JP2012522766A5 - - Google Patents

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Publication number
JP2012522766A5
JP2012522766A5 JP2012503371A JP2012503371A JP2012522766A5 JP 2012522766 A5 JP2012522766 A5 JP 2012522766A5 JP 2012503371 A JP2012503371 A JP 2012503371A JP 2012503371 A JP2012503371 A JP 2012503371A JP 2012522766 A5 JP2012522766 A5 JP 2012522766A5
Authority
JP
Japan
Prior art keywords
carbonyl
phenyl
naphtho
sulfanyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012503371A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012522766A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/SE2010/050354 external-priority patent/WO2010114471A1/en
Publication of JP2012522766A publication Critical patent/JP2012522766A/ja
Publication of JP2012522766A5 publication Critical patent/JP2012522766A5/ja
Pending legal-status Critical Current

Links

JP2012503371A 2009-04-03 2010-03-31 グルココルチコイド活性を有するステロイド性［３，２−ｃ］ピラゾール化合物の新規アミド誘導体 Pending JP2012522766A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16632409P 2009-04-03 2009-04-03
US61/166,324 2009-04-03
PCT/SE2010/050354 WO2010114471A1 (en) 2009-04-03 2010-03-31 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity

Publications (2)

Publication Number Publication Date
JP2012522766A JP2012522766A (ja) 2012-09-27
JP2012522766A5 true JP2012522766A5 (enExample) 2013-05-02

Family

ID=42826696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012503371A Pending JP2012522766A (ja) 2009-04-03 2010-03-31 グルココルチコイド活性を有するステロイド性［３，２−ｃ］ピラゾール化合物の新規アミド誘導体

Country Status (24)

Country Link
US (2) US20100256104A1 (enExample)
EP (1) EP2414375A4 (enExample)
JP (1) JP2012522766A (enExample)
KR (1) KR20120034608A (enExample)
CN (1) CN102459306A (enExample)
AR (1) AR076176A1 (enExample)
AU (1) AU2010231954B2 (enExample)
CA (1) CA2757423A1 (enExample)
CL (1) CL2011002461A1 (enExample)
CO (1) CO6501167A2 (enExample)
CR (1) CR20110518A (enExample)
CU (1) CU20110186A7 (enExample)
DO (1) DOP2011000305A (enExample)
EA (1) EA201190234A1 (enExample)
EC (1) ECSP11011368A (enExample)
IL (1) IL215342A0 (enExample)
MX (1) MX2011010263A (enExample)
NI (1) NI201100177A (enExample)
PE (1) PE20120544A1 (enExample)
SG (1) SG174506A1 (enExample)
TW (1) TW201040196A (enExample)
UY (1) UY32525A (enExample)
WO (1) WO2010114471A1 (enExample)
ZA (1) ZA201108050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
HK1222565A1 (zh) * 2013-09-25 2017-07-07 范安德尔研究所 高效糖皮質激素
US10954265B2 (en) 2016-10-14 2021-03-23 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids
WO2024159212A1 (en) * 2023-01-27 2024-08-02 University Of South Florida Compositions and methods of treating respiratory syncytial virus
CN117024499A (zh) * 2023-07-17 2023-11-10 陕西汉江药业集团股份有限公司 在2位引入亚甲基羟基的甾体化合物制备方法
AU2024396409A1 (en) * 2023-12-08 2026-07-09 Zhejiang Palo Alto Pharmaceuticals, Inc. High-efficacy glucocorticoid polymorph, preparation method therefor, and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) * 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
AR033290A1 (es) * 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

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