CA3000924A1 - Novel galactoside inhibitors of galectins - Google Patents
Novel galactoside inhibitors of galectins Download PDFInfo
- Publication number
- CA3000924A1 CA3000924A1 CA3000924A CA3000924A CA3000924A1 CA 3000924 A1 CA3000924 A1 CA 3000924A1 CA 3000924 A CA3000924 A CA 3000924A CA 3000924 A CA3000924 A CA 3000924A CA 3000924 A1 CA3000924 A1 CA 3000924A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- och3
- ocf3
- galectin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15193657 | 2015-11-09 | ||
| EP15193657.2 | 2015-11-09 | ||
| EP16172358 | 2016-06-01 | ||
| EP16172358.0 | 2016-06-01 | ||
| PCT/EP2016/076918 WO2017080973A1 (en) | 2015-11-09 | 2016-11-08 | 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3000924A1 true CA3000924A1 (en) | 2017-05-18 |
Family
ID=57281206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3000924A Pending CA3000924A1 (en) | 2015-11-09 | 2016-11-08 | Novel galactoside inhibitors of galectins |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10730902B2 (enExample) |
| EP (1) | EP3374368B1 (enExample) |
| JP (1) | JP6892859B2 (enExample) |
| CN (1) | CN108602848B (enExample) |
| CA (1) | CA3000924A1 (enExample) |
| ES (1) | ES2921500T3 (enExample) |
| WO (1) | WO2017080973A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109563119A (zh) * | 2016-07-12 | 2019-04-02 | 格莱克特生物技术公司 | 半乳糖凝集素的α-D-半乳糖苷抑制剂 |
| KR102626669B1 (ko) | 2017-05-12 | 2024-01-17 | 갈랙틴 사이언시즈, 엘엘씨 | 질환의 예방 및 치료를 위한 화합물 및 이의 용도 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| US11267811B2 (en) | 2017-09-27 | 2022-03-08 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| WO2019075045A1 (en) | 2017-10-11 | 2019-04-18 | Bristol-Myers Squibb Company | INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3 |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| EP3807290B1 (en) | 2018-06-15 | 2022-03-30 | Bristol-Myers Squibb Company | Tetrahydropyran-based thiodisaccharide mimics as galectin-3 inhibitors |
| WO2020117883A1 (en) | 2018-12-06 | 2020-06-11 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| JP7547345B2 (ja) | 2018-12-27 | 2024-09-09 | グリコミメティクス， インコーポレイテッド | ガレクチン－３阻害性ｃ－グリコシド |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| WO2021081881A1 (zh) * | 2019-10-31 | 2021-05-06 | 深圳先进技术研究院 | 一种基于tdg分子骨架的功能糖类分子及其制备方法 |
| CN113521283A (zh) * | 2020-04-14 | 2021-10-22 | 中国医学科学院药物研究所 | Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用 |
| US12275720B2 (en) | 2020-05-05 | 2025-04-15 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| WO2021231243A1 (en) | 2020-05-11 | 2021-11-18 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| CN115768768A (zh) | 2020-05-28 | 2023-03-07 | 百时美施贵宝公司 | 半乳凝素-3抑制剂 |
| WO2022171561A1 (en) * | 2021-02-10 | 2022-08-18 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| US8697862B2 (en) | 2008-05-16 | 2014-04-15 | Galecto Biotech Ab | Synthesis of galactoside inhibitors |
| ES2652488T3 (es) | 2009-04-28 | 2018-02-02 | Galecto Biotech Ab | Nuevos inhibidores de galactósidos de galectinas |
| KR102231732B1 (ko) | 2012-10-10 | 2021-03-23 | 갈렉틴 테라퓨틱스, 인크. | 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물 |
| IN2015DN02573A (enExample) * | 2012-10-31 | 2015-09-11 | Galecto Biotech Ab | |
| EP2919802A4 (en) * | 2012-11-15 | 2016-09-14 | Univ Tufts | METHOD, COMPOSITIONS AND KITS FOR TREATING, MODULATING OR PREVENTING ANGIOGENESIS OR FIBROSIS IN A PATIENT USING A GALECTINE PROTEIN HEMMER |
| JP6735680B2 (ja) * | 2014-07-09 | 2020-08-05 | ガレクト バイオテック エービー | ガレクチンの新規ハイブリッドガラクトシド阻害剤 |
| WO2016113335A1 (en) | 2015-01-16 | 2016-07-21 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
| CA2970062C (en) | 2015-01-30 | 2023-02-28 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
-
2016
- 2016-11-08 CA CA3000924A patent/CA3000924A1/en active Pending
- 2016-11-08 JP JP2018523432A patent/JP6892859B2/ja not_active Expired - Fee Related
- 2016-11-08 CN CN201680076549.6A patent/CN108602848B/zh not_active Expired - Fee Related
- 2016-11-08 ES ES16794292T patent/ES2921500T3/es active Active
- 2016-11-08 WO PCT/EP2016/076918 patent/WO2017080973A1/en not_active Ceased
- 2016-11-08 US US15/774,868 patent/US10730902B2/en active Active
- 2016-11-08 EP EP16794292.9A patent/EP3374368B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3374368B1 (en) | 2022-06-01 |
| JP2018534301A (ja) | 2018-11-22 |
| EP3374368A1 (en) | 2018-09-19 |
| CN108602848A (zh) | 2018-09-28 |
| US20180327440A1 (en) | 2018-11-15 |
| CN108602848B (zh) | 2022-01-18 |
| WO2017080973A1 (en) | 2017-05-18 |
| US10730902B2 (en) | 2020-08-04 |
| ES2921500T3 (es) | 2022-08-26 |
| JP6892859B2 (ja) | 2021-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3374368B1 (en) | 1,1'-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins | |
| US10889610B2 (en) | Alpha-D-galactoside inhibitors of galectins | |
| JP7486484B2 (ja) | ガレクチンのα－Ｄ－ガラクトシド阻害剤 | |
| US10988502B2 (en) | Alpha-D-galactoside inhibitors of galectins | |
| US12497428B2 (en) | Galactoside inhibitor of galectins | |
| US20210380623A1 (en) | Prodrug galactoside inhibitor of galectins | |
| JP6707548B2 (ja) | ガレクチンの新規なガラクトシド阻害剤 | |
| ES2784873T3 (es) | Novedoso inhibidor galactósido híbrido de galectinas | |
| US11827666B2 (en) | Galactoside inhibitor of galectins | |
| EP3993870A1 (en) | Novel galactoside inhibitor of galectins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20211104 |