JP2018519357A5 - - Google Patents
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- Publication number
- JP2018519357A5 JP2018519357A5 JP2018510695A JP2018510695A JP2018519357A5 JP 2018519357 A5 JP2018519357 A5 JP 2018519357A5 JP 2018510695 A JP2018510695 A JP 2018510695A JP 2018510695 A JP2018510695 A JP 2018510695A JP 2018519357 A5 JP2018519357 A5 JP 2018519357A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- nhc
- heterocycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SLWPRWSXSCAQDF-NSHDSACASA-N COc(ccc(Cl)c1)c1C(N(CC1)C[C@H]1C(NCC(COc(c(F)c(cc1F)F)c1F)=O)=O)=O Chemical compound COc(ccc(Cl)c1)c1C(N(CC1)C[C@H]1C(NCC(COc(c(F)c(cc1F)F)c1F)=O)=O)=O SLWPRWSXSCAQDF-NSHDSACASA-N 0.000 description 1
- SOCJXAGHTRHRHK-ZDUSSCGKSA-N COc(ccc(Cl)c1)c1C(N(CC1)C[C@H]1C(NCC(COc(c(F)ccc1)c1F)=O)=O)=O Chemical compound COc(ccc(Cl)c1)c1C(N(CC1)C[C@H]1C(NCC(COc(c(F)ccc1)c1F)=O)=O)=O SOCJXAGHTRHRHK-ZDUSSCGKSA-N 0.000 description 1
- RJCMMQRYZAOCME-UHFFFAOYSA-N COc(ccc(Cl)c1)c1C(N(CCC1)CC1C(NCC(COc(c(F)c(cc1F)F)c1F)=O)=O)=O Chemical compound COc(ccc(Cl)c1)c1C(N(CCC1)CC1C(NCC(COc(c(F)c(cc1F)F)c1F)=O)=O)=O RJCMMQRYZAOCME-UHFFFAOYSA-N 0.000 description 1
- RBXMNNZBZKBQNF-AWEZNQCLSA-N COc(ccc(Cl)c1)c1C(N(CCC1)C[C@H]1C(NCC(COc(c(F)ccc1)c1F)=O)=O)=O Chemical compound COc(ccc(Cl)c1)c1C(N(CCC1)C[C@H]1C(NCC(COc(c(F)ccc1)c1F)=O)=O)=O RBXMNNZBZKBQNF-AWEZNQCLSA-N 0.000 description 1
- XMKNRZMUYSQMLN-KRWDZBQOSA-N Cc1cccc(C)c1OCC(CNC([C@@H](CC1)CN1C(c(cc(cc1)Cl)c1OC)=O)=O)=O Chemical compound Cc1cccc(C)c1OCC(CNC([C@@H](CC1)CN1C(c(cc(cc1)Cl)c1OC)=O)=O)=O XMKNRZMUYSQMLN-KRWDZBQOSA-N 0.000 description 1
- GXLLQDDBHNKPTM-SFHVURJKSA-N Cc1cccc(C)c1OCC(CNC([C@@H](CCC1)CN1C(c(cc(cc1)Cl)c1OC)=O)=O)=O Chemical compound Cc1cccc(C)c1OCC(CNC([C@@H](CCC1)CN1C(c(cc(cc1)Cl)c1OC)=O)=O)=O GXLLQDDBHNKPTM-SFHVURJKSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562157915P | 2015-05-06 | 2015-05-06 | |
| US62/157,915 | 2015-05-06 | ||
| US201562158356P | 2015-05-07 | 2015-05-07 | |
| US62/158,356 | 2015-05-07 | ||
| PCT/US2016/031344 WO2016179558A1 (en) | 2015-05-06 | 2016-05-06 | K-ras modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519357A JP2018519357A (ja) | 2018-07-19 |
| JP2018519357A5 true JP2018519357A5 (enExample) | 2019-06-13 |
| JP6771023B2 JP6771023B2 (ja) | 2020-10-21 |
Family
ID=57218009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510695A Expired - Fee Related JP6771023B2 (ja) | 2015-05-06 | 2016-05-06 | Ｋ−ｒａｓ調節物質 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10857140B2 (enExample) |
| EP (1) | EP3291813A4 (enExample) |
| JP (1) | JP6771023B2 (enExample) |
| KR (1) | KR20180017013A (enExample) |
| CN (1) | CN107847495A (enExample) |
| AU (1) | AU2016258192B2 (enExample) |
| BR (1) | BR112017023821A2 (enExample) |
| CA (1) | CA2983927A1 (enExample) |
| CL (2) | CL2017002786A1 (enExample) |
| EA (1) | EA201792443A1 (enExample) |
| EC (1) | ECSP17073743A (enExample) |
| HK (2) | HK1251972A1 (enExample) |
| IL (1) | IL255417A (enExample) |
| MA (1) | MA42061A (enExample) |
| MX (1) | MX2017014163A (enExample) |
| PH (1) | PH12017501999A1 (enExample) |
| WO (1) | WO2016179558A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104379563B (zh) | 2012-04-10 | 2018-12-21 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| MA42061A (fr) | 2015-05-06 | 2021-03-31 | Leidos Biomedical Res Inc | Modulateurs de k-ras |
| CN109843856B (zh) | 2016-05-18 | 2023-05-02 | 米拉蒂治疗股份有限公司 | Kras g12c抑制剂 |
| WO2018195439A2 (en) * | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
| KR102861303B1 (ko) | 2017-11-15 | 2025-09-17 | 미라티 테라퓨틱스, 인크. | Ｋｒａｓ ｇ12ｃ 억제제 |
| US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
| CN119569702A (zh) | 2018-04-04 | 2025-03-07 | 阿尔维纳斯运营股份有限公司 | 蛋白水解调节剂及相关使用方法 |
| WO2019204505A2 (en) * | 2018-04-18 | 2019-10-24 | Theras, Inc. | K-ras modulators with a vinyl sulfonamide moiety |
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| KR102871791B1 (ko) | 2018-09-10 | 2025-10-15 | 미라티 테라퓨틱스, 인크. | 병용 요법 |
| ES3004338T3 (en) | 2018-09-10 | 2025-03-12 | Mirati Therapeutics Inc | Combination therapies |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| CA3112129A1 (en) | 2018-12-05 | 2020-06-11 | Mirati Therapeutics, Inc. | Combination therapies |
| JP7592601B2 (ja) | 2019-01-10 | 2024-12-02 | ミラティ セラピューティクス， インコーポレイテッド | Ｋｒａｓ ｇ１２ｃ阻害剤 |
| EP3946629A4 (en) * | 2019-03-26 | 2023-04-05 | University Of Massachusetts | THERAPEUTIC TARGETS FOR ONCOGENIC KRAS-DEPENDENT CANCERS |
| GB2606804B (en) | 2019-07-17 | 2023-12-27 | 2692372 Ontario Inc | Benzenesulfonamide derivatives and uses thereof |
| CA3148745A1 (en) | 2019-08-29 | 2021-03-04 | Xiaolun Wang | Kras g12d inhibitors |
| CN114761012B (zh) | 2019-09-24 | 2025-03-21 | 米拉蒂治疗股份有限公司 | 组合疗法 |
| CN114786777A (zh) * | 2019-11-04 | 2022-07-22 | 锐新医药公司 | Ras抑制剂 |
| CN110981943B (zh) * | 2019-12-02 | 2021-08-03 | 清华大学 | 多肽及其在制备药物中的用途和药物 |
| KR20220130126A (ko) | 2019-12-20 | 2022-09-26 | 미라티 테라퓨틱스, 인크. | Sos1 억제제 |
| WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
| CN115916346A (zh) * | 2020-04-27 | 2023-04-04 | 维瑞斯特姆股份有限公司 | 用于治疗异常细胞生长的方法 |
| TW202210633A (zh) | 2020-06-05 | 2022-03-16 | 法商昂席歐公司 | 用於治療癌症之dbait分子與kras抑制劑的組合 |
| KR20230042600A (ko) | 2020-06-18 | 2023-03-28 | 레볼루션 메디슨즈, 인크. | Ras 억제제에 대한 획득된 저항성을 지연, 예방, 및 치료하는 방법 |
| CA3187757A1 (en) | 2020-09-03 | 2022-03-24 | Ethan AHLER | Use of sos1 inhibitors to treat malignancies with shp2 mutations |
| US12286431B2 (en) | 2020-09-11 | 2025-04-29 | Mirati Therapeutics, Inc. | Crystalline forms of a KRas G12C inhibitor |
| US12398154B2 (en) | 2020-12-15 | 2025-08-26 | Mirati Therapeutics, Inc. | Azaquinazoline pan-KRas inhibitors |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| WO2022232142A1 (en) * | 2021-04-26 | 2022-11-03 | The Regents Of The University Of California | G-alpha-s inhibitors and uses thereof |
| EP4389751A1 (en) | 2021-09-03 | 2024-06-26 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
| WO2024155770A2 (en) * | 2023-01-18 | 2024-07-25 | Molecular Axiom, Llc | Compositions for modulating kras expression and uses thereof |
| CN121419983A (zh) | 2023-01-26 | 2026-01-27 | 阿尔维纳斯运营股份有限公司 | 基于小脑蛋白的kras降解protac及其相关用途 |
| EP4720059A1 (en) | 2023-05-24 | 2026-04-08 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| WO2025007000A1 (en) | 2023-06-30 | 2025-01-02 | Kumquat Biosciences Inc. | Substituted condensed tricyclic amine compounds and uses thereof as ras inhibitors |
| WO2025171055A1 (en) | 2024-02-06 | 2025-08-14 | Kumquat Biosciences Inc. | Heterocyclic conjugates and uses thereof |
| WO2025230971A1 (en) | 2024-04-30 | 2025-11-06 | Kumquat Biosciences Inc. | Macrocyclic heterocycles as anticancer agents |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE3131527A1 (de) | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPS61227567A (ja) | 1985-04-01 | 1986-10-09 | Eisai Co Ltd | １，４−ジヒドロピリジン誘導体 |
| DK626889A (da) | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same |
| WO1996006078A1 (en) | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists |
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| US5631251A (en) | 1995-06-07 | 1997-05-20 | Merck & Co., Inc. | 5-cyclopropyl-1,4 benzodiazepine-2-ones |
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| KR20020005769A (ko) | 1999-06-04 | 2002-01-17 | 다비드 에 질레스 | 메탈로프로테이나제의 억제제 |
| WO2001012189A1 (en) | 1999-08-12 | 2001-02-22 | Pharmacia Italia S.P.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| US20030207910A1 (en) | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| WO2003004474A1 (en) | 2001-07-06 | 2003-01-16 | Syngenta Participations Ag | Pesticidally active aminoacetonitriles |
| KR20050051691A (ko) | 2002-10-11 | 2005-06-01 | 아스트라제네카 아베 | 1,4-이치환 피페리딘 유도체 및 11-베타ｈｓｄ1억제제로서의 이들의 용도 |
| AU2004220321B2 (en) | 2003-03-12 | 2010-02-25 | Kudos Pharmaceuticals Ltd | Phthalazinone derivatives |
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| MA42061A (fr) | 2015-05-06 | 2021-03-31 | Leidos Biomedical Res Inc | Modulateurs de k-ras |
| IL307931A (en) | 2016-04-15 | 2023-12-01 | Epizyme Inc | Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors |
| WO2018195439A2 (en) | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
-
2016
- 2016-05-06 MA MA042061A patent/MA42061A/fr unknown
- 2016-05-06 KR KR1020177035079A patent/KR20180017013A/ko not_active Withdrawn
- 2016-05-06 WO PCT/US2016/031344 patent/WO2016179558A1/en not_active Ceased
- 2016-05-06 HK HK18111290.4A patent/HK1251972A1/zh unknown
- 2016-05-06 EA EA201792443A patent/EA201792443A1/ru unknown
- 2016-05-06 JP JP2018510695A patent/JP6771023B2/ja not_active Expired - Fee Related
- 2016-05-06 EP EP16790206.3A patent/EP3291813A4/en not_active Withdrawn
- 2016-05-06 CA CA2983927A patent/CA2983927A1/en not_active Abandoned
- 2016-05-06 HK HK18111150.3A patent/HK1251485A1/zh unknown
- 2016-05-06 AU AU2016258192A patent/AU2016258192B2/en not_active Ceased
- 2016-05-06 MX MX2017014163A patent/MX2017014163A/es unknown
- 2016-05-06 BR BR112017023821A patent/BR112017023821A2/pt not_active Application Discontinuation
- 2016-05-06 US US15/571,475 patent/US10857140B2/en not_active Expired - Fee Related
- 2016-05-06 CN CN201680037365.9A patent/CN107847495A/zh active Pending
-
2017
- 2017-11-02 PH PH12017501999A patent/PH12017501999A1/en unknown
- 2017-11-03 IL IL255417A patent/IL255417A/en unknown
- 2017-11-03 CL CL2017002786A patent/CL2017002786A1/es unknown
- 2017-11-06 EC ECIEPI201773743A patent/ECSP17073743A/es unknown
-
2018
- 2018-11-21 CL CL2018003316A patent/CL2018003316A1/es unknown
-
2020
- 2020-10-28 US US17/082,125 patent/US11541044B2/en active Active