JP2015157835A - ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 - Google Patents
ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 Download PDFInfo
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Abstract
【解決手段】ブドウ糖代謝拮抗物質を含む組成物を哺乳動物に投与することを含み、組成物は、ブドウ糖代謝拮抗物質の投与後の哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量のブドウ糖代謝拮抗物質を含む方法。ブドウ糖代謝拮抗物質が、2−デオキシ−D−グルコース、5−チオ−D−グルコース、無水糖、マンノヘプツロース等又はこれらの混合物から選択される方法。マンノヘプツロースを含む、アボカド若しくはアボカド抽出物を含む組成物を投与する方法。
【選択図】なし
Description
本発明は、哺乳動物における炎症及びストレスの低下方法である。本方法は、ブドウ糖代謝拮抗物質又はアボカド又はマンノヘプツロース又はアボカド抽出物を含む組成物を哺乳動物に投与することを含み、組成物は、ブドウ糖代謝拮抗物質、アボカド、アボカド抽出物又はマンノヘプツロースの投与後の哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量のブドウ糖代謝拮抗物質、アボカド、アボカド抽出物又はマンノヘプツロースを含む。
本組成物は、哺乳動物による使用に適合している。本発明の組成物は、好ましくは、哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させることにより、炎症及びストレスを低下させるために投与される。本発明の組成物は、湿性組成物(すなわち、製品の総含水率が約16重量%〜50重量%であるもの)及び/又は湿潤性組成物(すなわち、製品の総含水率が50重量%を超えるもの)及び/又は乾燥性組成物(すなわち、製品の総含水率が約0重量%〜約16重量%であるもの)であってよい。本明細書で特に記載しない限り、湿潤性組成物、湿性組成物及び/又は乾燥性組成物は、それらの組成又は調製方法に制限されない。
本発明の方法は、ブドウ糖代謝拮抗物質を含むことができる組成物を、哺乳動物に投与することを含む。ブドウ糖代謝拮抗物質は、炎症を低下させることにより、哺乳動物の血中において存在するCRPの濃度に影響し、それゆえに結果として、哺乳動物による、ブドウ糖代謝拮抗物質を含む組成物の摂取後のCRP濃度は低下する。
本発明の方法は、アボカドを含むことができる組成物を、哺乳動物に投与することを含む。アボカドは、炎症及びストレスを低下させることにより、哺乳動物の血中において存在するCRPの濃度に影響し、それゆえに結果として、哺乳動物による、アボカドを含む組成物の摂取後にCRP濃度は低下する。
本発明に記載されているブドウ糖代謝拮抗物質、アボカド、マンノヘプツロース又はアボカド抽出物は、哺乳動物への投与に適合した任意の組成物に添加することができると予測されている。
本発明の組成物は、広範囲のその他の任意成分を更に含むことができる。
組成物は、本明細書中に記載されている任意の方法を包含するがこれらに限定されない様々な方法のいずれかによって調製されてもよい。本明細書で開示するのは、本発明組成物の任意の調製方法である。しかし、組成物は、以下に記述される方法によるものに限定されないことが、当業者には理解されよう。
(a)植物体を供給する工程、
(b)植物体を水溶液及び所望により酵素と組み合わせて、更に所望により加熱して、消化植物混合物を供給する工程、
(c)存在する場合には、消化植物混合物中に存在する任意の破片を所望により分離して、炭水化物抽出物を供給する工程、
(d)消化植物混合物を濃縮してその中の炭水化物の濃度を高める工程並びに、
(e)消化植物混合物を1種以上の組成物構成要素と組み合わせる工程、を含んでもよい。
ディアソリン(Diasorin)試薬(カタログ番号86083)を使用するCRP分析 は、試料用の日立(Hitachi)911自動化学分析器での使用に適合してきた。全試料を日立911の小標本数機能で分析する。ディアソリン(Diasorin)キットの構成要素は、ポリマー希釈剤、抗体試薬及び生理食塩水を含む。CRP較正標準及びヒトCRP対照(カタログ番号 86108)を使用して、較正曲線を作成し、本方法が適切に較正されているかを確かめる。ディアソリン(Diasorin)CRP分析は、免疫沈降分析である。試料及び抗血清を一緒に混合して、不溶性複合体を形成し、濁度及び散乱光を生じさせる。次に吸光度を測定する。試料濃度を較正曲線から内挿する。ポリマー希釈剤をそのまま、試料分注の10秒後に分注するT1として使用する。生理食塩水で1:7に希釈した抗体試薬を、T1が分注される5分後に分注するT3として使用する。使用される較正タイプは、ブランク(生理食塩水)を使用するフルタイプであり、少なくとも3つのプログラム標準、5つのプログラム標準を使用して広範囲を確保する。ディアソリン(Diasorin)キットは、5つの標準を備えているが、100標準(#5)は使用せず、標準#2を生理食塩水で1:10に希釈して感応範囲を広げる。較正タイプは、Logit−Log4Pである。分析は、340nmの主波長及び700nmの2次波長で2ポイントエンド(試料−ブランク化エンドポイントアッセイ)を使用する。CRP対照及び生理食塩水試料を各ステップで分析する。試料分析を完了した後で、反応モニターを見て各試料について印刷する。反応モニターにより、吸光光度対時間のグラフ形態での図が得られる。CRPについて、セルを1〜5、6〜10、11〜5、16〜20、26〜30及び31〜35で測定する。セル16〜20をセル31〜35と比較し、セル16〜20が31〜35よりも高い場合には、希釈を行わなければならず(生理食塩水で1:5)、試料を再分析する。また、最初の分析で読み取り値が0.0である全ての試料も希釈して再分析し、セル比較に関わらず、偽陰性結果を防ぐ。結果をmg/L単位で報告する。
本方法は組成物の総含水率の分析に関する。分析はAOAC法930.15及びAACC法44−19に概説されている手順に基づく。
総含水率(%)=100−(スズ缶、蓋及び乾燥後の試料の重量−空のスズ缶及び蓋重量)×100/初期試料重量
以下の全ての実施例は、哺乳動物によって利用される組成物である。
Claims (30)
- 哺乳動物における炎症及びストレスの低下方法であって、
ブドウ糖代謝拮抗物質を含む組成物を前記哺乳動物に投与することを含み、
前記組成物が、ブドウ糖代謝拮抗物質の投与後の前記哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量のブドウ糖代謝拮抗物質を含む、方法。 - ブドウ糖代謝拮抗物質の投与後の前記血中におけるC反応性タンパク質の濃度が、約0mg/L〜約100mg/Lである、請求項1に記載の方法。
- 前記ブドウ糖代謝拮抗物質が、2−デオキシ−D−グルコース、5−チオ−D−グルコース、3−O−メチルグルコース、無水糖、1,5−無水−D−グルシトール、2,5−無水−D−マンニトール、マンノヘプツロース及びこれらの混合物からなる群から選択される、請求項1又は2に記載の方法。
- 前記投与が経口である、請求項1〜3のいずれか一項に記載の方法。
- 前記組成物が、前記組成物の約5重量%未満の前記ブドウ糖代謝拮抗物質を含む、請求項1〜4のいずれか一項に記載の方法。
- 前記組成物が、ペットフード、ドッグフード、キャットフード、トリーツ、チュー、ビスケット、グレービー、ソース、飲料、補助水及びこれらの組み合わせからなる群から選択される、請求項1〜5のいずれか一項に記載の方法。
- 前記組成物が、栄養的にバランスがとれているペットフード組成物である、請求項6に記載の方法。
- 動物性タンパク質、植物性タンパク質、デンプン質物質、野菜、果物、卵ベース材料、非変性タンパク質、食品用ポリマー接着剤、ゲル、ポリオール、デンプン、ゴム、風味剤、調味料、塩、着色剤、徐放性化合物、ミネラル、ビタミン、酸化防止剤、プレバイオティクス、プロバイオティクス、香気調整剤、脂質及びこれらの組み合わせを更に含む、請求項1〜7のいずれか一項に記載の組成物。
- 哺乳動物における炎症及びストレスの低下方法であって、
アボカドを含む組成物を前記哺乳動物に投与することを含み、
前記組成物が、アボカドの投与後の前記哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量の前記アボカドを含む、方法。 - 前記アボカドの投与後の前記血中におけるC反応性タンパク質の濃度が、約0mg/L〜約100mg/Lである、請求項9に記載の方法。
- 前記組成物が、前記組成物の約5重量%未満の前記アボカドを含む、請求項9又は10に記載の方法。
- 前記投与が経口である、請求項9〜11のいずれか一項に記載の方法。
- 前記組成物が、ペットフード、ドッグフード、キャットフード、トリーツ、チュー、ビスケット、グレービー、ソース、飲料、補助水及びこれらの組み合わせからなる群から選択される、請求項9〜12のいずれか一項に記載の方法。
- 前記組成物が、栄養的にバランスがとれているペットフード組成物である、請求項13に記載の方法。
- 動物性タンパク質、植物性タンパク質、デンプン質物質、野菜、果物、卵ベース材料、非変性タンパク質、食品用ポリマー接着剤、ゲル、ポリオール、デンプン、ゴム、風味剤、調味料、塩、着色剤、徐放性化合物、ミネラル、ビタミン、酸化防止剤、プレバイオティクス、プロバイオティクス、香気調整剤、脂質及びこれらの組み合わせを更に含む、請求項9〜14のいずれか一項に記載の組成物。
- 哺乳動物における炎症及びストレスの低下方法であって、
マンノヘプツロースを含む組成物を前記哺乳動物に投与することを含み、
前記組成物が、マンノヘプツロースの投与後の前記哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量の前記マンノヘプツロースを含む、方法。 - マンノヘプツロースの投与後の前記血中におけるC反応性タンパク質の濃度が、約0mg/L〜約100mg/Lである、請求項16に記載の方法。
- 前記マンノヘプツロースが、ブドウ糖代謝拮抗物質、植物体抽出物、アボカド抽出物、アボカド及びこれらの組み合わせからなる群から選択される、請求項16又は17に記載の方法。
- 前記投与が経口である、請求項16〜18のいずれか一項に記載の方法。
- 前記組成物が、前記組成物の約5重量%未満の前記マンノヘプツロースを含む、請求項16〜19のいずれか一項に記載の方法。
- 前記組成物が、ペットフード、ドッグフード、キャットフード、トリーツ、チュー、ビスケット、グレービー、ソース、飲料、補助水及びこれらの組み合わせからなる群から選択される、請求項16〜20のいずれか一項に記載の方法。
- 前記組成物が、栄養的にバランスがとれているペットフード組成物である、請求項21に記載の方法。
- 動物性タンパク質、植物性タンパク質、デンプン質物質、野菜、果物、卵ベース材料、非変性タンパク質、食品用ポリマー接着剤、ゲル、ポリオール、デンプン、ゴム、風味剤、調味料、塩、着色剤、徐放性化合物、ミネラル、ビタミン、酸化防止剤、プレバイオティクス、プロバイオティクス、香気調整剤、脂質及びこれらの組み合わせを更に含む、請求項16〜22のいずれか一項に記載の組成物。
- 哺乳動物における炎症及びストレスの低下方法であって、
アボカド抽出物を含む組成物を前記哺乳動物に投与することを含み、
前記組成物が、アボカド抽出物の投与後の前記哺乳動物の血中におけるC反応性タンパク質の濃度を、低下させるのに十分な量のアボカド抽出物を含む、方法。 - アボカド抽出物の投与後の前記血中におけるC反応性タンパク質の濃度が、約0mg/L〜約100mg/Lである、請求項24に記載の方法。
- 前記投与が経口である、請求項24又は25に記載の方法。
- 前記組成物が、前記組成物の約5重量%未満の前記アボカド抽出物を含む、請求項24〜26のいずれか一項に記載の方法。
- 前記組成物が、ペットフード、ドッグフード、キャットフード、トリーツ、チュー、ビスケット、グレービー、ソース、飲料、補助水及びこれらの組み合わせからなる群から選択される、請求項24〜27のいずれか一項に記載の方法。
- 前記組成物が、栄養的にバランスがとれているペットフード組成物である、請求項24〜28のいずれか一項に記載の方法。
- 動物性タンパク質、植物性タンパク質、デンプン質物質、野菜、果物、卵ベース材料、非変性タンパク質、食品用ポリマー接着剤、ゲル、ポリオール、デンプン、ゴム、風味剤、調味料、塩、着色剤、徐放性化合物、ミネラル、ビタミン、酸化防止剤、プレバイオティクス、プロバイオティクス、香気調整剤、脂質及びこれらの組み合わせを更に含む、請求項24〜29のいずれか一項に記載の組成物。
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CA2673465A1 (en) | 2008-08-07 |
ES2551719T3 (es) | 2015-11-23 |
PL2124966T3 (pl) | 2016-01-29 |
AU2008211600A1 (en) | 2008-08-07 |
CN101711158A (zh) | 2010-05-19 |
JP5799299B2 (ja) | 2015-10-21 |
WO2008093303A3 (en) | 2008-09-25 |
WO2008093303A2 (en) | 2008-08-07 |
RU2009127329A (ru) | 2011-03-10 |
RU2436581C2 (ru) | 2011-12-20 |
MX2009008166A (es) | 2009-08-12 |
AU2008211600B8 (en) | 2014-02-13 |
EP2124966A2 (en) | 2009-12-02 |
US9415083B2 (en) | 2016-08-16 |
EP2124966B1 (en) | 2015-09-09 |
AR065145A1 (es) | 2009-05-20 |
AU2008211600B2 (en) | 2014-01-23 |
JP2010516806A (ja) | 2010-05-20 |
US20080260866A1 (en) | 2008-10-23 |
BRPI0808391A2 (pt) | 2014-07-08 |
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