JP2015522036A5 - - Google Patents
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- Publication number
- JP2015522036A5 JP2015522036A5 JP2015520627A JP2015520627A JP2015522036A5 JP 2015522036 A5 JP2015522036 A5 JP 2015522036A5 JP 2015520627 A JP2015520627 A JP 2015520627A JP 2015520627 A JP2015520627 A JP 2015520627A JP 2015522036 A5 JP2015522036 A5 JP 2015522036A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- cycloalkyl
- compound according
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667894P | 2012-07-03 | 2012-07-03 | |
| US61/667,894 | 2012-07-03 | ||
| US201261698511P | 2012-09-07 | 2012-09-07 | |
| US61/698,511 | 2012-09-07 | ||
| US201261699819P | 2012-09-11 | 2012-09-11 | |
| US61/699,819 | 2012-09-11 | ||
| US201361785933P | 2013-03-14 | 2013-03-14 | |
| US61/785,933 | 2013-03-14 | ||
| PCT/US2013/048950 WO2014008197A1 (en) | 2012-07-03 | 2013-07-01 | Heterocyclic modulators of lipid synthesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522036A JP2015522036A (ja) | 2015-08-03 |
| JP2015522036A5 true JP2015522036A5 (enExample) | 2016-08-18 |
| JP6109934B2 JP6109934B2 (ja) | 2017-04-05 |
Family
ID=48790663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520627A Active JP6109934B2 (ja) | 2012-07-03 | 2013-07-01 | 脂質合成の複素環モジュレーター |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9428502B2 (enExample) |
| EP (1) | EP2870150B1 (enExample) |
| JP (1) | JP6109934B2 (enExample) |
| KR (1) | KR102071095B1 (enExample) |
| CN (1) | CN104507928B (enExample) |
| AU (2) | AU2013286894B2 (enExample) |
| BR (1) | BR112015000106B1 (enExample) |
| CA (1) | CA2877999C (enExample) |
| ES (1) | ES2738823T3 (enExample) |
| IL (1) | IL236407A (enExample) |
| IN (1) | IN2015DN00137A (enExample) |
| MX (1) | MX364815B (enExample) |
| NZ (2) | NZ729443A (enExample) |
| PL (1) | PL2870150T3 (enExample) |
| SG (1) | SG11201500024YA (enExample) |
| WO (1) | WO2014008197A1 (enExample) |
| ZA (1) | ZA201409477B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | ３ Ｖ生物科技公司 | 脂質合成之雜環調節劑 |
| KR102071095B1 (ko) * | 2012-07-03 | 2020-01-29 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
| CA2934251C (en) * | 2013-12-20 | 2024-01-02 | 3-V Biosciences, Inc. | A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer |
| JP6522007B2 (ja) * | 2014-01-07 | 2019-05-29 | ３−ブイ・バイオサイエンシーズ・インコーポレイテッド３−Ｖ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 癌及びウイルス感染症に対する使用のための脂質合成の複素環式モジュレータ |
| ES2833454T3 (es) * | 2014-08-15 | 2021-06-15 | Sagimet Biosciences Inc | Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente |
| CN107108581B (zh) * | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
| AU2015357169B2 (en) | 2014-12-03 | 2021-03-04 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2 PET ligands |
| JP6758314B2 (ja) * | 2015-03-19 | 2020-09-23 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式調節因子 |
| JP2018083758A (ja) * | 2015-03-25 | 2018-05-31 | 旭硝子株式会社 | ピラゾール誘導体の製造方法 |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| PE20180572A1 (es) | 2015-06-18 | 2018-04-04 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos |
| EA037941B1 (ru) | 2015-12-18 | 2021-06-09 | Янссен Фармацевтика Нв | ЛИГАНДЫ mGluR2/3 ДЛЯ PET, МЕЧЕННЫЕ РАДИОАКТИВНЫМИ ИЗОТОПАМИ |
| RS60981B1 (sr) | 2015-12-18 | 2020-11-30 | Janssen Pharmaceutica Nv | Radiooznačeni mglur2/3 pet ligandi |
| WO2017120429A1 (en) | 2016-01-07 | 2017-07-13 | CS Pharmasciences, Inc. | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
| WO2017119732A1 (en) | 2016-01-08 | 2017-07-13 | Samsung Electronics Co., Ltd. | Electronic device and operating method thereof |
| US11753626B2 (en) | 2016-03-09 | 2023-09-12 | Beijing Percans Oncology Co., Ltd. | Tumor cell suspension cultures and related methods |
| KR102644934B1 (ko) * | 2016-11-11 | 2024-03-08 | 새지메트 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
| US20220340556A1 (en) * | 2016-11-11 | 2022-10-27 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| CN107954852A (zh) * | 2017-11-30 | 2018-04-24 | 贝利化学（张家港）有限公司 | 2，5-二卤代苯甲酸的制备方法 |
| US12398155B2 (en) | 2018-12-26 | 2025-08-26 | Janssen Pharmaceutica Nv | Thienopyridinone compounds |
| US12628858B2 (en) * | 2019-03-21 | 2026-05-19 | Cornell University | Therapy for colorectal and small intestine cancers |
| CN111592495A (zh) * | 2020-07-06 | 2020-08-28 | 上海启讯医药科技有限公司 | 一种2-正丁基-4-氯-5甲酰基咪唑的制备方法 |
| CN116482278B (zh) * | 2023-05-06 | 2024-02-09 | 广州清瑞生物科技有限责任公司 | 一种用于检测阿昔洛韦的对照品的制备方法 |
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| WO2025086054A1 (zh) * | 2023-10-23 | 2025-05-01 | 歌礼生物科技（杭州）有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
| AU2024395542A1 (en) | 2023-12-07 | 2026-05-28 | Böse Pharmaceuticals Ab | Sulfonamide derivatives and use thereof in the treatment of cryptosporidium infections |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006011363D1 (de) | 2005-12-01 | 2010-02-04 | Hoffmann La Roche | Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer |
| AU2007292306A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| WO2008075077A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| US9624173B2 (en) * | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US20170119786A1 (en) * | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| LT2683244T (lt) | 2011-03-08 | 2017-04-10 | 3-V Biosciences, Inc. | Lipidų sintezės heterocikliniai moduliatoriai |
| TWI522348B (zh) * | 2011-03-08 | 2016-02-21 | ３ Ｖ生物科技公司 | 脂質合成之雜環調節劑 |
| KR102071095B1 (ko) * | 2012-07-03 | 2020-01-29 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
| CA2934251C (en) * | 2013-12-20 | 2024-01-02 | 3-V Biosciences, Inc. | A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer |
| JP6522007B2 (ja) * | 2014-01-07 | 2019-05-29 | ３−ブイ・バイオサイエンシーズ・インコーポレイテッド３−Ｖ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 癌及びウイルス感染症に対する使用のための脂質合成の複素環式モジュレータ |
| ES2833454T3 (es) * | 2014-08-15 | 2021-06-15 | Sagimet Biosciences Inc | Inhibidor de la ácido graso sintasa para su uso en el tratamiento de un cáncer farmacorresistente |
| JP6758314B2 (ja) * | 2015-03-19 | 2020-09-23 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式調節因子 |
-
2013
- 2013-07-01 KR KR1020157002727A patent/KR102071095B1/ko active Active
- 2013-07-01 AU AU2013286894A patent/AU2013286894B2/en active Active
- 2013-07-01 CN CN201380035602.4A patent/CN104507928B/zh active Active
- 2013-07-01 IN IN137DEN2015 patent/IN2015DN00137A/en unknown
- 2013-07-01 NZ NZ729443A patent/NZ729443A/en unknown
- 2013-07-01 BR BR112015000106-8A patent/BR112015000106B1/pt active IP Right Grant
- 2013-07-01 CA CA2877999A patent/CA2877999C/en active Active
- 2013-07-01 MX MX2015000151A patent/MX364815B/es active IP Right Grant
- 2013-07-01 JP JP2015520627A patent/JP6109934B2/ja active Active
- 2013-07-01 NZ NZ703162A patent/NZ703162A/en active IP Right Revival
- 2013-07-01 WO PCT/US2013/048950 patent/WO2014008197A1/en not_active Ceased
- 2013-07-01 PL PL13737098T patent/PL2870150T3/pl unknown
- 2013-07-01 SG SG11201500024YA patent/SG11201500024YA/en unknown
- 2013-07-01 ES ES13737098T patent/ES2738823T3/es active Active
- 2013-07-01 EP EP13737098.7A patent/EP2870150B1/en active Active
-
2014
- 2014-12-22 ZA ZA2014/09477A patent/ZA201409477B/en unknown
- 2014-12-23 IL IL236407A patent/IL236407A/en active IP Right Grant
- 2014-12-31 US US14/587,908 patent/US9428502B2/en active Active
-
2016
- 2016-07-05 US US15/201,824 patent/US10053450B2/en active Active
-
2017
- 2017-11-21 AU AU2017265027A patent/AU2017265027A1/en not_active Abandoned
-
2018
- 2018-03-30 US US15/941,387 patent/US10118913B2/en active Active
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