JP2011502956A5 - - Google Patents

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Publication number
JP2011502956A5
JP2011502956A5 JP2010504681A JP2010504681A JP2011502956A5 JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5 JP 2010504681 A JP2010504681 A JP 2010504681A JP 2010504681 A JP2010504681 A JP 2010504681A JP 2011502956 A5 JP2011502956 A5 JP 2011502956A5
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JP
Japan
Prior art keywords
alkyl
phenyl
methyl
compound
methoxy
Prior art date
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JP2010504681A
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English (en)
Japanese (ja)
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JP2011502956A (ja
JP5693951B2 (ja
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Priority claimed from PCT/EP2008/054975 external-priority patent/WO2008129070A1/en
Publication of JP2011502956A publication Critical patent/JP2011502956A/ja
Publication of JP2011502956A5 publication Critical patent/JP2011502956A5/ja
Application granted granted Critical
Publication of JP5693951B2 publication Critical patent/JP5693951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010504681A 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤 Expired - Fee Related JP5693951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2007003602 2007-04-24
EPPCT/EP2007/003602 2007-04-24
PCT/EP2008/054975 WO2008129070A1 (en) 2007-04-24 2008-04-24 Inhibitors of protein kinases

Publications (3)

Publication Number Publication Date
JP2011502956A JP2011502956A (ja) 2011-01-27
JP2011502956A5 true JP2011502956A5 (enExample) 2011-06-16
JP5693951B2 JP5693951B2 (ja) 2015-04-01

Family

ID=39588050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504681A Expired - Fee Related JP5693951B2 (ja) 2007-04-24 2008-04-24 プロテインキナーゼの阻害剤

Country Status (4)

Country Link
US (1) US8436007B2 (enExample)
JP (1) JP5693951B2 (enExample)
ES (1) ES2539518T3 (enExample)
WO (1) WO2008129070A1 (enExample)

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* Cited by examiner, † Cited by third party
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US8389521B2 (en) * 2007-04-24 2013-03-05 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
JP5693951B2 (ja) 2007-04-24 2015-04-01 アストラゼネカ エービー プロテインキナーゼの阻害剤
WO2008129080A1 (en) * 2007-04-24 2008-10-30 Ingenium Pharmaceuticals Gmbh 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases
DE112009005041T5 (de) * 2009-07-08 2012-09-27 Joben Bio-Medical Co., Ltd. Verfahren der Extraktzubereitung aus Longankern und die Anwendung des Longankernextrakts
JP2013107824A (ja) * 2010-03-17 2013-06-06 Dainippon Sumitomo Pharma Co Ltd 新規単環ピリミジン誘導体
US20130079345A1 (en) * 2010-03-22 2013-03-28 Bayer Intellectual Property Gmbh Pharmaceutically active disubstituted triazine derivatives
WO2012066065A1 (en) * 2010-11-17 2012-05-24 Novartis Ag Phenyl-heteroaryl amine compounds and their uses
JP5947818B2 (ja) * 2011-03-02 2016-07-06 リード ディスカバリー センター ゲーエムベーハー 薬学的活性化二置換ピリジン誘導体
CA2826464C (en) * 2011-03-02 2020-07-28 Lead Discovery Center Gmbh Pharmaceutically active disubstituted triazine derivatives
EP2699554B1 (en) * 2011-04-19 2016-11-02 Bayer Intellectual Property GmbH Substituted 4-aryl-n-phenyl-1,3,5-triazin-2-amines
EP2527332A1 (en) 2011-05-24 2012-11-28 Bayer Intellectual Property GmbH 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors
TWI555737B (zh) 2011-05-24 2016-11-01 拜耳知識產權公司 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺
JP5976814B2 (ja) * 2011-09-16 2016-08-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH スルホキシイミン基を含有する二置換5−フルオロピリミジン誘導体
EP2755956B1 (en) * 2011-09-16 2016-05-18 Bayer Intellectual Property GmbH 2,4-disubstituted 5-fluoro-pyrimidines as selective cdk9 inhibtors
WO2014060375A2 (en) * 2012-10-18 2014-04-24 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
CA2888383A1 (en) 2012-10-18 2014-04-24 Bayer Pharma Aktiengesellschaft N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group
CN105102434A (zh) * 2012-10-18 2015-11-25 拜耳药业股份公司 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺
CA2891244C (en) * 2012-11-15 2020-12-01 Ulrich Lucking 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
US9650340B2 (en) 2012-11-15 2017-05-16 Bayer Pharma Aktiengesellschaft 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group
TW201418243A (zh) 2012-11-15 2014-05-16 Bayer Pharma AG 含有磺醯亞胺基團之n-(吡啶-2-基)嘧啶-4-胺衍生物
EP3016945B1 (en) 2013-07-04 2017-05-03 Bayer Pharma Aktiengesellschaft Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors
WO2015136028A1 (en) 2014-03-13 2015-09-17 Bayer Pharma Aktiengesellschaft 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
US9790189B2 (en) 2014-04-01 2017-10-17 Bayer Pharma Aktiengesellschaft Disubstituted 5-fluoro pyrimidine derivatives containing a sulfondiimine group
WO2015155197A1 (en) 2014-04-11 2015-10-15 Bayer Pharma Aktiengesellschaft Novel macrocyclic compounds
CA2964696C (en) 2014-10-16 2022-09-06 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group
WO2016059011A1 (en) 2014-10-16 2016-04-21 Bayer Pharma Aktiengesellschaft Fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group
CA2980507A1 (en) 2015-03-24 2016-09-29 Public University Corporation Nagoya City University Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating lymphomas
CA2980493A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating multiple myeloma
WO2016150902A1 (en) 2015-03-24 2016-09-29 Bayer Pharma Aktiengesellschaft Use of 4-(4-fluoro-2-methoxyphenyl)-n-{3-[(s-methylsulfonimidoyl)methyl]phenyl}-1,3,5-triazin-2-amine for treating gastric cancers
ES2728356T3 (es) 2015-06-29 2019-10-23 Astrazeneca Ab Derivados de amidas policíclicas como inhibidores de CDK9
JP6847099B2 (ja) 2015-09-29 2021-03-24 バイエル ファーマ アクチエンゲゼルシャフト 新規な大環状スルホンジイミン化合物
ES2819869T3 (es) 2015-10-08 2021-04-19 Bayer Pharma AG Nuevos compuestos macrocíclicos modificados
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
ES2900199T3 (es) 2017-03-28 2022-03-16 Bayer Ag Novedosos compuestos macrocíclicos inhibidores de PTEFB
EP3601236A1 (en) 2017-03-28 2020-02-05 Bayer Aktiengesellschaft Novel ptefb inhibiting macrocyclic compounds
MX2020008447A (es) 2018-02-13 2020-09-28 Bayer Ag Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b.
CA3172328A1 (en) * 2020-03-27 2021-09-30 Haruhisa Inoue Nerve cell degeneration inhibitor

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GB9319568D0 (en) * 1993-09-22 1993-11-10 Euro Celtique Sa Pharmaceutical compositions and usages
CN100355751C (zh) * 2000-03-29 2007-12-19 西克拉塞尔有限公司 2-取代的4-杂芳基-嘧啶、其组合物及其用途
AU2003209077A1 (en) * 2002-02-08 2003-09-02 Smithkline Beecham Corporation Pyrimidine compounds
GB0205693D0 (en) * 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
EP1648875A1 (en) * 2003-07-30 2006-04-26 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
US8084457B2 (en) * 2003-09-15 2011-12-27 Lead Discovery Center Gmbh Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
ES2325035T3 (es) * 2004-12-21 2009-08-24 Smithkline Beecham Corporation Inhibidores de quinasa erbb de 2-pirimidinil pirazolopiridina.
WO2006125616A2 (en) 2005-05-25 2006-11-30 Ingenium Pharmaceuticals Ag Pyrimidine-based cdk inhibitors for treating pain
JP5693951B2 (ja) 2007-04-24 2015-04-01 アストラゼネカ エービー プロテインキナーゼの阻害剤
US8507511B2 (en) * 2007-04-24 2013-08-13 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
US8389521B2 (en) * 2007-04-24 2013-03-05 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases

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