JP2012532901A5 - - Google Patents
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- Publication number
- JP2012532901A5 JP2012532901A5 JP2012519902A JP2012519902A JP2012532901A5 JP 2012532901 A5 JP2012532901 A5 JP 2012532901A5 JP 2012519902 A JP2012519902 A JP 2012519902A JP 2012519902 A JP2012519902 A JP 2012519902A JP 2012532901 A5 JP2012532901 A5 JP 2012532901A5
- Authority
- JP
- Japan
- Prior art keywords
- het
- atoms
- nha
- proportions
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033392.4 | 2009-07-16 | ||
| DE102009033392A DE102009033392A1 (de) | 2009-07-16 | 2009-07-16 | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| PCT/EP2010/003661 WO2011006569A1 (de) | 2009-07-16 | 2010-06-17 | Heterocyclische verbindungen als autotaxin-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532901A JP2012532901A (ja) | 2012-12-20 |
| JP2012532901A5 true JP2012532901A5 (enExample) | 2013-08-08 |
Family
ID=42646326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519902A Pending JP2012532901A (ja) | 2009-07-16 | 2010-06-17 | オートタキシン阻害剤としての複素環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120115852A1 (enExample) |
| EP (1) | EP2454258A1 (enExample) |
| JP (1) | JP2012532901A (enExample) |
| KR (1) | KR20120090031A (enExample) |
| CN (1) | CN102471343A (enExample) |
| AR (1) | AR077488A1 (enExample) |
| AU (1) | AU2010272922A1 (enExample) |
| BR (1) | BR112012000792A2 (enExample) |
| CA (1) | CA2768095A1 (enExample) |
| DE (1) | DE102009033392A1 (enExample) |
| EA (1) | EA201200119A1 (enExample) |
| IL (1) | IL217466A0 (enExample) |
| MX (1) | MX2012000609A (enExample) |
| SG (1) | SG177522A1 (enExample) |
| WO (1) | WO2011006569A1 (enExample) |
| ZA (1) | ZA201201124B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6258928B2 (ja) | 2012-06-13 | 2018-01-10 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ジアザスピロシクロアルカンおよびアザスピロシクロアルカン |
| DK2900669T3 (da) * | 2012-09-25 | 2019-11-04 | Hoffmann La Roche | Hexahydropyrrolo[3,4-C]pyrrolderivater og relaterede forbindelser som autotaxin (ATX)-inhibitorer og som inhibitorer af lysophosphatidsyre (LPA)-produktion til behandling af f.eks. nyresygdomme |
| SG11201504633PA (en) | 2012-12-19 | 2015-07-30 | Novartis Ag | Autotaxin inhibitors |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| TW201446768A (zh) * | 2013-03-15 | 2014-12-16 | Biogen Idec Inc | S1p及/或atx調節劑 |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| WO2015048301A1 (en) | 2013-09-26 | 2015-04-02 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| EA030068B1 (ru) | 2013-11-22 | 2018-06-29 | Фармакеа, Инк. | Соединения-ингибиторы аутотаксина |
| JP2016537388A (ja) | 2013-11-22 | 2016-12-01 | ファーマケア，インク． | 四環系のオートタキシン阻害剤 |
| CA2923523A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
| UA118582C2 (uk) | 2014-03-26 | 2019-02-11 | Ф. Хоффманн-Ля Рош Аг | Біциклічні сполуки як інгібітори продукції аутотаксину (atx) і лізофосфатидилової кислоти (lpa) |
| AU2015238541B2 (en) * | 2014-03-26 | 2019-09-19 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| AP2016009496A0 (en) | 2014-04-04 | 2016-10-31 | X-Rx Inc | Substituted spirocydic inhibitors of autotaxin |
| EP3134079A4 (en) * | 2014-04-23 | 2017-12-20 | X-RX Discovery, Inc. | Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| ES2915267T3 (es) | 2015-05-27 | 2022-06-21 | Sabre Therapeutics Llc | Inhibidores de autotaxina y usos de los mismos |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| MX2018001890A (es) | 2015-09-24 | 2018-06-20 | Hoffmann La Roche | Compuestos biciclicos como inhibidores de autotaxina (atx). |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| SG11201908560SA (en) | 2017-03-16 | 2019-10-30 | Hoffmann La Roche | Heterocyclic compounds useful as dual atx/ca inhibitors |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| WO2019224885A1 (ja) * | 2018-05-21 | 2019-11-28 | 株式会社アシックス | ブラジャー |
| KR102623218B1 (ko) * | 2018-08-23 | 2024-01-11 | 가천대학교 산학협력단 | 페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
| WO2020072456A1 (en) * | 2018-10-02 | 2020-04-09 | Case Western Reserve University | Compounds for treating myelin related disorders |
| EP4476222A1 (en) * | 2022-02-10 | 2024-12-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| DE69911259T4 (de) * | 1999-01-19 | 2009-07-09 | Ortho-Mcneil Pharmaceutical, Inc. | Tricyclische benzodiazepine als vasopressin antagonisten |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| DK1233787T3 (da) * | 1999-11-09 | 2005-08-15 | Sod Conseils Rech Applic | Produkt, der inhiberer signaltransduktion fra heterotrimere G-proteiner, kombineret med et andet cancerbekæmpende middel til terapeutisk anvendelse i cancerbehandlingen |
-
2009
- 2009-07-16 DE DE102009033392A patent/DE102009033392A1/de not_active Withdrawn
-
2010
- 2010-06-17 MX MX2012000609A patent/MX2012000609A/es not_active Application Discontinuation
- 2010-06-17 CN CN2010800318870A patent/CN102471343A/zh active Pending
- 2010-06-17 KR KR1020127004105A patent/KR20120090031A/ko not_active Withdrawn
- 2010-06-17 EP EP10725398A patent/EP2454258A1/de not_active Withdrawn
- 2010-06-17 CA CA2768095A patent/CA2768095A1/en not_active Abandoned
- 2010-06-17 SG SG2012000774A patent/SG177522A1/en unknown
- 2010-06-17 WO PCT/EP2010/003661 patent/WO2011006569A1/de not_active Ceased
- 2010-06-17 AU AU2010272922A patent/AU2010272922A1/en not_active Abandoned
- 2010-06-17 US US13/383,908 patent/US20120115852A1/en not_active Abandoned
- 2010-06-17 EA EA201200119A patent/EA201200119A1/ru unknown
- 2010-06-17 JP JP2012519902A patent/JP2012532901A/ja active Pending
- 2010-06-17 BR BR112012000792A patent/BR112012000792A2/pt not_active Application Discontinuation
- 2010-07-16 AR ARP100102610A patent/AR077488A1/es unknown
-
2012
- 2012-01-10 IL IL217466A patent/IL217466A0/en unknown
- 2012-02-15 ZA ZA2012/01124A patent/ZA201201124B/en unknown
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