JP2014515346A5 - - Google Patents
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- JP2014515346A5 JP2014515346A5 JP2014510888A JP2014510888A JP2014515346A5 JP 2014515346 A5 JP2014515346 A5 JP 2014515346A5 JP 2014510888 A JP2014510888 A JP 2014510888A JP 2014510888 A JP2014510888 A JP 2014510888A JP 2014515346 A5 JP2014515346 A5 JP 2014515346A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- optionally substituted
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382158.1 | 2011-05-19 | ||
| EP11382158 | 2011-05-19 | ||
| EP12275024.3 | 2012-03-09 | ||
| EP12275024 | 2012-03-09 | ||
| PCT/GB2012/051134 WO2012156756A2 (en) | 2011-05-19 | 2012-05-18 | New compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515346A JP2014515346A (ja) | 2014-06-30 |
| JP2014515346A5 true JP2014515346A5 (enExample) | 2015-05-07 |
| JP5997763B2 JP5997763B2 (ja) | 2016-09-28 |
Family
ID=46796665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510888A Active JP5997763B2 (ja) | 2011-05-19 | 2012-05-18 | タンパク質キナーゼ阻害剤としての大環状化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9284334B2 (enExample) |
| EP (1) | EP2710018B8 (enExample) |
| JP (1) | JP5997763B2 (enExample) |
| KR (1) | KR101953210B1 (enExample) |
| CN (1) | CN103748099B (enExample) |
| AU (1) | AU2012257513B2 (enExample) |
| BR (1) | BR112013029711B1 (enExample) |
| CA (1) | CA2872979C (enExample) |
| DK (1) | DK2710018T3 (enExample) |
| ES (1) | ES2907071T3 (enExample) |
| HR (1) | HRP20220319T1 (enExample) |
| MX (1) | MX349366B (enExample) |
| NZ (1) | NZ618157A (enExample) |
| PH (1) | PH12013502400A1 (enExample) |
| PL (1) | PL2710018T3 (enExample) |
| PT (1) | PT2710018T (enExample) |
| RU (1) | RU2598840C2 (enExample) |
| SG (1) | SG11201400681UA (enExample) |
| WO (1) | WO2012156756A2 (enExample) |
| ZA (1) | ZA201309128B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| AU2012257513B2 (en) | 2011-05-19 | 2017-05-11 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Macrocyclic compounds as protein kinase inhibitors |
| PT2760453T (pt) * | 2011-09-30 | 2016-08-02 | Ipsen Pharma Sas | Inibidores macrocíclicos da cinase lrrk2 |
| CN103788071A (zh) * | 2012-11-01 | 2014-05-14 | 中国人民解放军第二军医大学 | N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途 |
| TWI574962B (zh) | 2012-11-14 | 2017-03-21 | 加拓科學公司 | 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途 |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| TWI662030B (zh) | 2013-01-15 | 2019-06-11 | 英塞特控股公司 | 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物 |
| KR102148681B1 (ko) | 2013-02-21 | 2020-08-27 | 칼리토르 사이언시즈, 엘엘씨 | Pi3 키나제 모듈레이터로서의 헤테로방향족 화합물 |
| EP2970297A1 (en) * | 2013-03-14 | 2016-01-20 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CA2914414A1 (en) * | 2013-06-06 | 2014-12-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
| CN104341299B (zh) * | 2013-07-29 | 2016-08-24 | 漳州金富顺生物科技有限公司 | 一种脱臭脂肪酸的酯化 |
| US9556197B2 (en) | 2013-08-23 | 2017-01-31 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| CN104418853B (zh) * | 2013-08-28 | 2016-09-07 | 北大方正集团有限公司 | 取代的萘啶-2-酮化合物、制备方法、用途及药物组合物 |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| TW201542550A (zh) | 2013-09-06 | 2015-11-16 | Lexicon Pharmaceuticals Inc | 吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法 |
| ES2728932T3 (es) * | 2014-01-09 | 2019-10-29 | Intra Cellular Therapies Inc | Compuestos orgánicos |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| CN105693744B (zh) * | 2014-11-27 | 2018-06-19 | 北大方正集团有限公司 | 一种取代的噻吩并嘧啶化合物及其制备方法 |
| WO2016112295A1 (en) | 2015-01-09 | 2016-07-14 | Warp Drive Bio, Inc. | Compounds that participate in cooperative binding and uses thereof |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| CN104961725B (zh) * | 2015-06-18 | 2017-04-19 | 浙江大学 | 4‑α,β不饱和酰胺基喹啉类化合物及制备和应用 |
| CN106467545B (zh) * | 2015-08-20 | 2018-10-16 | 北大方正集团有限公司 | 一种噻吩并嘧啶化合物 |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| CA3000822A1 (en) | 2015-10-01 | 2017-04-06 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2017112777A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CR20180499A (es) * | 2016-04-22 | 2019-01-25 | Astrazeneca Ab | Inhibidores de mcl1 macrocicliclos para tratar el cancer |
| WO2017197151A1 (en) * | 2016-05-11 | 2017-11-16 | Emory University | Phosphotidylinositol 3-kinase inhibitors |
| JP2019519593A (ja) * | 2016-07-06 | 2019-07-11 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉｃｈｉｇａｎ | ＭＥＫ／ＰＩ３Ｋ及びｍＴＯＲ／ＭＥＫ／ＰＩ３Ｋ生物学的経路の多官能性阻害剤、並びに同多官能性阻害剤を用いた治療方法 |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| AU2017302019A1 (en) * | 2016-07-28 | 2019-02-07 | Turning Point Therapeutics, Inc. | Macrocycle kinase inhibitors |
| EP3596091B1 (en) | 2017-03-16 | 2021-08-25 | Waters Technologies Corporation | Chromatographic compositions |
| KR102736865B1 (ko) | 2017-06-21 | 2024-12-03 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
| MX2020001719A (es) * | 2017-08-15 | 2020-11-06 | Abbvie Inc | Inhibidores macrocíclicos de mcl-1 y metodos de uso. |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| LT3841101T (lt) * | 2018-08-24 | 2023-06-26 | Bayer Aktiengesellschaft | 2-[(3r)-3-metilmorfolin-4-il]-4-[1-metil-1h-pirazol-5-il)-8-(1h pirazol-5-il)-1,7-naftiridino gavimo būdas |
| CN113166155A (zh) | 2018-11-09 | 2021-07-23 | 山东轩竹医药科技有限公司 | 大环类酪氨酸激酶抑制剂及其用途 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
| IL317393A (en) * | 2018-12-21 | 2025-02-01 | Revolution Medicines Inc | Compounds that participate in covalent bonds and their uses |
| ES2974634T3 (es) | 2018-12-21 | 2024-06-28 | Celgene Corp | Inhibidores de tienopiridinas de RIPK2 |
| CN109988165B (zh) * | 2018-12-24 | 2022-10-25 | 华东师范大学 | 作为PI3K/mTOR激酶调节剂芳杂环化合物及其制备方法和应用 |
| CN121471132A (zh) | 2019-11-04 | 2026-02-06 | 锐新医药公司 | Ras抑制剂 |
| MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| WO2021091956A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| EP4132921A4 (en) * | 2020-04-09 | 2024-03-27 | Purdue Research Foundation | Pi3 kinase inhibitors and uses thereof |
| CN113620974B (zh) * | 2020-05-08 | 2023-01-31 | 山东轩竹医药科技有限公司 | 大环类酪氨酸激酶抑制剂的晶型及其制备方法 |
| CN113620976B (zh) * | 2020-05-09 | 2023-09-26 | 中国医学科学院药物研究所 | 噻唑并嘧啶类化合物及其制备方法、用途和药物组合物 |
| WO2021262596A1 (en) | 2020-06-22 | 2021-12-30 | Pmv Pharmaceuticals, Inc. | Methods and compounds for restoring mutant p53 function |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| IL308195A (en) | 2021-05-05 | 2024-01-01 | Revolution Medicines Inc | RAS inhibitors for cancer treatment |
| CN113416181B (zh) * | 2021-08-02 | 2022-05-03 | 四川大学 | 喹唑啉类衍生物及其用途 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN116262758B (zh) * | 2021-12-15 | 2025-02-28 | 上海博悦生物科技有限公司 | 7-甲基噻唑并[5,4-d]嘧啶类化合物、制备方法及其用途 |
| WO2025061125A1 (zh) * | 2023-09-22 | 2025-03-27 | 四川汇宇制药股份有限公司 | 一种大环化合物及其制备方法和用途 |
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| US1147478A (en) | 1914-11-03 | 1915-07-20 | Charles H Barker | War-maneuvering game. |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
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| DK2193133T3 (en) | 2007-09-27 | 2015-10-05 | Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii | IMIDAZOLOTHIADIAZOLES USED AS PROTEINKINASE INHIBITORS |
| JP2011500823A (ja) * | 2007-10-22 | 2011-01-06 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害物質としてのピリドスルホンアミド誘導体 |
| ES2668834T3 (es) * | 2008-09-08 | 2018-05-22 | Merck Serono Sa | Pirimidinas macrociclicas como inhibidores de proteína quinasas |
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| JP5709766B2 (ja) | 2009-03-12 | 2015-04-30 | ジェネンテック， インコーポレイテッド | 造血器腫瘍の治療のためのホスホイノシチド３キナーゼ阻害剤化合物と化学療法剤の併用 |
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| AU2010231162B2 (en) | 2009-04-02 | 2014-12-11 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Imidazo [2, 1-b] [ 1, 3, 4 ] thiadiazole derivatives |
| UA111579C2 (uk) | 2009-08-17 | 2016-05-25 | Інтеллікіне Ллк | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ |
| AU2012257513B2 (en) | 2011-05-19 | 2017-05-11 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Macrocyclic compounds as protein kinase inhibitors |
| WO2013001310A1 (en) | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
-
2012
- 2012-05-18 AU AU2012257513A patent/AU2012257513B2/en active Active
- 2012-05-18 EP EP12754044.1A patent/EP2710018B8/en active Active
- 2012-05-18 WO PCT/GB2012/051134 patent/WO2012156756A2/en not_active Ceased
- 2012-05-18 NZ NZ618157A patent/NZ618157A/en unknown
- 2012-05-18 CA CA2872979A patent/CA2872979C/en active Active
- 2012-05-18 ES ES12754044T patent/ES2907071T3/es active Active
- 2012-05-18 JP JP2014510888A patent/JP5997763B2/ja active Active
- 2012-05-18 BR BR112013029711-5A patent/BR112013029711B1/pt active IP Right Grant
- 2012-05-18 CN CN201280024265.4A patent/CN103748099B/zh active Active
- 2012-05-18 DK DK12754044.1T patent/DK2710018T3/da active
- 2012-05-18 MX MX2013013462A patent/MX349366B/es active IP Right Grant
- 2012-05-18 US US14/118,009 patent/US9284334B2/en active Active
- 2012-05-18 SG SG11201400681UA patent/SG11201400681UA/en unknown
- 2012-05-18 PT PT127540441T patent/PT2710018T/pt unknown
- 2012-05-18 KR KR1020137033694A patent/KR101953210B1/ko active Active
- 2012-05-18 RU RU2013156361/04A patent/RU2598840C2/ru active
- 2012-05-18 HR HRP20220319TT patent/HRP20220319T1/hr unknown
- 2012-05-18 PH PH1/2013/502400A patent/PH12013502400A1/en unknown
- 2012-05-18 PL PL12754044T patent/PL2710018T3/pl unknown
-
2013
- 2013-12-04 ZA ZA2013/09128A patent/ZA201309128B/en unknown
-
2016
- 2016-01-26 US US15/006,755 patent/US9808466B2/en active Active
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