JP2010540509A5 - - Google Patents
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- Publication number
- JP2010540509A5 JP2010540509A5 JP2010526364A JP2010526364A JP2010540509A5 JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5 JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- compound according
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719038.2 | 2007-09-28 | ||
| GB0719038A GB0719038D0 (en) | 2007-09-28 | 2007-09-28 | Compound |
| GB0806844A GB0806844D0 (en) | 2008-04-15 | 2008-04-15 | Compound |
| GB0806844.7 | 2008-04-15 | ||
| PCT/GB2008/003305 WO2009040556A1 (en) | 2007-09-28 | 2008-09-29 | Pyrimidine derivatives as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Division JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540509A JP2010540509A (ja) | 2010-12-24 |
| JP2010540509A5 true JP2010540509A5 (enExample) | 2011-10-06 |
| JP5410432B2 JP5410432B2 (ja) | 2014-02-05 |
Family
ID=40199600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526364A Active JP5410432B2 (ja) | 2007-09-28 | 2008-09-29 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8563542B2 (enExample) |
| EP (2) | EP2610256B1 (enExample) |
| JP (2) | JP5410432B2 (enExample) |
| CN (1) | CN101878216B (enExample) |
| CA (1) | CA2700979C (enExample) |
| ES (2) | ES2457394T3 (enExample) |
| PL (2) | PL2205603T3 (enExample) |
| RU (2) | RU2478100C2 (enExample) |
| WO (1) | WO2009040556A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2652648C (en) | 2006-02-14 | 2016-10-25 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| MX2010001677A (es) | 2007-08-15 | 2010-03-11 | Vertex Pharma | Derivados de 4-(9-(3,3-difluorociclopentil)-5,7,7-trimetil-6-oxo-6 ,7,8,9-tetrahidro-5h-pirimido[4,5-b][1,4]diazepin-2-ilamino)-3-me toxibenzamida como inhibidores de las proteinas cinasas humanas plk1 a plk4 para el tratamiento de enfermedades proli |
| US20110201818A1 (en) | 2007-09-25 | 2011-08-18 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| PL2205603T3 (pl) * | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| AU2009271663B2 (en) | 2008-06-23 | 2014-04-17 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors |
| CN102076690A (zh) | 2008-06-23 | 2011-05-25 | 维泰克斯制药公司 | 蛋白激酶抑制剂 |
| TWI483941B (zh) | 2009-06-17 | 2015-05-11 | Vertex Pharma | 流感病毒複製之抑制劑 |
| WO2011038185A2 (en) | 2009-09-25 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| RU2012116525A (ru) | 2009-09-25 | 2013-10-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения перемидиновых производных, пригодных в качестве ингибиторов протеинкиназ |
| AU2011260323A1 (en) | 2010-06-04 | 2012-11-15 | F. Hoffmann-La Roche Ag | Aminopyrimidine derivatives as LRRK2 modulators |
| CA3017869C (en) | 2010-11-10 | 2021-07-27 | Genentech, Inc. | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
| MX2013006836A (es) | 2010-12-16 | 2013-09-26 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| GB201205752D0 (en) * | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
| EP2970317A4 (en) | 2013-03-15 | 2016-11-02 | Dana Farber Cancer Inst Inc | PYRIMIDODIAZEPINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES |
| BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
| MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
| SMT201900450T1 (it) | 2013-11-13 | 2019-09-09 | Vertex Pharma | Inibitori della replicazione di virus dell’influenza |
| JP2017504651A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体の使用 |
| WO2015117053A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| KR101517414B1 (ko) * | 2014-04-24 | 2015-05-04 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| BR112017002369A2 (pt) | 2014-08-08 | 2017-12-05 | Dana Farber Cancer Inst Inc | derivados de diazepana e usos dos mesmos |
| US10011630B2 (en) | 2014-12-16 | 2018-07-03 | Invivogen | Cyclic dinucleotides for cytokine induction |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3307728A4 (en) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS |
| CN108472300A (zh) | 2015-09-11 | 2018-08-31 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |
| AU2016319785C1 (en) | 2015-09-11 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
| US10738016B2 (en) | 2015-10-13 | 2020-08-11 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | BRD4-kinase inhibitors as cancer therapeutics |
| KR20180081809A (ko) | 2015-11-25 | 2018-07-17 | 다나-파버 캔서 인스티튜트 인크. | 2가 브로모도메인 억제제 및 그의 용도 |
| CA3012516A1 (en) * | 2016-03-04 | 2017-09-08 | Anhui New Star Pharmaceutical Development Co., Ltd | Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition therefor, and uses thereof |
| EP3440084B1 (en) * | 2016-04-07 | 2022-12-21 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders |
| MX2020004534A (es) * | 2017-11-02 | 2020-10-19 | Calico Life Sciences Llc | Moduladores de la vía integrada del estrés. |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| DK4013502T3 (da) | 2019-08-16 | 2025-11-10 | Cyclacel Pharmaceuticals Inc | Fremgangsmåde til fremstillingen af et pyrimidino-diazepinderivat |
| EP4574154A3 (en) * | 2019-08-16 | 2025-09-24 | Cyclacel Pharmaceuticals, Inc. | Crystalline forms of pyrimidino diazepine derivative |
| WO2021061894A1 (en) * | 2019-09-27 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | Erk5 degraders as therapeutics in cancer and inflammatory diseases |
| TW202404636A (zh) | 2022-04-08 | 2024-02-01 | 美商英伊布里克斯公司 | Dr5促效劑及plk1抑制劑或cdk抑制劑之組合療法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117635D0 (en) | 1991-08-15 | 1991-10-02 | British Telecomm | Phase shifter |
| GB0302220D0 (en) | 2003-01-30 | 2003-03-05 | Cyclacel Ltd | Use |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| CN101200457A (zh) | 2003-02-26 | 2008-06-18 | 贝林格尔英格海姆法玛两合公司 | 二氢蝶啶酮、其制法及作为药物制剂的用途 |
| US8710009B2 (en) | 2004-05-26 | 2014-04-29 | The Texas A&M University System | HSP20 inhibits amyloidogenesis and neurotoxicity |
| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| CA2612723A1 (en) | 2005-06-24 | 2007-01-04 | Eli Lilly And Company | Tetrahydrocarbazole derivatives useful as androgen receptor modulators |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| CA2652648C (en) * | 2006-02-14 | 2016-10-25 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
| EP2139892B1 (en) * | 2007-03-22 | 2011-09-14 | Takeda Pharmaceutical Company Limited | Substituted pyrimidodiazepines useful as plk1 inhibitors |
| US20110201818A1 (en) * | 2007-09-25 | 2011-08-18 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| PL2205603T3 (pl) | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| US20090291938A1 (en) * | 2007-11-19 | 2009-11-26 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| US8710068B2 (en) | 2009-01-19 | 2014-04-29 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| GB201205752D0 (en) | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
-
2008
- 2008-09-29 PL PL08806455T patent/PL2205603T3/pl unknown
- 2008-09-29 JP JP2010526364A patent/JP5410432B2/ja active Active
- 2008-09-29 ES ES08806455T patent/ES2457394T3/es active Active
- 2008-09-29 CN CN2008801182902A patent/CN101878216B/zh active Active
- 2008-09-29 WO PCT/GB2008/003305 patent/WO2009040556A1/en not_active Ceased
- 2008-09-29 PL PL13156251.4T patent/PL2610256T3/pl unknown
- 2008-09-29 US US12/680,353 patent/US8563542B2/en active Active
- 2008-09-29 EP EP13156251.4A patent/EP2610256B1/en active Active
- 2008-09-29 ES ES13156251.4T patent/ES2585110T3/es active Active
- 2008-09-29 CA CA2700979A patent/CA2700979C/en active Active
- 2008-09-29 EP EP20080806455 patent/EP2205603B1/en active Active
- 2008-09-29 RU RU2010116759/04A patent/RU2478100C2/ru active
-
2013
- 2013-02-26 RU RU2013108456A patent/RU2623221C2/ru active
- 2013-06-05 US US13/910,349 patent/US9133199B2/en active Active
- 2013-11-06 JP JP2013230231A patent/JP5863196B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-07 US US14/820,711 patent/US9493471B2/en not_active Expired - Fee Related
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