BR112012006652A2 - métodos para preparar os derivados de pirimidina úteis como inibidores de proteína cinase - Google Patents

métodos para preparar os derivados de pirimidina úteis como inibidores de proteína cinase

Info

Publication number
BR112012006652A2
BR112012006652A2 BR112012006652A BR112012006652A BR112012006652A2 BR 112012006652 A2 BR112012006652 A2 BR 112012006652A2 BR 112012006652 A BR112012006652 A BR 112012006652A BR 112012006652 A BR112012006652 A BR 112012006652A BR 112012006652 A2 BR112012006652 A2 BR 112012006652A2
Authority
BR
Brazil
Prior art keywords
methods
protein kinase
kinase inhibitors
pyrimidine derivatives
derivatives useful
Prior art date
Application number
BR112012006652A
Other languages
English (en)
Inventor
Jean-Damien Charrier
Michael O'donnell
Steven Durrant
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR112012006652A2 publication Critical patent/BR112012006652A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/10—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with an aromatic or hetero-aromatic ring directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112012006652A 2009-09-25 2010-09-24 métodos para preparar os derivados de pirimidina úteis como inibidores de proteína cinase BR112012006652A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24577309P 2009-09-25 2009-09-25
PCT/IB2010/002655 WO2011036566A1 (en) 2009-09-25 2010-09-24 Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BR112012006652A2 true BR112012006652A2 (pt) 2015-09-08

Family

ID=43370578

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012006652A BR112012006652A2 (pt) 2009-09-25 2010-09-24 métodos para preparar os derivados de pirimidina úteis como inibidores de proteína cinase

Country Status (16)

Country Link
US (1) US8592577B2 (pt)
EP (1) EP2480550B1 (pt)
JP (3) JP2013505927A (pt)
KR (1) KR20120094920A (pt)
CN (1) CN102548994A (pt)
AU (1) AU2010299579A1 (pt)
BR (1) BR112012006652A2 (pt)
CA (1) CA2773742C (pt)
ES (1) ES2567280T3 (pt)
IL (1) IL218790A0 (pt)
MX (1) MX2012003484A (pt)
NZ (1) NZ599356A (pt)
RU (1) RU2012116525A (pt)
SG (1) SG179206A1 (pt)
WO (1) WO2011036566A1 (pt)
ZA (1) ZA201201977B (pt)

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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
JP5999177B2 (ja) 2011-05-04 2016-09-28 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
US9351974B2 (en) 2011-11-10 2016-05-31 OSI Pharmaceuticals, LLC Substituted pteridinones for the treatment of cancer
US20150166591A1 (en) 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
RU2016105108A (ru) 2013-07-25 2017-08-30 Дана-Фарбер Кэнсер Инститьют, Инк. Ингибиторы факторов транскрипции и их применение
KR20160115953A (ko) 2014-01-31 2016-10-06 다나-파버 캔서 인스티튜트 인크. 디아미노피리미딘 벤젠술폰 유도체 및 그의 용도
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
CA2955074A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
CA2996974A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
PE20181086A1 (es) 2015-09-11 2018-07-05 Dana Farber Cancer Inst Inc Acetamida tienotrizolodiazepinas y usos de las mismas
EP3380100A4 (en) 2015-11-25 2019-10-02 Dana-Farber Cancer Institute, Inc. BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF

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JPS51110202A (en) 1975-03-24 1976-09-29 Susumu Nojima Denwakyono hyojisochi
GB8927872D0 (en) 1989-12-08 1990-02-14 Beecham Group Plc Pharmaceuticals
ZA973884B (en) 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
BR0013952A (pt) 1999-09-15 2002-05-14 Warner Lambert Co Pteridinonas como inibidores de cinase
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JP3876254B2 (ja) * 2001-09-04 2007-01-31 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規なジヒドロプテリジノン、その製造方法及びその医薬組成物としての使用
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Also Published As

Publication number Publication date
MX2012003484A (es) 2012-04-20
CA2773742A1 (en) 2011-03-31
JP2013505927A (ja) 2013-02-21
ES2567280T3 (es) 2016-04-21
JP2015129176A (ja) 2015-07-16
ZA201201977B (en) 2013-05-29
CA2773742C (en) 2017-12-05
WO2011036566A1 (en) 2011-03-31
US8592577B2 (en) 2013-11-26
NZ599356A (en) 2013-08-30
EP2480550A1 (en) 2012-08-01
CN102548994A (zh) 2012-07-04
JP2016190858A (ja) 2016-11-10
KR20120094920A (ko) 2012-08-27
RU2012116525A (ru) 2013-10-27
US20120271045A1 (en) 2012-10-25
EP2480550B1 (en) 2016-02-10
SG179206A1 (en) 2012-04-27
IL218790A0 (en) 2012-06-28
AU2010299579A1 (en) 2012-05-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2334 DE 29/09/2015.