JP6359520B2 - Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体 - Google Patents

Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体 Download PDF

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JP6359520B2
JP6359520B2 JP2015505765A JP2015505765A JP6359520B2 JP 6359520 B2 JP6359520 B2 JP 6359520B2 JP 2015505765 A JP2015505765 A JP 2015505765A JP 2015505765 A JP2015505765 A JP 2015505765A JP 6359520 B2 JP6359520 B2 JP 6359520B2
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JP2015513920A (ja
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ノーブル コッフェンダーファー、ジェームズ
ノーブル コッフェンダーファー、ジェームズ
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Immunology (AREA)
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  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015505765A 2012-04-11 2013-03-15 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体 Active JP6359520B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622600P 2012-04-11 2012-04-11
US61/622,600 2012-04-11
PCT/US2013/032029 WO2013154760A1 (en) 2012-04-11 2013-03-15 Chimeric antigen receptors targeting b-cell maturation antigen

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JP2018117381A Division JP6657317B2 (ja) 2012-04-11 2018-06-20 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体

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JP2015513920A JP2015513920A (ja) 2015-05-18
JP2015513920A5 JP2015513920A5 (enExample) 2016-05-12
JP6359520B2 true JP6359520B2 (ja) 2018-07-18

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JP2015505765A Active JP6359520B2 (ja) 2012-04-11 2013-03-15 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2018117381A Active JP6657317B2 (ja) 2012-04-11 2018-06-20 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2020018005A Active JP6989634B2 (ja) 2012-04-11 2020-02-05 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2021196490A Active JP7778549B2 (ja) 2012-04-11 2021-12-02 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2023146498A Pending JP2023175763A (ja) 2012-04-11 2023-09-08 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2025147544A Pending JP2025186319A (ja) 2012-04-11 2025-09-05 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体

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JP2018117381A Active JP6657317B2 (ja) 2012-04-11 2018-06-20 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2020018005A Active JP6989634B2 (ja) 2012-04-11 2020-02-05 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2021196490A Active JP7778549B2 (ja) 2012-04-11 2021-12-02 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2023146498A Pending JP2023175763A (ja) 2012-04-11 2023-09-08 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
JP2025147544A Pending JP2025186319A (ja) 2012-04-11 2025-09-05 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体

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US (20) US9765342B2 (enExample)
EP (3) EP4653456A3 (enExample)
JP (6) JP6359520B2 (enExample)
KR (5) KR102086874B1 (enExample)
CN (4) CN110295186A (enExample)
AU (5) AU2013246443B2 (enExample)
BR (1) BR112014024893B8 (enExample)
CA (1) CA2869562C (enExample)
EA (2) EA033110B1 (enExample)
ES (1) ES3065694T3 (enExample)
HK (1) HK1203393A1 (enExample)
HR (1) HRP20260443T1 (enExample)
IL (4) IL290471B2 (enExample)
IS (1) IS9056A (enExample)
MX (3) MX394639B (enExample)
NZ (1) NZ700362A (enExample)
PL (1) PL3689383T3 (enExample)
RS (1) RS67930B1 (enExample)
RU (2) RU2650805C2 (enExample)
SG (1) SG11201406414WA (enExample)
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JP2018161140A (ja) * 2012-04-11 2018-10-18 アメリカ合衆国 Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
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US12214037B2 (en) 2014-07-21 2025-02-04 Novartis Ag Treatment of cancer using humanized anti-BCMA chimeric antigen receptor
US12383601B2 (en) 2019-11-26 2025-08-12 Novartis Ag Chimeric antigen receptors and uses thereof

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