JP2018534301A5 - - Google Patents
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- JP2018534301A5 JP2018534301A5 JP2018523432A JP2018523432A JP2018534301A5 JP 2018534301 A5 JP2018534301 A5 JP 2018534301A5 JP 2018523432 A JP2018523432 A JP 2018523432A JP 2018523432 A JP2018523432 A JP 2018523432A JP 2018534301 A5 JP2018534301 A5 JP 2018534301A5
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- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000005842 heteroatom Chemical group 0.000 claims 7
- -1 Morphorinyl Chemical group 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 3
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical group C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 102000000795 Galectin 1 Human genes 0.000 claims 1
- 108010001498 Galectin 1 Proteins 0.000 claims 1
- 102000000802 Galectin 3 Human genes 0.000 claims 1
- 108010001517 Galectin 3 Proteins 0.000 claims 1
- 102000007563 Galectins Human genes 0.000 claims 1
- 108010046569 Galectins Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000009787 cardiac fibrosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15193657 | 2015-11-09 | ||
| EP15193657.2 | 2015-11-09 | ||
| EP16172358 | 2016-06-01 | ||
| EP16172358.0 | 2016-06-01 | ||
| PCT/EP2016/076918 WO2017080973A1 (en) | 2015-11-09 | 2016-11-08 | 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018534301A JP2018534301A (ja) | 2018-11-22 |
| JP2018534301A5 true JP2018534301A5 (enExample) | 2021-02-12 |
| JP6892859B2 JP6892859B2 (ja) | 2021-06-23 |
Family
ID=57281206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018523432A Expired - Fee Related JP6892859B2 (ja) | 2015-11-09 | 2016-11-08 | 新規ガラクトシドによるガレクチン阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10730902B2 (enExample) |
| EP (1) | EP3374368B1 (enExample) |
| JP (1) | JP6892859B2 (enExample) |
| CN (1) | CN108602848B (enExample) |
| CA (1) | CA3000924A1 (enExample) |
| ES (1) | ES2921500T3 (enExample) |
| WO (1) | WO2017080973A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10889610B2 (en) * | 2016-07-12 | 2021-01-12 | Galecto Biotech Ab | Alpha-D-galactoside inhibitors of galectins |
| AU2018265571B2 (en) | 2017-05-12 | 2022-09-29 | Galectin Sciences, Llc | Compounds for the prevention and treatment of diseases and the use thereof |
| EP3658172A4 (en) * | 2017-07-25 | 2021-05-05 | TrueBinding, Inc. | TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND |
| WO2019067702A1 (en) | 2017-09-27 | 2019-04-04 | Bristol-Myers Squibb Company | INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| EP3732186A1 (en) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| JP7190513B2 (ja) | 2018-06-15 | 2022-12-15 | ブリストル－マイヤーズ スクイブ カンパニー | ガレクチン－３抑制剤を模したテトラヒドロピラン系チオ二糖類 |
| WO2020117883A1 (en) | 2018-12-06 | 2020-06-11 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CA3122321A1 (en) | 2018-12-27 | 2020-07-02 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| CN113711036B (zh) | 2019-01-30 | 2025-03-18 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| WO2021081881A1 (zh) * | 2019-10-31 | 2021-05-06 | 深圳先进技术研究院 | 一种基于tdg分子骨架的功能糖类分子及其制备方法 |
| CN113521283A (zh) * | 2020-04-14 | 2021-10-22 | 中国医学科学院药物研究所 | Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用 |
| CN115551855A (zh) | 2020-05-05 | 2022-12-30 | 百时美施贵宝公司 | 半乳凝素-3的小分子抑制剂 |
| US12286424B2 (en) | 2020-05-11 | 2025-04-29 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| CN115768768A (zh) | 2020-05-28 | 2023-03-07 | 百时美施贵宝公司 | 半乳凝素-3抑制剂 |
| WO2022171561A1 (en) * | 2021-02-10 | 2022-08-18 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| EP2679595B1 (en) * | 2008-05-16 | 2016-12-28 | Galecto Biotech AB | Di-(3-deoxy-3-1H-1,2,3-triazol-1-yl)-beta-D-galacto-pyranosyl)sulfane derivatives as galectin-3 inhibitors |
| US8703720B2 (en) * | 2009-04-28 | 2014-04-22 | Galecto Biotech Ab | Galactoside inhibitors of galectins |
| ES2698101T3 (es) | 2012-10-10 | 2019-01-31 | Galectin Therapeutics Inc | Compuestos de carbohidrato con restos de galactosa para el tratamiento de la nefropatía diabética y trastornos asociados |
| EP2914269B1 (en) | 2012-10-31 | 2020-07-29 | Galecto Biotech AB | Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis |
| WO2014078655A1 (en) * | 2012-11-15 | 2014-05-22 | Tufts University | Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor |
| CN106536537B (zh) * | 2014-07-09 | 2020-07-07 | 卡雷多生物技术公司 | 半乳凝素的新型杂合半乳糖苷抑制剂 |
| ES2776255T3 (es) | 2015-01-16 | 2020-07-29 | Galecto Biotech Ab | Novedoso inhibidor de galactósido de galectinas |
| EP3250581B1 (en) | 2015-01-30 | 2021-01-20 | Galecto Biotech AB | Alpha-d-galactoside inhibitors of galectins |
-
2016
- 2016-11-08 EP EP16794292.9A patent/EP3374368B1/en active Active
- 2016-11-08 ES ES16794292T patent/ES2921500T3/es active Active
- 2016-11-08 US US15/774,868 patent/US10730902B2/en active Active
- 2016-11-08 JP JP2018523432A patent/JP6892859B2/ja not_active Expired - Fee Related
- 2016-11-08 CN CN201680076549.6A patent/CN108602848B/zh not_active Expired - Fee Related
- 2016-11-08 WO PCT/EP2016/076918 patent/WO2017080973A1/en not_active Ceased
- 2016-11-08 CA CA3000924A patent/CA3000924A1/en active Pending
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