JP2013518050A5 - - Google Patents
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- JP2013518050A5 JP2013518050A5 JP2012550137A JP2012550137A JP2013518050A5 JP 2013518050 A5 JP2013518050 A5 JP 2013518050A5 JP 2012550137 A JP2012550137 A JP 2012550137A JP 2012550137 A JP2012550137 A JP 2012550137A JP 2013518050 A5 JP2013518050 A5 JP 2013518050A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- heteroaryl
- aryl
- ring
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 120
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 60
- 125000003107 substituted aryl group Chemical group 0.000 claims description 60
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 125000000623 heterocyclic group Chemical group 0.000 claims description 45
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 30
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 30
- 125000002252 acyl group Chemical group 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 15
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 15
- 125000002619 bicyclic group Chemical group 0.000 claims description 15
- 125000002837 carbocyclic group Chemical group 0.000 claims description 15
- 125000001188 haloalkyl group Chemical group 0.000 claims description 15
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 15
- 150000002148 esters Chemical class 0.000 claims description 12
- 229940002612 prodrug Drugs 0.000 claims description 12
- 239000000651 prodrug Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 208000034578 Multiple myelomas Diseases 0.000 claims description 7
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 102000003964 Histone deacetylase Human genes 0.000 claims description 6
- 108090000353 Histone deacetylase Proteins 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims description 2
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims description 2
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical compound C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33646010P | 2010-01-22 | 2010-01-22 | |
| US61/336,460 | 2010-01-22 | ||
| PCT/US2011/021982 WO2011091213A2 (en) | 2010-01-22 | 2011-01-21 | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016100346A Division JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518050A JP2013518050A (ja) | 2013-05-20 |
| JP2013518050A5 true JP2013518050A5 (enExample) | 2016-05-12 |
| JP5940984B2 JP5940984B2 (ja) | 2016-06-29 |
Family
ID=44307593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550137A Active JP5940984B2 (ja) | 2010-01-22 | 2011-01-21 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
| JP2016100346A Pending JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016100346A Pending JP2016153425A (ja) | 2010-01-22 | 2016-05-19 | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US8394810B2 (enExample) |
| EP (2) | EP2526093B1 (enExample) |
| JP (2) | JP5940984B2 (enExample) |
| KR (1) | KR101808874B1 (enExample) |
| CN (3) | CN102933558B (enExample) |
| AU (1) | AU2016213729A1 (enExample) |
| BR (1) | BR112012018246B1 (enExample) |
| CA (1) | CA2787756C (enExample) |
| CL (1) | CL2012002026A1 (enExample) |
| CY (1) | CY1118156T1 (enExample) |
| DK (1) | DK2526093T3 (enExample) |
| EA (1) | EA026514B1 (enExample) |
| ES (1) | ES2592278T3 (enExample) |
| HR (1) | HRP20161367T1 (enExample) |
| HU (1) | HUE030679T2 (enExample) |
| LT (1) | LT2526093T (enExample) |
| MX (1) | MX2012008553A (enExample) |
| NZ (1) | NZ601655A (enExample) |
| PH (1) | PH12012501492B1 (enExample) |
| PL (1) | PL2526093T3 (enExample) |
| PT (1) | PT2526093T (enExample) |
| RS (1) | RS55227B1 (enExample) |
| SG (2) | SG10201500444TA (enExample) |
| SI (1) | SI2526093T1 (enExample) |
| SM (1) | SMT201600382B (enExample) |
| TW (3) | TW201735926A (enExample) |
| WO (1) | WO2011091213A2 (enExample) |
| ZA (1) | ZA201206063B (enExample) |
Families Citing this family (79)
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| WO2012018499A2 (en) * | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
| DK2624832T3 (en) | 2010-10-08 | 2018-01-08 | Vib Vzw | HDAC INHIBITORS FOR TREATMENT OF CHARCOT-MARIE-TOOTHS DISEASE |
| US8614223B2 (en) | 2010-11-16 | 2013-12-24 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| WO2012117421A1 (en) | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
| FR2975911A1 (fr) * | 2011-06-06 | 2012-12-07 | Univ Strasbourg | Bisacodyl et analogues comme medicaments destines au traitement du cancer |
| US9512083B2 (en) | 2011-07-20 | 2016-12-06 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
| KR101359571B1 (ko) | 2011-10-06 | 2014-02-10 | 서울대학교산학협력단 | Ｈｄａｃ 저해제와 알파칼슘설페이트를 유효성분으로 함유하는 치주질환 예방 및 치료용 약학적 조성물 |
| EP2827869A4 (en) | 2012-03-23 | 2015-09-23 | Dennis Brown | COMPOSITIONS AND METHODS FOR IMPROVING THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGUE THEREOF, WITH MEISOINDIGO |
| EP2839037B1 (en) * | 2012-04-19 | 2018-12-26 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| EP3054952B1 (en) * | 2013-10-08 | 2022-10-26 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer |
| WO2015054474A1 (en) * | 2013-10-10 | 2015-04-16 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| JP6584391B2 (ja) * | 2013-10-10 | 2019-10-02 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 非ホジキンリンパ腫を治療するための、ｈｄａｃ阻害剤単独またはｐｉ３ｋ阻害剤との組み合わせ |
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| US10660890B2 (en) | 2013-10-24 | 2020-05-26 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) | Treatment of polycystic diseases with an HDAC6 inhibitor |
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| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| ES2694053T3 (es) | 2014-03-12 | 2018-12-17 | Chong Kun Dang Pharmaceutical Corp. | Compuestos novedosos como inhibidores de histona desacetilasa 6 y composiciones farmacéuticas que comprenden los mismos |
| CN106456580B (zh) * | 2014-05-14 | 2020-09-04 | 科罗拉多州立大学董事会法人团体 | 作为蛋白质脱乙酰酶抑制剂和蛋白质脱乙酰酶-蛋白质激酶双重抑制剂的杂环异羟肟酸及其使用方法 |
| CN107205988A (zh) * | 2014-07-07 | 2017-09-26 | 埃斯泰隆制药公司 | 利用组蛋白脱乙酰酶抑制剂治疗白血病 |
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| ES2816641T3 (es) | 2014-12-12 | 2021-04-05 | Regenacy Pharmaceuticals Inc | Derivados de piperidina en calidad de inhibidores de HDAC1/2 |
| US10239845B2 (en) | 2015-02-02 | 2019-03-26 | Forma Therapeutics, Inc. | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors |
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| US10421778B2 (en) | 2015-05-05 | 2019-09-24 | Washington University | Isoform-selective lysine deacetylase inhibitors |
| CN108026057B (zh) * | 2015-05-22 | 2021-08-06 | 株式会社钟根堂 | 用作选择性组蛋白脱乙酰酶抑制剂的杂环烷基衍生化合物及含其的药物组合物 |
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| CN105017135A (zh) * | 2015-07-19 | 2015-11-04 | 佛山市赛维斯医药科技有限公司 | 一类二吡啶叔醇结构的11β-HSD1抑制剂、制备方法及其用途 |
| US10584117B2 (en) | 2015-07-27 | 2020-03-10 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| MY197262A (en) | 2015-07-27 | 2023-06-08 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| CN107980040B (zh) | 2015-07-27 | 2021-11-26 | 株式会社钟根堂 | 作为组蛋白去乙酰酶6抑制剂的1,3,4-噁二唑磺酰胺衍生物及含其的医药组合物 |
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| KR102576148B1 (ko) | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| CA3185923A1 (en) | 2020-07-14 | 2022-01-20 | Jae Kwang Lee | Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same |
| KR20230059801A (ko) | 2020-08-17 | 2023-05-03 | 알리고스 테라퓨틱스 인코포레이티드 | Pd-l1을 표적화하기 위한 방법 및 조성물 |
| KR102685058B1 (ko) | 2020-09-02 | 2024-07-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물 |
| KR20220139752A (ko) | 2021-04-08 | 2022-10-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 싸이오카보닐 화합물 및 이를 포함하는 약제학적 조성물 |
| KR20230144686A (ko) | 2022-04-07 | 2023-10-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| CN114621754A (zh) * | 2022-04-18 | 2022-06-14 | 武汉轻工大学 | 一种荧光探针的制备及其在组蛋白去乙酰化酶中的应用 |
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