JP2008503591A5 - - Google Patents

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Publication number
JP2008503591A5
JP2008503591A5 JP2007518253A JP2007518253A JP2008503591A5 JP 2008503591 A5 JP2008503591 A5 JP 2008503591A5 JP 2007518253 A JP2007518253 A JP 2007518253A JP 2007518253 A JP2007518253 A JP 2007518253A JP 2008503591 A5 JP2008503591 A5 JP 2008503591A5
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JP
Japan
Prior art keywords
alkyl
heteroaryl
mono
aryl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007518253A
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English (en)
Japanese (ja)
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JP2008503591A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/022157 external-priority patent/WO2006002284A1/en
Publication of JP2008503591A publication Critical patent/JP2008503591A/ja
Publication of JP2008503591A5 publication Critical patent/JP2008503591A5/ja
Pending legal-status Critical Current

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JP2007518253A 2004-06-22 2005-06-22 ユビキチンリガーゼ阻害剤 Pending JP2008503591A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58226104P 2004-06-22 2004-06-22
US64610205P 2005-01-21 2005-01-21
PCT/US2005/022157 WO2006002284A1 (en) 2004-06-22 2005-06-22 Ubiquitin ligase inhibitors

Publications (2)

Publication Number Publication Date
JP2008503591A JP2008503591A (ja) 2008-02-07
JP2008503591A5 true JP2008503591A5 (enExample) 2008-08-14

Family

ID=34979690

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007518253A Pending JP2008503591A (ja) 2004-06-22 2005-06-22 ユビキチンリガーゼ阻害剤

Country Status (4)

Country Link
US (1) US20050282818A1 (enExample)
EP (1) EP1758873A1 (enExample)
JP (1) JP2008503591A (enExample)
WO (1) WO2006002284A1 (enExample)

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US20100189648A1 (en) * 2006-11-02 2010-07-29 Lan Huang Inhibitors for disrupting the interaction of ubiquitination related enzymes and uses thereof
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ES2659763T3 (es) 2011-02-14 2018-03-19 The Regents Of The University Of Michigan Composiciones y procedimientos para el tratamiento de obesidad y trastornos relacionados
JP6038150B2 (ja) 2011-08-24 2016-12-07 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｎｅｄｄ８活性化酵素阻害剤
WO2013052943A2 (en) * 2011-10-06 2013-04-11 The Regents Of The University Of Michgian Small molecule inhibitors of mcl-1 and uses thereof
ES2396764B1 (es) 2011-11-02 2013-12-19 Universidad Autónoma de Madrid FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES.
GEP201706687B (en) 2012-02-17 2017-06-26 Millennium Pharmaceuticals Inc (A Delaware Corporation) Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
GB201212456D0 (en) 2012-07-12 2012-08-29 Univ Sheffield Treatment of muscular dystrophy
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EP2991647B1 (en) 2013-05-02 2019-04-24 The Regents Of The University Of Michigan Deuterated amlexanox with improved metabolic stability
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JP6378759B2 (ja) 2013-07-02 2018-08-22 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｓｕｍｏ活性化酵素阻害剤として有用なヘテロアリール化合物
LT3110812T (lt) * 2014-02-27 2019-07-10 Treventis Corporation Anti-amiloidų junginiai, turintys benzofurazano
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US11117877B2 (en) 2014-11-21 2021-09-14 Bsim Therapeutics, S.A. 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof
BR112017027205A2 (pt) 2015-06-15 2019-06-18 Bsim2 Biomolecular Simulations S A derivados de bis-furano como estabilizadores de transtirretina (ttr) e inibidores da amilóide para o tratamento de polineuropatia amiloidótica familiar (fap).
WO2017132538A1 (en) 2016-01-29 2017-08-03 The Regents Of The University Of Michigan Amlexanox analogs
CR20190063A (es) 2016-07-12 2019-05-27 Revolution Medicines Inc 3-metil pirazinas 2,5-disustituídas y 3-metil pirazinas 2,5,6-trisustituídas como inhibidores alostéricos de shp2
CN106565694B (zh) * 2016-10-09 2019-10-15 北京化工大学 一种nbd-有机胺类荧光探针及其制备方法和应用
BR112019015075A2 (pt) 2017-01-23 2020-03-10 Revolution Medicines, Inc. Compostos bicíclicos como inibidores de shp2 alostéricos
CN110431134A (zh) 2017-01-23 2019-11-08 锐新医药公司 作为变构shp2抑制剂的吡啶化合物
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CN113149930B (zh) * 2021-04-16 2022-09-02 天津大学 一种细胞糖转运通道抑制剂
CN113582940B (zh) * 2021-09-07 2022-05-20 四川大学华西医院 一类脂滴特异性荧光探针及其合成方法
WO2025117672A1 (en) * 2023-12-01 2025-06-05 Hotspot Therapeutics, Inc. Indazolyl-piperidine sulfonamides and related compounds and their use in therapy

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