JP2015513920A5 - - Google Patents

Info

Publication number

JP2015513920A5

JP2015513920A5 JP2015505765A JP2015505765A JP2015513920A5 JP 2015513920 A5 JP2015513920 A5 JP 2015513920A5 JP 2015505765 A JP2015505765 A JP 2015505765A JP 2015505765 A JP2015505765 A JP 2015505765A JP 2015513920 A5 JP2015513920 A5 JP 2015513920A5

Authority

JP

Japan

Prior art keywords

seq

isolated

nucleic acid

car

protein

Prior art date

2013-03-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000007523 nucleic acids Chemical class 0.000 claims description 24
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 18
• 210000004027 cell Anatomy 0.000 claims description 17
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 14
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
• 239000000427 antigen Substances 0.000 claims description 11
• 102000036639 antigens Human genes 0.000 claims description 11
• 108091007433 antigens Proteins 0.000 claims description 11
• 230000005754 cellular signaling Effects 0.000 claims description 8
• 239000013598 vector Substances 0.000 claims description 7
• BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 6
• 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 6
• 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 6
• 230000006044 T cell activation Effects 0.000 claims description 5
• 102100027207 CD27 antigen Human genes 0.000 claims description 3
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 3
• 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
• 102000050320 human TNFRSF4 Human genes 0.000 claims description 2
• 108020004707 nucleic acids Proteins 0.000 claims 10
• 102000039446 nucleic acids Human genes 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 201000011510 cancer Diseases 0.000 claims 7
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 230000011748 cell maturation Effects 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 230000006303 immediate early viral mRNA transcription Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 210000000822 natural killer cell Anatomy 0.000 claims 1
• 230000001086 cytosolic effect Effects 0.000 description 15
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 10
• 108010076504 Protein Sorting Signals Proteins 0.000 description 9
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 8
• 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 description 8
• 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 description 8
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 7
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 7
• 108090000765 processed proteins & peptides Proteins 0.000 description 6
• 229920001184 polypeptide Polymers 0.000 description 5
• 102000004196 processed proteins & peptides Human genes 0.000 description 5
• 230000011664 signaling Effects 0.000 description 5
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 4
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 4
• 239000012634 fragment Substances 0.000 description 3
• 230000003834 intracellular effect Effects 0.000 description 3
• 239000013612 plasmid Substances 0.000 description 3
• 108010087819 Fc receptors Proteins 0.000 description 2
• 102000009109 Fc receptors Human genes 0.000 description 2
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 2
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 2
• 101100226902 Mus musculus Fcrlb gene Proteins 0.000 description 2
• 210000000805 cytoplasm Anatomy 0.000 description 2
• 239000000539 dimer Substances 0.000 description 2
• 125000001894 2,4,6-trinitrophenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O 0.000 description 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 description 1
• 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 description 1
• 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 101710150344 Protein Rev Proteins 0.000 description 1
• 230000020385 T cell costimulation Effects 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 241000711975 Vesicular stomatitis virus Species 0.000 description 1
• 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 150000001413 amino acids Chemical group 0.000 description 1
• 239000002771 cell marker Substances 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 230000000139 costimulatory effect Effects 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• 102000046157 human CSF2 Human genes 0.000 description 1
• 102000027596 immune receptors Human genes 0.000 description 1
• 108091008915 immune receptors Proteins 0.000 description 1
• 238000009169 immunotherapy Methods 0.000 description 1
• 230000004068 intracellular signaling Effects 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 108010089520 pol Gene Products Proteins 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 230000009258 tissue cross reactivity Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1