JP2018526033A5 - - Google Patents

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Publication number
JP2018526033A5
JP2018526033A5 JP2018532485A JP2018532485A JP2018526033A5 JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5 JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018532485 A JP2018532485 A JP 2018532485A JP 2018526033 A5 JP2018526033 A5 JP 2018526033A5
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JP
Japan
Prior art keywords
receptor
cancer
cell
dysfunctional
chimeric antigen
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JP2018532485A
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English (en)
Japanese (ja)
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JP2018526033A (ja
JP6957471B2 (ja
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Priority claimed from PCT/AU2016/050851 external-priority patent/WO2017041143A1/en
Publication of JP2018526033A publication Critical patent/JP2018526033A/ja
Publication of JP2018526033A5 publication Critical patent/JP2018526033A5/ja
Priority to JP2021164222A priority Critical patent/JP7253020B2/ja
Application granted granted Critical
Publication of JP6957471B2 publication Critical patent/JP6957471B2/ja
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JP2018532485A 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用 Active JP6957471B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021164222A JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903719 2015-09-11
AU2015903719A AU2015903719A0 (en) 2015-09-11 Chimeric antigen receptor and uses thereof
PCT/AU2016/050851 WO2017041143A1 (en) 2015-09-11 2016-09-10 Chimeric antigen receptors and uses thereof

Related Child Applications (1)

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JP2021164222A Division JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用

Publications (3)

Publication Number Publication Date
JP2018526033A JP2018526033A (ja) 2018-09-13
JP2018526033A5 true JP2018526033A5 (enExample) 2020-09-10
JP6957471B2 JP6957471B2 (ja) 2021-11-02

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Family Applications (4)

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JP2018532485A Active JP6957471B2 (ja) 2015-09-11 2016-09-10 キメラ抗原受容体およびその使用
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Active JP7822340B2 (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021164222A Active JP7253020B2 (ja) 2015-09-11 2021-10-05 キメラ抗原受容体およびその使用
JP2023047606A Active JP7822340B2 (ja) 2015-09-11 2023-03-24 キメラ抗原受容体およびその使用
JP2025052912A Pending JP2025098188A (ja) 2015-09-11 2025-03-27 キメラ抗原受容体およびその使用

Country Status (8)

Country Link
US (3) US12121539B2 (enExample)
EP (2) EP3347474B1 (enExample)
JP (4) JP6957471B2 (enExample)
KR (2) KR20250058773A (enExample)
CN (2) CN114891116A (enExample)
AU (4) AU2016318230B2 (enExample)
ES (1) ES2848478T3 (enExample)
WO (1) WO2017041143A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3872094A3 (en) 2014-12-05 2021-12-08 Memorial Sloan Kettering Cancer Center Antibodies targeting b-cell maturation antigen and methods of use
AU2016318230B2 (en) * 2015-09-11 2020-05-21 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors and uses thereof
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
MX2020004572A (es) 2017-11-01 2020-10-07 Juno Therapeutics Inc Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos.
EP3706754A1 (en) 2017-11-06 2020-09-16 Juno Therapeutics, Inc. Combination of a cell therapy and a gamma secretase inhibitor
CA3084445A1 (en) 2017-12-08 2019-06-13 Juno Therapeutics, Inc. Process for producing a composition of engineered t cells
CA3086832A1 (en) 2018-01-03 2019-07-11 Qu Biologics Inc. Innate targeting of adoptive cellular therapies
WO2019166453A1 (en) * 2018-03-01 2019-09-06 F. Hoffmann-La Roche Ag Specificity assay for novel target antigen binding moieties
EP3765093A4 (en) * 2018-03-15 2021-12-08 Fundamental Solutions Corporation PROGRAMMABLE IMMUNOCYTE RECEPTOR COMPLEX SYSTEM
CN112166193A (zh) * 2018-05-21 2021-01-01 生物权威(英国)有限公司 具有经修饰的接头结构域的嵌合抗原受体及其用途
CN110856724B (zh) * 2018-08-24 2022-05-27 杭州康万达医药科技有限公司 包含核酸及car修饰的免疫细胞的治疗剂及其应用
SG11202104188VA (en) 2018-11-01 2021-05-28 Juno Therapeutics Inc Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen
US20220251187A1 (en) * 2019-07-26 2022-08-11 Biosceptre (Aust) Pty Ltd P2x7 receptor targeted therapy
CA3211323A1 (en) * 2021-03-11 2022-09-15 Patrick Schlegel Novel cell therapy system
AU2022341030A1 (en) * 2021-09-01 2023-11-30 Biosceptre (Aust) Pty Ltd Methods and compositions for stimulating immune activity
JP2025531675A (ja) * 2022-09-14 2025-09-25 バイオセプター (オースト) プロプライエタリー・リミテッド 操作された免疫細胞の富化
JP2025531030A (ja) * 2022-09-14 2025-09-19 バイオセプター (オースト) プロプライエタリー・リミテッド 免疫細胞のインビボ検出
US20260085104A1 (en) * 2022-09-14 2026-03-26 Biosceptre (Aust) Pty Ltd Methods of detecting immune cells
TW202525839A (zh) * 2023-09-06 2025-07-01 美國加利福尼亞大學董事會 治療癌症之方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4940661A (en) 1984-05-17 1990-07-10 Genentech, Inc. Metallothionein transcription control sequences and use thereof
US5512483A (en) 1993-05-21 1996-04-30 Mcgill University Expression vectors responsive to steroid hormones
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
CZ372297A3 (cs) 1995-05-26 1998-03-18 Zeneca Limited Přepínání genové exprese využívající receptoru pro ekdyson
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
AUPP991199A0 (en) 1999-04-21 1999-05-13 University Of Sydney, The Methods for diagnosing pre-cancerous and cancerous conditions
WO2001020155A1 (fr) 1999-09-16 2001-03-22 Liangqi Zhang Membrane de reduction de pression pour carburateur
AUPQ968700A0 (en) 2000-08-28 2000-09-21 Intreat Pty Limited Treatment of urinary incontinence
AUPR201500A0 (en) 2000-12-11 2001-01-11 Biosceptre Pty Ltd Methods for identifying pre-neoplastic and neoplastic states in mammals
CA2434490C (en) 2001-01-17 2014-06-03 Intreat Pty Limited Antibodies to non-functional p2x7 receptor diagnosis and treatment of cancers and other conditions
US20030203411A1 (en) * 2001-06-05 2003-10-30 Sabbadini Roger A. Methods of minicell-based delivery
NZ549019A (en) 2001-09-03 2008-05-30 Intreat Pty Ltd Antibody that binds to a P2X7 receptor in which proline at position 210 is in a cis conformation
CA2402930A1 (en) * 2002-09-19 2004-03-19 William Herman Targeted ligands
DK2330121T3 (en) 2004-06-02 2014-12-15 Adalta Pty Ltd Binding moieties based on shark IgNar domains
US8067550B2 (en) 2006-10-10 2011-11-29 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
WO2008043146A1 (en) 2006-10-10 2008-04-17 Biosceptre International Limited Antibodies against non functional p2x7 receptor
MX2010001684A (es) * 2007-08-15 2010-04-21 Amunix Inc Composiciones y metodos para modificar propiedades de polipeptidos biologicamente activos.
CA2737126C (en) * 2007-09-14 2018-05-01 Biosceptre International Limited Novel p2x7 epitopes
NZ583896A (en) 2007-09-14 2011-05-27 Biosceptre Int Ltd Purinergic (p2x) receptors in extra-cellular body fluid
US8840186B2 (en) 2007-11-07 2014-09-23 L&P Swiss Holding Ag Support assembly and corresponding seat structure
AU2009266430B2 (en) * 2008-07-04 2014-08-14 Biosceptre International Limited Anti- P2X7 peptides and epitopes
JP5164806B2 (ja) 2008-11-12 2013-03-21 サンデン株式会社 車両用通信制御装置
CN102858985A (zh) * 2009-07-24 2013-01-02 西格马-奥尔德里奇有限责任公司 基因组编辑方法
JP5936067B2 (ja) * 2009-08-20 2016-06-15 バイオセプター・(オーストラリア)・ピーティーワイ・リミテッド 抗p2x7受容体抗体およびその断片
BR112012015561B1 (pt) 2009-12-24 2019-11-12 Biosceptre International Limited anticorpos dirigidos contra receptores p2x7 oligoméricos não funcionais
WO2012031333A1 (en) 2010-09-10 2012-03-15 Biosceptre International Limited Companion animal treatments
US20140154241A1 (en) 2010-12-03 2014-06-05 Cyclogenix Ltd Binding peptides i
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP3693017A1 (en) 2010-12-14 2020-08-12 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
BR112013033974A2 (pt) 2011-07-01 2017-02-14 Biosceptre Int Ltd terapia de combinação
WO2014055657A1 (en) * 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
AU2015216875B2 (en) * 2014-02-14 2021-02-25 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
CA2969704C (en) 2014-12-05 2023-05-02 City Of Hope Cs1 targeted chimeric antigen receptor-modified t cells
EP3250611B1 (en) 2015-01-26 2021-04-21 The University of Chicago Car t-cells recognizing cancer-specific il 13r-alpha2
CN107614528A (zh) 2015-04-02 2018-01-19 生物权威(英国)有限公司 疼痛治疗
AU2016318230B2 (en) 2015-09-11 2020-05-21 Biosceptre (Aust) Pty Ltd Chimeric antigen receptors and uses thereof
CN109310764B (zh) 2016-04-15 2022-01-14 达特茅斯大学理事会 高亲和力b7-h6抗体和抗体片段
WO2018017649A1 (en) 2016-07-19 2018-01-25 Unum Therapeutics Inc. Use of antibody-coupled t cell receptor (actr) with multiple anti-cancer antibodies in cancer treatment
WO2018064626A1 (en) 2016-09-30 2018-04-05 Baylor College Of Medicine Adaptive chimeric antigen receptor t-cell design
CN109862883A (zh) 2016-10-21 2019-06-07 生物权威(英国)有限公司 细胞毒性颗粒
CN112166193A (zh) 2018-05-21 2021-01-01 生物权威(英国)有限公司 具有经修饰的接头结构域的嵌合抗原受体及其用途
US20220251187A1 (en) 2019-07-26 2022-08-11 Biosceptre (Aust) Pty Ltd P2x7 receptor targeted therapy

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