CA3000924A1 - Novel galactoside inhibitors of galectins - Google Patents
Novel galactoside inhibitors of galectins Download PDFInfo
- Publication number
- CA3000924A1 CA3000924A1 CA3000924A CA3000924A CA3000924A1 CA 3000924 A1 CA3000924 A1 CA 3000924A1 CA 3000924 A CA3000924 A CA 3000924A CA 3000924 A CA3000924 A CA 3000924A CA 3000924 A1 CA3000924 A1 CA 3000924A1
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- CA
- Canada
- Prior art keywords
- optionally substituted
- och3
- ocf3
- galectin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| EP15193657 | 2015-11-09 | ||
| EP15193657.2 | 2015-11-09 | ||
| EP16172358 | 2016-06-01 | ||
| EP16172358.0 | 2016-06-01 | ||
| PCT/EP2016/076918 WO2017080973A1 (en) | 2015-11-09 | 2016-11-08 | 1,1 '-sulfanediyl-di-beta-d-galactopyranosides as inhibitors of galectins |
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| CA3000924A1 true CA3000924A1 (en) | 2017-05-18 |
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| EP (1) | EP3374368B1 (enExample) |
| JP (1) | JP6892859B2 (enExample) |
| CN (1) | CN108602848B (enExample) |
| CA (1) | CA3000924A1 (enExample) |
| ES (1) | ES2921500T3 (enExample) |
| WO (1) | WO2017080973A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3025867A1 (en) * | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| WO2018209255A1 (en) | 2017-05-12 | 2018-11-15 | Galectin Sciences, Llc | Compounds for the prevention and treatment of diseases and the use thereof |
| JP7368856B2 (ja) * | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| WO2019067702A1 (en) | 2017-09-27 | 2019-04-04 | Bristol-Myers Squibb Company | INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3 |
| US11072626B2 (en) | 2017-10-11 | 2021-07-27 | Bristol-Myers Squibb Company | Small molecule inhibitors of Galectin-3 |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| CN112292386B (zh) | 2018-06-15 | 2024-06-11 | 百时美施贵宝公司 | 作为半乳凝素-3抑制剂的基于四氢吡喃的硫代二糖模拟物 |
| EP3891144A1 (en) | 2018-12-06 | 2021-10-13 | Bristol-Myers Squibb Company | Small molecule inhibitors of galectin-3 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| AU2019416330A1 (en) | 2018-12-27 | 2021-07-01 | Glycomimetics, Inc. | Galectin-3 inhibiting c-glycosides |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2021081881A1 (zh) * | 2019-10-31 | 2021-05-06 | 深圳先进技术研究院 | 一种基于tdg分子骨架的功能糖类分子及其制备方法 |
| CN113521283A (zh) * | 2020-04-14 | 2021-10-22 | 中国医学科学院药物研究所 | Galectin-3作为靶标在寻找保护胰岛功能药物或者生物制剂中的应用 |
| JP7705884B2 (ja) | 2020-05-05 | 2025-07-10 | ブリストル－マイヤーズ スクイブ カンパニー | ガレクチン－３の低分子阻害剤 |
| CN115551850A (zh) | 2020-05-11 | 2022-12-30 | 百时美施贵宝公司 | 半乳凝素-3的小分子抑制剂 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| US12291522B2 (en) | 2020-05-28 | 2025-05-06 | Bristol-Myers Squibb Company | Galectin-3 inhibitors |
| US20240059728A1 (en) * | 2021-02-10 | 2024-02-22 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100172D0 (sv) * | 2001-01-22 | 2001-01-22 | Ulf Nilsson | New inhibitors against galectins |
| SE0401301D0 (sv) * | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| CN103497228B (zh) * | 2008-05-16 | 2016-08-10 | 格莱克特生物技术公司 | 半乳糖苷抑制剂的合成 |
| WO2010126435A1 (en) | 2009-04-28 | 2010-11-04 | Forskarpatent I Syd Ab | Novel galactoside inhibitors of galectins |
| WO2014067986A1 (en) * | 2012-10-31 | 2014-05-08 | Galecto Biotech Ab | Galactoside inhibitor of galectin-3 and its use for treating pulmonary fibrosis |
| AU2013329148B2 (en) | 2012-10-10 | 2018-03-29 | Galectin Therapeutics, Inc. | Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders |
| JP6366598B2 (ja) * | 2012-11-15 | 2018-08-01 | タフツ ユニバーシティー | ガレクチンタンパク質阻害剤を用いて被験体の眼の血管新生または繊維症を処置し、調節し、または、予防する方法、組成物、およびキット |
| CA2949441A1 (en) * | 2014-07-09 | 2016-01-14 | Galecto Biotech Ab | Novel hybrid galactoside inhibitor of galectins |
| WO2016113335A1 (en) * | 2015-01-16 | 2016-07-21 | Galecto Biotech Ab | Novel galactoside inhibitor of galectins |
| JP6904906B2 (ja) | 2015-01-30 | 2021-07-21 | ガレクト・バイオテック・エイビイ | ガレクチンの新規なガラクトシド阻害剤 |
-
2016
- 2016-11-08 EP EP16794292.9A patent/EP3374368B1/en active Active
- 2016-11-08 CA CA3000924A patent/CA3000924A1/en active Pending
- 2016-11-08 ES ES16794292T patent/ES2921500T3/es active Active
- 2016-11-08 US US15/774,868 patent/US10730902B2/en active Active
- 2016-11-08 WO PCT/EP2016/076918 patent/WO2017080973A1/en not_active Ceased
- 2016-11-08 JP JP2018523432A patent/JP6892859B2/ja not_active Expired - Fee Related
- 2016-11-08 CN CN201680076549.6A patent/CN108602848B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP3374368A1 (en) | 2018-09-19 |
| JP2018534301A (ja) | 2018-11-22 |
| JP6892859B2 (ja) | 2021-06-23 |
| CN108602848A (zh) | 2018-09-28 |
| EP3374368B1 (en) | 2022-06-01 |
| WO2017080973A1 (en) | 2017-05-18 |
| US10730902B2 (en) | 2020-08-04 |
| US20180327440A1 (en) | 2018-11-15 |
| CN108602848B (zh) | 2022-01-18 |
| ES2921500T3 (es) | 2022-08-26 |
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