JP2015511232A5 - - Google Patents
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- Publication number
- JP2015511232A5 JP2015511232A5 JP2014555589A JP2014555589A JP2015511232A5 JP 2015511232 A5 JP2015511232 A5 JP 2015511232A5 JP 2014555589 A JP2014555589 A JP 2014555589A JP 2014555589 A JP2014555589 A JP 2014555589A JP 2015511232 A5 JP2015511232 A5 JP 2015511232A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- compound according
- pharmaceutically acceptable
- halo
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- QZLFJWDXXUKGEK-AKXYIILFSA-N n-[(1s)-2,2,2-trifluoro-1-[4-[[[(2s)-2-(5-fluoropyridin-2-yl)oxy-3-methoxypropyl]amino]methyl]phenyl]ethyl]methanesulfonamide;hydrochloride Chemical compound Cl.C([C@@H](COC)OC=1N=CC(F)=CC=1)NCC1=CC=C([C@H](NS(C)(=O)=O)C(F)(F)F)C=C1 QZLFJWDXXUKGEK-AKXYIILFSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261592717P | 2012-01-31 | 2012-01-31 | |
| US61/592,717 | 2012-01-31 | ||
| EP12382432.8 | 2012-11-06 | ||
| EP12382432 | 2012-11-06 | ||
| PCT/US2013/022870 WO2013116075A1 (en) | 2012-01-31 | 2013-01-24 | Benzyl sulfonamide derivatives useful as mogat - 2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015511232A JP2015511232A (ja) | 2015-04-16 |
| JP2015511232A5 true JP2015511232A5 (enExample) | 2017-03-02 |
Family
ID=47148691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555589A Ceased JP2015511232A (ja) | 2012-01-31 | 2013-01-24 | Ｍｏｇａｔ−２阻害剤として有用なベンジルスルホンアミド誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8575352B2 (enExample) |
| EP (1) | EP2809651B1 (enExample) |
| JP (1) | JP2015511232A (enExample) |
| KR (1) | KR20140106750A (enExample) |
| CN (1) | CN104066719B (enExample) |
| AP (1) | AP2014007794A0 (enExample) |
| AR (1) | AR089771A1 (enExample) |
| AU (1) | AU2013215468A1 (enExample) |
| BR (1) | BR112014018636A8 (enExample) |
| CA (1) | CA2859995A1 (enExample) |
| CL (1) | CL2014001861A1 (enExample) |
| CO (1) | CO7010839A2 (enExample) |
| CR (1) | CR20140322A (enExample) |
| DO (1) | DOP2014000178A (enExample) |
| EA (1) | EA201491276A1 (enExample) |
| ES (1) | ES2590929T3 (enExample) |
| GT (1) | GT201400167A (enExample) |
| HK (1) | HK1199025A1 (enExample) |
| IL (1) | IL233712A0 (enExample) |
| MA (1) | MA35886B1 (enExample) |
| MX (1) | MX2014008599A (enExample) |
| PE (1) | PE20141679A1 (enExample) |
| PH (1) | PH12014501711A1 (enExample) |
| SG (1) | SG11201404106QA (enExample) |
| TW (1) | TW201343629A (enExample) |
| WO (1) | WO2013116075A1 (enExample) |
| ZA (1) | ZA201404836B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013112323A1 (en) | 2012-01-23 | 2013-08-01 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors |
| WO2013116065A1 (en) | 2012-01-31 | 2013-08-08 | Eli Lilly And Company | Novel morpholinyl derivatives useful as mogat-2 inhibitors |
| MX2015005739A (es) | 2012-11-06 | 2015-09-16 | Lilly Co Eli | Compuestos novedosos de bencil sulfonamida utiles como inhibidores de mogat-2. |
| DK3307262T3 (da) | 2015-06-15 | 2021-08-09 | Nmd Pharma As | Forbindelser til anvendelse ved behandling af neuromuskulære lidelser |
| TWI782056B (zh) | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| US11591284B2 (en) | 2017-12-14 | 2023-02-28 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US12440477B2 (en) | 2017-12-14 | 2025-10-14 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11730714B2 (en) | 2017-12-14 | 2023-08-22 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US10385028B2 (en) | 2017-12-14 | 2019-08-20 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| US11147788B2 (en) | 2017-12-14 | 2021-10-19 | Nmd Pharma A/S | Compounds for the treatment of neuromuscular disorders |
| KR20210114001A (ko) | 2019-01-11 | 2021-09-17 | 시오노기 앤드 컴파니, 리미티드 | Mgat2 저해 활성을 갖는 다이하이드로피라졸로피라지논 유도체 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1659113A1 (en) * | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| EP1655283A1 (en) * | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| WO2006051378A1 (en) * | 2004-11-10 | 2006-05-18 | Pfizer Japan Inc. | Substituted n-sulfonylaminobenzyl-2-phenoxy acetamide compounds |
| CN101087771A (zh) * | 2004-11-10 | 2007-12-12 | 辉瑞大药厂 | 经取代n－磺酰基氨基苄基－2－苯氧基乙酰胺化合物 |
| CN101511808A (zh) * | 2006-09-08 | 2009-08-19 | 辉瑞产品公司 | 二芳基醚衍生物及其用途 |
| WO2008038768A1 (en) * | 2006-09-28 | 2008-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the compound |
| JP2010509392A (ja) * | 2006-11-13 | 2010-03-25 | ファイザー・プロダクツ・インク | ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用 |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CA2751244A1 (en) | 2009-02-23 | 2010-08-26 | Msd K.K. | Pyrimidin-4(3h)-one derivatives |
| WO2013112323A1 (en) | 2012-01-23 | 2013-08-01 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors |
| WO2013116065A1 (en) | 2012-01-31 | 2013-08-08 | Eli Lilly And Company | Novel morpholinyl derivatives useful as mogat-2 inhibitors |
-
2013
- 2013-01-21 TW TW102102260A patent/TW201343629A/zh unknown
- 2013-01-21 AR ARP130100180A patent/AR089771A1/es unknown
- 2013-01-24 JP JP2014555589A patent/JP2015511232A/ja not_active Ceased
- 2013-01-24 KR KR1020147021127A patent/KR20140106750A/ko not_active Ceased
- 2013-01-24 ES ES13703234.8T patent/ES2590929T3/es active Active
- 2013-01-24 EA EA201491276A patent/EA201491276A1/ru unknown
- 2013-01-24 BR BR112014018636A patent/BR112014018636A8/pt not_active IP Right Cessation
- 2013-01-24 AU AU2013215468A patent/AU2013215468A1/en not_active Abandoned
- 2013-01-24 WO PCT/US2013/022870 patent/WO2013116075A1/en not_active Ceased
- 2013-01-24 AP AP2014007794A patent/AP2014007794A0/xx unknown
- 2013-01-24 US US13/748,627 patent/US8575352B2/en not_active Expired - Fee Related
- 2013-01-24 SG SG11201404106QA patent/SG11201404106QA/en unknown
- 2013-01-24 MX MX2014008599A patent/MX2014008599A/es unknown
- 2013-01-24 HK HK14112466.4A patent/HK1199025A1/xx unknown
- 2013-01-24 CN CN201380007085.XA patent/CN104066719B/zh active Active
- 2013-01-24 EP EP13703234.8A patent/EP2809651B1/en active Active
- 2013-01-24 CA CA2859995A patent/CA2859995A1/en not_active Abandoned
- 2013-01-24 PE PE2014001197A patent/PE20141679A1/es not_active Application Discontinuation
-
2014
- 2014-06-30 ZA ZA2014/04836A patent/ZA201404836B/en unknown
- 2014-07-04 CR CR20140322A patent/CR20140322A/es unknown
- 2014-07-15 CL CL2014001861A patent/CL2014001861A1/es unknown
- 2014-07-17 IL IL233712A patent/IL233712A0/en unknown
- 2014-07-24 MA MA37244A patent/MA35886B1/fr unknown
- 2014-07-24 CO CO14161422A patent/CO7010839A2/es unknown
- 2014-07-29 GT GT201400167A patent/GT201400167A/es unknown
- 2014-07-30 DO DO2014000178A patent/DOP2014000178A/es unknown
- 2014-07-30 PH PH12014501711A patent/PH12014501711A1/en unknown