HRP20220319T1 - Makrociklički spojevi kao inhibitori protein kinaze - Google Patents

Makrociklički spojevi kao inhibitori protein kinaze Download PDF

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Publication number
HRP20220319T1
HRP20220319T1 HRP20220319TT HRP20220319T HRP20220319T1 HR P20220319 T1 HRP20220319 T1 HR P20220319T1 HR P20220319T T HRP20220319T T HR P20220319TT HR P20220319 T HRP20220319 T HR P20220319T HR P20220319 T1 HRP20220319 T1 HR P20220319T1
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Croatia
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HRP20220319TT
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Joaquin PASTOR FERNÁNDEZ
Rosa María ÁLVAREZ ESCOBAR
Rosario Concepción RIESCO FAGUNDO
Ana Belén GARCÍA GARCÍA
Antonio RODRÍGUEZ HERGUETA
Jose Ignacio MARTÍN HERNANDO
Carmen Blanco Aparicio
David Álvaro CEBRIÁN MUÑOZ
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Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO)
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Publication of HRP20220319T1 publication Critical patent/HRP20220319T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/16—Peri-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
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    • A—HUMAN NECESSITIES
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
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    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Physical Education & Sports Medicine (AREA)
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HRP20220319TT 2011-05-19 2012-05-18 Makrociklički spojevi kao inhibitori protein kinaze HRP20220319T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11382158 2011-05-19
EP12275024 2012-03-09
EP12754044.1A EP2710018B8 (en) 2011-05-19 2012-05-18 Macrocyclic compounds as protein kinase inhibitors
PCT/GB2012/051134 WO2012156756A2 (en) 2011-05-19 2012-05-18 New compounds

Publications (1)

Publication Number Publication Date
HRP20220319T1 true HRP20220319T1 (hr) 2022-05-13

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HRP20220319TT HRP20220319T1 (hr) 2011-05-19 2012-05-18 Makrociklički spojevi kao inhibitori protein kinaze

Country Status (20)

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US (2) US9284334B2 (enExample)
EP (1) EP2710018B8 (enExample)
JP (1) JP5997763B2 (enExample)
KR (1) KR101953210B1 (enExample)
CN (1) CN103748099B (enExample)
AU (1) AU2012257513B2 (enExample)
BR (1) BR112013029711B1 (enExample)
CA (1) CA2872979C (enExample)
DK (1) DK2710018T3 (enExample)
ES (1) ES2907071T3 (enExample)
HR (1) HRP20220319T1 (enExample)
MX (1) MX349366B (enExample)
NZ (1) NZ618157A (enExample)
PH (1) PH12013502400A1 (enExample)
PL (1) PL2710018T3 (enExample)
PT (1) PT2710018T (enExample)
RU (1) RU2598840C2 (enExample)
SG (1) SG11201400681UA (enExample)
WO (1) WO2012156756A2 (enExample)
ZA (1) ZA201309128B (enExample)

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US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
KR101953210B1 (ko) 2011-05-19 2019-02-28 푼다시온 센트로 나시오날 드 인베스티가시오네스 온콜로기카스 카를로스Ⅲ 단백질 키나아제 억제제로서의 대환식 화합물
MX342177B (es) * 2011-09-30 2016-09-20 Ipsen Pharma Sas Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.
CN103788071A (zh) * 2012-11-01 2014-05-14 中国人民解放军第二军医大学 N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
TWI574962B (zh) 2012-11-14 2017-03-21 加拓科學公司 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
CA2897200C (en) 2013-01-14 2021-07-06 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
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