JP2016196492A5 - - Google Patents
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- Publication number
- JP2016196492A5 JP2016196492A5 JP2016124235A JP2016124235A JP2016196492A5 JP 2016196492 A5 JP2016196492 A5 JP 2016196492A5 JP 2016124235 A JP2016124235 A JP 2016124235A JP 2016124235 A JP2016124235 A JP 2016124235A JP 2016196492 A5 JP2016196492 A5 JP 2016196492A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- substituted
- unsubstituted
- het
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 tetrahydroimidazolyl Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000005052 dihydropyrazolyl group Chemical group N1(NCC=C1)* 0.000 claims 1
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 1
- 125000005054 dihydropyrrolyl group Chemical group [H]C1=C([H])C([H])([H])C([H])([H])N1* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000005945 imidazopyridyl group Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488997P | 2011-05-23 | 2011-05-23 | |
| US61/488,997 | 2011-05-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512837A Division JP6054954B2 (ja) | 2011-05-23 | 2012-04-11 | ピリジン−及びピラジン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061990A Division JP6763904B2 (ja) | 2011-05-23 | 2018-03-28 | ピリジン−及びピラジン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016196492A JP2016196492A (ja) | 2016-11-24 |
| JP2016196492A5 true JP2016196492A5 (enExample) | 2017-12-07 |
Family
ID=45976540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512837A Expired - Fee Related JP6054954B2 (ja) | 2011-05-23 | 2012-04-11 | ピリジン−及びピラジン誘導体 |
| JP2016124235A Pending JP2016196492A (ja) | 2011-05-23 | 2016-06-23 | ピリジン−及びピラジン誘導体 |
| JP2018061990A Expired - Fee Related JP6763904B2 (ja) | 2011-05-23 | 2018-03-28 | ピリジン−及びピラジン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512837A Expired - Fee Related JP6054954B2 (ja) | 2011-05-23 | 2012-04-11 | ピリジン−及びピラジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018061990A Expired - Fee Related JP6763904B2 (ja) | 2011-05-23 | 2018-03-28 | ピリジン−及びピラジン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9273029B2 (enExample) |
| EP (1) | EP2714677B1 (enExample) |
| JP (3) | JP6054954B2 (enExample) |
| KR (1) | KR101581522B1 (enExample) |
| CN (1) | CN103748086B (enExample) |
| AU (1) | AU2012259333B2 (enExample) |
| BR (1) | BR112013029640A2 (enExample) |
| CA (1) | CA2832605C (enExample) |
| DK (1) | DK2714677T3 (enExample) |
| EA (1) | EA023364B1 (enExample) |
| ES (1) | ES2699256T3 (enExample) |
| HR (1) | HRP20181884T1 (enExample) |
| IL (1) | IL229528A (enExample) |
| LT (1) | LT2714677T (enExample) |
| MX (1) | MX352975B (enExample) |
| PL (1) | PL2714677T3 (enExample) |
| PT (1) | PT2714677T (enExample) |
| RS (1) | RS58015B1 (enExample) |
| SG (1) | SG194105A1 (enExample) |
| SI (1) | SI2714677T1 (enExample) |
| WO (1) | WO2012161877A1 (enExample) |
| ZA (1) | ZA201307429B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2714677T3 (en) * | 2011-05-23 | 2018-11-26 | Merck Patent Gmbh | PYRIDINE AND PYRAZINE DERIVATIVES |
| GB201303109D0 (en) | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
| KR102249564B1 (ko) * | 2013-08-07 | 2021-05-07 | 메르크 파텐트 게엠베하 | 피페리딘 우레아 유도체 |
| CA2932353A1 (en) | 2013-12-13 | 2015-06-18 | Steven P. Treon | Methods to treat lymphoplasmacytic lymphoma |
| JP6879740B2 (ja) | 2013-12-13 | 2021-06-02 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | リンパ形質細胞性リンパ腫を処置する方法 |
| JP2017505346A (ja) | 2014-02-12 | 2017-02-16 | アイティーオス セラペウティクス | 新規な３−（インドール−３−イル）−ピリジン誘導体、医薬組成物、および使用方法 |
| UY36122A (es) | 2014-05-15 | 2016-01-08 | Iteos Therapeutics | ?derivados de pirrolidina-2,5-diona, composiciones farmacéuticas y métodos para usar como inhibidores ido1? |
| TW201613916A (en) | 2014-06-03 | 2016-04-16 | Gilead Sciences Inc | TANK-binding kinase inhibitor compounds |
| NZ729618A (en) | 2014-09-26 | 2018-07-27 | Gilead Sciences Inc | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| US9994547B2 (en) | 2014-10-06 | 2018-06-12 | Takeda Pharmaceutical Company Limited | Heteroarylamide inhibitors of TBK1 |
| JP6788583B2 (ja) | 2014-10-22 | 2020-11-25 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 増殖性疾患を処置するためのチアゾリル含有化合物 |
| MA41598A (fr) * | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | Composés thérapeutiques de pyridazine et leurs utilisations |
| EP3271354A1 (en) | 2015-03-17 | 2018-01-24 | Pfizer Inc | Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| CA2994917A1 (en) | 2015-08-10 | 2017-02-16 | Pfizer Inc. | 3-indol substituted derivatives, pharmaceutical compositions and methods for use |
| SG11201804294WA (en) | 2015-12-17 | 2018-07-30 | Gilead Sciences Inc | Tank-binding kinase inhibitor compounds |
| US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| HRP20241015T1 (hr) | 2016-07-20 | 2024-11-08 | Novartis Ag | Derivati aminopiridina i njihova uporaba kao selektivnih alk-2 inhibitora |
| DE102016113714A1 (de) | 2016-07-26 | 2018-02-01 | Rosa Karl | Transfektionsverfahren mit nicht-viralen Genliefersystemen |
| GB201702947D0 (en) | 2017-02-23 | 2017-04-12 | Domainex Ltd | Novel compounds |
| PE20191788A1 (es) * | 2017-04-27 | 2019-12-24 | Ishihara Sangyo Kaisha | Compuesto de n-(4-piridil)nicotinamida o sal del mismo |
| AU2020388638A1 (en) | 2019-11-22 | 2022-06-30 | Incyte Corporation | Combination therapy comprising an ALK2 inhibitor and a JAK2 inhibitor |
| JP2023530316A (ja) | 2020-06-16 | 2023-07-14 | インサイト・コーポレイション | 貧血の治療のためのａｌｋ２阻害剤 |
| CN116710090A (zh) * | 2020-10-09 | 2023-09-05 | Napa医疗有限公司 | Cd38的杂芳基酰胺抑制剂 |
| CN116099004B (zh) * | 2022-12-30 | 2024-01-30 | 深圳开悦生命科技有限公司 | Rna解旋酶dhx33抑制剂在制备用于治疗膀胱癌的药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| SE0102438D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0102439D0 (sv) * | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
| SE0203754D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| AU2005215379A1 (en) * | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
| TW200800203A (en) * | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
| US20090076009A1 (en) | 2006-05-03 | 2009-03-19 | Arnould Jean-Claude Retired | Thiazole derivatives and their use as anti-tumour agents |
| WO2009030890A1 (en) | 2007-09-03 | 2009-03-12 | University Court Of The University Of Dundee | Pyrimidine compounds for the treatment of cancer, septic shock and/or primary open angle glaucoma |
| EP2215085B1 (en) | 2007-10-25 | 2011-09-07 | AstraZeneca AB | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
| WO2009122180A1 (en) | 2008-04-02 | 2009-10-08 | Medical Research Council | Pyrimidine derivatives capable of inhibiting one or more kinases |
| PT3354650T (pt) * | 2008-12-19 | 2022-06-20 | Vertex Pharma | Compostos úteis como inibidores da cinase atr |
| GB0903759D0 (en) | 2009-03-04 | 2009-04-15 | Medical Res Council | Compound |
| BR112012017884A2 (pt) * | 2010-01-19 | 2019-09-24 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, derivado de pirazina, métodos para o tratamento ou prevenção, para promoção óssea, e, para tratar lesões ósseas em cânceres |
| DK2714677T3 (en) * | 2011-05-23 | 2018-11-26 | Merck Patent Gmbh | PYRIDINE AND PYRAZINE DERIVATIVES |
-
2012
- 2012-04-11 DK DK12715279.1T patent/DK2714677T3/en active
- 2012-04-11 CA CA2832605A patent/CA2832605C/en active Active
- 2012-04-11 PL PL12715279T patent/PL2714677T3/pl unknown
- 2012-04-11 JP JP2014512837A patent/JP6054954B2/ja not_active Expired - Fee Related
- 2012-04-11 PT PT12715279T patent/PT2714677T/pt unknown
- 2012-04-11 ES ES12715279T patent/ES2699256T3/es active Active
- 2012-04-11 CN CN201280025133.3A patent/CN103748086B/zh not_active Expired - Fee Related
- 2012-04-11 AU AU2012259333A patent/AU2012259333B2/en not_active Ceased
- 2012-04-11 US US14/118,845 patent/US9273029B2/en not_active Expired - Fee Related
- 2012-04-11 BR BR112013029640A patent/BR112013029640A2/pt active Search and Examination
- 2012-04-11 RS RS20181427A patent/RS58015B1/sr unknown
- 2012-04-11 EA EA201301302A patent/EA023364B1/ru not_active IP Right Cessation
- 2012-04-11 SG SG2013074638A patent/SG194105A1/en unknown
- 2012-04-11 WO PCT/US2012/032983 patent/WO2012161877A1/en not_active Ceased
- 2012-04-11 HR HRP20181884TT patent/HRP20181884T1/hr unknown
- 2012-04-11 MX MX2013012979A patent/MX352975B/es active IP Right Grant
- 2012-04-11 LT LTEP12715279.1T patent/LT2714677T/lt unknown
- 2012-04-11 SI SI201231465T patent/SI2714677T1/sl unknown
- 2012-04-11 KR KR1020137030982A patent/KR101581522B1/ko not_active Expired - Fee Related
- 2012-04-11 EP EP12715279.1A patent/EP2714677B1/en active Active
-
2013
- 2013-10-04 ZA ZA2013/07429A patent/ZA201307429B/en unknown
- 2013-11-21 IL IL229528A patent/IL229528A/en active IP Right Grant
-
2016
- 2016-06-23 JP JP2016124235A patent/JP2016196492A/ja active Pending
-
2018
- 2018-03-28 JP JP2018061990A patent/JP6763904B2/ja not_active Expired - Fee Related
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