JP2021531826A5 - - Google Patents

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Publication number
JP2021531826A5
JP2021531826A5 JP2021524132A JP2021524132A JP2021531826A5 JP 2021531826 A5 JP2021531826 A5 JP 2021531826A5 JP 2021524132 A JP2021524132 A JP 2021524132A JP 2021524132 A JP2021524132 A JP 2021524132A JP 2021531826 A5 JP2021531826 A5 JP 2021531826A5
Authority
JP
Japan
Prior art keywords
antibody
trop2
optionally substituted
represented
same
Prior art date
Application number
JP2021524132A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021531826A (ja
JPWO2020016662A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2019/000875 external-priority patent/WO2020016662A2/en
Publication of JP2021531826A publication Critical patent/JP2021531826A/ja
Publication of JP2021531826A5 publication Critical patent/JP2021531826A5/ja
Publication of JPWO2020016662A5 publication Critical patent/JPWO2020016662A5/ja
Abandoned legal-status Critical Current

Links

JP2021524132A 2018-07-09 2019-06-26 栄養膜細胞表面抗原2(trop2)に対する特異的な抗体 Abandoned JP2021531826A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862695515P 2018-07-09 2018-07-09
US62/695,515 2018-07-09
PCT/IB2019/000875 WO2020016662A2 (en) 2018-07-09 2019-06-26 Antibodies specific to trophoblast antigen 2 (trop2)

Publications (3)

Publication Number Publication Date
JP2021531826A JP2021531826A (ja) 2021-11-25
JP2021531826A5 true JP2021531826A5 (https=) 2022-06-23
JPWO2020016662A5 JPWO2020016662A5 (https=) 2022-06-23

Family

ID=69165234

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021524132A Abandoned JP2021531826A (ja) 2018-07-09 2019-06-26 栄養膜細胞表面抗原2(trop2)に対する特異的な抗体

Country Status (7)

Country Link
US (1) US20210221907A1 (https=)
EP (1) EP3821005A4 (https=)
JP (1) JP2021531826A (https=)
CN (4) CN112771161A (https=)
AU (1) AU2019304175A1 (https=)
TW (1) TW202016148A (https=)
WO (1) WO2020016662A2 (https=)

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AU2020241686A1 (en) 2019-03-15 2021-11-04 Bolt Biotherapeutics, Inc. Immunoconjugates targeting HER2
IL288485B2 (en) * 2019-05-29 2026-04-01 Daiichi Sankyo Co Ltd Anti-TROP2 antibody conjugates - a drug for use in cancer treatment
US20230101266A1 (en) * 2019-12-31 2023-03-30 Genequantum Healthcare (Suzhou) Co., Ltd. Anti-trop2 antibodies, antibody-drug conjugates, and application of the same
CN115803062B (zh) * 2020-06-03 2025-09-09 博泰康医药公司 滋养层细胞表面抗原2(trop-2)抗体
EP4169952A4 (en) * 2020-06-22 2025-01-29 Systimmune, Inc. Anti-trop2 antibody
CN112321715B (zh) * 2020-11-03 2022-05-10 博奥信生物技术(南京)有限公司 抗trop2纳米抗体及其制备方法和应用
CN114685669A (zh) * 2020-12-30 2022-07-01 和铂医药(苏州)有限公司 结合trop2的抗体及其用途
AU2022232548A1 (en) * 2021-03-08 2023-10-12 Genequantum Healthcare (Suzhou) Co., Ltd. Antibody-immune agonist conjugate and applications thereof
TWI910028B (zh) 2021-06-11 2025-12-21 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
JP7673255B2 (ja) 2021-06-11 2025-05-08 ギリアード サイエンシーズ, インコーポレイテッド Mcl-1阻害剤と抗体薬物コンジュゲートとの組み合わせ
CN115536747B (zh) * 2021-06-30 2024-08-27 益科思特(北京)医药科技发展有限公司 一种结合trop2的抗体及靶向trop2和cd3的双特异性抗体及其制备方法与应用
CN115558026A (zh) * 2021-07-02 2023-01-03 和迈生物科技有限公司 抗trop2单域抗体及其应用
CN118541392A (zh) * 2021-09-28 2024-08-23 准星生物医药有限公司 多种形式的分子复合物
US20230183216A1 (en) 2021-10-28 2023-06-15 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
EP4422756A1 (en) 2021-10-29 2024-09-04 Gilead Sciences, Inc. Cd73 compounds
US11814394B2 (en) 2021-11-16 2023-11-14 Genequantum Healthcare (Suzhou) Co., Ltd. Exatecan derivatives, linker-payloads, and conjugates and thereof
CN118488946A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
EP4452415B1 (en) 2021-12-22 2026-02-25 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
CA3253296A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Zinc Finger Degradation Agents of the Ikaros Family and Their Uses
CN119173276A (zh) 2022-04-13 2024-12-20 吉利德科学公司 用于治疗表达Trop-2的癌症的组合疗法
US20250249115A1 (en) 2022-04-13 2025-08-07 Gilead Sciences, Inc. Combination therapy for treating tumor antigen expressing cancers
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
CN117264062A (zh) * 2022-06-14 2023-12-22 上海恒润达生生物科技股份有限公司 一种特异性结合Trop2的抗体或其抗原结合片段及其制备方法和应用
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
KR20250075560A (ko) * 2022-07-15 2025-05-28 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. 항-trop2 항체 및 이의 접합체
WO2024097812A1 (en) 2022-11-04 2024-05-10 Gilead Sciences, Inc. Therapy for treating bladder cancer
EP4638436A1 (en) 2022-12-22 2025-10-29 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
CN118045103B (zh) * 2023-04-10 2025-03-14 英百瑞(杭州)生物医药有限公司 抗Trop2抗体-自然杀伤细胞偶联物及其用途
CN120882725A (zh) 2023-04-11 2025-10-31 吉利德科学公司 Kras调节化合物
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20250042922A1 (en) 2023-06-30 2025-02-06 Gilead Sciences, Inc. Kras modulating compounds
AU2024297978A1 (en) 2023-07-26 2026-02-05 Gilead Sciences, Inc. Parp7 inhibitors
US20250066328A1 (en) 2023-07-26 2025-02-27 Gilead Sciences, Inc. Parp7 inhibitors
WO2025054347A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Kras g12d modulating compounds
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
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AU2012335205A1 (en) * 2011-11-11 2014-05-29 Rinat Neuroscience Corp. Antibodies specific for Trop-2 and their uses
CA2920192A1 (en) * 2013-09-27 2015-04-02 Immunomedics, Inc. Anti-trop-2 antibody-drug conjugates and uses thereof
LT3424955T (lt) * 2013-12-25 2025-06-25 Daiichi Sankyo Company, Limited Anti-trop2 antikūno ir vaisto konjugato gamybos būdas
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
JP7379795B2 (ja) * 2016-04-27 2023-11-15 イミューノメディクス、インコーポレイテッド チェックポイント阻害薬に再発/耐性を示す腫瘍を治療するための抗Trop-2-SN-38抗体薬物複合体の効果
CN105925536B (zh) * 2016-06-24 2020-02-07 安徽未名细胞治疗有限公司 Trop2嵌合抗原受体修饰的T淋巴细胞及其应用
CN107446050A (zh) * 2017-08-11 2017-12-08 百奥泰生物科技(广州)有限公司 Trop2阳性疾病治疗的化合物及方法

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