JP2018526033A5 - - Google Patents

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Publication number
JP2018526033A5
JP2018526033A5 JP2018532485A JP2018532485A JP2018526033A5 JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5 JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5
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JP
Japan
Prior art keywords
receptor
cancer
cell
dysfunctional
chimeric antigen
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JP2018532485A
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English (en)
Japanese (ja)
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JP6957471B2 (ja
JP2018526033A (ja
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Priority claimed from PCT/AU2016/050851 external-priority patent/WO2017041143A1/en
Publication of JP2018526033A publication Critical patent/JP2018526033A/ja
Publication of JP2018526033A5 publication Critical patent/JP2018526033A5/ja
Priority to JP2021164222A priority Critical patent/JP7253020B2/ja
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Publication of JP6957471B2 publication Critical patent/JP6957471B2/ja
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JP2018532485A 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用 Active JP6957471B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021164222A JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903719A AU2015903719A0 (en) 2015-09-11 Chimeric antigen receptor and uses thereof
AU2015903719 2015-09-11
PCT/AU2016/050851 WO2017041143A1 (en) 2015-09-11 2016-09-10 Chimeric antigen receptors and uses thereof

Related Child Applications (1)

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JP2021164222A Division JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Publications (3)

Publication Number Publication Date
JP2018526033A JP2018526033A (ja) 2018-09-13
JP2018526033A5 true JP2018526033A5 (enExample) 2020-09-10
JP6957471B2 JP6957471B2 (ja) 2021-11-02

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018532485A Active JP6957471B2 (ja) 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Pending JP2023082052A (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Pending JP2023082052A (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Country Status (8)

Country Link
US (3) US12121539B2 (enExample)
EP (2) EP3816294A1 (enExample)
JP (4) JP6957471B2 (enExample)
KR (2) KR20180043841A (enExample)
CN (2) CN114891116A (enExample)
AU (4) AU2016318230B2 (enExample)
ES (1) ES2848478T3 (enExample)
WO (1) WO2017041143A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113429485A (zh) 2014-12-05 2021-09-24 纪念斯隆-凯特琳癌症中心 靶向b-细胞成熟抗原的抗体及其用途
JP6957471B2 (ja) 2015-09-11 2021-11-02 バイオセプター・(ユーケー)・リミテッド キメラ抗原受容体およびその使用
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
PE20200850A1 (es) 2017-11-01 2020-08-20 Juno Therapeutics Inc Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos
MA50564A (fr) 2017-11-06 2020-09-16 Hutchinson Fred Cancer Res Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase
CA3086832A1 (en) 2018-01-03 2019-07-11 Qu Biologics Inc. Innate targeting of adoptive cellular therapies
WO2019166453A1 (en) * 2018-03-01 2019-09-06 F. Hoffmann-La Roche Ag Specificity assay for novel target antigen binding moieties
WO2019178342A1 (en) * 2018-03-15 2019-09-19 Fundamental Solutions Corporation Programmable immunocyte receptor complex system
EP3797164A4 (en) * 2018-05-21 2022-03-02 Biosceptre (Aust) Pty Ltd CHEMERA ANTIGEN RECEPTORS WITH MODIFIED BINDING DOMAINS AND USES THEREOF
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
SG11202104188VA (en) 2018-11-01 2021-05-28 Juno Therapeutics Inc Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
MX2021015593A (es) * 2019-07-26 2022-04-11 Biosceptre Aust Pty Ltd Métodos de tratamiento.
JP2024510739A (ja) * 2021-03-11 2024-03-11 バイオセプター (オースト) プロプライエタリー・リミテッド 新規な細胞治療システム
AU2022341030A1 (en) * 2021-09-01 2023-11-30 Biosceptre (Aust) Pty Ltd Methods and compositions for stimulating immune activity
WO2024055075A1 (en) * 2022-09-14 2024-03-21 Biosceptre (Aust) Pty Ltd In vivo detection of immune cells
AU2023343787A1 (en) * 2022-09-14 2025-02-20 Biosceptre (Aust) Pty Ltd Methods of detecting immune cells
CN120187747A (zh) * 2022-09-14 2025-06-20 生物权威(澳大利亚)有限责任公司 工程化免疫细胞的富集
WO2025054416A1 (en) * 2023-09-06 2025-03-13 The Regents Of The University Of California Methods for treating cancer

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4940661A (en) 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US5512483A (en) 1993-05-21 1996-04-30 Mcgill University Expression vectors responsive to steroid hormones
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
WO1996037609A1 (en) 1995-05-26 1996-11-28 Zeneca Limited A gene switch comprising an ecdysone receptor
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
AUPP991199A0 (en) 1999-04-21 1999-05-13 University Of Sydney, The Methods for diagnosing pre-cancerous and cancerous conditions
WO2001020155A1 (fr) 1999-09-16 2001-03-22 Liangqi Zhang Membrane de reduction de pression pour carburateur
AUPQ968700A0 (en) 2000-08-28 2000-09-21 Intreat Pty Limited Treatment of urinary incontinence
AUPR201500A0 (en) 2000-12-11 2001-01-11 Biosceptre Pty Ltd Methods for identifying pre-neoplastic and neoplastic states in mammals
DK1961767T3 (da) 2001-01-17 2012-05-29 Biosceptre Int Ltd Diagnose og behandling af cancere og andre lidelser
US20030203411A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Methods of minicell-based delivery
JP4467973B2 (ja) 2001-09-03 2010-05-26 イントリート ピーティーワイ リミテッド 非機能性p2x7リセプターに対応する抗体、癌及びその他の症状の診断及び治療
CA2402930A1 (en) * 2002-09-19 2004-03-19 William Herman Targeted ligands
JP2008511286A (ja) 2004-06-02 2008-04-17 ダイアテック・ピーティワイ・リミテッド サメ類のIgNARドメインに基づく結合成分
US8067550B2 (en) 2006-10-10 2011-11-29 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
WO2008043146A1 (en) 2006-10-10 2008-04-17 Biosceptre International Limited Antibodies against non functional p2x7 receptor
US8933197B2 (en) * 2007-08-15 2015-01-13 Amunix Operating Inc. Compositions comprising modified biologically active polypeptides
WO2009033233A1 (en) 2007-09-14 2009-03-19 Biosceptre International Limited Novel p2x7 epitopes
JP5624885B2 (ja) 2007-09-14 2014-11-12 バイオセプター・インターナショナル・リミテッド 細胞外体液中のプリン作動性(p2x)受容体
US8840186B2 (en) 2007-11-07 2014-09-23 L&P Swiss Holding Ag Support assembly and corresponding seat structure
US8597643B2 (en) 2008-07-04 2013-12-03 Biosceptre International Limited Antibodies for binding to non-functional P2X7 receptors in trimeric form
JP5164806B2 (ja) 2008-11-12 2013-03-21 サンデン株式会社 車両用通信制御装置
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
EP2966090B1 (en) * 2009-08-20 2018-10-10 Biosceptre (Aust) Pty Ltd Anti p2x7 receptor antibodies and fragments thereof
CA2784345C (en) * 2009-12-24 2018-11-13 Julian Alexander Barden Antibodies to non-functional oligomeric p2x7 receptors
US9562094B2 (en) 2010-09-10 2017-02-07 Biosceptre (Aust) Pty Ltd Companion animal treatments
WO2012073048A2 (en) 2010-12-03 2012-06-07 Cyclogenix Ltd Binding peptides i
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP3693017A1 (en) * 2010-12-14 2020-08-12 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
ES2689272T3 (es) 2011-07-01 2018-11-13 Biosceptre (Aust) Pty Ltd Terapia de combinación
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3105317B1 (en) * 2014-02-14 2018-09-19 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
WO2016090369A1 (en) 2014-12-05 2016-06-09 City Of Hope Cs1 targeted chimeric antigen receptor-modified t cells
CN107835820B (zh) 2015-01-26 2021-10-15 芝加哥大学 识别癌症特异性IL13Rα2的CAR T细胞
JP6790062B2 (ja) 2015-04-02 2020-11-25 バイオセプター・(ユーケー)・リミテッド 疼痛治療
JP6957471B2 (ja) * 2015-09-11 2021-11-02 バイオセプター・(ユーケー)・リミテッド キメラ抗原受容体およびその使用
CN114634569B (zh) 2016-04-15 2024-08-20 达特茅斯大学理事会 高亲和力b7-h6抗体和抗体片段
EP3487877A4 (en) 2016-07-19 2020-01-01 Unum Therapeutics Inc. USE OF THE ANTIBODY COUPLED T CELL RECEPTOR (ACTR) WITH MULTIPLE CANCER ANTIBODIES IN THE TREATMENT OF CANCER
EP3518944A4 (en) 2016-09-30 2020-06-17 Baylor College of Medicine ADAPTIVE CHIMERIC ANTIGENT RECEPTOR T-CELL DESIGN
JP7127021B2 (ja) 2016-10-21 2022-08-29 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 細胞傷害性粒子
EP3797164A4 (en) 2018-05-21 2022-03-02 Biosceptre (Aust) Pty Ltd CHEMERA ANTIGEN RECEPTORS WITH MODIFIED BINDING DOMAINS AND USES THEREOF
MX2021015593A (es) 2019-07-26 2022-04-11 Biosceptre Aust Pty Ltd Métodos de tratamiento.

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