JP6359520B2 - B細胞成熟抗原を標的指向するキメラ抗原受容体 - Google Patents
B細胞成熟抗原を標的指向するキメラ抗原受容体 Download PDFInfo
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- JP6359520B2 JP6359520B2 JP2015505765A JP2015505765A JP6359520B2 JP 6359520 B2 JP6359520 B2 JP 6359520B2 JP 2015505765 A JP2015505765 A JP 2015505765A JP 2015505765 A JP2015505765 A JP 2015505765A JP 6359520 B2 JP6359520 B2 JP 6359520B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622600P | 2012-04-11 | 2012-04-11 | |
| US61/622,600 | 2012-04-11 | ||
| PCT/US2013/032029 WO2013154760A1 (en) | 2012-04-11 | 2013-03-15 | Chimeric antigen receptors targeting b-cell maturation antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117381A Division JP6657317B2 (ja) | 2012-04-11 | 2018-06-20 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513920A JP2015513920A (ja) | 2015-05-18 |
| JP2015513920A5 JP2015513920A5 (enExample) | 2016-05-12 |
| JP6359520B2 true JP6359520B2 (ja) | 2018-07-18 |
Family
ID=48045750
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505765A Active JP6359520B2 (ja) | 2012-04-11 | 2013-03-15 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2018117381A Active JP6657317B2 (ja) | 2012-04-11 | 2018-06-20 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2020018005A Active JP6989634B2 (ja) | 2012-04-11 | 2020-02-05 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2021196490A Active JP7778549B2 (ja) | 2012-04-11 | 2021-12-02 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2023146498A Pending JP2023175763A (ja) | 2012-04-11 | 2023-09-08 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2025147544A Pending JP2025186319A (ja) | 2012-04-11 | 2025-09-05 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018117381A Active JP6657317B2 (ja) | 2012-04-11 | 2018-06-20 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2020018005A Active JP6989634B2 (ja) | 2012-04-11 | 2020-02-05 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2021196490A Active JP7778549B2 (ja) | 2012-04-11 | 2021-12-02 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2023146498A Pending JP2023175763A (ja) | 2012-04-11 | 2023-09-08 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| JP2025147544A Pending JP2025186319A (ja) | 2012-04-11 | 2025-09-05 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
Country Status (17)
| Country | Link |
|---|---|
| US (20) | US9765342B2 (enExample) |
| EP (3) | EP2836239A1 (enExample) |
| JP (6) | JP6359520B2 (enExample) |
| KR (5) | KR102229945B1 (enExample) |
| CN (3) | CN104379179A (enExample) |
| AU (5) | AU2013246443B2 (enExample) |
| BR (1) | BR112014024893B8 (enExample) |
| CA (1) | CA2869562C (enExample) |
| EA (2) | EA201990959A1 (enExample) |
| HK (1) | HK1203393A1 (enExample) |
| IL (4) | IL234870B (enExample) |
| IS (1) | IS9056A (enExample) |
| MX (3) | MX357823B (enExample) |
| NZ (1) | NZ700362A (enExample) |
| RU (2) | RU2766608C2 (enExample) |
| SG (1) | SG11201406414WA (enExample) |
| WO (1) | WO2013154760A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018161140A (ja) * | 2012-04-11 | 2018-10-18 | アメリカ合衆国 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| US11608382B2 (en) | 2018-06-13 | 2023-03-21 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| US12214037B2 (en) | 2014-07-21 | 2025-02-04 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| US12383601B2 (en) | 2019-11-26 | 2025-08-12 | Novartis Ag | Chimeric antigen receptors and uses thereof |
Families Citing this family (277)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| WO2014122143A1 (en) | 2013-02-05 | 2014-08-14 | Engmab Ag | Method for the selection of antibodies against bcma |
| SG11201506974XA (en) | 2013-03-14 | 2015-10-29 | Bellicum Pharmaceuticals Inc | Methods for controlling t cell proliferation |
| AU2014265487B2 (en) | 2013-05-14 | 2020-10-22 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (CAR) T-cells |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| AU2014348657A1 (en) | 2013-11-13 | 2016-05-19 | Novartis Ag | mTOR inhibitors for enhancing the immune response |
| US10323077B2 (en) | 2014-02-10 | 2019-06-18 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| ES2764471T3 (es) | 2014-02-14 | 2020-06-03 | Univ Texas | Receptores de antígeno quimérico y procedimientos de fabricación |
| CN111849912B (zh) * | 2014-02-14 | 2024-03-15 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| ES2737690T3 (es) | 2014-02-27 | 2020-01-15 | Ucl Business Ltd | Variantes de APRIL |
| TR201910814T4 (tr) | 2014-03-19 | 2019-08-21 | Cellectis | Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri. |
| JP2017515464A (ja) | 2014-04-10 | 2017-06-15 | シアトル チルドレンズ ホスピタル, ディービーエー シアトル チルドレンズ リサーチ インスティテュート | 細胞免疫療法のための方法および組成物 |
| JP6698546B2 (ja) * | 2014-04-14 | 2020-05-27 | セレクティスCellectis | 癌免疫療法のためのbcma(cd269)特異的キメラ抗原受容体 |
| LT3134432T (lt) | 2014-04-25 | 2020-04-10 | Bluebird Bio, Inc. | Mnd promotorius chimerinių antigenų receptoriams |
| JP6817069B2 (ja) * | 2014-04-25 | 2021-01-20 | ブルーバード バイオ, インコーポレイテッド | 養子細胞療法薬を製造するための改善された方法 |
| CN107074929B (zh) | 2014-05-02 | 2021-09-03 | 宾夕法尼亚大学董事会 | 嵌合自身抗体受体t细胞的组合物和方法 |
| KR20240093757A (ko) * | 2014-06-02 | 2024-06-24 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | Cd19를 표적화하는 키메라 항원 수용체 |
| CN106793780B (zh) * | 2014-06-06 | 2020-05-26 | 蓝鸟生物公司 | 改善的t细胞组合物 |
| EP3167058B1 (en) * | 2014-07-11 | 2020-05-27 | Celgene Corporation | Methods of improving vector transduction efficiency into t lymphocytes |
| KR20170032406A (ko) | 2014-07-15 | 2017-03-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 조작된 세포 |
| SG11201700418VA (en) | 2014-07-21 | 2017-02-27 | Novartis Ag | Treatment of cancer using a cll-1 chimeric antigen receptor |
| WO2016014789A2 (en) * | 2014-07-24 | 2016-01-28 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| EP3453406B1 (en) * | 2014-07-29 | 2021-04-14 | Cellectis | Ror1 (ntrkr1) specific chimeric antigen receptors for cancer immunotherapy |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| US10888608B2 (en) | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
| EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| MX2017007244A (es) * | 2014-12-05 | 2018-01-25 | Memorial Sloan Kettering Cancer Center | Receptores de antigeno quimerico que se dirigen al antigeno de maduracion de celulas b y sus usos. |
| CN113429485A (zh) | 2014-12-05 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 靶向b-细胞成熟抗原的抗体及其用途 |
| WO2016094304A2 (en) | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| CN108064252A (zh) | 2014-12-19 | 2018-05-22 | 达纳-法伯癌症研究所公司 | 嵌合抗原受体及其使用方法 |
| HUE046054T2 (hu) | 2014-12-24 | 2020-01-28 | Aadigen Llc | Peptidek és nanorészecskék molekulák intracelluláris célba juttatásához |
| MX389057B (es) * | 2015-01-26 | 2025-03-20 | Allogene Therapeutics Inc | Sistemas de receptor de antigeno quimerico impulsado por mab para clasificar/reducir celulas inmunes diseñadas. |
| JP2018510160A (ja) * | 2015-03-20 | 2018-04-12 | ブルーバード バイオ, インコーポレイテッド | ベクター製剤 |
| CN107530427A (zh) | 2015-03-27 | 2018-01-02 | 南加利福尼亚大学 | 针对用于实体肿瘤的治疗的lhr的car t细胞疗法 |
| JP6913025B2 (ja) | 2015-04-13 | 2021-08-04 | ファイザー・インク | 治療抗体およびその使用 |
| DK3283520T3 (da) * | 2015-04-13 | 2020-07-20 | Pfizer | Kimæriske antigenreceptorer målrettet b-celle- modningsantigen |
| US20180117155A1 (en) | 2015-04-25 | 2018-05-03 | The General Hospital Corporation | Anti-fugetactic agent and anti-cancer agent combination therapy and compositions for the treatment of cancer |
| GB201507119D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| CA2986359A1 (en) | 2015-05-20 | 2016-11-24 | Novartis Ag | Pharmaceutical combination of everolimus with dactolisib |
| US10711064B2 (en) * | 2015-06-04 | 2020-07-14 | University Of Southern California | Lym-1 and Lym-2 targeted CAR cell immunotherapy |
| EP3307282A4 (en) * | 2015-06-12 | 2019-05-01 | Immunomedics, Inc. | DISEASE THERAPY WITH CONSTRUCTS OF CHIMERIC ANTIGEN RECEPTOR (CAR) AND T-CELL (CAR-T) OR NK-CELL (CAR-NK) EXPRESSIVE CAR CONSTRUCTS |
| EP3310805B1 (en) | 2015-06-19 | 2021-02-17 | Kobold, Sebastian | Pd-1-cd28 fusion proteins and their use in medicine |
| MA42895A (fr) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| HUE048939T2 (hu) * | 2015-08-03 | 2020-09-28 | Engmab Sarl | Human B sejt érési antigén elleni monoklonális antitestek (BCMA) |
| AU2016306209B2 (en) | 2015-08-07 | 2023-07-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific CAR T-cells for solid tumor targeting |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| JP7010487B2 (ja) | 2015-08-17 | 2022-03-03 | ソウル大学校産学協力団 | 抗コチニン抗体が連結したキメラ抗原受容体およびその使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018161140A (ja) * | 2012-04-11 | 2018-10-18 | アメリカ合衆国 | B細胞成熟抗原を標的指向するキメラ抗原受容体 |
| US12214037B2 (en) | 2014-07-21 | 2025-02-04 | Novartis Ag | Treatment of cancer using humanized anti-BCMA chimeric antigen receptor |
| US11608382B2 (en) | 2018-06-13 | 2023-03-21 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| US11939389B2 (en) | 2018-06-13 | 2024-03-26 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| US11952428B2 (en) | 2018-06-13 | 2024-04-09 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
| US12383601B2 (en) | 2019-11-26 | 2025-08-12 | Novartis Ag | Chimeric antigen receptors and uses thereof |
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