EA201591775A1 - Замещенные ароматические соединения и связанный с ними способ лечения фиброза - Google Patents

Замещенные ароматические соединения и связанный с ними способ лечения фиброза

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Publication number
EA201591775A1
EA201591775A1 EA201591775A EA201591775A EA201591775A1 EA 201591775 A1 EA201591775 A1 EA 201591775A1 EA 201591775 A EA201591775 A EA 201591775A EA 201591775 A EA201591775 A EA 201591775A EA 201591775 A1 EA201591775 A1 EA 201591775A1
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EA
Eurasian Patent Office
Prior art keywords
fibrosis
compound
treatment
aromatic compounds
substituted aromatic
Prior art date
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EA201591775A
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English (en)
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EA030651B1 (ru
Inventor
Було Закари
Шон Эбботт
Лин Ганьон
Пьер Лорин
Брижит Груа
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Прометик Биосайнсиз Инк.
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Application filed by Прометик Биосайнсиз Инк. filed Critical Прометик Биосайнсиз Инк.
Publication of EA201591775A1 publication Critical patent/EA201591775A1/ru
Publication of EA030651B1 publication Critical patent/EA030651B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к соединению:или его фармацевтически приемлемой соли, где А представляет собой Салкил, Салкил, Салкенил, Салкенил, С(О)-(СН)-СНили СН(ОН)-(СН)-СН, причем n равен 3 или 4; Rпредставляет собой Н, F или ОН; Rпредставляет собой Салкил, Салкил, Салкенил, Салкенил, С(О)-(СН)-СНили СН(ОН)-(СН)-СН, причем n равен 3 или 4; Rпредставляет собой Н, F, ОН или CHPh; Rпредставляет собой Н, F или ОН; Q представляет собой 1) (CH)C(O)OH, причем m равен 1 или 2, 2) СН(СН)С(О)ОН, 3) С(СН)С(О)ОН, 4) CH(F)-C(O)OH, 5) CF-C(O)OH или 6) С(О)-С(О)ОН; а также к композициям, содержащим указанное соединение и способу применения указанного соединения для предотвращения или лечения различных фиброзных заболеваний и состояний у субъекта, включая фиброз легких, фиброз печени, фиброз кожи, фиброз почек, фиброз поджелудочной железы, системный склероз, фиброз сердца или макулярную дегенерацию.
EA201591775A 2013-03-15 2014-03-14 Замещенные ароматические соединения и связанный с ними способ лечения фиброза EA030651B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798269P 2013-03-15 2013-03-15
PCT/CA2014/000236 WO2014138906A1 (en) 2013-03-15 2014-03-14 Substituted aromatic compounds and related method for the treatment of fibrosis

Publications (2)

Publication Number Publication Date
EA201591775A1 true EA201591775A1 (ru) 2016-05-31
EA030651B1 EA030651B1 (ru) 2018-09-28

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US (3) US10023518B2 (ru)
EP (1) EP2970089B1 (ru)
JP (1) JP6448562B2 (ru)
KR (1) KR102196721B1 (ru)
CN (2) CN110105200B (ru)
AR (1) AR095429A1 (ru)
AU (1) AU2014231648B2 (ru)
BR (1) BR112015022008A2 (ru)
CA (1) CA2905621C (ru)
CL (1) CL2015002535A1 (ru)
DK (1) DK2970089T3 (ru)
EA (1) EA030651B1 (ru)
ES (1) ES2741439T3 (ru)
HK (1) HK1220440A1 (ru)
IL (1) IL241178B (ru)
MX (1) MX2015011878A (ru)
MY (1) MY180305A (ru)
NZ (1) NZ712797A (ru)
PH (1) PH12015502011B1 (ru)
PL (1) PL2970089T3 (ru)
PT (1) PT2970089T (ru)
SG (1) SG11201507408XA (ru)
TW (1) TWI689490B (ru)
UY (1) UY35402A (ru)
WO (1) WO2014138906A1 (ru)
ZA (1) ZA201507061B (ru)

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WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
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RU2769364C1 (ru) * 2018-09-14 2022-03-30 Селлионбиомед Инк. Композиция для лечения фибротических заболеваний, содержащая бензгидрилтиоацетамид в качестве активного компонента

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ZA201507061B (en) 2017-03-26
AR095429A1 (es) 2015-10-14
EA030651B1 (ru) 2018-09-28
MY180305A (en) 2020-11-27
CN110105200A (zh) 2019-08-09
ES2741439T3 (es) 2020-02-11
TWI689490B (zh) 2020-04-01
US20160039736A1 (en) 2016-02-11
IL241178A0 (en) 2015-11-30
IL241178B (en) 2020-09-30
CA2905621A1 (en) 2014-09-18
BR112015022008A2 (pt) 2021-05-25
PH12015502011A1 (en) 2016-01-11
KR102196721B1 (ko) 2020-12-30
US10023518B2 (en) 2018-07-17
US20200172462A1 (en) 2020-06-04
SG11201507408XA (en) 2015-10-29
EP2970089B1 (en) 2019-05-08
HK1220440A1 (zh) 2017-05-05
KR20160051676A (ko) 2016-05-11
US10550066B2 (en) 2020-02-04
US11524930B2 (en) 2022-12-13
MX2015011878A (es) 2016-06-07
CA2905621C (en) 2021-06-29
NZ712797A (en) 2020-08-28
TW201441186A (zh) 2014-11-01
EP2970089A1 (en) 2016-01-20
UY35402A (es) 2014-10-31
PH12015502011B1 (en) 2016-01-11
DK2970089T3 (da) 2019-08-05
EP2970089A4 (en) 2016-10-12
AU2014231648A1 (en) 2015-10-22
US20180237374A1 (en) 2018-08-23
CN105189438A (zh) 2015-12-23
CN110105200B (zh) 2022-04-12
JP2016512202A (ja) 2016-04-25
AU2014231648B2 (en) 2018-02-08
WO2014138906A1 (en) 2014-09-18
PT2970089T (pt) 2019-09-04
JP6448562B2 (ja) 2019-01-09
PL2970089T3 (pl) 2020-01-31
CL2015002535A1 (es) 2016-03-28

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