JP2018127459A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018127459A5 JP2018127459A5 JP2018040100A JP2018040100A JP2018127459A5 JP 2018127459 A5 JP2018127459 A5 JP 2018127459A5 JP 2018040100 A JP2018040100 A JP 2018040100A JP 2018040100 A JP2018040100 A JP 2018040100A JP 2018127459 A5 JP2018127459 A5 JP 2018127459A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- cycloalkyl
- branched alkyl
- linear alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*)[n]1c(O*)c(*)nc1C(*)=NC Chemical compound CC(*)[n]1c(O*)c(*)nc1C(*)=NC 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40942210P | 2010-11-02 | 2010-11-02 | |
| US61/409,422 | 2010-11-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016028303A Division JP6574721B2 (ja) | 2010-11-02 | 2016-02-17 | 新規セレンテラジン基質及び使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018127459A JP2018127459A (ja) | 2018-08-16 |
| JP2018127459A5 true JP2018127459A5 (enExample) | 2019-03-28 |
| JP6752839B2 JP6752839B2 (ja) | 2020-09-09 |
Family
ID=44983728
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537799A Active JP5889910B2 (ja) | 2010-11-02 | 2011-11-02 | 新規セレンテラジン基質及び使用法 |
| JP2013537800A Active JP6155424B2 (ja) | 2010-11-02 | 2011-11-02 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
| JP2016024952A Active JP6374420B2 (ja) | 2010-11-02 | 2016-02-12 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
| JP2016028303A Active JP6574721B2 (ja) | 2010-11-02 | 2016-02-17 | 新規セレンテラジン基質及び使用法 |
| JP2017084390A Active JP6539689B2 (ja) | 2010-11-02 | 2017-04-21 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
| JP2018040100A Active JP6752839B2 (ja) | 2010-11-02 | 2018-03-06 | 新規セレンテラジン基質及び使用法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537799A Active JP5889910B2 (ja) | 2010-11-02 | 2011-11-02 | 新規セレンテラジン基質及び使用法 |
| JP2013537800A Active JP6155424B2 (ja) | 2010-11-02 | 2011-11-02 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
| JP2016024952A Active JP6374420B2 (ja) | 2010-11-02 | 2016-02-12 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
| JP2016028303A Active JP6574721B2 (ja) | 2010-11-02 | 2016-02-17 | 新規セレンテラジン基質及び使用法 |
| JP2017084390A Active JP6539689B2 (ja) | 2010-11-02 | 2017-04-21 | オキヒオドシエビ属由来ルシフェラーゼ、新規セレンテラジン基質、及び使用法 |
Country Status (15)
| Country | Link |
|---|---|
| US (11) | US8809529B2 (enExample) |
| EP (4) | EP3498709B1 (enExample) |
| JP (6) | JP5889910B2 (enExample) |
| KR (2) | KR101939553B1 (enExample) |
| CN (3) | CN103443121B (enExample) |
| AU (2) | AU2011323418B2 (enExample) |
| BR (2) | BR112013010855A2 (enExample) |
| CA (3) | CA2817102C (enExample) |
| DK (2) | DK2635595T3 (enExample) |
| ES (2) | ES2723773T3 (enExample) |
| IL (5) | IL225867B (enExample) |
| PL (2) | PL2635582T3 (enExample) |
| PT (1) | PT2635595T (enExample) |
| SG (5) | SG10201607774RA (enExample) |
| WO (2) | WO2012061530A2 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005038029A2 (en) | 2003-10-10 | 2005-04-28 | Promega Corporation | Luciferase biosensor |
| EP2327768B1 (en) | 2006-04-03 | 2015-09-09 | Promega Corporation | Permuted and nonpermuted luciferase biosensors |
| ATE542903T1 (de) | 2008-05-19 | 2012-02-15 | Promega Corp | Luciferase-biosensoren für camp |
| CN108192950B (zh) | 2009-05-01 | 2021-09-03 | 普罗梅加公司 | 具有增强的光输出的合成的刺虾萤光素酶 |
| US9290794B2 (en) * | 2010-05-11 | 2016-03-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| EP3508570B1 (en) | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| DK2635595T3 (en) | 2010-11-02 | 2019-03-04 | Promega Corp | OPLOPHORUS-DERIVATED LUCIFERASES, UNKNOWN COELENTERAZINE SUBSTRATES AND PROCEDURES FOR USE THEREOF |
| US9487520B2 (en) | 2010-11-02 | 2016-11-08 | Promega Corporation | Coelenterazine derivatives and methods of using same |
| WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
| EP2931305B1 (en) | 2012-12-12 | 2018-11-28 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| KR102150479B1 (ko) | 2012-12-12 | 2020-09-01 | 프로메가 코포레이션 | 세포내 생물발광 공명 에너지 전이를 이용하여 생물활성제에 의한 세포 표적 결합의 인식 |
| US10067149B2 (en) | 2012-12-12 | 2018-09-04 | Promega Corporation | Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer |
| JP6511720B2 (ja) * | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| US11072811B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
| CN117024548A (zh) | 2013-03-15 | 2023-11-10 | 普洛麦格公司 | 通过结构互补激活生物发光 |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| CN105392892A (zh) * | 2013-03-27 | 2016-03-09 | 六品科技公司 | 重组噬菌体和细菌检测方法 |
| JP6040846B2 (ja) * | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| US9828625B2 (en) | 2013-06-19 | 2017-11-28 | Phage Diagnostics, Inc. | Phage-based bacterial detection assay |
| HK1222673A1 (zh) * | 2013-07-12 | 2017-07-07 | The Children's Hospital Of Philadelphia | Aav载体和用於抗aav(腺相关病毒)中和抗体的检测 |
| CA2918426C (en) | 2013-07-18 | 2021-10-19 | Ecole Polytechnique Federale De Lausanne (Epfl) | Means and methods for bioluminescence resonance energy transfer (bret) analysis in a biological sample |
| JP6484987B2 (ja) | 2013-10-21 | 2019-03-20 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| WO2015067302A1 (en) | 2013-11-05 | 2015-05-14 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sensor molecules and uses thereof |
| JP6442825B2 (ja) | 2013-12-26 | 2018-12-26 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| WO2015116867A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| JP6588917B2 (ja) | 2014-01-29 | 2019-10-09 | プロメガ コーポレイションPromega Corporation | 生細胞への適用のためのプロ基質 |
| JP6256118B2 (ja) * | 2014-03-11 | 2018-01-10 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質のキメラ遺伝子及びその使用法 |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| WO2015179864A1 (en) | 2014-05-23 | 2015-11-26 | Promega Corporation | Compositions and methods for stabilizing luminogenic substrates |
| EP3191600A1 (en) | 2014-09-11 | 2017-07-19 | Promega Corporation | Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence |
| US11365402B2 (en) * | 2014-09-12 | 2022-06-21 | Promega Corporation | Internal protein tags |
| EP3191601B1 (en) * | 2014-09-12 | 2022-11-02 | Promega Corporation | Internal protein tags |
| US20190054117A1 (en) * | 2014-12-19 | 2019-02-21 | Novartis Ag | Dimerization switches and uses thereof |
| US10571471B2 (en) | 2015-02-05 | 2020-02-25 | Promega Corporation | Luciferase-based thermal shift assays |
| EP3304078B1 (en) | 2015-06-05 | 2022-08-31 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
| JP6862368B2 (ja) | 2015-06-25 | 2021-04-21 | プロメガ コーポレイションPromega Corporation | チエノピロール化合物、及びそのOplophorus由来ルシフェラーゼの阻害剤としての使用 |
| US20170029798A1 (en) * | 2015-07-27 | 2017-02-02 | Cellivery Therapeutics, Inc. | Development of Improved Cell-Permeable (iCP) Parkin Recombinant Protein as a Protein-Based Anti-Neurodegenerative Agent for the Treatment of Parkinson's Disease-Associated Phenotypes by Utilizing BBB-Penetrating Protein Delivery System MITT, Enabled by Advanced Macromolecule Transduction Domain (aMTD) |
| EP3416968B1 (en) | 2016-02-15 | 2022-07-27 | Promega Corporation | Coelenterazine analogues |
| WO2017155036A1 (ja) | 2016-03-11 | 2017-09-14 | 国立研究開発法人産業技術総合研究所 | 発光酵素タンパク質 |
| US10634680B2 (en) | 2016-04-26 | 2020-04-28 | University Of Utah Research Foundation | Target-binding activated split reporter systems for analyte detection and related components and methods |
| CN105968114B (zh) * | 2016-05-27 | 2018-11-09 | 山东大学 | 一种腔肠素类似物及其制备方法与应用 |
| DK3490991T3 (da) | 2016-07-28 | 2021-01-25 | Promega Corp | Coelenterazine analogues |
| US10202584B2 (en) * | 2016-09-01 | 2019-02-12 | The Regents Of The University Of California | Red-shifted luciferase-luciferin pairs for enhanced bioluminescence |
| WO2018049241A1 (en) | 2016-09-09 | 2018-03-15 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| WO2018085367A1 (en) | 2016-11-01 | 2018-05-11 | Promega Corporation | Coelenterazine analogues tethered to energy acceptors |
| WO2018102693A1 (en) * | 2016-12-01 | 2018-06-07 | Promega Corporation | Cell impermeable coelenterazine analogues |
| EP3548470B1 (en) * | 2016-12-01 | 2023-11-01 | Promega Corporation | 5,5-disubstituted luciferins and their use in luciferase-based assays |
| JP7161475B2 (ja) | 2016-12-28 | 2022-10-26 | プロメガ コーポレイション | 官能化nanoluc阻害剤 |
| EP3630994B1 (en) | 2017-05-30 | 2022-08-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Sensors, methods and kits for detecting nadph based on resonance energy transfer. |
| EP3649130B1 (en) | 2017-07-06 | 2024-05-22 | Promega Corporation | Serum stable pro-coelenterazine analogues |
| CN108107209B (zh) * | 2017-09-19 | 2020-07-24 | 中国中医科学院医学实验中心 | 一种检测分泌型报告蛋白含量的优化方法及其所用生物材料 |
| EP3788048A1 (en) * | 2018-05-01 | 2021-03-10 | Promega Corporation | Coelenterazine compounds as nanoluc suicide substrates |
| JP7432529B2 (ja) | 2018-05-30 | 2024-02-16 | プロメガ コーポレイション | 広域スペクトルキナーゼ結合剤 |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| CN112567028A (zh) * | 2018-06-12 | 2021-03-26 | 普洛麦格公司 | 多部分萤光素酶 |
| US10962538B2 (en) | 2018-06-14 | 2021-03-30 | The Trustees Of Columbia University In The City Of New York | Assays using arrestin recruitment and unmodified receptors |
| WO2020023871A1 (en) | 2018-07-27 | 2020-01-30 | Promega Corporation | Quinone-containing conjugates |
| US11691976B2 (en) | 2018-08-23 | 2023-07-04 | Promega Corporation | Coelenterazine analogues |
| JP7447101B2 (ja) | 2018-10-03 | 2024-03-11 | プロメガ コーポレイション | セレンテラジンならびにその類似体及び誘導体を安定化させるための組成物及び方法 |
| JP7703446B2 (ja) | 2018-11-28 | 2025-07-07 | プロメガ コーポレイション | 反応性ペプチド標識付け |
| JP7634479B2 (ja) | 2018-12-04 | 2025-02-21 | プロメガ コーポレイション | 広域スペクトルgpcr結合剤 |
| US20220259574A1 (en) * | 2019-02-27 | 2022-08-18 | University Of Virginia Patent Foundation | Atp-independent bioluminescent reporter variants to improve in vivo imaging |
| US11913944B2 (en) | 2019-03-20 | 2024-02-27 | Promega Corporation | Photoaffinity probes |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| AU2020308448A1 (en) | 2019-06-24 | 2022-02-03 | Promega Corporation | Modified polyamine polymers for delivery of biomolecules into cells |
| CA3158729A1 (en) | 2019-11-27 | 2021-06-03 | Virginia Kincaid | Multipartite luciferase peptides and polypeptides |
| EP4073512B1 (en) | 2019-12-10 | 2025-11-12 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
| JP7790724B2 (ja) * | 2020-03-17 | 2025-12-23 | 国立研究開発法人産業技術総合研究所 | 発光基質化合物 |
| EP3882632A1 (en) | 2020-03-18 | 2021-09-22 | Universite De Bordeaux | Novel ion conducting channel fusion subunits and methods of use thereof |
| CN113527231A (zh) * | 2020-04-15 | 2021-10-22 | 深圳华大生命科学研究院 | 杂环取代腔肠素类化合物的合成方法 |
| EP3904508A1 (en) | 2020-04-27 | 2021-11-03 | Institut Pasteur | Luciferase linked immunosorbent assay |
| US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
| CN116391129A (zh) | 2020-08-28 | 2023-07-04 | 普罗美加公司 | 针对ras蛋白的靶标接合测定法 |
| TW202242415A (zh) | 2020-12-25 | 2022-11-01 | 日商中外製藥股份有限公司 | 能夠與複數的目標分子共同形成複合體之候補分子的篩選方法 |
| CN118703457A (zh) * | 2021-04-01 | 2024-09-27 | 深圳华大生命科学研究院 | 一种刺虾荧光素酶Nluc的突变体及其应用 |
| CN118139895A (zh) * | 2021-08-24 | 2024-06-04 | 巴斯德研究所 | 基于发光的抗原测定法 |
| JP2025515179A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 円順列置換デハロゲナーゼバリアント |
| US20240174992A1 (en) | 2022-05-04 | 2024-05-30 | Promega Corporation | Split modified dehalogenase variants |
| JP2025515181A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 伸長表面ループ領域を有する修飾デハロゲナーゼ |
| JP2025515176A (ja) | 2022-05-04 | 2025-05-13 | プロメガ コーポレイション | 光活性化可能な化合物及びその使用 |
| CN115349611B (zh) * | 2022-08-05 | 2023-10-24 | 江南大学 | 一种改善南美白对虾虾糜凝胶品质的方法 |
| CN116068198B (zh) * | 2022-11-30 | 2024-01-09 | 深圳湾实验室 | Ppi原位检测方法及其载体、诊断试剂、试剂盒和应用 |
| US20240377404A1 (en) * | 2023-03-24 | 2024-11-14 | Promega Corporation | Bioluminescence-triggered photocatalytic activation |
| JP7482563B1 (ja) | 2023-06-21 | 2024-05-14 | 国立大学法人大阪大学 | シイノトモシビタケ由来の発光関連遺伝子 |
| DE102023120682B3 (de) | 2023-08-03 | 2024-10-24 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut | Zytotoxizitätstest zum Nachweis von Zellschäden |
| GB202404021D0 (en) | 2024-03-20 | 2024-05-01 | Ipsen Biopharm Ltd | Cell-based neurotoxin assay |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3477549D1 (en) | 1983-08-17 | 1989-05-11 | Allied Signal Inc | Gas generator and method of generating gas |
| JPH0515398A (ja) | 1991-07-15 | 1993-01-26 | Nippon Oil & Fats Co Ltd | オキシダーゼ酵素の定量方法 |
| US5368484A (en) | 1992-05-22 | 1994-11-29 | Atari Games Corp. | Vehicle simulator with realistic operating feedback |
| EP0689587B1 (en) | 1994-01-03 | 2008-04-09 | Promega Corporation | Mutant luciferases |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| GB9501170D0 (en) | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| JP3648763B2 (ja) | 1994-08-23 | 2005-05-18 | 日本油脂株式会社 | ウミホタルルシフェリン誘導体および糖加水分解酵素の定量方法 |
| GB9417593D0 (en) | 1994-09-01 | 1994-10-19 | Secr Defence | Luciferase labelling method |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| CA2210354C (en) | 1995-01-20 | 2008-01-08 | The Secretary Of State For Defence | Mutant luciferases |
| JPH08294397A (ja) | 1995-04-27 | 1996-11-12 | Nippon Oil & Fats Co Ltd | 免疫学的活性物質の測定方法 |
| US5998204A (en) | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| WO1998046739A1 (fr) | 1997-04-16 | 1998-10-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Molecules immunomodulatrices et leur procede de production |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| AU754312C (en) * | 1997-09-19 | 2005-11-10 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| JP3694181B2 (ja) * | 1999-01-05 | 2005-09-14 | キッコーマン株式会社 | 変異型ルシフェラーゼ、変異型ルシフェラーゼ遺伝子、新規な組み換え体dna及び変異型ルシフェラーゼの製造法 |
| GB9925161D0 (en) | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| WO2001031028A2 (en) | 1999-10-26 | 2001-05-03 | The Secretary Of State For Defence | Mutant luciferase |
| US20010046687A1 (en) | 2000-03-31 | 2001-11-29 | Dicesare Joseph L. | Method for the enhancement of luminescence intensity from a reaction between adenosine triphosphate (ATP) and a luciferase/luciferin reactant system |
| EP1156103B1 (en) | 2000-04-26 | 2010-08-11 | Chisso Corporation | Oplophorus luciferase |
| JP4613441B2 (ja) * | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| US7118878B1 (en) | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| EP2388254B1 (en) | 2002-02-01 | 2016-08-10 | Promega Corporation | Bioluminescent protease assay |
| JP2006508339A (ja) | 2002-09-20 | 2006-03-09 | プロメガ コーポレイション | シトクロムp450活性を測定するための発光を利用する方法およびプローブ |
| ES2237643T3 (es) * | 2002-10-21 | 2005-08-01 | Axxam S.R.L. | Fotoproteina con bioluminiscencia mejorada. |
| US7741067B2 (en) | 2002-12-23 | 2010-06-22 | Promega Corporation | Luciferase-based assays |
| EP2455458B1 (en) | 2003-01-31 | 2015-01-07 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| CA2515217A1 (en) | 2003-02-12 | 2004-08-26 | Promega Corporation | Methods and kits for dual enzymatic assays whereby light is quenched from luminescent reactions |
| US20040178545A1 (en) | 2003-03-14 | 2004-09-16 | Cates Larry E. | System for optically analyzing a molten metal bath |
| WO2005038029A2 (en) | 2003-10-10 | 2005-04-28 | Promega Corporation | Luciferase biosensor |
| DE602005016648D1 (de) | 2004-01-08 | 2009-10-29 | Univ Zuerich | Metallkomplexe mit vitamin b12 als ligand |
| US7416854B2 (en) | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US7553632B2 (en) | 2004-01-22 | 2009-06-30 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| EP3179252B1 (en) | 2004-07-30 | 2018-11-14 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| US20070087400A1 (en) | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| JP3844082B2 (ja) * | 2005-04-08 | 2006-11-08 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体dna及び耐熱性ホタルルシフェラーゼの製造法 |
| EP1935986B1 (en) | 2005-05-31 | 2014-04-16 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| EP3312292B1 (en) | 2005-05-31 | 2019-09-25 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| US7495579B2 (en) | 2005-06-13 | 2009-02-24 | Sirota J Marcos | Traffic light status remote sensor system |
| US20090305239A1 (en) | 2005-08-17 | 2009-12-10 | Tawfik Dan S | Methods and compositions for determing a level of biologically active serum paraoxonase |
| JP4999341B2 (ja) | 2005-09-06 | 2012-08-15 | 株式会社バイオエネックス | 変異型ホタルルシフェラーゼ、遺伝子、組換えベクター、形質転換体、及び変異型ホタルルシフェラーゼの製造方法 |
| EP2327768B1 (en) | 2006-04-03 | 2015-09-09 | Promega Corporation | Permuted and nonpermuted luciferase biosensors |
| JP2007306871A (ja) | 2006-05-19 | 2007-11-29 | Chisso Corp | 封入体可溶化方法及び精製方法 |
| EP2374875B1 (en) | 2006-10-30 | 2015-09-02 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and funcitional expression |
| WO2008086035A2 (en) | 2007-01-10 | 2008-07-17 | Promega Corporation | Split mutant hydrolase fusion reporter and uses thereof |
| US20080248511A1 (en) | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
| JP2011502509A (ja) | 2007-11-05 | 2011-01-27 | プロメガ コーポレイション | ハイブリッド融合レポーター及びその使用 |
| ATE542903T1 (de) | 2008-05-19 | 2012-02-15 | Promega Corp | Luciferase-biosensoren für camp |
| US8183007B2 (en) | 2008-07-22 | 2012-05-22 | Promega Corporation | ADP detection based methods using adenylate cyclase and bioluminescence |
| TWI375901B (en) | 2008-08-05 | 2012-11-01 | Elan Microelectronics Corp | Touch screen and method for positioning coordinate |
| JP5582505B2 (ja) * | 2009-02-09 | 2014-09-03 | Jnc株式会社 | セレンテラジン類縁体及びその製造方法 |
| JPWO2010119721A1 (ja) * | 2009-04-17 | 2012-10-22 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
| CN108192950B (zh) * | 2009-05-01 | 2021-09-03 | 普罗梅加公司 | 具有增强的光输出的合成的刺虾萤光素酶 |
| WO2011038219A1 (en) | 2009-09-24 | 2011-03-31 | Promega Corporation | Proteases having improved stability, solubility and activity |
| JP5605727B2 (ja) * | 2010-04-06 | 2014-10-15 | Jnc株式会社 | セレンテラジン類縁体及びセレンテラミド類縁体 |
| EP3508570B1 (en) | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| EP2611929B1 (en) | 2010-09-01 | 2016-01-13 | Promega Corporation | Oxidized glutathione assay |
| US9284188B2 (en) | 2010-09-03 | 2016-03-15 | The Regents Of The University Of California | Cytosolic delivery of materials with endosome-disrupting colloids |
| DK2635595T3 (en) | 2010-11-02 | 2019-03-04 | Promega Corp | OPLOPHORUS-DERIVATED LUCIFERASES, UNKNOWN COELENTERAZINE SUBSTRATES AND PROCEDURES FOR USE THEREOF |
| US9487520B2 (en) * | 2010-11-02 | 2016-11-08 | Promega Corporation | Coelenterazine derivatives and methods of using same |
| US9273343B2 (en) | 2011-09-02 | 2016-03-01 | Promega Corporation | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H |
-
2011
- 2011-11-02 DK DK11785534.6T patent/DK2635595T3/en active
- 2011-11-02 CA CA2817102A patent/CA2817102C/en active Active
- 2011-11-02 ES ES11785534T patent/ES2723773T3/es active Active
- 2011-11-02 WO PCT/US2011/059018 patent/WO2012061530A2/en not_active Ceased
- 2011-11-02 EP EP19150036.2A patent/EP3498709B1/en active Active
- 2011-11-02 KR KR1020137014030A patent/KR101939553B1/ko active Active
- 2011-11-02 US US13/287,992 patent/US8809529B2/en active Active
- 2011-11-02 EP EP11782732.9A patent/EP2635582B1/en active Active
- 2011-11-02 PT PT11785534T patent/PT2635595T/pt unknown
- 2011-11-02 CN CN201180063659.6A patent/CN103443121B/zh active Active
- 2011-11-02 ES ES11782732T patent/ES2567410T3/es active Active
- 2011-11-02 SG SG10201607774RA patent/SG10201607774RA/en unknown
- 2011-11-02 CN CN201180062485.1A patent/CN103370319B/zh active Active
- 2011-11-02 JP JP2013537799A patent/JP5889910B2/ja active Active
- 2011-11-02 EP EP19150069.3A patent/EP3498710A1/en active Pending
- 2011-11-02 US US13/287,986 patent/US8669103B2/en active Active
- 2011-11-02 BR BR112013010855A patent/BR112013010855A2/pt not_active Application Discontinuation
- 2011-11-02 PL PL11782732T patent/PL2635582T3/pl unknown
- 2011-11-02 SG SG2013030366A patent/SG189496A1/en unknown
- 2011-11-02 SG SG10202103336SA patent/SG10202103336SA/en unknown
- 2011-11-02 BR BR112013010487-2A patent/BR112013010487B1/pt active IP Right Grant
- 2011-11-02 WO PCT/US2011/059017 patent/WO2012061529A1/en not_active Ceased
- 2011-11-02 EP EP11785534.6A patent/EP2635595B1/en active Active
- 2011-11-02 DK DK11782732.9T patent/DK2635582T3/da active
- 2011-11-02 AU AU2011323418A patent/AU2011323418B2/en active Active
- 2011-11-02 CN CN201610172245.1A patent/CN106148362B/zh active Active
- 2011-11-02 SG SG10201608550SA patent/SG10201608550SA/en unknown
- 2011-11-02 SG SG2013033675A patent/SG190104A1/en unknown
- 2011-11-02 CA CA2815227A patent/CA2815227C/en active Active
- 2011-11-02 CA CA3081115A patent/CA3081115A1/en active Pending
- 2011-11-02 JP JP2013537800A patent/JP6155424B2/ja active Active
- 2011-11-02 KR KR1020137014102A patent/KR101538624B1/ko active Active
- 2011-11-02 PL PL11785534T patent/PL2635595T3/pl unknown
-
2013
- 2013-04-21 IL IL225867A patent/IL225867B/en active IP Right Grant
- 2013-05-02 IL IL226114A patent/IL226114B/en active IP Right Grant
-
2014
- 2014-01-21 US US14/160,282 patent/US9951373B2/en active Active
- 2014-01-21 US US14/160,278 patent/US9840730B2/en active Active
- 2014-08-18 US US14/461,610 patent/US9139836B2/en active Active
-
2015
- 2015-09-21 US US14/859,715 patent/US9938564B2/en active Active
-
2016
- 2016-02-12 JP JP2016024952A patent/JP6374420B2/ja active Active
- 2016-02-17 JP JP2016028303A patent/JP6574721B2/ja active Active
- 2016-08-12 AU AU2016213854A patent/AU2016213854B2/en active Active
-
2017
- 2017-04-21 JP JP2017084390A patent/JP6539689B2/ja active Active
-
2018
- 2018-03-06 JP JP2018040100A patent/JP6752839B2/ja active Active
- 2018-04-09 US US15/948,070 patent/US10774364B2/en active Active
- 2018-04-18 IL IL258790A patent/IL258790B/en active IP Right Grant
-
2020
- 2020-04-28 IL IL274316A patent/IL274316B/en unknown
- 2020-09-03 US US17/011,597 patent/US11661623B2/en active Active
-
2021
- 2021-05-27 US US17/332,459 patent/US12215375B2/en active Active
- 2021-11-14 IL IL288070A patent/IL288070B2/en unknown
-
2023
- 2023-09-21 US US18/471,901 patent/US12435354B2/en active Active
-
2025
- 2025-10-07 US US19/352,238 patent/US20260028662A1/en active Pending