|
ES324609A1
(es)
|
1966-03-24 |
1966-12-16 |
Patronato De Investigacien Cie |
Procedimiento para la preparaciën de indolil-alquil hidrazinas
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS5666928A
(en)
|
1979-11-05 |
1981-06-05 |
Hitachi Ltd |
Pulse generating circuit
|
|
US4352795A
(en)
|
1981-01-29 |
1982-10-05 |
Warner-Lambert Company |
7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
ZW10887A1
(en)
|
1986-06-25 |
1987-10-28 |
Injectall Ltd |
Improvements in apparatus for injecting substances into liquids
|
|
DK8189A
(da)
|
1988-01-12 |
1989-07-13 |
Bunge Australia |
Antigen-antistof-konjugater, deres fremstilling og anvendelse
|
|
DE3815826A1
(de)
|
1988-05-09 |
1989-11-23 |
Henkel Kgaa |
Verfahren zur herstellung von vicinal diacyloxysubstituierten verbindungen
|
|
US5470829A
(en)
|
1988-11-17 |
1995-11-28 |
Prisell; Per |
Pharmaceutical preparation
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5089261A
(en)
|
1989-01-23 |
1992-02-18 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
ES2136595T5
(es)
|
1989-04-19 |
2004-04-01 |
Enzon, Inc. |
Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
IL90193A
(en)
|
1989-05-04 |
1993-02-21 |
Biomedical Polymers Int |
Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
|
|
US5650388A
(en)
|
1989-11-22 |
1997-07-22 |
Enzon, Inc. |
Fractionated polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
NL194941C
(nl)
|
1990-02-15 |
2003-08-04 |
Cordis Corp |
Werkwijze voor het aanbrengen van een fysiologisch actieve verbinding op een substraatoppervlak.
|
|
US5275838A
(en)
|
1990-02-28 |
1994-01-04 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5171264A
(en)
|
1990-02-28 |
1992-12-15 |
Massachusetts Institute Of Technology |
Immobilized polyethylene oxide star molecules for bioapplications
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
WO1992000748A1
(en)
|
1990-07-06 |
1992-01-23 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2672053B1
(fr)
|
1991-01-30 |
1993-04-23 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
CA2082160C
(en)
|
1991-03-06 |
2003-05-06 |
Mary M. Bendig |
Humanised and chimeric monoclonal antibodies
|
|
FR2673946B1
(fr)
|
1991-03-15 |
1993-05-28 |
Atochem |
Polyether bloc amides, leur procede de synthese.
|
|
JPH06506217A
(ja)
|
1991-03-18 |
1994-07-14 |
エンゾン，インコーポレーテッド |
ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
AU669124B2
(en)
|
1991-09-18 |
1996-05-30 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing humanized chimera antibody
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
GB9125979D0
(en)
|
1991-12-06 |
1992-02-05 |
Wellcome Found |
Antibody
|
|
AU660534B2
(en)
|
1992-02-13 |
1995-06-29 |
Novo Nordisk A/S |
Polyethylene or polypropylene glycol containing polymer
|
|
CA2130436C
(en)
|
1992-02-19 |
2001-04-10 |
John S. Abrams |
Cloning and expression of humanized monoclonal antibodies against human interleukin-4
|
|
US5686072A
(en)
|
1992-06-17 |
1997-11-11 |
Board Of Regents, The University Of Texas |
Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
|
|
US5614549A
(en)
|
1992-08-21 |
1997-03-25 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
AU5006993A
(en)
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
US5484892A
(en)
|
1993-05-21 |
1996-01-16 |
Dana-Farber Cancer Institute, Inc. |
Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
|
|
AU7109494A
(en)
|
1993-06-16 |
1995-01-03 |
Enzon, Inc. |
Conjugated biodhesives
|
|
US5880131A
(en)
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5840900A
(en)
|
1993-10-20 |
1998-11-24 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5965566A
(en)
|
1993-10-20 |
1999-10-12 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5605976A
(en)
|
1995-05-15 |
1997-02-25 |
Enzon, Inc. |
Method of preparing polyalkylene oxide carboxylic acids
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
US5618528A
(en)
|
1994-02-28 |
1997-04-08 |
Sterling Winthrop Inc. |
Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
|
|
AU2826495A
(en)
|
1994-06-02 |
1996-01-04 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
DE69534530T2
(de)
|
1994-08-12 |
2006-07-06 |
Immunomedics, Inc. |
Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5705154A
(en)
|
1995-03-08 |
1998-01-06 |
Schering Corporation |
Humanized monoclonal antibodies against human interleukin-4
|
|
US5756593A
(en)
|
1995-05-15 |
1998-05-26 |
Enzon, Inc. |
Method of preparing polyalkyene oxide carboxylic acids
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
CA2226299A1
(en)
|
1995-08-11 |
1997-02-27 |
Dendritech, Inc. |
Hyper comb-branched polymer conjugates
|
|
WO1997013529A1
(en)
|
1995-10-13 |
1997-04-17 |
The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services |
Immunotoxin containing a disulfide-stabilized antibody fragment
|
|
WO1997022371A1
(en)
|
1995-12-18 |
1997-06-26 |
Collagen Corporation |
Crosslinked polymer compositions and methods for their use
|
|
US6900304B2
(en)
|
1996-01-31 |
2005-05-31 |
The Regents Of The University Of California |
Emission ratiometric indicators of phosphorylation
|
|
US8669074B2
(en)
|
1996-01-31 |
2014-03-11 |
The Regents Of The University Of California |
Chimeric phosphorylation indicator
|
|
ATE267610T1
(de)
|
1996-03-20 |
2004-06-15 |
Immunomedics Inc |
Glykosylierte igg antikörper
|
|
EP0964702B1
(en)
|
1996-08-02 |
2006-10-04 |
Ortho-McNeil Pharmaceutical, Inc. |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
US6653104B2
(en)
|
1996-10-17 |
2003-11-25 |
Immunomedics, Inc. |
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
|
|
US7541034B1
(en)
|
1997-03-20 |
2009-06-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
|
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
KR100816621B1
(ko)
|
1997-04-07 |
2008-03-24 |
제넨테크, 인크. |
항-ｖｅｇｆ 항체
|
|
PT971959E
(pt)
|
1997-04-07 |
2006-05-31 |
Genentech Inc |
Anticorpos humanizados e metodos para formar anticorpos humanizados
|
|
EP0979102A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
DETAILED POLYPEPTIDE MODIFIED BY POLYALKYLENE OXIDE
|
|
JP3835827B2
(ja)
|
1997-05-02 |
2006-10-18 |
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンティッド バイ ザ セクレタリーオブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
悪性細胞に対する、ｏｎｃタンパク質を含む、免疫毒素
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
GB9712892D0
(en)
|
1997-06-20 |
1997-08-20 |
Eclagen Ltd |
Identification of mhc binding peptides
|
|
GB9718913D0
(en)
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
|
US6011042A
(en)
|
1997-10-10 |
2000-01-04 |
Enzon, Inc. |
Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
|
|
US6111107A
(en)
|
1997-11-20 |
2000-08-29 |
Enzon, Inc. |
High yield method for stereoselective acylation of tertiary alcohols
|
|
US6180095B1
(en)
|
1997-12-17 |
2001-01-30 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
WO1999030727A1
(en)
|
1997-12-17 |
1999-06-24 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5965119A
(en)
|
1997-12-30 |
1999-10-12 |
Enzon, Inc. |
Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
|
|
JP4078032B2
(ja)
|
1998-03-12 |
2008-04-23 |
ネクター セラピューティックス エイエル，コーポレイション |
近位の反応性基を持つポリ（エチレングリコール）誘導体
|
|
US6153655A
(en)
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
DE69925133T2
(de)
|
1998-08-27 |
2006-01-19 |
Spirogen Ltd., Ryde |
Pyrrolobenzodiazepine
|
|
AU6059699A
(en)
|
1998-09-23 |
2000-04-10 |
Regents Of The University Of California, The |
Synthetic peptides, conjugation reagents and methods
|
|
DE60042785D1
(de)
|
1999-06-09 |
2009-10-01 |
Immunomedics Inc |
Immuntherapie von autoimmunerkrankungen durch die verwendung von b-zell spezifischen antikörpern
|
|
DK1455839T3
(da)
|
1999-10-08 |
2013-05-06 |
Nektar Therapeutics |
Heterobifunktioneller poly(ethylenglycol)-derivater og fremgangsmåder til fremstilling heraf
|
|
AU2001281463A1
(en)
|
2000-03-16 |
2001-09-24 |
The Regents Of The University Of California |
Chemoselective ligation
|
|
US7097840B2
(en)
|
2000-03-16 |
2006-08-29 |
Genentech, Inc. |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
|
|
US6911535B2
(en)
|
2000-03-22 |
2005-06-28 |
Solvlink Biosciences |
Biomolecule/polymer conjugates
|
|
US20050201981A1
(en)
|
2004-03-10 |
2005-09-15 |
Chih-Ping Liu |
Method of optimizing treatment with interferon-tau
|
|
ME00502B
(me)
|
2001-01-05 |
2011-10-10 |
Amgen Fremont Inc |
Antitjela za insulinu sličan receptor faktora i rasta
|
|
US7321026B2
(en)
|
2001-06-27 |
2008-01-22 |
Skytech Technology Limited |
Framework-patched immunoglobulins
|
|
US7355012B2
(en)
|
2001-09-26 |
2008-04-08 |
United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells
|
|
WO2003072736A2
(en)
|
2002-02-21 |
2003-09-04 |
Duke University |
Reagents and treatment methods for autoimmune diseases
|
|
GB0210121D0
(en)
|
2002-05-02 |
2002-06-12 |
Celltech R&D Ltd |
Biological products
|
|
US7456260B2
(en)
|
2002-06-17 |
2008-11-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Humanized antibody
|
|
WO2004016740A2
(en)
|
2002-08-15 |
2004-02-26 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
|
EP1391213A1
(en)
|
2002-08-21 |
2004-02-25 |
Boehringer Ingelheim International GmbH |
Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
|
|
US8188116B2
(en)
|
2002-09-04 |
2012-05-29 |
Vanderbilt University |
Agents for therapy efficacy monitoring and deep tissue imaging
|
|
US7754884B2
(en)
|
2005-01-03 |
2010-07-13 |
Vanderbilt University |
Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
CA2515708A1
(en)
|
2003-02-11 |
2004-08-26 |
Transkaryotic Therapies, Inc. |
Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies
|
|
AU2003259718A1
(en)
|
2003-08-07 |
2005-03-07 |
Epitomics, Inc. |
Methods for humanizing rabbit monoclonal antibodies
|
|
WO2005023818A2
(en)
|
2003-09-10 |
2005-03-17 |
Gpc Biotech Ag |
Heterobicyclic compounds as pharmaceutically active agents
|
|
CA2542220A1
(en)
|
2003-10-22 |
2005-05-06 |
Eli Lilly And Company |
Novel mch receptor antagonists
|
|
US20050239806A1
(en)
|
2004-01-13 |
2005-10-27 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
|
CN1560035A
(zh)
|
2004-03-12 |
2005-01-05 |
沈阳药科大学 |
5－羟基吲哚－3－羧酸脂类衍生物
|
|
WO2005113765A2
(en)
|
2004-05-06 |
2005-12-01 |
Biomarin Pharmaceutical Inc. |
Methods of activation of sulfatases and methods and compositions of using the same
|
|
JP4806680B2
(ja)
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
KR20070037719A
(ko)
|
2004-06-30 |
2007-04-06 |
노파르티스 아게 |
항종양제로서의 항체와 듀오카르마이신 유도체의컨쥬게이트
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
CA2583764C
(en)
|
2004-10-25 |
2009-06-09 |
Ligand Pharmaceuticals, Inc. |
Thrombopoietin activity modulating compounds and methods
|
|
US7255012B2
(en)
|
2004-12-01 |
2007-08-14 |
Rosemount Inc. |
Process fluid flow device with variable orifice
|
|
AU2006210724A1
(en)
|
2005-02-03 |
2006-08-10 |
Antitope Limited |
Human antibodies and proteins
|
|
JP5142707B2
(ja)
|
2005-02-08 |
2013-02-13 |
一般財団法人化学及血清療法研究所 |
抗体の改良方法
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
ES2708763T3
(es)
|
2005-07-07 |
2019-04-11 |
Seattle Genetics Inc |
Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
|
|
TW200745096A
(en)
|
2005-08-23 |
2007-12-16 |
Organon Nv |
Indole derivatives
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
JP2009532336A
(ja)
|
2006-03-06 |
2009-09-10 |
メディミューン，エルエルシー |
ヒト化抗ｃｄ２２抗体、並びに腫瘍、移植及び自己免疫疾患の治療におけるこれらの使用
|
|
EP2032606B1
(en)
|
2006-05-30 |
2013-11-27 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
CN101490087B
(zh)
*
|
2006-05-30 |
2013-11-06 |
健泰科生物技术公司 |
抗体和免疫偶联物及其用途
|
|
EP2040698A4
(en)
|
2006-07-14 |
2011-08-10 |
Shionogi & Co |
OXIM CONNECTIONS AND ITS USE
|
|
WO2008019303A2
(en)
|
2006-08-04 |
2008-02-14 |
Enanta Pharmaceuticals, Inc. |
Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
US8481683B2
(en)
|
2006-12-01 |
2013-07-09 |
Medarex, Inc. |
Human antibodies that bind CD22 and uses thereof
|
|
WO2009120611A2
(en)
|
2008-03-27 |
2009-10-01 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
JP5798489B2
(ja)
|
2009-01-12 |
2015-10-21 |
ストロ バイオファーマ， インコーポレイテッド |
インビトロタンパク質合成システムを用いて非天然アミノ酸をタンパク質に選択的に導入するためのモノチャージシステム
|
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
EP2416765B1
(en)
|
2009-04-06 |
2016-03-30 |
PTC Therapeutics, Inc. |
Hcv inhibitor and therapeutic agent combinations
|
|
TW201117814A
(en)
|
2009-10-02 |
2011-06-01 |
Sanofi Aventis |
New maytansinoids and the use of said maytansinoids to prepare conjugates with an antibody
|
|
SG181893A1
(en)
|
2009-12-22 |
2012-08-30 |
Hoffmann La Roche |
Sequence dependent aggregation
|
|
KR20110093055A
(ko)
|
2010-02-11 |
2011-08-18 |
다우어드밴스드디스플레이머티리얼 유한회사 |
신규한 유기 발광 화합물 및 이를 채용하고 있는 유기 전계 발광 소자
|
|
UY33679A
(es)
|
2010-10-22 |
2012-03-30 |
Esbatech |
Anticuerpos estables y solubles
|
|
CA2819373A1
(en)
|
2010-12-09 |
2012-06-14 |
Amgen Inc. |
Bicyclic compounds as pim inhibitors
|
|
WO2012097333A2
(en)
*
|
2011-01-14 |
2012-07-19 |
Redwood Bioscience, Inc. |
Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
|
|
US20170049906A1
(en)
|
2012-05-21 |
2017-02-23 |
President And Fellows Of Harvard College |
Translocation of non-natural chemical entities through anthrax protective antigen pore
|
|
US20140004097A1
(en)
|
2012-06-29 |
2014-01-02 |
Shire Human Genetic Therapies, Inc. |
Method of producing recombinant iduronate-2-sulfatase
|
|
EP3539563A1
(en)
|
2012-07-19 |
2019-09-18 |
Redwood Bioscience, Inc. |
Antibody specific for cd22 and methods of use thereof
|
|
US9439972B2
(en)
|
2012-09-10 |
2016-09-13 |
Ad Lunam Labs, Inc. |
Antifungal serum
|
|
AU2013341711A1
(en)
|
2012-11-12 |
2015-05-21 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
|
US9310374B2
(en)
*
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
CN107753954A
(zh)
|
2012-12-13 |
2018-03-06 |
免疫医疗公司 |
功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量
|
|
CN105722859B
(zh)
|
2013-07-25 |
2021-05-07 |
西托姆克斯治疗公司 |
多特异性抗体、多特异性可活化抗体及其使用方法
|
|
CN115504924A
(zh)
*
|
2013-11-27 |
2022-12-23 |
雷德伍德生物科技股份有限公司 |
肼基-吡咯并化合物及用于生成缀合物的方法
|
|
KR102486180B1
(ko)
|
2014-06-06 |
2023-01-11 |
레드우드 바이오사이언스 인코포레이티드 |
항-her2 항체-메이탄신 컨쥬게이트 및 이것의 사용 방법
|
|
JP6785777B2
(ja)
|
2015-02-05 |
2020-11-18 |
アール．ピー． シェーラー テクノロジーズ エルエルシー |
活性化ホルミルグリシン生成酵素ならびにその生成方法及び使用方法
|
|
JP6980980B2
(ja)
|
2015-06-25 |
2021-12-15 |
イミューノメディクス、インコーポレイテッドImmunomedics, Inc. |
抗ｈｌａ‐ｄｒまたは抗ｔｒｏｐ‐２抗体と微小管阻害剤、ｐａｒｐ阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド３‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する
|
|
EP3373937B1
(en)
|
2015-11-09 |
2021-12-22 |
R.P. Scherer Technologies, LLC |
Anti-cd22 antibody-maytansine conjugates and methods of use thereof
|
|
KR20200117992A
(ko)
|
2017-12-11 |
2020-10-14 |
트리페이스 리서치 앤드 디벨로프먼트 쓰리 코포레이션 |
항-cd22 항체-메이탄신 컨쥬게이트, 그것의 조합, 및 사용 방법
|