AU2012257513B2 - Macrocyclic compounds as protein kinase inhibitors - Google Patents

Macrocyclic compounds as protein kinase inhibitors Download PDF

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AU2012257513B2
AU2012257513B2 AU2012257513A AU2012257513A AU2012257513B2 AU 2012257513 B2 AU2012257513 B2 AU 2012257513B2 AU 2012257513 A AU2012257513 A AU 2012257513A AU 2012257513 A AU2012257513 A AU 2012257513A AU 2012257513 B2 AU2012257513 B2 AU 2012257513B2
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AU2012257513A1 (en
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Rosa Maria Alvarez Escobar
Carmen Blanco Aparicio
David Alvaro Cebrian Munoz
Ana Belen Garcia Garcia
Jose Ignacio Martin Hernando
Joaquin Pastor Fernandez
Rosario Concepcion Riesco Fagundo
Antonio Rodriguez Hergueta
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Fundacion del Sector Publico Estatal Centro Nacional de Investigaciones Oncologicas Carlos III FSP CNIO
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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AU2012257513A 2011-05-19 2012-05-18 Macrocyclic compounds as protein kinase inhibitors Active AU2012257513B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11382158.1 2011-05-19
EP11382158 2011-05-19
EP12275024.3 2012-03-09
EP12275024 2012-03-09
PCT/GB2012/051134 WO2012156756A2 (en) 2011-05-19 2012-05-18 New compounds

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AU2012257513A1 AU2012257513A1 (en) 2013-12-12
AU2012257513B2 true AU2012257513B2 (en) 2017-05-11

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EP (1) EP2710018B8 (enExample)
JP (1) JP5997763B2 (enExample)
KR (1) KR101953210B1 (enExample)
CN (1) CN103748099B (enExample)
AU (1) AU2012257513B2 (enExample)
BR (1) BR112013029711B1 (enExample)
CA (1) CA2872979C (enExample)
DK (1) DK2710018T3 (enExample)
ES (1) ES2907071T3 (enExample)
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US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
AU2012257513B2 (en) 2011-05-19 2017-05-11 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Macrocyclic compounds as protein kinase inhibitors
PT2760453T (pt) * 2011-09-30 2016-08-02 Ipsen Pharma Sas Inibidores macrocíclicos da cinase lrrk2
CN103788071A (zh) * 2012-11-01 2014-05-14 中国人民解放军第二军医大学 N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
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