PL2710018T3 - Związki makrocykliczne jako inhibitory kinaz białkowych - Google Patents

Związki makrocykliczne jako inhibitory kinaz białkowych

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Publication number
PL2710018T3
PL2710018T3 PL12754044T PL12754044T PL2710018T3 PL 2710018 T3 PL2710018 T3 PL 2710018T3 PL 12754044 T PL12754044 T PL 12754044T PL 12754044 T PL12754044 T PL 12754044T PL 2710018 T3 PL2710018 T3 PL 2710018T3
Authority
PL
Poland
Prior art keywords
protein kinase
kinase inhibitors
macrocyclic compounds
macrocyclic
compounds
Prior art date
Application number
PL12754044T
Other languages
English (en)
Polish (pl)
Inventor
Joaquín PASTOR FERNÁNDEZ
Rosa María ÁLVAREZ ESCOBAR
Rosario Concepción RIESCO FAGUNDO
Ana Belén GARCÍA GARCÍA
Antonio RODRÍGUEZ HERGUETA
Jose Ignacio MARTÍN HERNANDO
Carmen Blanco Aparicio
David Álvaro CEBRIÁN MUÑOZ
Original Assignee
Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) filed Critical Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO)
Publication of PL2710018T3 publication Critical patent/PL2710018T3/pl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
PL12754044T 2011-05-19 2012-05-18 Związki makrocykliczne jako inhibitory kinaz białkowych PL2710018T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11382158 2011-05-19
EP12275024 2012-03-09
PCT/GB2012/051134 WO2012156756A2 (en) 2011-05-19 2012-05-18 New compounds
EP12754044.1A EP2710018B8 (en) 2011-05-19 2012-05-18 Macrocyclic compounds as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
PL2710018T3 true PL2710018T3 (pl) 2022-04-04

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Application Number Title Priority Date Filing Date
PL12754044T PL2710018T3 (pl) 2011-05-19 2012-05-18 Związki makrocykliczne jako inhibitory kinaz białkowych

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US (2) US9284334B2 (enExample)
EP (1) EP2710018B8 (enExample)
JP (1) JP5997763B2 (enExample)
KR (1) KR101953210B1 (enExample)
CN (1) CN103748099B (enExample)
AU (1) AU2012257513B2 (enExample)
BR (1) BR112013029711B1 (enExample)
CA (1) CA2872979C (enExample)
DK (1) DK2710018T3 (enExample)
ES (1) ES2907071T3 (enExample)
HR (1) HRP20220319T1 (enExample)
MX (1) MX349366B (enExample)
NZ (1) NZ618157A (enExample)
PH (1) PH12013502400A1 (enExample)
PL (1) PL2710018T3 (enExample)
PT (1) PT2710018T (enExample)
RU (1) RU2598840C2 (enExample)
SG (1) SG11201400681UA (enExample)
WO (1) WO2012156756A2 (enExample)
ZA (1) ZA201309128B (enExample)

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* Cited by examiner, † Cited by third party
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US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
HRP20220319T1 (hr) 2011-05-19 2022-05-13 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Makrociklički spojevi kao inhibitori protein kinaze
EP2760453B1 (en) * 2011-09-30 2016-05-25 Ipsen Pharma S.A.S. Macrocyclic lrrk2 kinase inhibitors
CN103788071A (zh) * 2012-11-01 2014-05-14 中国人民解放军第二军医大学 N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
TWI574962B (zh) 2012-11-14 2017-03-21 加拓科學公司 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
ES2941292T3 (es) 2013-01-15 2023-05-19 Incyte Holdings Corp Tiazolecarboxamidas y compuestos de piridinecarboxamida útiles como inhibidores de PIM quinasa
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