JP2020528889A5 - - Google Patents

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Publication number
JP2020528889A5
JP2020528889A5 JP2020502955A JP2020502955A JP2020528889A5 JP 2020528889 A5 JP2020528889 A5 JP 2020528889A5 JP 2020502955 A JP2020502955 A JP 2020502955A JP 2020502955 A JP2020502955 A JP 2020502955A JP 2020528889 A5 JP2020528889 A5 JP 2020528889A5
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JP
Japan
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alkyl
membered
aryl
hydroxy
alkoxy
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JP2020502955A
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English (en)
Japanese (ja)
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JP2020528889A (ja
JP7349981B2 (ja
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Priority claimed from PCT/US2018/043330 external-priority patent/WO2019023145A1/en
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Publication of JP2020528889A5 publication Critical patent/JP2020528889A5/ja
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Publication of JP7349981B2 publication Critical patent/JP7349981B2/ja
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JP2020502955A 2017-07-24 2018-07-23 Nlrp活性に関連する状態を治療するための化合物及び組成物 Active JP7349981B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762536352P 2017-07-24 2017-07-24
US62/536,352 2017-07-24
US201762573935P 2017-10-18 2017-10-18
US62/573,935 2017-10-18
PCT/US2018/043330 WO2019023145A1 (en) 2017-07-24 2018-07-23 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

Publications (3)

Publication Number Publication Date
JP2020528889A JP2020528889A (ja) 2020-10-01
JP2020528889A5 true JP2020528889A5 (enExample) 2021-09-02
JP7349981B2 JP7349981B2 (ja) 2023-09-25

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ID=63143409

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JP2020502955A Active JP7349981B2 (ja) 2017-07-24 2018-07-23 Nlrp活性に関連する状態を治療するための化合物及び組成物

Country Status (6)

Country Link
US (2) US11370763B2 (enExample)
EP (1) EP3658538B1 (enExample)
JP (1) JP7349981B2 (enExample)
CN (1) CN111094242B (enExample)
ES (1) ES2949404T3 (enExample)
WO (1) WO2019023145A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE066566T2 (hu) 2017-07-24 2024-08-28 Novartis Ag Vegyületek és készítmények NLRP aktivitással összefüggõ állapotok kezelésére
TW201910316A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
JP2021529186A (ja) * 2018-07-03 2021-10-28 ノバルティス アーゲー Nlrp調節剤
CA3103664A1 (en) * 2018-07-03 2020-01-09 Novartis Ag Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
CN112672995A (zh) 2018-08-15 2021-04-16 英夫拉索姆有限公司 新型磺酰胺脲化合物
PL3880660T3 (pl) * 2018-11-13 2025-11-12 Novartis Ag Związki i kompozycje do leczenia stanów związanych z aktywnością nlrp
ES2957692T3 (es) 2018-11-13 2024-01-24 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP
WO2020102574A1 (en) * 2018-11-16 2020-05-22 Novartis Inflammasome Research, Inc. The compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
EP3986879B1 (en) 2019-06-21 2024-10-02 AC Immune SA Fused 1,2-thiazoles and 1,2-thiazines which act as nlrp3 modulators
WO2021002887A1 (en) * 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Gut-targeted nlrp3 antagonists and their use in therapy
EP4013761A1 (en) 2019-08-16 2022-06-22 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
TW202115095A (zh) 2019-08-16 2021-04-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Nlrp3阻害剤
US20230121952A1 (en) 2020-02-18 2023-04-20 Inflazome Limited Compounds
EP4132505A4 (en) 2020-03-25 2024-04-24 Olatec Therapeutics, Inc. Method for treating diabetes
IL299084A (en) 2020-06-19 2023-02-01 Ac Immune Sa History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
CN116917282A (zh) * 2021-05-10 2023-10-20 成都百裕制药股份有限公司 酰胺衍生物及其应用
US20250109126A1 (en) 2021-12-22 2025-04-03 Ac Immune Sa Dihydro-oxazol derivative compounds
EP4554945A1 (en) 2022-07-14 2025-05-21 AC Immune SA Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
CA3261365A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa NEW COMPOUNDS
EP4719599A1 (en) 2023-06-02 2026-04-08 Merck Sharp & Dohme LLC 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025153624A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025153625A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
WO2026057747A1 (en) 2024-09-11 2026-03-19 Ac Immune Sa Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds
CN119680348A (zh) * 2025-02-05 2025-03-25 上海惠志环保科技有限公司 一种应用于含高浓度二氯甲烷废气处理方法及其系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104088A0 (en) * 1991-12-20 1993-05-13 Lilly Co Eli Sulfonimidamides
HUE055755T2 (hu) * 2015-02-16 2021-12-28 Univ Queensland Szulfonolkarmabidok és rokon vegyületeik valamint felhasználásuk
US11339136B2 (en) * 2016-04-18 2022-05-24 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
WO2017184604A1 (en) * 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
CA3103664A1 (en) * 2018-07-03 2020-01-09 Novartis Ag Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist

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