JP2013518050A5 - - Google Patents
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- JP2013518050A5 JP2013518050A5 JP2012550137A JP2012550137A JP2013518050A5 JP 2013518050 A5 JP2013518050 A5 JP 2013518050A5 JP 2012550137 A JP2012550137 A JP 2012550137A JP 2012550137 A JP2012550137 A JP 2012550137A JP 2013518050 A5 JP2013518050 A5 JP 2013518050A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- heteroaryl
- aryl
- ring
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 120
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 60
- 125000003107 substituted aryl group Chemical group 0.000 claims description 60
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 125000000623 heterocyclic group Chemical group 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 30
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 30
- 125000002252 acyl group Chemical group 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 15
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 15
- 125000002619 bicyclic group Chemical group 0.000 claims description 15
- 125000002837 carbocyclic group Chemical group 0.000 claims description 15
- 125000001188 haloalkyl group Chemical group 0.000 claims description 15
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 12
- 229940002612 prodrug Drugs 0.000 claims description 12
- 239000000651 prodrug Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 208000034578 Multiple myelomas Diseases 0.000 claims description 7
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 102000003964 Histone deacetylase Human genes 0.000 claims description 6
- 108090000353 Histone deacetylase Proteins 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims description 2
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims description 2
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical compound C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33646010P | 2010-01-22 | 2010-01-22 | |
| US61/336,460 | 2010-01-22 | ||
| PCT/US2011/021982 WO2011091213A2 (en) | 2010-01-22 | 2011-01-21 | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016100346A Division JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518050A JP2013518050A (ja) | 2013-05-20 |
| JP2013518050A5 true JP2013518050A5 (enExample) | 2016-05-12 |
| JP5940984B2 JP5940984B2 (ja) | 2016-06-29 |
Family
ID=44307593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550137A Active JP5940984B2 (ja) | 2010-01-22 | 2011-01-21 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
| JP2016100346A Pending JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016100346A Pending JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US8394810B2 (enExample) |
| EP (2) | EP2526093B1 (enExample) |
| JP (2) | JP5940984B2 (enExample) |
| KR (1) | KR101808874B1 (enExample) |
| CN (3) | CN105753739A (enExample) |
| AU (1) | AU2016213729A1 (enExample) |
| BR (1) | BR112012018246B1 (enExample) |
| CA (1) | CA2787756C (enExample) |
| CL (1) | CL2012002026A1 (enExample) |
| CY (1) | CY1118156T1 (enExample) |
| DK (1) | DK2526093T3 (enExample) |
| EA (1) | EA026514B1 (enExample) |
| ES (1) | ES2592278T3 (enExample) |
| HR (1) | HRP20161367T1 (enExample) |
| HU (1) | HUE030679T2 (enExample) |
| LT (1) | LT2526093T (enExample) |
| MX (1) | MX2012008553A (enExample) |
| NZ (1) | NZ601655A (enExample) |
| PH (1) | PH12012501492B1 (enExample) |
| PL (1) | PL2526093T3 (enExample) |
| PT (1) | PT2526093T (enExample) |
| RS (1) | RS55227B1 (enExample) |
| SG (2) | SG182646A1 (enExample) |
| SI (1) | SI2526093T1 (enExample) |
| SM (1) | SMT201600382B (enExample) |
| TW (3) | TWI600638B (enExample) |
| WO (1) | WO2011091213A2 (enExample) |
| ZA (1) | ZA201206063B (enExample) |
Families Citing this family (79)
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| EA025345B1 (ru) | 2010-11-16 | 2016-12-30 | Эситайлон Фармасьютикалз, Инк. | Гидроксиамидные соединения пиримидина в качестве ингибиторов деацетилаз белков и фармацевтические композиции для лечения заболевания, обусловленного hdac6, включающие эти соединения |
| WO2012117421A1 (en) | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
| FR2975911A1 (fr) * | 2011-06-06 | 2012-12-07 | Univ Strasbourg | Bisacodyl et analogues comme medicaments destines au traitement du cancer |
| US9512083B2 (en) | 2011-07-20 | 2016-12-06 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
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| CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
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| HUE061174T2 (hu) | 2015-07-27 | 2023-05-28 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazol-szulfonamid-származék vegyületek mint hiszton-deacetiláz-6 inhibitorok, és az ilyen vegyületeket tartalmazó gyógyszerkészímény |
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