JP2016506368A5 - - Google Patents

Download PDF

Info

Publication number
JP2016506368A5
JP2016506368A5 JP2015541882A JP2015541882A JP2016506368A5 JP 2016506368 A5 JP2016506368 A5 JP 2016506368A5 JP 2015541882 A JP2015541882 A JP 2015541882A JP 2015541882 A JP2015541882 A JP 2015541882A JP 2016506368 A5 JP2016506368 A5 JP 2016506368A5
Authority
JP
Japan
Prior art keywords
substituted
alkyl
membered
heteroatoms selected
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015541882A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016506368A (ja
JP6259463B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/068842 external-priority patent/WO2014074660A1/en
Publication of JP2016506368A publication Critical patent/JP2016506368A/ja
Publication of JP2016506368A5 publication Critical patent/JP2016506368A5/ja
Application granted granted Critical
Publication of JP6259463B2 publication Critical patent/JP6259463B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015541882A 2012-11-08 2013-11-07 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物 Active JP6259463B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723854P 2012-11-08 2012-11-08
US61/723,854 2012-11-08
PCT/US2013/068842 WO2014074660A1 (en) 2012-11-08 2013-11-07 ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES

Publications (3)

Publication Number Publication Date
JP2016506368A JP2016506368A (ja) 2016-03-03
JP2016506368A5 true JP2016506368A5 (enExample) 2016-11-17
JP6259463B2 JP6259463B2 (ja) 2018-01-10

Family

ID=49667568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015541882A Active JP6259463B2 (ja) 2012-11-08 2013-11-07 IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用であるアルキルアミド置換ピリジル化合物

Country Status (15)

Country Link
US (1) US9315494B2 (enExample)
EP (1) EP2922841B8 (enExample)
JP (1) JP6259463B2 (enExample)
KR (1) KR102233252B1 (enExample)
CN (1) CN104781252B (enExample)
AR (1) AR093403A1 (enExample)
AU (1) AU2013341185B2 (enExample)
BR (1) BR112015010244A8 (enExample)
CA (1) CA2890929A1 (enExample)
EA (1) EA028526B1 (enExample)
IL (1) IL238554A0 (enExample)
MX (1) MX2015005272A (enExample)
SG (1) SG11201503396UA (enExample)
TW (1) TWI620737B (enExample)
WO (1) WO2014074660A1 (enExample)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2890935A1 (en) 2012-11-08 2014-05-15 Bristol-Myers Squibb Company Alkyl amide-substituted pyrimidine compounds useful in the modulation of il-12, il-23 and/or ifn.alpha.
PT2922846T (pt) 2012-11-08 2018-12-19 Bristol Myers Squibb Co Compostos heterocíclicos substituídos por amida úteis como moduladores de il-12, il-23 e/ou ie'n-alfa
CA2890983A1 (en) 2012-11-08 2014-05-15 Bristol-Myers Squibb Company Heteroaryl substituted pyridyl compounds useful as kinase modulators
AR094537A1 (es) 2013-11-07 2015-08-12 Bristol Myers Squibb Co COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
ES2702126T3 (es) 2013-12-10 2019-02-27 Bristol Myers Squibb Co Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa
TW201609693A (zh) 2014-01-03 2016-03-16 必治妥美雅史谷比公司 雜芳基取代之菸鹼醯胺化合物
WO2016001341A1 (en) * 2014-07-03 2016-01-07 F. Hoffmann-La Roche Ag Sulfonylaminopyridine compounds, compositions and methods of use
WO2016022626A1 (en) * 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
CN107849039B (zh) 2015-06-24 2020-07-03 百时美施贵宝公司 经杂芳基取代的氨基吡啶化合物
TW201713663A (zh) 2015-06-24 2017-04-16 必治妥美雅史谷比公司 經雜芳基取代之胺基吡啶化合物
KR102641263B1 (ko) 2015-06-24 2024-02-26 브리스톨-마이어스 스큅 컴퍼니 헤테로아릴 치환된 아미노피리딘 화합물
MX379776B (es) * 2015-11-26 2025-03-11 Novartis Ag Derivados de diamino piridina para usarse en el tratamiento de dermatitis atópica o psoriasis.
JP7082130B2 (ja) 2016-10-14 2022-06-07 ニンバス ラクシュミ, インコーポレイテッド Tyk2阻害剤およびその使用
AU2017345736B2 (en) 2016-10-21 2022-04-07 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
AR110351A1 (es) * 2016-12-13 2019-03-20 Bristol Myers Squibb Co COMPUESTOS DE HETEROARILO SUSTITUIDOS CON FOSFINÓXIDO ALQUILAMIDA COMO MODULADORES DE RESPUESTAS DE IL-12, IL-23 Y/O IFNa
EP4338802A3 (en) 2017-03-08 2024-09-04 Takeda Pharmaceutical Company Limited Tyk2 inhibitors, uses, and methods for production thereof
US10829496B2 (en) 2017-05-11 2020-11-10 Bristol-Myers Squibb Company Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
TWI776810B (zh) * 2017-05-12 2022-09-11 瑞士商諾華公司 新穎二胺基吡啶衍生物
CN111194317A (zh) 2017-07-28 2020-05-22 林伯士拉克许米公司 Tyk2抑制剂与其用途
EP3713930A1 (en) * 2017-11-21 2020-09-30 Bristol-Myers Squibb Company Sulfone pyridine alkyl amide-substituted heteroaryl compounds
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2019160875A1 (en) 2018-02-13 2019-08-22 Rutgers, The State University Of New Jersey Antibacterial agents: soluble salts and aqueous formulations of pyronins
WO2019160873A1 (en) 2018-02-13 2019-08-22 Rutgers, The State University Of New Jersey Antibacterial agents: o-alkyl-deuterated pyronins
US11572337B2 (en) 2018-03-06 2023-02-07 Rutgers, The State University Of New Jersey Antibacterial agents: arylalkylcarboxamido phloroglucinols
JP6557436B1 (ja) 2018-03-12 2019-08-07 アッヴィ・インコーポレイテッド チロシンキナーゼ2媒介性シグナル伝達の阻害剤
KR102741437B1 (ko) * 2018-03-22 2024-12-10 브리스톨-마이어스 스큅 컴퍼니 Il-12, il-23 및/또는 ifn 알파 반응의 조정제로서 유용한 피리딘을 포함하는 헤테로시클릭 화합물
US12454520B2 (en) 2018-07-06 2025-10-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
CN113271940A (zh) 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
KR102858043B1 (ko) * 2018-10-30 2025-09-10 브리스톨-마이어스 스큅 컴퍼니 Il-12, il-23 및/또는 ifn-알파의 조정과 관련된 상태의 치료를 위한 아미드-치환된 헤테로시클릭 화합물
KR102891608B1 (ko) 2018-11-30 2025-11-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
WO2020112937A1 (en) 2018-11-30 2020-06-04 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
WO2020154474A1 (en) 2019-01-23 2020-07-30 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
CN115448910B (zh) * 2019-01-28 2024-04-19 江苏豪森药业集团有限公司 一种哒嗪类衍生物抑制剂、其制备方法和应用
KR20220035447A (ko) 2019-07-18 2022-03-22 브리스톨-마이어스 스큅 컴퍼니 IRAK4 억제제로서 유용한 피라졸로[3,4-d]피롤로[1,2-b]피리다지닐 화합물
WO2021011724A1 (en) 2019-07-18 2021-01-21 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
US12304916B2 (en) 2019-07-23 2025-05-20 Bristol-Myers Squibb Company Thienopyridinyl and thiazolopyridinyl compounds useful as IRAK4 inhibitors
ES2983263T3 (es) 2019-08-06 2024-10-22 Bristol Myers Squibb Co Compuestos heterocíclicos bicíclicos útiles como inhibidores de IRAK4
MX2022002877A (es) 2019-09-13 2022-08-08 Nimbus Saturn Inc Antagonistas de cinasa progenitora hematopoyetica 1 (hpk1) y sus usos.
US12391702B2 (en) 2020-02-03 2025-08-19 Bristol-Myers Squibb Company Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors
WO2021158498A1 (en) 2020-02-03 2021-08-12 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
US20220330549A1 (en) * 2020-03-11 2022-10-20 Northwest A&F University Use of n-benzylbenzamide-based compound as herbicide
CN115702145A (zh) * 2020-04-14 2023-02-14 戈萨默生物服务公司 用于治疗炎性疾病的取代的吡啶
WO2021222153A1 (en) * 2020-04-28 2021-11-04 Bristol-Myers Squibb Company Substituted n-(methyl-d3)pyridazine-3-carboxamide or n-(methyl-d3)-nicotinamide compounds as il-12, il-23 and/or ifnalpha modulators
KR20230038740A (ko) * 2020-08-07 2023-03-21 파마블럭 사이언시스 (난징), 인코포레이티드 Cdk9 억제제 및 이의 용도
CN114181257B (zh) * 2020-09-14 2025-02-14 四川科伦博泰生物医药股份有限公司 吡啶类化合物,包含其的药物组合物,其制备方法及其用途
JP2023546996A (ja) 2020-10-23 2023-11-08 ニンバス クロソー, インコーポレイテッド Ctps1阻害剤およびその使用
US20240076285A1 (en) * 2020-12-16 2024-03-07 Shankar Venkatraman Compounds and compositions for treating conditions associated with sting activity
CN116867758A (zh) 2020-12-30 2023-10-10 凯麦拉医疗公司 Irak降解剂和其用途
CA3206501A1 (en) 2021-02-02 2022-08-11 Shaun Abbott Gpr84 antagonists and uses thereof
EP4288430A1 (en) 2021-02-02 2023-12-13 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
MX2023009527A (es) 2021-02-15 2023-08-24 Kymera Therapeutics Inc Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos.
WO2022175747A1 (en) 2021-02-19 2022-08-25 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
WO2022175745A1 (en) * 2021-02-19 2022-08-25 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
KR20230159421A (ko) * 2021-02-19 2023-11-21 수도 바이오사이언시즈 리미티드 Tyk2 억제제 및 이의 용도
BR112023016678A2 (pt) * 2021-02-19 2023-11-14 Sudo Biosciences Ltd Inibidores de tyk2 e usos dos mesmos
US11926625B2 (en) 2021-03-05 2024-03-12 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン, インコーポレイテッド Hpk1アンタゴニスト及びその使用
WO2022217276A1 (en) 2021-04-09 2022-10-13 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
IL312397A (en) 2021-10-29 2024-06-01 Kymera Therapeutics Inc IRAK4 subunits and their synthesis
WO2023108536A1 (en) * 2021-12-16 2023-06-22 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof
JP2025503448A (ja) 2021-12-16 2025-02-04 リンク ファーマシューティカルズ シーオー.エルティーディー. Tyk2阻害剤および組成物ならびにその方法
US12091411B2 (en) 2022-01-31 2024-09-17 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用
CN119585250A (zh) * 2022-04-19 2025-03-07 蓝图药品公司 Kit抑制剂
WO2023227946A1 (en) * 2022-05-27 2023-11-30 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
IL318576A (en) 2022-08-02 2025-03-01 Liminal Biosciences Ltd Pyridoxine-substituted GPR84 antagonists and their uses
AU2023317740A1 (en) 2022-08-02 2025-03-13 Liminal Biosciences Limited Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
KR20250057801A (ko) 2022-08-02 2025-04-29 리미널 바이오사이언시스 리미티드 아릴-트라이아졸릴 및 관련 gpr84 길항제 및 이의 용도
WO2024249855A1 (en) * 2023-06-02 2024-12-05 Idrx, Inc. Combination therapy comprising kit inhibitors for use in the treatment of cancer
WO2025062372A1 (en) 2023-09-21 2025-03-27 Takeda Pharmaceutical Company Limited Tyk2 inhibitors for use in the treatment of inflammatory bowel disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
GB0719644D0 (en) * 2007-10-05 2007-11-14 Cancer Rec Tech Ltd Therapeutic compounds and their use
WO2010058846A1 (ja) * 2008-11-21 2010-05-27 アステラス製薬株式会社 4,6-ジアミノニコチンアミド化合物
WO2012062704A1 (en) * 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors

Similar Documents

Publication Publication Date Title
JP2016506368A5 (enExample)
JP2016506369A5 (enExample)
JP2016501185A5 (enExample)
ES2625744T3 (es) Imidazo[1,2-a]piridinas sustituidas con 3-arilo y su uso
JP2015520140A5 (enExample)
JP2015503621A5 (enExample)
JP2017501236A5 (enExample)
CN114728912A (zh) Mta-协同prmt5抑制剂
JP2017509689A5 (enExample)
JP2015503620A5 (enExample)
JP2017501237A5 (enExample)
JP2016525075A5 (enExample)
JP2013534245A5 (enExample)
JP2018515438A5 (enExample)
JP2017511357A5 (enExample)
JP2015503622A5 (enExample)
JP2014508811A5 (enExample)
RU2019119893A (ru) Ингибиторы jak2 и alk2 и способы их использования
JP2015535277A5 (enExample)
RU2020110780A (ru) Ингибитор fgfr и его медицинское применение
JP2013536235A5 (enExample)
JP2016513660A5 (enExample)
ME02892B (me) Hemijska jedinjenja
JP2016515560A5 (enExample)
JP2015537017A5 (enExample)