JP2016510976A5 - - Google Patents
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- JP2016510976A5 JP2016510976A5 JP2015559516A JP2015559516A JP2016510976A5 JP 2016510976 A5 JP2016510976 A5 JP 2016510976A5 JP 2015559516 A JP2015559516 A JP 2015559516A JP 2015559516 A JP2015559516 A JP 2015559516A JP 2016510976 A5 JP2016510976 A5 JP 2016510976A5
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- JP
- Japan
- Prior art keywords
- use according
- component
- group
- carbon atoms
- deep eutectic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 230000005496 eutectics Effects 0.000 claims 11
- 239000002904 solvent Substances 0.000 claims 11
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- -1 halide anion Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 125000002009 alkene group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- AVQQQNCBBIEMEU-UHFFFAOYSA-N 1,1,3,3-tetramethylurea Chemical compound CN(C)C(=O)N(C)C AVQQQNCBBIEMEU-UHFFFAOYSA-N 0.000 claims 1
- 229940057054 1,3-dimethylurea Drugs 0.000 claims 1
- KKKDZZRICRFGSD-UHFFFAOYSA-N 1-benzylimidazole Chemical compound C1=CN=CN1CC1=CC=CC=C1 KKKDZZRICRFGSD-UHFFFAOYSA-N 0.000 claims 1
- IQNHBUQSOSYAJU-UHFFFAOYSA-N 2,2,2-trifluoro-n-methylacetamide Chemical compound CNC(=O)C(F)(F)F IQNHBUQSOSYAJU-UHFFFAOYSA-N 0.000 claims 1
- NRKYWOKHZRQRJR-UHFFFAOYSA-N 2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F NRKYWOKHZRQRJR-UHFFFAOYSA-N 0.000 claims 1
- VZBAIMIVLDKBTE-UHFFFAOYSA-N 2,2,2-trifluoroethanethioamide Chemical compound NC(=S)C(F)(F)F VZBAIMIVLDKBTE-UHFFFAOYSA-N 0.000 claims 1
- QASPDCZPPDUIIE-UHFFFAOYSA-N 2,2-difluoro-2-phenylacetamide Chemical compound NC(=O)C(F)(F)C1=CC=CC=C1 QASPDCZPPDUIIE-UHFFFAOYSA-N 0.000 claims 1
- XJGBNZRVGOENRN-UHFFFAOYSA-N 2,2-difluoropropanamide Chemical compound CC(F)(F)C(N)=O XJGBNZRVGOENRN-UHFFFAOYSA-N 0.000 claims 1
- RBYZOKNDDRTADS-UHFFFAOYSA-N 2-[2-(trifluoromethyl)phenyl]acetamide Chemical compound NC(=O)CC1=CC=CC=C1C(F)(F)F RBYZOKNDDRTADS-UHFFFAOYSA-N 0.000 claims 1
- GFFIJCYHQYHUHB-UHFFFAOYSA-N 2-acetylsulfanylethyl(trimethyl)azanium Chemical compound CC(=O)SCC[N+](C)(C)C GFFIJCYHQYHUHB-UHFFFAOYSA-N 0.000 claims 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 1
- JJCWKVUUIFLXNZ-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCO JJCWKVUUIFLXNZ-UHFFFAOYSA-M 0.000 claims 1
- MZBSJLAGBUNNLH-UHFFFAOYSA-N 3,3,3-trifluoropropanamide Chemical compound NC(=O)CC(F)(F)F MZBSJLAGBUNNLH-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 235000019743 Choline chloride Nutrition 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- MGJKQDOBUOMPEZ-UHFFFAOYSA-N N,N'-dimethylurea Chemical compound CNC(=O)NC MGJKQDOBUOMPEZ-UHFFFAOYSA-N 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 1
- 229960004373 acetylcholine Drugs 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- YRIBGSCJIMXMPJ-UHFFFAOYSA-N butyrylcholine Chemical compound CCCC(=O)OCC[N+](C)(C)C YRIBGSCJIMXMPJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical group [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 1
- 229960003178 choline chloride Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- WHYUWYVXDNNLTR-UHFFFAOYSA-J dizinc;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Zn+2].[Zn+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O WHYUWYVXDNNLTR-UHFFFAOYSA-J 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000000834 fixative Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical group C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 1
- 238000003365 immunocytochemistry Methods 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000000386 microscopy Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 1
- 239000003161 ribonuclease inhibitor Substances 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 235000017709 saponins Nutrition 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical group [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1303666.0A GB201303666D0 (en) | 2013-03-01 | 2013-03-01 | Sample fixation and stabilisation |
| GB1303666.0 | 2013-03-01 | ||
| PCT/EP2014/054009 WO2014131906A1 (en) | 2013-03-01 | 2014-02-28 | Sample fixation and stabilisation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018064225A Division JP6527616B2 (ja) | 2013-03-01 | 2018-03-29 | 試料固定及び安定化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510976A JP2016510976A (ja) | 2016-04-14 |
| JP2016510976A5 true JP2016510976A5 (enExample) | 2017-04-06 |
| JP6317372B2 JP6317372B2 (ja) | 2018-04-25 |
Family
ID=48142243
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559516A Active JP6317372B2 (ja) | 2013-03-01 | 2014-02-28 | 試料固定及び安定化 |
| JP2018064225A Active JP6527616B2 (ja) | 2013-03-01 | 2018-03-29 | 試料固定及び安定化 |
| JP2019089830A Pending JP2019141098A (ja) | 2013-03-01 | 2019-05-10 | 試料固定及び安定化 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018064225A Active JP6527616B2 (ja) | 2013-03-01 | 2018-03-29 | 試料固定及び安定化 |
| JP2019089830A Pending JP2019141098A (ja) | 2013-03-01 | 2019-05-10 | 試料固定及び安定化 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9696247B2 (enExample) |
| EP (3) | EP3788873A1 (enExample) |
| JP (3) | JP6317372B2 (enExample) |
| CN (1) | CN105392363B (enExample) |
| AU (1) | AU2014222618B2 (enExample) |
| CA (1) | CA2904765C (enExample) |
| ES (1) | ES2709064T3 (enExample) |
| GB (1) | GB201303666D0 (enExample) |
| WO (1) | WO2014131906A1 (enExample) |
Families Citing this family (118)
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|---|---|---|---|---|
| EP3733871A1 (en) | 2008-05-27 | 2020-11-04 | Dako Denmark A/S | Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers |
| EP2401396B1 (en) | 2009-02-26 | 2016-11-23 | Dako Denmark A/S | Methods for performing a stringent wash step in hybridization applications |
| EP4397770A1 (en) | 2011-09-26 | 2024-07-10 | PreAnalytiX GmbH | Stabilisation and isolation of extracellular nucleic acids |
| US10676780B2 (en) | 2011-09-26 | 2020-06-09 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| CA2884915C (en) | 2012-09-25 | 2022-05-17 | Qiagen Gmbh | Stabilisation of biological samples |
| GB201303666D0 (en) * | 2013-03-01 | 2013-04-17 | Goldsborough Andrew S | Sample fixation and stabilisation |
| CN105121643A (zh) | 2013-03-18 | 2015-12-02 | 凯杰有限公司 | 细胞外核酸的稳定化和分离 |
| CN105283550A (zh) | 2013-03-18 | 2016-01-27 | 凯杰有限公司 | 生物样品的稳定化 |
| FI126757B (en) * | 2014-02-28 | 2017-05-15 | Teknologian Tutkimuskeskus Vtt Oy | EUTEXT SOLVENT MIXTURES AND THEIR USE |
| JP6664332B2 (ja) * | 2014-03-18 | 2020-03-13 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| CN104023526B (zh) * | 2014-03-24 | 2016-01-13 | 金仕生物科技（常熟）有限公司 | 一种处理生物材料的方法及经该方法处理的生物材料 |
| US20150337372A1 (en) * | 2014-05-22 | 2015-11-26 | Zoetis Services Llc | Methods and apparatus for selectively processing eggs according to gender and other characteristics |
| CN115184120A (zh) * | 2014-05-28 | 2022-10-14 | 凯杰有限公司 | 用于含细胞液体样品的固定剂组合物 |
| JP6605606B2 (ja) | 2014-12-17 | 2019-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | ソルターゼを使用した単一工程での二重ポリペプチドコンジュゲーションのための酵素ワンポット反応 |
| EP3234177A1 (en) | 2014-12-17 | 2017-10-25 | F. Hoffmann-La Roche AG | Activity assay for bond forming enzymes |
| US10111842B2 (en) * | 2014-12-31 | 2018-10-30 | University Of Oslo | Eutectic solvents and uses thereof |
| US9896682B2 (en) | 2015-03-06 | 2018-02-20 | Bio-Rad Laboratories, Inc. | Stabilized RNA solutions |
| CN104887723A (zh) * | 2015-06-18 | 2015-09-09 | 天津理工大学 | 一种利用低共熔溶剂提取银杏叶中黄酮类化合物的方法 |
| GB201513492D0 (en) | 2015-07-30 | 2015-09-16 | Arcis Biotechnology Holdings Ltd | Method and composition |
| US20180355345A1 (en) * | 2015-07-30 | 2018-12-13 | Arcis Biotechnology Holdings Limited | Method and composition |
| US20180237314A1 (en) * | 2015-08-07 | 2018-08-23 | Yangchuan Xing | Synthesis of deep eutectic solvent chemical precursors and their use in the production of metal oxides |
| CN105158129B (zh) * | 2015-08-26 | 2018-04-17 | 武汉东方华康科技有限公司 | 一种红细胞沉降率标准品及其制备方法 |
| WO2017050874A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Process for producing thioesters employing a sortase a |
| WO2017050872A1 (en) | 2015-09-25 | 2017-03-30 | F. Hoffmann-La Roche Ag | Transamidation employing sortase a in deep eutectic solvents |
| CN108138158B (zh) | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
| JP2017082063A (ja) * | 2015-10-26 | 2017-05-18 | 日本化薬株式会社 | 深共晶溶媒を含む光波長変換要素およびその光波長変換要素を含む物品 |
| CA3005694A1 (en) | 2015-11-20 | 2017-05-26 | Qiagen Gmbh | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| JP7014725B2 (ja) * | 2016-02-05 | 2022-02-01 | エフ．ホフマン－ラ ロシュ アーゲー | チオールベースの深共融溶媒 |
| EP3974387B1 (en) | 2016-03-07 | 2025-10-29 | X-Zell Inc. | Compositions and methods for identifying rare cells |
| KR101978828B1 (ko) * | 2016-03-21 | 2019-05-15 | 주식회사 엘지생활건강 | 바이오필름 제거용 조성물 |
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| EP3481771A4 (en) * | 2016-07-08 | 2019-12-25 | President and Fellows of Harvard College | DETERMINATION OF RNA IN BLOOD OR OTHER LIQUIDS |
| FR3058905B1 (fr) * | 2016-11-18 | 2020-02-28 | Universite Du Littoral Cote D'opale | Procede d'epuration d'un effluent gazeux |
| EP3571314B1 (en) * | 2017-01-22 | 2023-12-20 | Chryos, LLC | Composition and method of use of the same for preserving cells for analysis |
| EP3576625A4 (en) * | 2017-02-03 | 2020-12-16 | Streck, Inc. | SAMPLE COLLECTION TUBE WITH PRESERVATIVE |
| DE102017003171A1 (de) * | 2017-03-31 | 2018-10-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tieftemperatur-indikatormischung, vorrichtung und verfahren zur überwachung eines temperaturübergangs bei tiefen temperaturen |
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| CN109837272B (zh) * | 2017-11-27 | 2021-07-16 | 北京自然博物馆 | 血液组织rna成分保存剂及其制备方法 |
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| CN108251414A (zh) * | 2018-01-17 | 2018-07-06 | 云健康基因科技（上海）有限公司 | 骨髓细胞基因组dna的提取方法及提取试剂盒 |
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- 2014-02-28 ES ES14708231T patent/ES2709064T3/es active Active
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