MX349366B - Compuestos novedosos. - Google Patents

Compuestos novedosos.

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Publication number
MX349366B
MX349366B MX2013013462A MX2013013462A MX349366B MX 349366 B MX349366 B MX 349366B MX 2013013462 A MX2013013462 A MX 2013013462A MX 2013013462 A MX2013013462 A MX 2013013462A MX 349366 B MX349366 B MX 349366B
Authority
MX
Mexico
Prior art keywords
compounds
protein kinase
kinase inhibitors
macrocyclic compounds
treatment
Prior art date
Application number
MX2013013462A
Other languages
English (en)
Other versions
MX2013013462A (es
Inventor
Fernández Joaquin Pastor
Escobar Rosa María Álvarez
Fagundo Rosario Concepcion Riesco
García Ana Belén García
Hergueta Antonio Rodríguez
Hernando Jose Ignacio Martín
Aparicio Carmen Blanco
Álvaro Cebrían Muñoz David
Original Assignee
Centro Nac De Investigaciones Oncologicas (Cnio)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Nac De Investigaciones Oncologicas (Cnio) filed Critical Centro Nac De Investigaciones Oncologicas (Cnio)
Publication of MX2013013462A publication Critical patent/MX2013013462A/es
Publication of MX349366B publication Critical patent/MX349366B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

Se proporcionan compuestos de fórmula I, (Ver Formula) donde R1, R2a, R2b, R2C, X, Y, Z, R3 y el anillo NB tienen el significado dado en la descripción y ésteres, amidas, solvatos o sus sales farmacéuticamente aceptables, compuestos los cuales son útiles en el tratamiento de enfermedades en que la inhibición de una proteína o lípido quinasa (por ejemplo, P13-K, particularmente PI3K clase 1, familia PIM quinasa y/o mTOR) es deseada y/o requerida, y en particular en el tratamiento del cáncer; la invención también se refiere a las combinaciones que contienen dichos compuestos.
MX2013013462A 2011-05-19 2012-05-18 Compuestos novedosos. MX349366B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11382158 2011-05-19
EP12275024 2012-03-09
PCT/GB2012/051134 WO2012156756A2 (en) 2011-05-19 2012-05-18 New compounds

Publications (2)

Publication Number Publication Date
MX2013013462A MX2013013462A (es) 2014-02-27
MX349366B true MX349366B (es) 2017-07-26

Family

ID=46796665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013462A MX349366B (es) 2011-05-19 2012-05-18 Compuestos novedosos.

Country Status (20)

Country Link
US (2) US9284334B2 (es)
EP (1) EP2710018B8 (es)
JP (1) JP5997763B2 (es)
KR (1) KR101953210B1 (es)
CN (1) CN103748099B (es)
AU (1) AU2012257513B2 (es)
BR (1) BR112013029711B1 (es)
CA (1) CA2872979C (es)
DK (1) DK2710018T3 (es)
ES (1) ES2907071T3 (es)
HR (1) HRP20220319T1 (es)
MX (1) MX349366B (es)
NZ (1) NZ618157A (es)
PH (1) PH12013502400A1 (es)
PL (1) PL2710018T3 (es)
PT (1) PT2710018T (es)
RU (1) RU2598840C2 (es)
SG (1) SG11201400681UA (es)
WO (1) WO2012156756A2 (es)
ZA (1) ZA201309128B (es)

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US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
AU2012257513B2 (en) 2011-05-19 2017-05-11 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Macrocyclic compounds as protein kinase inhibitors
BR112014007654A8 (pt) * 2011-09-30 2018-06-12 Ipsen Pharma Inibidores de lrrk2 quinase macrocíclicos.
CN103788071A (zh) * 2012-11-01 2014-05-14 中国人民解放军第二军医大学 N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
TWI574962B (zh) 2012-11-14 2017-03-21 加拓科學公司 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
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