JP2018115201A5 - - Google Patents
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- Publication number
- JP2018115201A5 JP2018115201A5 JP2018061990A JP2018061990A JP2018115201A5 JP 2018115201 A5 JP2018115201 A5 JP 2018115201A5 JP 2018061990 A JP2018061990 A JP 2018061990A JP 2018061990 A JP2018061990 A JP 2018061990A JP 2018115201 A5 JP2018115201 A5 JP 2018115201A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- substituted
- unsubstituted
- unbranched
- branched alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- -1 furo [3,2-b] pyridyl Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488997P | 2011-05-23 | 2011-05-23 | |
| US61/488,997 | 2011-05-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016124235A Division JP2016196492A (ja) | 2011-05-23 | 2016-06-23 | ピリジン−及びピラジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018115201A JP2018115201A (ja) | 2018-07-26 |
| JP2018115201A5 true JP2018115201A5 (enExample) | 2020-08-13 |
| JP6763904B2 JP6763904B2 (ja) | 2020-09-30 |
Family
ID=45976540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512837A Expired - Fee Related JP6054954B2 (ja) | 2011-05-23 | 2012-04-11 | ピリジン−及びピラジン誘導体 |
| JP2016124235A Pending JP2016196492A (ja) | 2011-05-23 | 2016-06-23 | ピリジン−及びピラジン誘導体 |
| JP2018061990A Expired - Fee Related JP6763904B2 (ja) | 2011-05-23 | 2018-03-28 | ピリジン−及びピラジン誘導体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512837A Expired - Fee Related JP6054954B2 (ja) | 2011-05-23 | 2012-04-11 | ピリジン−及びピラジン誘導体 |
| JP2016124235A Pending JP2016196492A (ja) | 2011-05-23 | 2016-06-23 | ピリジン−及びピラジン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9273029B2 (enExample) |
| EP (1) | EP2714677B1 (enExample) |
| JP (3) | JP6054954B2 (enExample) |
| KR (1) | KR101581522B1 (enExample) |
| CN (1) | CN103748086B (enExample) |
| AU (1) | AU2012259333B2 (enExample) |
| BR (1) | BR112013029640A2 (enExample) |
| CA (1) | CA2832605C (enExample) |
| DK (1) | DK2714677T3 (enExample) |
| EA (1) | EA023364B1 (enExample) |
| ES (1) | ES2699256T3 (enExample) |
| HR (1) | HRP20181884T1 (enExample) |
| IL (1) | IL229528A (enExample) |
| LT (1) | LT2714677T (enExample) |
| MX (1) | MX352975B (enExample) |
| PL (1) | PL2714677T3 (enExample) |
| PT (1) | PT2714677T (enExample) |
| RS (1) | RS58015B1 (enExample) |
| SG (1) | SG194105A1 (enExample) |
| SI (1) | SI2714677T1 (enExample) |
| WO (1) | WO2012161877A1 (enExample) |
| ZA (1) | ZA201307429B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9273029B2 (en) * | 2011-05-23 | 2016-03-01 | Merck Patent Gmbh | Pyridine-and pyrazine derivatives |
| GB201303109D0 (en) | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| EP3030554B1 (en) * | 2013-08-07 | 2018-02-28 | Merck Patent GmbH | Piperidine urea derivatives |
| JP6879740B2 (ja) | 2013-12-13 | 2021-06-02 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | リンパ形質細胞性リンパ腫を処置する方法 |
| EP3079682A4 (en) * | 2013-12-13 | 2017-08-30 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| WO2015121812A1 (en) * | 2014-02-12 | 2015-08-20 | Iteos Therapeutics | Novel 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use |
| WO2015173764A1 (en) | 2014-05-15 | 2015-11-19 | Iteos Therapeutics | Pyrrolidine-2,5-dione derivatives, pharmaceutical compositions and methods for use as ido1 inhibitors |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| US10040781B2 (en) | 2014-09-26 | 2018-08-07 | Gilead Sciences, Inc. | Tank-binding kinase inhibitor compounds |
| US9994547B2 (en) | 2014-10-06 | 2018-06-12 | Takeda Pharmaceutical Company Limited | Heteroarylamide inhibitors of TBK1 |
| CA2965178C (en) | 2014-10-22 | 2023-09-26 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| MA41598A (fr) * | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | Composés thérapeutiques de pyridazine et leurs utilisations |
| US9873690B2 (en) | 2015-03-17 | 2018-01-23 | Pfizer Inc | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| US10544095B2 (en) | 2015-08-10 | 2020-01-28 | Pfizer Inc. | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| BR112017002594A2 (pt) | 2015-12-17 | 2017-12-19 | Gilead Sciences Inc | compostos inibidores de cinase de ligação de tank |
| EP3390387B1 (en) | 2015-12-18 | 2021-11-17 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| SMT202100723T1 (it) | 2016-07-20 | 2022-01-10 | Novartis Ag | Derivati di amminopiridina e loro uso come inibitori selettivi di alk-2 |
| DE102016113714A1 (de) | 2016-07-26 | 2018-02-01 | Rosa Karl | Transfektionsverfahren mit nicht-viralen Genliefersystemen |
| GB201702947D0 (en) | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| TWI771410B (zh) * | 2017-04-27 | 2022-07-21 | 日商石原產業股份有限公司 | N-(4-吡啶基)菸鹼醯胺化合物或其鹽 |
| PE20230251A1 (es) | 2019-11-22 | 2023-02-07 | Incyte Corp | Terapia de combinacion que comprende un inhibidor de alk2 y un inhibidor de jak2 |
| JP2023530316A (ja) | 2020-06-16 | 2023-07-14 | インサイト・コーポレイション | 貧血の治療のためのａｌｋ２阻害剤 |
| AU2021356641A1 (en) * | 2020-10-09 | 2023-06-15 | Buck Institute For Research On Aging | Heteroaryl amide inhibitors of cd38 |
| CN116099004B (zh) * | 2022-12-30 | 2024-01-30 | 深圳开悦生命科技有限公司 | Rna解旋酶dhx33抑制剂在制备用于治疗膀胱癌的药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203754D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| AU2005215379A1 (en) * | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
| TW200800203A (en) | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
| CN101484452A (zh) | 2006-05-03 | 2009-07-15 | 阿斯利康(瑞典)有限公司 | 噻唑衍生物及其作为抗肿瘤药物的用途 |
| WO2009030890A1 (en) | 2007-09-03 | 2009-03-12 | University Court Of The University Of Dundee | Pyrimidine compounds for the treatment of cancer, septic shock and/or primary open angle glaucoma |
| WO2009053737A2 (en) | 2007-10-25 | 2009-04-30 | Astrazeneca Ab | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
| WO2009122180A1 (en) | 2008-04-02 | 2009-10-08 | Medical Research Council | Pyrimidine derivatives capable of inhibiting one or more kinases |
| CN106518856B (zh) * | 2008-12-19 | 2020-04-28 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
| GB0903759D0 (en) | 2009-03-04 | 2009-04-15 | Medical Res Council | Compound |
| KR20120120307A (ko) * | 2010-01-19 | 2012-11-01 | 아스트라제네카 아베 | 피라진 유도체 |
| US9273029B2 (en) * | 2011-05-23 | 2016-03-01 | Merck Patent Gmbh | Pyridine-and pyrazine derivatives |
-
2012
- 2012-04-11 US US14/118,845 patent/US9273029B2/en not_active Expired - Fee Related
- 2012-04-11 SG SG2013074638A patent/SG194105A1/en unknown
- 2012-04-11 AU AU2012259333A patent/AU2012259333B2/en not_active Ceased
- 2012-04-11 EA EA201301302A patent/EA023364B1/ru not_active IP Right Cessation
- 2012-04-11 CA CA2832605A patent/CA2832605C/en active Active
- 2012-04-11 ES ES12715279T patent/ES2699256T3/es active Active
- 2012-04-11 WO PCT/US2012/032983 patent/WO2012161877A1/en not_active Ceased
- 2012-04-11 CN CN201280025133.3A patent/CN103748086B/zh not_active Expired - Fee Related
- 2012-04-11 SI SI201231465T patent/SI2714677T1/sl unknown
- 2012-04-11 HR HRP20181884TT patent/HRP20181884T1/hr unknown
- 2012-04-11 LT LTEP12715279.1T patent/LT2714677T/lt unknown
- 2012-04-11 PT PT12715279T patent/PT2714677T/pt unknown
- 2012-04-11 KR KR1020137030982A patent/KR101581522B1/ko not_active Expired - Fee Related
- 2012-04-11 EP EP12715279.1A patent/EP2714677B1/en active Active
- 2012-04-11 PL PL12715279T patent/PL2714677T3/pl unknown
- 2012-04-11 MX MX2013012979A patent/MX352975B/es active IP Right Grant
- 2012-04-11 DK DK12715279.1T patent/DK2714677T3/en active
- 2012-04-11 JP JP2014512837A patent/JP6054954B2/ja not_active Expired - Fee Related
- 2012-04-11 BR BR112013029640A patent/BR112013029640A2/pt active Search and Examination
- 2012-04-11 RS RS20181427A patent/RS58015B1/sr unknown
-
2013
- 2013-10-04 ZA ZA2013/07429A patent/ZA201307429B/en unknown
- 2013-11-21 IL IL229528A patent/IL229528A/en active IP Right Grant
-
2016
- 2016-06-23 JP JP2016124235A patent/JP2016196492A/ja active Pending
-
2018
- 2018-03-28 JP JP2018061990A patent/JP6763904B2/ja not_active Expired - Fee Related