EA032971B1 - Соль берберина и урсодезоксихолевой кислоты и ее применение - Google Patents

Соль берберина и урсодезоксихолевой кислоты и ее применение

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Publication number
EA032971B1
EA032971B1 EA201790124A EA201790124A EA032971B1 EA 032971 B1 EA032971 B1 EA 032971B1 EA 201790124 A EA201790124 A EA 201790124A EA 201790124 A EA201790124 A EA 201790124A EA 032971 B1 EA032971 B1 EA 032971B1
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EA
Eurasian Patent Office
Prior art keywords
liver
diseases
berberine
salt
application
Prior art date
Application number
EA201790124A
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English (en)
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EA201790124A1 (ru
Inventor
Липин Лю
Original Assignee
Шэньчжэнь Хайтайд Биофармасьютикал, Лтд.
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Application filed by Шэньчжэнь Хайтайд Биофармасьютикал, Лтд. filed Critical Шэньчжэнь Хайтайд Биофармасьютикал, Лтд.
Publication of EA201790124A1 publication Critical patent/EA201790124A1/ru
Publication of EA032971B1 publication Critical patent/EA032971B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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  • Health & Medical Sciences (AREA)
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Abstract

Предложена соль следующей формулы:а также фармацевтические композиции, содержащие указанную соль, и их применение для лечения различных заболеваний или расстройств. Соли и фармацевтические композиции согласно настоящему изобретению можно применять для лечения различных заболеваний или расстройств, таких как диабет, осложнения диабета, дислипидемия, гиперлипидемия, ожирение, метаболические синдромы, нарушения метаболизма, предшествующие диабету заболевания и состояния печени, такие как жировой гепатоз, неалкогольная жировая болезнь печени, неалкогольный стеатогепатит, холестатические заболевания печени или заболевание печени "трансплантат против хозяина". Предложенные соли также можно применять для улучшения функций печени при хронических вирусных заболеваниях печени и алкогольных заболеваниях печени.
EA201790124A 2014-07-29 2015-07-28 Соль берберина и урсодезоксихолевой кислоты и ее применение EA032971B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462030147P 2014-07-29 2014-07-29
US201462030140P 2014-07-29 2014-07-29
US201562128077P 2015-03-04 2015-03-04
PCT/CN2015/085350 WO2016015634A1 (en) 2014-07-29 2015-07-28 Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof

Publications (2)

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EA201790124A1 EA201790124A1 (ru) 2017-07-31
EA032971B1 true EA032971B1 (ru) 2019-08-30

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US (4) US10301303B2 (ru)
EP (1) EP3174874B1 (ru)
JP (4) JP6917144B2 (ru)
KR (2) KR102573865B1 (ru)
CN (2) CN106687460B (ru)
AU (2) AU2015296098B2 (ru)
BR (1) BR112017001623B1 (ru)
CA (2) CA2945609C (ru)
DK (1) DK3174874T3 (ru)
EA (1) EA032971B1 (ru)
ES (1) ES2835874T3 (ru)
IL (3) IL294063A (ru)
MX (3) MX2017001372A (ru)
NZ (1) NZ728488A (ru)
SG (1) SG11201700481YA (ru)
WO (1) WO2016015634A1 (ru)

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