BR112021006298A2 - composições e métodos para estabilizar coelenterazina e análogos e derivados da mesma - Google Patents
composições e métodos para estabilizar coelenterazina e análogos e derivados da mesmaInfo
- Publication number
- BR112021006298A2 BR112021006298A2 BR112021006298A BR112021006298A BR112021006298A2 BR 112021006298 A2 BR112021006298 A2 BR 112021006298A2 BR 112021006298 A BR112021006298 A BR 112021006298A BR 112021006298 A BR112021006298 A BR 112021006298A BR 112021006298 A2 BR112021006298 A2 BR 112021006298A2
- Authority
- BR
- Brazil
- Prior art keywords
- coelenterazine
- analogues
- derivatives
- stabilizing
- compositions
- Prior art date
Links
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oplophorus luciferin Chemical compound C1=CC(O)=CC=C1CC(C(N1C=C(N2)C=3C=CC(O)=CC=3)=O)=NC1=C2CC1=CC=CC=C1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 title abstract 8
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000000087 stabilizing effect Effects 0.000 title abstract 3
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0018—Pullulan, i.e. (alpha-1,4)(alpha-1,6)-D-glucan; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/34—Heterocyclic compounds having nitrogen in the ring
- C08K5/3442—Heterocyclic compounds having nitrogen in the ring having two nitrogen atoms in the ring
- C08K5/3462—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
- C08L25/02—Homopolymers or copolymers of hydrocarbons
- C08L25/04—Homopolymers or copolymers of styrene
- C08L25/06—Polystyrene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Abstract
composições e métodos para estabilizar coelenterazina e análogos e derivados da mesma. trata-se de composições e métodos para estabilizar coelenterazina e análogos ou derivados da mesma e para melhorar eficácia de reconstituição e solubilidade de coelenterazina e análogos e derivados da mesma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862740622P | 2018-10-03 | 2018-10-03 | |
US201962805517P | 2019-02-14 | 2019-02-14 | |
PCT/US2019/054501 WO2020072775A2 (en) | 2018-10-03 | 2019-10-03 | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021006298A2 true BR112021006298A2 (pt) | 2021-07-06 |
Family
ID=68296818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021006298A BR112021006298A2 (pt) | 2018-10-03 | 2019-10-03 | composições e métodos para estabilizar coelenterazina e análogos e derivados da mesma |
Country Status (11)
Country | Link |
---|---|
US (2) | US11534504B2 (pt) |
EP (2) | EP4015644A1 (pt) |
JP (1) | JP7447101B2 (pt) |
KR (1) | KR20210072040A (pt) |
CN (1) | CN112996923A (pt) |
AU (1) | AU2019355136A1 (pt) |
BR (1) | BR112021006298A2 (pt) |
CA (1) | CA3114424A1 (pt) |
IL (1) | IL281844A (pt) |
SG (1) | SG11202103289SA (pt) |
WO (1) | WO2020072775A2 (pt) |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
US7659078B1 (en) | 2002-07-17 | 2010-02-09 | University Of Kentucky Research Foundation | Method and kit for determination of prostacyclin in plasma |
EP2778234B1 (en) | 2005-05-31 | 2017-09-27 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
WO2008118445A1 (en) | 2007-03-26 | 2008-10-02 | Promega Corporation | Methods to quench light from optical reactions |
GB0905410D0 (en) | 2009-03-28 | 2009-05-13 | Gentronix Ltd | Genotoxicity testing |
JP6038649B2 (ja) | 2009-05-01 | 2016-12-07 | プロメガ コーポレイションPromega Corporation | 増大した光出力を有する合成オプロフォルスルシフェラーゼ |
US8847872B2 (en) | 2010-07-07 | 2014-09-30 | Himax Display, Inc. | Display for driving a pixel circuitry with positive and negative polarities during a frame period and pixel circuitry |
SG10202103336SA (en) | 2010-11-02 | 2021-04-29 | Promega Corp | Novel coelenterazine substrates and methods of use |
WO2012061477A1 (en) | 2010-11-02 | 2012-05-10 | Promega Corporation | Coelenterazine derivatives and methods of using same |
US20130272966A1 (en) | 2012-04-12 | 2013-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Ret2ir conjugates, ret2ir conjugate systems and methods of use thereof |
AU2013204332B2 (en) * | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
EP2893327B1 (en) * | 2012-09-01 | 2020-11-04 | Prolume, Ltd. | Coelenterazine compounds and methods of use |
EP2900833B1 (en) | 2012-09-26 | 2018-05-30 | Promega Corporation | Real-time monitoring |
SG10201601929YA (en) | 2013-03-15 | 2016-04-28 | Promega Corp | Activation Of Bioluminescence By Structural Complementation |
AU2013394649B2 (en) * | 2013-07-18 | 2020-07-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | Means and methods for bioluminescence resonance energy transfer (BRET) analysis in a biological sample |
JP6588917B2 (ja) | 2014-01-29 | 2019-10-09 | プロメガ コーポレイションPromega Corporation | 生細胞への適用のためのプロ基質 |
EP2930497A1 (en) | 2014-04-07 | 2015-10-14 | Institut Pasteur | Enzyme-independent photon emission |
SG11201609382WA (en) | 2014-05-23 | 2016-12-29 | Promega Corp | Compositions and methods for stabilizing luminogenic substrates |
JP6688499B2 (ja) | 2014-10-27 | 2020-04-28 | 国立大学法人 鹿児島大学 | 安定性が増加したウミシイタケ(Renillareniformis)由来ルシフェラーゼ変異体 |
EP3259365B1 (en) | 2015-02-16 | 2020-04-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Sensors, methods and kits for detecting nicotinamide adenine dinucleotides |
US9908918B2 (en) | 2015-06-30 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Cyan-excitable orange-red fluorescent proteins and bioluminescent resonance energy transfer systems |
EP4086261A1 (en) | 2016-02-15 | 2022-11-09 | Promega Corporation | Process for the preparation of coelenterazine analogues |
WO2018022865A1 (en) | 2016-07-28 | 2018-02-01 | Promega Corporation | Coelenterazine analogues |
JP6978492B2 (ja) | 2016-09-09 | 2021-12-08 | プロメガ コーポレイションPromega Corporation | 二重保護されたプロセレンテラジン基質 |
EP3535270B1 (en) | 2016-11-01 | 2022-07-27 | Promega Corporation | Coelenterazine analogues tethered to energy acceptors |
EP4279490A3 (en) | 2016-12-01 | 2024-04-10 | Promega Corporation | Cell impermeable coelenterazine analogues |
US11959121B2 (en) | 2017-05-30 | 2024-04-16 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Sensors, methods and kits for detecting NADPH based on resonance energy transfer |
KR102660777B1 (ko) | 2017-08-08 | 2024-04-24 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | 탄수화물 센서 |
US20200393450A1 (en) | 2017-08-25 | 2020-12-17 | Technische Universiteit Eindhoven | Detection device for bioluminescent detection of biomarkers from a biological fluid sample using luminescent sensing proteins |
US11655247B2 (en) | 2018-05-01 | 2023-05-23 | Promega Corporation | Nanoluc suicide substrates |
US20200085990A1 (en) | 2018-06-29 | 2020-03-19 | International Paper Company | Chemiluminescent wetness indicator for absorbent products |
US11691976B2 (en) | 2018-08-23 | 2023-07-04 | Promega Corporation | Coelenterazine analogues |
-
2019
- 2019-10-03 EP EP21211779.0A patent/EP4015644A1/en active Pending
- 2019-10-03 AU AU2019355136A patent/AU2019355136A1/en active Pending
- 2019-10-03 KR KR1020217013444A patent/KR20210072040A/ko not_active Application Discontinuation
- 2019-10-03 CA CA3114424A patent/CA3114424A1/en active Pending
- 2019-10-03 EP EP19791094.6A patent/EP3861128A2/en active Pending
- 2019-10-03 JP JP2021518706A patent/JP7447101B2/ja active Active
- 2019-10-03 CN CN201980073774.8A patent/CN112996923A/zh active Pending
- 2019-10-03 BR BR112021006298A patent/BR112021006298A2/pt unknown
- 2019-10-03 WO PCT/US2019/054501 patent/WO2020072775A2/en unknown
- 2019-10-03 US US16/592,310 patent/US11534504B2/en active Active
- 2019-10-03 SG SG11202103289SA patent/SG11202103289SA/en unknown
-
2021
- 2021-03-25 IL IL281844A patent/IL281844A/en unknown
-
2022
- 2022-11-21 US US18/057,578 patent/US20230092932A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3114424A1 (en) | 2020-04-09 |
JP7447101B2 (ja) | 2024-03-11 |
WO2020072775A3 (en) | 2020-07-23 |
CN112996923A (zh) | 2021-06-18 |
EP3861128A2 (en) | 2021-08-11 |
US20230092932A1 (en) | 2023-03-23 |
US11534504B2 (en) | 2022-12-27 |
KR20210072040A (ko) | 2021-06-16 |
WO2020072775A2 (en) | 2020-04-09 |
SG11202103289SA (en) | 2021-04-29 |
IL281844A (en) | 2021-05-31 |
JP2022512611A (ja) | 2022-02-07 |
US20200109146A1 (en) | 2020-04-09 |
EP4015644A1 (en) | 2022-06-22 |
AU2019355136A1 (en) | 2021-04-29 |
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