JP6892859B2 - 新規ガラクトシドによるガレクチン阻害剤 - Google Patents
新規ガラクトシドによるガレクチン阻害剤 Download PDFInfo
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- JP6892859B2 JP6892859B2 JP2018523432A JP2018523432A JP6892859B2 JP 6892859 B2 JP6892859 B2 JP 6892859B2 JP 2018523432 A JP2018523432 A JP 2018523432A JP 2018523432 A JP2018523432 A JP 2018523432A JP 6892859 B2 JP6892859 B2 JP 6892859B2
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
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| PCT/EP2016/076918 WO2017080973A1 (en) | 2015-11-09 | 2016-11-08 | 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins |
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| WO2018011094A1 (en) * | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| EP3621973A4 (en) | 2017-05-12 | 2021-10-27 | Galectin Sciences, LLC | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF DISEASES AND THEIR USE |
| US12227567B2 (en) | 2017-07-25 | 2025-02-18 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| US11267811B2 (en) | 2017-09-27 | 2022-03-08 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| WO2019133878A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| EP3807290B1 (en) | 2018-06-15 | 2022-03-30 | Bristol-Myers Squibb Company | Tetrahydropyran-based thiodisaccharide mimics as galectin-3 inhibitors |
| CN113166122A (zh) | 2018-12-06 | 2021-07-23 | 百时美施贵宝公司 | 半乳糖凝集素-3的小分子抑制剂 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| EP3902797A1 (en) | 2018-12-27 | 2021-11-03 | GlycoMimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND THEIR USES |
| WO2021081881A1 (zh) * | 2019-10-31 | 2021-05-06 | 深圳先进技术研究院 | 一种基于tdg分子骨架的功能糖类分子及其制备方法 |
| CN113521283A (zh) * | 2020-04-14 | 2021-10-22 | 中国医学科学院药物研究所 | Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用 |
| JP7705884B2 (ja) | 2020-05-05 | 2025-07-10 | ブリストル－マイヤーズ スクイブ カンパニー | ガレクチン－３の低分子阻害剤 |
| US12286424B2 (en) | 2020-05-11 | 2025-04-29 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| CA3185040A1 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| KR20230018431A (ko) | 2020-05-28 | 2023-02-07 | 브리스톨-마이어스 스큅 컴퍼니 | 갈렉틴-3 억제제 |
| WO2022171561A1 (en) * | 2021-02-10 | 2022-08-18 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
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| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| CN102066393B (zh) * | 2008-05-16 | 2014-07-02 | 格莱克特生物技术公司 | 半乳糖苷抑制剂的合成 |
| WO2010126435A1 (en) | 2009-04-28 | 2010-11-04 | Forskarpatent I Syd Ab | Novel galactoside inhibitors of galectins |
| ES2698101T3 (es) | 2012-10-10 | 2019-01-31 | Galectin Therapeutics Inc | Compuestos de carbohidrato con restos de galactosa para el tratamiento de la nefropatía diabética y trastornos asociados |
| ES2817888T3 (es) * | 2012-10-31 | 2021-04-08 | Galecto Biotech Ab | Inhibidor de galactósido de galectina-3 y su uso para tratar fibrosis pulmonar |
| WO2014078655A1 (en) * | 2012-11-15 | 2014-05-22 | Tufts University | Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor |
| EP3415522A1 (en) * | 2014-07-09 | 2018-12-19 | Galecto Biotech AB | Novel hybrid galactoside inhibitor of galectins |
| US10464964B2 (en) | 2015-01-16 | 2019-11-05 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| EP3828191A3 (en) | 2015-01-30 | 2021-08-18 | Galecto Biotech AB | Novel galactoside inhibitor of galectins |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA3000924A1 (en) | 2017-05-18 |
| JP2018534301A (ja) | 2018-11-22 |
| CN108602848B (zh) | 2022-01-18 |
| US20180327440A1 (en) | 2018-11-15 |
| WO2017080973A1 (en) | 2017-05-18 |
| US10730902B2 (en) | 2020-08-04 |
| ES2921500T3 (es) | 2022-08-26 |
| CN108602848A (zh) | 2018-09-28 |
| EP3374368B1 (en) | 2022-06-01 |
| EP3374368A1 (en) | 2018-09-19 |
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