JP2011502956A5 - - Google Patents

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Publication number
JP2011502956A5
JP2011502956A5 JP2010504681A JP2010504681A JP2011502956A5 JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5 JP 2010504681 A JP2010504681 A JP 2010504681A JP 2010504681 A JP2010504681 A JP 2010504681A JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5
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JP
Japan
Prior art keywords
alkyl
phenyl
methyl
compound
methoxy
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JP2010504681A
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English (en)
Japanese (ja)
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JP2011502956A (ja
JP5693951B2 (ja
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Priority claimed from PCT/EP2008/054975 external-priority patent/WO2008129070A1/en
Publication of JP2011502956A publication Critical patent/JP2011502956A/ja
Publication of JP2011502956A5 publication Critical patent/JP2011502956A5/ja
Application granted granted Critical
Publication of JP5693951B2 publication Critical patent/JP5693951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010504681A 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤 Expired - Fee Related JP5693951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2007003602 2007-04-24
EPPCT/EP2007/003602 2007-04-24
PCT/EP2008/054975 WO2008129070A1 (en) 2007-04-24 2008-04-24 Inhibitors of protein kinases

Publications (3)

Publication Number Publication Date
JP2011502956A JP2011502956A (ja) 2011-01-27
JP2011502956A5 true JP2011502956A5 (enExample) 2011-06-16
JP5693951B2 JP5693951B2 (ja) 2015-04-01

Family

ID=39588050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504681A Expired - Fee Related JP5693951B2 (ja) 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤

Country Status (4)

Country Link
US (1) US8436007B2 (enExample)
JP (1) JP5693951B2 (enExample)
ES (1) ES2539518T3 (enExample)
WO (1) WO2008129070A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP5693951B2 (ja) 2007-04-24 2015-04-01 アストラゼネカ エービー プロテインキナーゼの阻害剤
JP5566880B2 (ja) * 2007-04-24 2014-08-06 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤としての4,6−二置換アミノピリミジン誘導体
JP5566879B2 (ja) * 2007-04-24 2014-08-06 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤
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JP2013107824A (ja) * 2010-03-17 2013-06-06 Dainippon Sumitomo Pharma Co Ltd 新規単環ピリミジン誘導体
JP5921525B2 (ja) * 2010-03-22 2016-05-24 リード ディスカバリー センター ゲゼルシャフト ミット ベシュレンクテル ハフツング 医薬的に活性のある二置換のトリアジン誘導体
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WO2012117048A1 (en) 2011-03-02 2012-09-07 Lead Discovery Center Gmbh Pharmaceutically active disubstituted triazine derivatives
ES2567066T3 (es) * 2011-03-02 2016-04-19 Lead Discovery Center Gmbh Derivados de piridina disustituida farmacéuticamente activos
KR20140019381A (ko) * 2011-04-19 2014-02-14 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 4-아릴-n-페닐-1,3,5-트리아진-2-아민
TW201636330A (zh) 2011-05-24 2016-10-16 拜耳知識產權公司 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺
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ES2622583T3 (es) * 2012-11-15 2017-07-06 Bayer Pharma Aktiengesellschaft 4-(Orto)-fluorofenil-5-fluoropirimidin-2-ilaminas que contienen un grupo sulfoximina
US9650340B2 (en) 2012-11-15 2017-05-16 Bayer Pharma Aktiengesellschaft 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物
US9770445B2 (en) 2013-07-04 2017-09-26 Bayer Pharma Aktiengesellschaft Sulfoximine substituted 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives and their use as CDK9 kinase inhibitors
CA2942119A1 (en) 2014-03-13 2015-09-17 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
EP3126338B1 (en) 2014-04-01 2019-09-04 Bayer Pharma Aktiengesellschaft Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group
CR20160471A (es) 2014-04-11 2016-12-21 Bayer Pharma AG Compuestos novedosos macrocíclicos
CN107207475A (zh) 2014-10-16 2017-09-26 拜耳医药股份有限公司 含有砜基团的氟化苯并呋喃基‑嘧啶衍生物
EP3207038B1 (en) 2014-10-16 2018-08-22 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
WO2016150902A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating gastric cancers
CA2980493A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating multiple myeloma
CA2980507A1 (en) 2015-03-24 2016-09-29 Public University Corporation Nagoya City University Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating lymphomas
ES2902148T3 (es) 2015-06-29 2022-03-25 Astrazeneca Ab Derivados de amidas policíclicas como inhibidores de CDK9
JP6847099B2 (ja) 2015-09-29 2021-03-24 バイエル ファーマ アクチエンゲゼルシャフト 新規な大環状スルホンジイミン化合物
CN108368129B (zh) 2015-10-08 2021-08-17 拜耳医药股份有限公司 改性大环化合物
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
EP3601253B1 (en) 2017-03-28 2021-09-15 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
WO2018177889A1 (en) 2017-03-28 2018-10-04 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
KR102764122B1 (ko) 2018-02-13 2025-02-05 바이엘 악티엔게젤샤프트 미만성 거대 b-세포 림프종을 치료하기 위한 5-플루오로-4-(4-플루오로-2-메톡시페닐)-n-[4-[(s-메틸술폰이미도일)메틸]피리딘-2-일]피리딘-2-아민의 용도
CN115335058B (zh) * 2020-03-27 2024-12-06 国立大学法人京都大学 神经细胞变性抑制剂

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JP2008542219A (ja) * 2005-05-25 2008-11-27 インゲニウム ファーマシューティカルズ ジーエムビーエイチ 疼痛処置法
JP5693951B2 (ja) 2007-04-24 2015-04-01 アストラゼネカ エービー プロテインキナーゼの阻害剤
EP2137165B1 (en) * 2007-04-24 2013-04-24 Ingenium Pharmaceuticals GmbH Inhibitors of protein kinases
JP5566879B2 (ja) * 2007-04-24 2014-08-06 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤

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