MX2012004780A - Inhibidores de akt. - Google Patents

Inhibidores de akt.

Info

Publication number
MX2012004780A
MX2012004780A MX2012004780A MX2012004780A MX2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A
Authority
MX
Mexico
Prior art keywords
formula
akt inhibitors
compounds
present
provides
Prior art date
Application number
MX2012004780A
Other languages
English (en)
Spanish (es)
Inventor
Douglas Wade Beight
Jason Scott Sawyer
Saravanan Parthasarathy
Timothy Paul Burkholder
Mark Edward Rempala
Joshua Ryan Clayton
Marijean Eggen
Deidre Michelle Johns
Huaxing Pei
Kenneth James Junior Henry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2012004780A publication Critical patent/MX2012004780A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX2012004780A 2009-10-23 2010-10-20 Inhibidores de akt. MX2012004780A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25430809P 2009-10-23 2009-10-23
PCT/US2010/053295 WO2011050016A1 (en) 2009-10-23 2010-10-20 Akt inhibitors

Publications (1)

Publication Number Publication Date
MX2012004780A true MX2012004780A (es) 2012-08-23

Family

ID=43467018

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004780A MX2012004780A (es) 2009-10-23 2010-10-20 Inhibidores de akt.

Country Status (12)

Country Link
US (1) US8436002B2 (enExample)
EP (1) EP2491032B1 (enExample)
JP (1) JP5581390B2 (enExample)
KR (1) KR101398268B1 (enExample)
CN (1) CN102574852B (enExample)
AU (1) AU2010310786B2 (enExample)
BR (1) BR112012011328A2 (enExample)
CA (1) CA2778291C (enExample)
EA (1) EA020151B1 (enExample)
ES (1) ES2465094T3 (enExample)
MX (1) MX2012004780A (enExample)
WO (1) WO2011050016A1 (enExample)

Families Citing this family (17)

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CA2873654C (en) * 2012-05-17 2021-06-22 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
WO2013173736A1 (en) 2012-05-17 2013-11-21 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
CA2873658C (en) 2012-05-17 2021-01-26 Genentech, Inc. Process for making amino acid compounds
PE20150725A1 (es) 2012-05-17 2015-05-17 Genentech Inc Formas y formulaciones de un compuesto de pirimidinilciclopentano, composiciones y metodos de este
NZ702950A (en) 2012-05-17 2016-09-30 Genentech Inc Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
US9315517B2 (en) * 2012-11-16 2016-04-19 Merck Patent Gmbh Imidazol-piperidinyl derivatives as modulators of kinase activity
SG10201900954SA (en) 2013-03-11 2019-02-27 Merck Patent Gmbh Heterocycles as Modulators of Kinase Activity
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
US10526660B2 (en) 2013-09-12 2020-01-07 Dana-Farber Cancer Institute, Inc. Methods for evaluating and treating Waldenstrom's macroglobulinemia
GB201401198D0 (en) * 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds
WO2015130585A1 (en) 2014-02-28 2015-09-03 Merck Sharp & Dohme Corp. Method for treating cancer
MA45048A (fr) * 2016-05-20 2019-03-27 Taiho Pharmaceutical Co Ltd Nouveau dérivé de 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one
CA3127884A1 (en) * 2019-01-29 2020-08-06 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Akt inhibitor
CN115485276B (zh) * 2020-05-15 2024-05-31 南京正大天晴制药有限公司 氘代akt激酶抑制剂
JP7472391B2 (ja) * 2020-07-22 2024-04-22 南京正大天晴制薬有限公司 ジヒドロピリド［２，３－ｄ］ピリミジノン誘導体の塩及び結晶形
CN115916350B (zh) * 2020-07-22 2024-11-05 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物
WO2022017449A1 (zh) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
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AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
EP1478648B1 (en) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Phosphorus-containing compounds and uses thereof
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
AU2005249380C1 (en) 2004-04-23 2012-09-20 Exelixis, Inc. Kinase modulators and methods of use
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US7767687B2 (en) * 2004-12-13 2010-08-03 Biogen Idec Ma Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
EP1848719B1 (en) 2004-12-28 2012-02-01 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
MX2007016203A (es) 2005-06-29 2008-03-10 Compumedics Ltd Ensamble de sensor con puente conductivo.
JP2009534456A (ja) * 2006-04-25 2009-09-24 アステックス、セラピューティックス、リミテッド 医薬化合物
EP3719018B1 (en) 2006-04-25 2025-08-27 Astex Therapeutics Ltd Purine and deazapurine derivatives as pharmaceutical compounds
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
AR064416A1 (es) * 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme

Also Published As

Publication number Publication date
WO2011050016A1 (en) 2011-04-28
JP2013508382A (ja) 2013-03-07
CN102574852B (zh) 2014-06-25
KR20120068941A (ko) 2012-06-27
EP2491032A1 (en) 2012-08-29
JP5581390B2 (ja) 2014-08-27
EA020151B1 (ru) 2014-09-30
ES2465094T3 (es) 2014-06-05
AU2010310786A1 (en) 2012-04-19
BR112012011328A2 (pt) 2016-11-22
US8436002B2 (en) 2013-05-07
EA201270590A1 (ru) 2012-09-28
CN102574852A (zh) 2012-07-11
EP2491032B1 (en) 2014-04-16
AU2010310786B2 (en) 2014-03-27
CA2778291A1 (en) 2011-04-28
CA2778291C (en) 2014-02-11
US20120149684A1 (en) 2012-06-14
KR101398268B1 (ko) 2014-05-23

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