JP2013508382A5 - - Google Patents
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- Publication number
- JP2013508382A5 JP2013508382A5 JP2012535319A JP2012535319A JP2013508382A5 JP 2013508382 A5 JP2013508382 A5 JP 2013508382A5 JP 2012535319 A JP2012535319 A JP 2012535319A JP 2012535319 A JP2012535319 A JP 2012535319A JP 2013508382 A5 JP2013508382 A5 JP 2013508382A5
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- methyl
- pharmaceutically acceptable
- dihydropyrido
- tetrahydropyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25430809P | 2009-10-23 | 2009-10-23 | |
| US61/254,308 | 2009-10-23 | ||
| PCT/US2010/053295 WO2011050016A1 (en) | 2009-10-23 | 2010-10-20 | Akt inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013508382A JP2013508382A (ja) | 2013-03-07 |
| JP2013508382A5 true JP2013508382A5 (enExample) | 2013-06-06 |
| JP5581390B2 JP5581390B2 (ja) | 2014-08-27 |
Family
ID=43467018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012535319A Expired - Fee Related JP5581390B2 (ja) | 2009-10-23 | 2010-10-20 | Ａｋｔ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8436002B2 (enExample) |
| EP (1) | EP2491032B1 (enExample) |
| JP (1) | JP5581390B2 (enExample) |
| KR (1) | KR101398268B1 (enExample) |
| CN (1) | CN102574852B (enExample) |
| AU (1) | AU2010310786B2 (enExample) |
| BR (1) | BR112012011328A2 (enExample) |
| CA (1) | CA2778291C (enExample) |
| EA (1) | EA020151B1 (enExample) |
| ES (1) | ES2465094T3 (enExample) |
| MX (1) | MX2012004780A (enExample) |
| WO (1) | WO2011050016A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6284928B2 (ja) | 2012-05-17 | 2018-02-28 | アレイ バイオファーマ、インコーポレイテッド | ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス |
| DK2861583T3 (en) | 2012-05-17 | 2016-10-03 | Array Biopharma Inc | METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER |
| NZ702939A (en) | 2012-05-17 | 2016-08-26 | Genentech Inc | Process for making amino acid compounds |
| RS60417B9 (sr) | 2012-05-17 | 2021-07-30 | Genentech Inc | Amorfni oblik aktivnog jedinjenja koje inhibira pirimidinil-ciklopentansko jedinjenje, smeše i njegove metode |
| MX354373B (es) | 2012-05-17 | 2018-02-28 | Genentech Inc | Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. |
| EP2920154B1 (en) * | 2012-11-16 | 2017-10-11 | Merck Patent GmbH | Novel imidazol-piperidinyl derivatives as modulators of kinase activity |
| KR20150124957A (ko) * | 2013-03-11 | 2015-11-06 | 메르크 파텐트 게엠베하 | 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체 |
| CA2938626A1 (en) | 2013-07-26 | 2015-01-29 | John Rothman | Compositions to improve the therapeutic benefit of bisantrene |
| AU2014318614B2 (en) | 2013-09-12 | 2021-01-07 | Dana-Farber Cancer Institute Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
| GB201401198D0 (en) * | 2014-01-24 | 2014-03-12 | Bial Portela & Ca Sa | Process for the syntheis of substituted urea compounds |
| WO2015130585A1 (en) | 2014-02-28 | 2015-09-03 | Merck Sharp & Dohme Corp. | Method for treating cancer |
| PL3459953T3 (pl) * | 2016-05-20 | 2021-11-22 | Taiho Pharmaceutical Co., Ltd. | Nowa pochodna 5h-pirolo[2,3-d]pirymidyn-6(7h)-onu |
| PL3919491T3 (pl) * | 2019-01-29 | 2025-10-20 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | Inhibitor akt |
| CN115485276B (zh) * | 2020-05-15 | 2024-05-31 | 南京正大天晴制药有限公司 | 氘代akt激酶抑制剂 |
| WO2022017449A1 (zh) * | 2020-07-22 | 2022-01-27 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途 |
| US20230271958A1 (en) * | 2020-07-22 | 2023-08-31 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE |
| CA3186565A1 (en) * | 2020-07-22 | 2022-01-27 | Lei Miao | Unit dosage composition of akt inhibitor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
| JP4547911B2 (ja) | 2002-02-01 | 2010-09-22 | アリアド・ファーマシューティカルズ・インコーポレイテッド | リン含有化合物およびその用途 |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| JP5213229B2 (ja) | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| EP1828186A1 (en) * | 2004-12-13 | 2007-09-05 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| JP5274842B2 (ja) * | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| KR101280096B1 (ko) | 2005-06-29 | 2013-06-28 | 컴퓨메딕스 리미티드 | 전도성 브리지를 포함하는 센서 어셈블리 |
| EP2029592A1 (en) * | 2006-04-25 | 2009-03-04 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2007125321A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| AR064416A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| AR074072A1 (es) * | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
-
2010
- 2010-10-20 EA EA201270590A patent/EA020151B1/ru not_active IP Right Cessation
- 2010-10-20 KR KR1020127010282A patent/KR101398268B1/ko not_active Expired - Fee Related
- 2010-10-20 MX MX2012004780A patent/MX2012004780A/es active IP Right Grant
- 2010-10-20 WO PCT/US2010/053295 patent/WO2011050016A1/en not_active Ceased
- 2010-10-20 ES ES10774072.2T patent/ES2465094T3/es active Active
- 2010-10-20 CN CN201080046941.9A patent/CN102574852B/zh not_active Expired - Fee Related
- 2010-10-20 AU AU2010310786A patent/AU2010310786B2/en not_active Ceased
- 2010-10-20 BR BR112012011328A patent/BR112012011328A2/pt not_active IP Right Cessation
- 2010-10-20 JP JP2012535319A patent/JP5581390B2/ja not_active Expired - Fee Related
- 2010-10-20 US US13/391,895 patent/US8436002B2/en not_active Expired - Fee Related
- 2010-10-20 CA CA2778291A patent/CA2778291C/en not_active Expired - Fee Related
- 2010-10-20 EP EP10774072.2A patent/EP2491032B1/en not_active Not-in-force
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