JP2020528889A5 - - Google Patents

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JP2020528889A5
JP2020528889A5 JP2020502955A JP2020502955A JP2020528889A5 JP 2020528889 A5 JP2020528889 A5 JP 2020528889A5 JP 2020502955 A JP2020502955 A JP 2020502955A JP 2020502955 A JP2020502955 A JP 2020502955A JP 2020528889 A5 JP2020528889 A5 JP 2020528889A5
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Japan
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alkyl
membered
aryl
hydroxy
alkoxy
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JP2020502955A
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Japanese (ja)
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JP2020528889A (ja
JP7349981B2 (ja
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Priority claimed from PCT/US2018/043330 external-priority patent/WO2019023145A1/en
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JP2020502955A 2017-07-24 2018-07-23 Nlrp活性に関連する状態を治療するための化合物及び組成物 Active JP7349981B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762536352P 2017-07-24 2017-07-24
US62/536,352 2017-07-24
US201762573935P 2017-10-18 2017-10-18
US62/573,935 2017-10-18
PCT/US2018/043330 WO2019023145A1 (en) 2017-07-24 2018-07-23 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

Publications (3)

Publication Number Publication Date
JP2020528889A JP2020528889A (ja) 2020-10-01
JP2020528889A5 true JP2020528889A5 (enExample) 2021-09-02
JP7349981B2 JP7349981B2 (ja) 2023-09-25

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JP2020502955A Active JP7349981B2 (ja) 2017-07-24 2018-07-23 Nlrp活性に関連する状態を治療するための化合物及び組成物

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US (2) US11370763B2 (enExample)
EP (1) EP3658538B1 (enExample)
JP (1) JP7349981B2 (enExample)
CN (1) CN111094242B (enExample)
ES (1) ES2949404T3 (enExample)
WO (1) WO2019023145A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7412328B2 (ja) 2017-07-24 2024-01-12 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
MX2020001776A (es) 2017-08-15 2020-03-24 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3.
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
US20210395241A1 (en) * 2018-07-03 2021-12-23 Novartis Ag Nlrp modulators
JP2021529780A (ja) * 2018-07-03 2021-11-04 ノバルティス アーゲー Nlrp3アンタゴニストを使用するtnf阻害剤に対して抵抗性の対象のための治療の方法又は治療を選択する方法
SG11202101480XA (en) 2018-08-15 2021-03-30 Inflazome Ltd Novel sulfonamideurea compounds
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
CR20210235A (es) * 2018-11-13 2021-06-30 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad de nlrp
CN113166081A (zh) * 2018-11-13 2021-07-23 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
EP3880658A1 (en) * 2018-11-16 2021-09-22 Novartis AG The compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
CN114008030A (zh) 2019-06-21 2022-02-01 Ac免疫有限公司 用作nlrp3调节剂的稠合的1,2-噻唑和1,2-噻嗪
WO2021002887A1 (en) * 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Gut-targeted nlrp3 antagonists and their use in therapy
JP2022545407A (ja) 2019-08-16 2022-10-27 インフレイゾーム リミテッド Nlrp3阻害剤として有用な大環状スルホニルアミド誘導体
JP2022545400A (ja) 2019-08-16 2022-10-27 インフレイゾーム リミテッド Nlrp3阻害剤として有用な大環状スルホニル尿素誘導体
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Nlrp3阻害剤
US20230121952A1 (en) 2020-02-18 2023-04-20 Inflazome Limited Compounds
WO2021194975A1 (en) * 2020-03-25 2021-09-30 Olatec Therapeutics Llc Method for treating diabetes
US12624010B2 (en) 2020-06-19 2026-05-12 Ac Immune Sa Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
CN116917282B (zh) * 2021-05-10 2026-08-11 康百达(四川)生物医药科技有限公司 酰胺衍生物及其应用
JP2025502732A (ja) 2021-12-22 2025-01-28 エーシー・イミューン・エス・アー ジヒドロオキサゾール誘導体化合物
JP2025524640A (ja) 2022-07-14 2025-07-30 エーシー・イミューン・エス・アー Nlrp3インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体
WO2024023266A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa Novel compounds
AU2024280075A1 (en) 2023-06-02 2025-12-11 Merck Sharp & Dohme Llc 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Nlrp3及glp-1a組合療法
CN122555708A (zh) 2024-01-17 2026-08-11 Ac免疫有限公司 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物
CN122555707A (zh) 2024-01-17 2026-08-11 Ac免疫有限公司 用作nlrp3炎症小体通路抑制剂的咪唑并[1,2-d][1,2,4]三嗪衍生物
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
WO2026057747A1 (en) 2024-09-11 2026-03-19 Ac Immune Sa Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds
WO2026132518A1 (en) 2024-12-20 2026-06-25 Ac Immune Sa Heterocyclic compounds modulating the nlrp3 inflammasome pathway
CN119680348A (zh) * 2025-02-05 2025-03-25 上海惠志环保科技有限公司 一种应用于含高浓度二氯甲烷废气处理方法及其系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2085297A1 (en) * 1991-12-20 1993-06-21 James Edward Ray Sulfonimidamides
JP6929792B2 (ja) * 2015-02-16 2021-09-01 ザ ユニバーシティ オブ クィーンズランド スルホニル尿素及び関連化合物並びにその使用
MA44729A (fr) * 2016-04-18 2021-05-12 Novartis Ag Composés et compositions pour traiter des états associés à une activité de nlrp
US11447460B2 (en) * 2016-04-18 2022-09-20 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
JP2021529780A (ja) * 2018-07-03 2021-11-04 ノバルティス アーゲー Nlrp3アンタゴニストを使用するtnf阻害剤に対して抵抗性の対象のための治療の方法又は治療を選択する方法

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