MX2020008447A - Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b. - Google Patents

Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b.

Info

Publication number
MX2020008447A
MX2020008447A MX2020008447A MX2020008447A MX2020008447A MX 2020008447 A MX2020008447 A MX 2020008447A MX 2020008447 A MX2020008447 A MX 2020008447A MX 2020008447 A MX2020008447 A MX 2020008447A MX 2020008447 A MX2020008447 A MX 2020008447A
Authority
MX
Mexico
Prior art keywords
pyridin
fluoro
cell lymphoma
diffuse large
methoxyphenyl
Prior art date
Application number
MX2020008447A
Other languages
English (en)
Inventor
Arne Scholz
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020008447A publication Critical patent/MX2020008447A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere al uso de 5-Fluoro-4-(4-fluoro-2- metoxifenil)-N-{4-[(Smetilsulfonimidoil) metil]piridin-2-il}piridi n-2-amina (compuesto A), más específicamente (+)5-Fluoro-4-(4- fluoro-2-metoxifenil)-N-{4-[(S-metilsulfonimidoil)metil]piridin-2 -il}piridin-5 2-amina (compuesto A´), para el tratamiento del linfoma difuso de células grandes B (LDCGB), especialmente en el tipo de células B del centro germinal del linfoma difuso de células grandes B y especialmente en el linfoma difuso de células grandes B cuyas células tienen una amplificación o translocación del gen MYC y/o del gen BCL2 y/o una sobreexpresión de MYC y/o BCL2.
MX2020008447A 2018-02-13 2019-02-12 Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b. MX2020008447A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18156576 2018-02-13
PCT/EP2019/053407 WO2019158517A1 (en) 2018-02-13 2019-02-12 Use of 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-n-{4-[(s-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine for treating diffuse large b-cell lymphoma

Publications (1)

Publication Number Publication Date
MX2020008447A true MX2020008447A (es) 2020-09-28

Family

ID=61223765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008447A MX2020008447A (es) 2018-02-13 2019-02-12 Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b.

Country Status (16)

Country Link
US (1) US11701347B2 (es)
EP (1) EP3752487A1 (es)
JP (1) JP7280286B2 (es)
KR (1) KR20200119800A (es)
CN (1) CN111727183B (es)
AU (1) AU2019221019B2 (es)
BR (1) BR112020016389A2 (es)
CA (1) CA3090843A1 (es)
CL (1) CL2020002087A1 (es)
EA (1) EA202091894A1 (es)
IL (1) IL276437B2 (es)
JO (1) JOP20200196A1 (es)
MA (1) MA51820A (es)
MX (1) MX2020008447A (es)
SG (1) SG11202006470RA (es)
WO (1) WO2019158517A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3047491A1 (en) 2016-12-21 2018-06-28 Bayer Aktiengesellschaft Prodrugs of cytotoxic active agents having enzymatically cleavable groups
MX2020008447A (es) 2018-02-13 2020-09-28 Bayer Ag Uso de 5-fluoro-4-(4-fluoro-2-metoxifenil)-n-{4-[(s-metilsulfonimi doil)metil]piridin-2-il}piridin-2-amina para el tratamiento del linfoma difuso de celulas grandes b.

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Also Published As

Publication number Publication date
AU2019221019B2 (en) 2024-05-02
JP2021514386A (ja) 2021-06-10
EP3752487A1 (en) 2020-12-23
MA51820A (fr) 2021-05-19
KR20200119800A (ko) 2020-10-20
CN111727183A (zh) 2020-09-29
US20210015806A1 (en) 2021-01-21
BR112020016389A2 (pt) 2020-12-15
JP7280286B2 (ja) 2023-05-23
CN111727183B (zh) 2023-12-29
IL276437B2 (en) 2024-03-01
IL276437B1 (en) 2023-11-01
CA3090843A1 (en) 2019-08-22
EA202091894A1 (ru) 2020-12-28
SG11202006470RA (en) 2020-08-28
AU2019221019A1 (en) 2020-07-23
CL2020002087A1 (es) 2020-12-11
US11701347B2 (en) 2023-07-18
JOP20200196A1 (ar) 2020-08-13
WO2019158517A1 (en) 2019-08-22
IL276437A (en) 2020-09-30

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