン・インコーポレーテッド |
細胞傷害性ベンゾジアゼピン誘導体
|
|
WO2012113847A1
(en)
|
2011-02-25 |
2012-08-30 |
Lonza Ltd |
Branched linker for protein drug conjugates
|
|
KR102356286B1
(ko)
|
2011-05-27 |
2022-02-08 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
EP2750681B1
(en)
|
2011-08-30 |
2020-05-27 |
Quanta Biodesign, Ltd. |
Branched discrete peg constructs
|
|
SG11201400770SA
(en)
|
2011-09-20 |
2014-04-28 |
Spirogen Sarl |
Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
|
|
EP2751111B1
(en)
|
2011-10-14 |
2017-04-26 |
MedImmune Limited |
Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
CN103997893B
(zh)
|
2011-10-14 |
2019-04-12 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
SG11201404354UA
(en)
|
2012-02-17 |
2014-10-30 |
Seattle Genetics Inc |
ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER
|
|
US20130225789A1
(en)
|
2012-02-29 |
2013-08-29 |
Yi Sun |
Polyethylene Glycol Having Hetero Multiple Functional Groups
|
|
CA2873112A1
(en)
|
2012-05-11 |
2013-11-14 |
Alexander Krantz |
Site-specific labeling and targeted delivery of proteins for the treatment of cancer
|
|
WO2013173337A2
(en)
|
2012-05-15 |
2013-11-21 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
CN104640572B
(zh)
|
2012-05-15 |
2018-04-27 |
索伦托医疗有限公司 |
药物偶联物，偶联方法，及其用途
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
US20130309223A1
(en)
|
2012-05-18 |
2013-11-21 |
Seattle Genetics, Inc. |
CD33 Antibodies And Use Of Same To Treat Cancer
|
|
US9650331B2
(en)
|
2012-06-18 |
2017-05-16 |
Polytherics Limited |
Conjugation reagents
|
|
WO2014061277A1
(ja)
|
2012-10-19 |
2014-04-24 |
第一三共株式会社 |
親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
|
|
US20150290342A1
(en)
|
2012-10-24 |
2015-10-15 |
Polytherics Limited |
Drug-protein conjugates
|
|
AU2014229529B2
(en)
|
2013-03-13 |
2018-02-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
ES2701051T3
(es)
|
2013-03-15 |
2019-02-20 |
Novartis Ag |
Conjugados de anticuerpo-fármaco
|
|
US9430462B2
(en)
|
2013-07-30 |
2016-08-30 |
Edanz Group Ltd. |
Guided article authorship
|
|
NZ758049A
(en)
|
2013-10-15 |
2024-03-22 |
Seagen Inc |
Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
|
|
KR102442906B1
(ko)
*
|
2013-12-19 |
2022-09-14 |
씨젠 인크. |
표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
|
|
FI3900742T3
(fi)
|
2014-09-11 |
2024-08-16 |
Seagen Inc |
Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen
|
|
GB201416960D0
(en)
|
2014-09-25 |
2014-11-12 |
Antikor Biopharma Ltd |
Biological materials and uses thereof
|
|
DK3270965T3
(da)
|
2015-03-18 |
2020-06-08 |
Seattle Genetics Inc |
Cd48-antistoffer og konjugater deraf
|
|
CN109843919A
(zh)
*
|
2016-03-25 |
2019-06-04 |
西雅图基因公司 |
用于制备聚乙二醇化的药物-接头及其中间体的方法
|
|
TWI851531B
(zh)
|
2016-08-09 |
2024-08-11 |
美商思進公司 |
具有改善之生理化學性質之具自我穩定連接子之藥物結合物
|
|
KR102648564B1
(ko)
|
2017-03-24 |
2024-03-19 |
씨젠 인크. |
글루쿠로니드 약물-링커의 제조 공정 및 그 중간물
|