JP2016506368A5 - - Google Patents

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Publication number
JP2016506368A5
JP2016506368A5 JP2015541882A JP2015541882A JP2016506368A5 JP 2016506368 A5 JP2016506368 A5 JP 2016506368A5 JP 2015541882 A JP2015541882 A JP 2015541882A JP 2015541882 A JP2015541882 A JP 2015541882A JP 2016506368 A5 JP2016506368 A5 JP 2016506368A5
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JP
Japan
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substituted
alkyl
membered
heteroatoms selected
pharmaceutically acceptable
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JP2015541882A
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English (en)
Japanese (ja)
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JP2016506368A (ja
JP6259463B2 (ja
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Priority claimed from PCT/US2013/068842 external-priority patent/WO2014074660A1/en
Publication of JP2016506368A publication Critical patent/JP2016506368A/ja
Publication of JP2016506368A5 publication Critical patent/JP2016506368A5/ja
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JP2015541882A 2012-11-08 2013-11-07 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物 Active JP6259463B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723854P 2012-11-08 2012-11-08
US61/723,854 2012-11-08
PCT/US2013/068842 WO2014074660A1 (en) 2012-11-08 2013-11-07 ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES

Publications (3)

Publication Number Publication Date
JP2016506368A JP2016506368A (ja) 2016-03-03
JP2016506368A5 true JP2016506368A5 (enExample) 2016-11-17
JP6259463B2 JP6259463B2 (ja) 2018-01-10

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ID=49667568

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Application Number Title Priority Date Filing Date
JP2015541882A Active JP6259463B2 (ja) 2012-11-08 2013-11-07 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物

Country Status (15)

Country Link
US (1) US9315494B2 (enExample)
EP (1) EP2922841B8 (enExample)
JP (1) JP6259463B2 (enExample)
KR (1) KR102233252B1 (enExample)
CN (1) CN104781252B (enExample)
AR (1) AR093403A1 (enExample)
AU (1) AU2013341185B2 (enExample)
BR (1) BR112015010244A8 (enExample)
CA (1) CA2890929A1 (enExample)
EA (1) EA028526B1 (enExample)
IL (1) IL238554A0 (enExample)
MX (1) MX2015005272A (enExample)
SG (1) SG11201503396UA (enExample)
TW (1) TWI620737B (enExample)
WO (1) WO2014074660A1 (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20150953A1 (es) * 2012-11-08 2015-06-20 Bristol Myers Squibb Co Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa
SG11201503395TA (en) 2012-11-08 2015-05-28 Bristol Myers Squibb Co ALKYL AMIDE-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL IN THE MODULATION OF IL-12, IL-23 AND/OR IFNα
EP2922846B1 (en) * 2012-11-08 2018-10-03 Bristol-Myers Squibb Company Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn-alpha
TWI582077B (zh) 2013-11-07 2017-05-11 必治妥美雅史谷比公司 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物
CN105992768B (zh) 2013-12-10 2018-04-20 百时美施贵宝公司 用作IL‑12、IL‑23和/或IFNα响应的调节剂的咪唑并哒嗪化合物
TW201609693A (zh) 2014-01-03 2016-03-16 必治妥美雅史谷比公司 雜芳基取代之菸鹼醯胺化合物
WO2016001341A1 (en) * 2014-07-03 2016-01-07 F. Hoffmann-La Roche Ag Sulfonylaminopyridine compounds, compositions and methods of use
WO2016022626A1 (en) * 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
AR105113A1 (es) 2015-06-24 2017-09-06 Bristol Myers Squibb Co Compuestos de aminopiridina sustituida con heteroarilo
US10618903B2 (en) 2015-06-24 2020-04-14 Bristol-Myers Squibb Company Heteroaryl substituted aminopyridine compounds
UY36747A (es) 2015-06-24 2016-12-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de aminopiridina sustituida con heteroarilo como inhibidores de quinasa y modulantes de irak-4 y composiciones farmacéuticas que los contienen
DK3380465T3 (da) * 2015-11-26 2020-10-26 Novartis Ag Diaminopyridinderivativer
CN115448916A (zh) 2016-10-14 2022-12-09 林伯士拉克许米公司 Tyk2抑制剂及其用途
AU2017345736B2 (en) 2016-10-21 2022-04-07 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
AR110351A1 (es) * 2016-12-13 2019-03-20 Bristol Myers Squibb Co COMPUESTOS DE HETEROARILO SUSTITUIDOS CON FOSFINÓXIDO ALQUILAMIDA COMO MODULADORES DE RESPUESTAS DE IL-12, IL-23 Y/O IFNa
CA3055209A1 (en) 2017-03-08 2018-09-13 Nimbus Lakshmi, Inc. Tyk2 inhibitors, uses, and methods for production thereof
US10899745B2 (en) * 2017-03-30 2021-01-26 Bristol-Myers Squibb Company Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide
MY200228A (en) 2017-05-11 2023-12-15 Bristol Myers Squibb Co Thienopyridines and benzothiophenes useful as irak4 inhibitors
TWI776810B (zh) * 2017-05-12 2022-09-11 瑞士商諾華公司 新穎二胺基吡啶衍生物
JP7216705B2 (ja) 2017-07-28 2023-02-02 ニンバス ラクシュミ, インコーポレイテッド Tyk2阻害剤およびその使用方法
CA3083122A1 (en) * 2017-11-21 2019-05-31 Bristol-Myers Squibb Company Sulfone pyridine alkyl amide-substituted heteroaryl compounds
IL315310A (en) * 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11685723B2 (en) 2018-02-13 2023-06-27 Rutgers, The State University Of New Jersey Antibacterial agents: O-alkyl-deuterated pyronins
US12209082B2 (en) 2018-02-13 2025-01-28 Rutgers, The State University Of New Jersey Antibacterial agents: soluble salts and aqueous formulations of pyronins
WO2019173507A1 (en) 2018-03-06 2019-09-12 Rutgers, The State University Of New Jersey Antibacterial agents : arylalkylcarboxamido phloroglucinols
AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
CN111936486B (zh) * 2018-03-22 2023-09-22 百时美施贵宝公司 用作IL-12、IL-23和/或IFNα响应的调节剂的包含吡啶的杂环化合物
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11414431B2 (en) 2018-10-15 2022-08-16 Nimbus Lakshmi, Inc. Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
SG11202104307VA (en) * 2018-10-30 2021-05-28 Bristol Myers Squibb Co Amide-substituted heterocyclic compounds for the treatment of conditions related to the modulation of il-12, il-23 and/or ifn-alpha
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CA3120866A1 (en) 2018-11-30 2020-06-04 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
US11174264B2 (en) 2019-01-23 2021-11-16 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
JP7652697B2 (ja) * 2019-01-28 2025-03-27 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 ピリダジン系誘導体阻害剤、その製造方法及び使用
MX2021015995A (es) 2019-06-28 2022-03-11 Kymera Therapeutics Inc Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
US12558427B2 (en) 2019-07-17 2026-02-24 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021011727A1 (en) 2019-07-18 2021-01-21 Bristol-Myers Squibb Company PYRAZOLO[3,4-d]PYRROLO[1,2-b]PYRIDAZINYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS
WO2021011724A1 (en) 2019-07-18 2021-01-21 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
JP7573596B2 (ja) 2019-07-23 2024-10-25 ブリストル-マイヤーズ スクイブ カンパニー Irak4阻害剤として有用なチエノピリジニルおよびチアゾロピリジニル化合物
CN114174279B (zh) 2019-08-06 2024-07-02 百时美施贵宝公司 可用作irak4抑制剂的双环杂环化合物
US12570659B2 (en) 2019-08-13 2026-03-10 Bristol-Myers Squibb Company Bicyclic heteroaryl compounds useful as IRAK4 inhibitors
CN119874700A (zh) 2019-09-13 2025-04-25 林伯士萨顿公司 Hpk1拮抗剂和其用途
US12551564B2 (en) 2019-12-10 2026-02-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
CN115052627A (zh) 2019-12-17 2022-09-13 凯麦拉医疗公司 Irak降解剂和其用途
CN115335380B (zh) 2020-02-03 2024-08-02 百时美施贵宝公司 可用作irak4抑制剂的三环杂芳基化合物
US12391702B2 (en) 2020-02-03 2025-08-19 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors
US20220330549A1 (en) * 2020-03-11 2022-10-20 Northwest A&F University Use of n-benzylbenzamide-based compound as herbicide
CA3174845A1 (en) * 2020-04-14 2021-10-21 Craig Alan Coburn Substituted pyridines for the treatment of inflammatory diseases
US12479831B2 (en) 2020-04-28 2025-11-25 Bristol-Myers Squibb Company Substituted N(-methyl-D3)pyridazine-3-carboxamide or M-(methyl-D3)-nicotinamide compounds as IL-12, IL-23 and/or IFNα modulators
JP7537002B2 (ja) * 2020-08-07 2024-08-20 南京薬石科技股▲フン▼有限公司 Cdk9阻害剤およびその使用
CN114181257B (zh) * 2020-09-14 2025-02-14 四川科伦博泰生物医药股份有限公司 吡啶类化合物,包含其的药物组合物,其制备方法及其用途
EP4232425A4 (en) 2020-10-23 2024-07-24 Nimbus Clotho, Inc. Ctps1 inhibitors and uses thereof
WO2022133046A2 (en) * 2020-12-16 2022-06-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CA3202360A1 (en) 2020-12-30 2022-07-07 Nello Mainolfi Irak degraders and uses thereof
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.
CN117098757A (zh) 2021-02-02 2023-11-21 里米诺生物科学有限公司 Gpr84拮抗剂和其用途
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
CA3207049A1 (en) 2021-02-15 2022-08-18 Jared Gollob Irak4 degraders and uses thereof
EP4294806A1 (en) * 2021-02-19 2023-12-27 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
WO2022175745A1 (en) * 2021-02-19 2022-08-25 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
TW202246233A (zh) 2021-02-19 2022-12-01 英商蘇多生物科學有限公司 Tyk2抑制劑及其用途
TW202246232A (zh) * 2021-02-19 2022-12-01 英商蘇多生物科學有限公司 Tyk2抑制劑及其用途
US11926625B2 (en) 2021-03-05 2024-03-12 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン, インコーポレイテッド Hpk1アンタゴニスト及びその使用
US12325697B2 (en) 2021-04-09 2025-06-10 Nimbus Clio, Inc. CBL-B modulators and uses thereof
IL308422A (en) * 2021-05-14 2024-01-01 Bristol Myers Squibb Co substituted heterocyclic compounds
CA3236262A1 (en) 2021-10-25 2023-05-04 Isaac Marx Tyk2 degraders and uses thereof
CA3236265A1 (en) 2021-10-29 2023-05-04 William Leong Irak4 degraders and synthesis thereof
WO2023108536A1 (en) * 2021-12-16 2023-06-22 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
AU2022412835A1 (en) * 2021-12-16 2024-06-20 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
US12091411B2 (en) 2022-01-31 2024-09-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用
EP4511366A1 (en) * 2022-04-19 2025-02-26 Blueprint Medicines Corporation Kit inhibitors
WO2023227946A1 (en) * 2022-05-27 2023-11-30 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
EP4565568A1 (en) 2022-08-02 2025-06-11 Liminal Biosciences Limited Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
CN119894873A (zh) 2022-08-02 2025-04-25 里米诺生物科学有限公司 芳基三唑基和相关gpr84拮抗剂及其用途
KR20250056924A (ko) 2022-08-02 2025-04-28 리미널 바이오사이언시스 리미티드 치환된 피리돈 gpr84 길항제 및 이의 용도
CN121194786A (zh) * 2023-06-02 2025-12-23 Idrx股份有限公司 用于治疗癌症的包含kit抑制剂的组合疗法
WO2025062372A1 (en) 2023-09-21 2025-03-27 Takeda Pharmaceutical Company Limited Tyk2 inhibitors for use in the treatment of inflammatory bowel disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
GB0719644D0 (en) * 2007-10-05 2007-11-14 Cancer Rec Tech Ltd Therapeutic compounds and their use
WO2010058846A1 (ja) * 2008-11-21 2010-05-27 アステラス製薬株式会社 4,6-ジアミノニコチンアミド化合物
CN103298794A (zh) * 2010-11-09 2013-09-11 塞尔卓姆有限公司 作为tyk2抑制剂的吡啶化合物及其氮杂类似物

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