EA032971B1 - Соль берберина и урсодезоксихолевой кислоты и ее применение - Google Patents

Соль берберина и урсодезоксихолевой кислоты и ее применение

Info

Publication number
EA032971B1
EA032971B1 EA201790124A EA201790124A EA032971B1 EA 032971 B1 EA032971 B1 EA 032971B1 EA 201790124 A EA201790124 A EA 201790124A EA 201790124 A EA201790124 A EA 201790124A EA 032971 B1 EA032971 B1 EA 032971B1
Authority
EA
Eurasian Patent Office
Prior art keywords
liver
diseases
berberine
salt
application
Prior art date
Application number
EA201790124A
Other languages
English (en)
Other versions
EA201790124A1 (ru
Inventor
Липин Лю
Original Assignee
Шэньчжэнь Хайтайд Биофармасьютикал, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шэньчжэнь Хайтайд Биофармасьютикал, Лтд. filed Critical Шэньчжэнь Хайтайд Биофармасьютикал, Лтд.
Publication of EA201790124A1 publication Critical patent/EA201790124A1/ru
Publication of EA032971B1 publication Critical patent/EA032971B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Предложена соль следующей формулы:а также фармацевтические композиции, содержащие указанную соль, и их применение для лечения различных заболеваний или расстройств. Соли и фармацевтические композиции согласно настоящему изобретению можно применять для лечения различных заболеваний или расстройств, таких как диабет, осложнения диабета, дислипидемия, гиперлипидемия, ожирение, метаболические синдромы, нарушения метаболизма, предшествующие диабету заболевания и состояния печени, такие как жировой гепатоз, неалкогольная жировая болезнь печени, неалкогольный стеатогепатит, холестатические заболевания печени или заболевание печени "трансплантат против хозяина". Предложенные соли также можно применять для улучшения функций печени при хронических вирусных заболеваниях печени и алкогольных заболеваниях печени.
EA201790124A 2014-07-29 2015-07-28 Соль берберина и урсодезоксихолевой кислоты и ее применение EA032971B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462030147P 2014-07-29 2014-07-29
US201462030140P 2014-07-29 2014-07-29
US201562128077P 2015-03-04 2015-03-04
PCT/CN2015/085350 WO2016015634A1 (en) 2014-07-29 2015-07-28 Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof

Publications (2)

Publication Number Publication Date
EA201790124A1 EA201790124A1 (ru) 2017-07-31
EA032971B1 true EA032971B1 (ru) 2019-08-30

Family

ID=55216773

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790124A EA032971B1 (ru) 2014-07-29 2015-07-28 Соль берберина и урсодезоксихолевой кислоты и ее применение

Country Status (16)

Country Link
US (4) US10301303B2 (ru)
EP (1) EP3174874B1 (ru)
JP (4) JP6917144B2 (ru)
KR (2) KR20230134598A (ru)
CN (2) CN110179792A (ru)
AU (2) AU2015296098B2 (ru)
BR (1) BR112017001623B1 (ru)
CA (2) CA3194562A1 (ru)
DK (1) DK3174874T3 (ru)
EA (1) EA032971B1 (ru)
ES (1) ES2835874T3 (ru)
IL (3) IL282156B (ru)
MX (3) MX2017001372A (ru)
NZ (1) NZ728488A (ru)
SG (1) SG11201700481YA (ru)
WO (1) WO2016015634A1 (ru)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US10155003B2 (en) * 2014-05-05 2018-12-18 The Board Of Regents Of The University Of Texas System Methods and compositions comprising ursolic acid and/or resveratrol for treating diabetes, or cancer
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
US10174289B2 (en) 2014-05-28 2019-01-08 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
BR112017001623B1 (pt) * 2014-07-29 2022-11-29 Shenzhen Hightide Biopharmaceutical, Ltd Sal de adição ácido-base em uma forma substancialmente pura, composição farmacêutica compreendendo uma quantidade do referido sal e seus usos
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
JP2018517666A (ja) * 2015-04-06 2018-07-05 シンセン ハイタイド バイオファーマシューティカル リミテッド ウルソデオキシコール酸、ベルベリンまたはl−カルニチンのコンジュゲート化合物、ならびにその組成物および方法
CN105168228B (zh) * 2015-11-04 2016-06-22 北京凯因科技股份有限公司 奥贝胆酸和小檗碱的复方组合物及其应用
WO2017193563A1 (zh) * 2015-11-13 2017-11-16 深圳君圣泰生物技术有限公司 一种组合物及其用途、药物制剂
CN106692973A (zh) * 2015-11-13 2017-05-24 深圳君圣泰生物技术有限公司 一种组合物及其用途、药物制剂
CN105693805A (zh) * 2016-03-15 2016-06-22 合肥华方医药科技有限公司 一种胆酸类小檗碱偶合物的制备及医药用途
CN105801663A (zh) * 2016-03-15 2016-07-27 合肥华方医药科技有限公司 一种熊果酸小檗碱偶合物的制备方法及医药用途
GB201605013D0 (en) * 2016-03-24 2016-05-11 Inst Of Food Res S-methylcysteine sulfoxide for prostate cancer treatment
ITUA20163025A1 (it) 2016-04-29 2017-10-29 Sochim Int S P A Composizione per il trattamento della sindrome dell’ovaio policistico
US11066650B2 (en) 2016-05-05 2021-07-20 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
WO2017218004A1 (en) * 2016-06-17 2017-12-21 Michael Hudnall Medical food for patients with chronic liver disease
CN105963306B (zh) * 2016-07-05 2018-08-17 福州大学 一种具有协同抗肿瘤转移活性的药物组合物
US10702567B2 (en) 2016-09-14 2020-07-07 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
WO2018053123A1 (en) * 2016-09-14 2018-03-22 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
US10596186B2 (en) 2016-09-14 2020-03-24 Phoenix Biotechnology, Inc. Method and compositions for treating viral infections
US10729735B1 (en) 2016-09-14 2020-08-04 Phoenix Biotechnology, Inc. Method and compostitions for treating coronavirus infection
US10703761B2 (en) * 2016-10-18 2020-07-07 City Of Hope Bile acid receptor modulators and methods of use thereof
KR102546194B1 (ko) 2016-11-04 2023-06-21 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
AU2017373767B2 (en) 2016-12-05 2021-09-16 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US10471007B2 (en) * 2016-12-16 2019-11-12 Jeffrey R Olynyk Sublingual therapeutic solutions and methods
IT201700032960A1 (it) * 2017-03-24 2018-09-24 Akademy Pharma S R L Composto nutraceutico per il trattamento dell’eccesso di peso e della moderata ipercolesterolemia e disglicemia
US20200188327A1 (en) * 2017-04-25 2020-06-18 Buck Institute For Research On Aging Formulations for extending lifespan and healthspan
CN108864077B (zh) * 2017-05-12 2020-05-22 深圳君圣泰生物技术有限公司 小檗碱有机酸盐的固体形式及其制备方法
WO2019023245A1 (en) * 2017-07-25 2019-01-31 Cedars-Sinai Medical Center METHODS OF TREATING HEPATIC DISEASES
AU2018315094B2 (en) * 2017-08-11 2024-05-16 Shenzhen Hightide Biopharmaceutical Ltd. Methods and compositions for treatment of inflammatory bowel disease
KR20200088433A (ko) * 2017-11-29 2020-07-22 바스프 에스이 보관 안정한 효소 제제, 이것의 제조 및 용도
AU2019350699B2 (en) 2018-09-25 2024-05-23 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
CN109303921B (zh) * 2018-10-30 2021-02-09 中国药科大学 Fxr激动剂与sirt1激动剂联用在制备抗肝纤维化药物中的应用
IT201800011155A1 (it) * 2018-12-17 2020-06-17 S&R Farm S P A uso di una miscela di berberina e resveratrolo per il controllo delle dislipidemie
CN111499626A (zh) * 2019-01-31 2020-08-07 西南大学 一种表小檗碱的合成方法及应用
CN109999034A (zh) * 2019-02-11 2019-07-12 浙江理工大学 肿瘤蛋白tnik激酶靶向天然小分子抑制剂及其应用
JPWO2020179747A1 (ru) * 2019-03-01 2020-09-10
CN109806264B (zh) * 2019-04-10 2021-04-02 江苏海钥医药科技有限公司 药物组合物及其应用
CN112076199A (zh) * 2019-06-13 2020-12-15 谢亚坚 一种降血糖降血脂和降血胆固醇方剂
CN110368392A (zh) * 2019-08-20 2019-10-25 延边大学 科罗索酸在制备抗肝损伤药物或抗肝损伤保健品中的应用
CN112851660B (zh) * 2019-11-12 2022-03-18 广东药科大学 含有小檗碱的酸-碱加成盐、其制备方法及其作为药物的用途
CN111116578B (zh) * 2019-12-26 2021-06-04 深圳市老年医学研究所 去亚甲基小檗碱的制备方法及其应用
KR102150821B1 (ko) * 2020-01-22 2020-09-03 주식회사 에이스바이오메드 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친 복합제제
US11806359B2 (en) 2020-03-31 2023-11-07 Phoenix Biotechnology, Inc. Method and compositions for treating Coronavirus infection
US20230181547A1 (en) * 2020-05-15 2023-06-15 Nguyen Anh VAN Solid lipid nano-composition containing berberine and cinnamonaldehyde effective in treating diabetes, dyslipidemia, and method of preparing the same
EP4157254A1 (en) * 2020-06-02 2023-04-05 Glykon Technologies Group, LLC. Methods and pharmaceutical preparations for elevating ketone utilization
KR102636847B1 (ko) * 2020-09-18 2024-02-19 경북대학교 산학협력단 티아민 유도체를 포함하는 이식편대숙주질환 예방 또는 치료용 약학적 조성물
CN114195850A (zh) * 2020-09-18 2022-03-18 成都贝诺科成生物科技有限公司 一种用于防治肝病的化合物及其制药用途
WO2022161468A1 (en) * 2021-01-28 2022-08-04 Shenzhen Hightide Biopharmaceutical Ltd. Compositions of berberine ursodeoxycholate and methods thereof for treating primary sclerosing cholangitis
CN113143962B (zh) * 2021-05-11 2022-08-05 四川九章生物科技有限公司 一种治疗高脂血症的药物组合物及其制备方法
AU2022332894A1 (en) * 2021-08-23 2024-02-29 Paxmedica, Inc. Methods for treating nervous system disorders with antipurinergic agents
CN113577064B (zh) * 2021-09-09 2023-07-04 浙江中医药大学 一种增强肿瘤免疫的联合用药物组合物及其应用
TW202333660A (zh) * 2021-11-01 2023-09-01 日商小林製藥股份有限公司 軟骨再生促進劑
WO2023091173A1 (en) * 2021-11-16 2023-05-25 Michael Hudnall Methods of liver disease treatment
WO2023088463A1 (en) * 2021-11-22 2023-05-25 Shenzhen Hightide Biopharmaceutical Ltd. Compositions and methods of berberine ursodeoxycholate for modulating gut microbiome compositions
CN116178384A (zh) * 2021-11-29 2023-05-30 湖南师范大学 四种小檗碱中短链脂肪酸盐的制备
CN114716498B (zh) * 2022-01-20 2024-01-23 成都贝诺科成生物科技有限公司 一种高稳定性的失碳熊去氧胆酸小檗碱盐晶型及其制备方法
WO2024006537A1 (en) * 2022-07-01 2024-01-04 Intercept Pharmaceuticals, Inc. Methods for ameliorating cognitive impairment using bile acid derivatives
CN115011661A (zh) * 2022-07-22 2022-09-06 湖南科瑞生物制药股份有限公司 一种3β-熊去氧胆酸的合成方法
KR20240050140A (ko) * 2022-10-11 2024-04-18 주식회사 알트메디칼 이소퀴놀린 유도체를 유효성분으로 포함하는 파킨슨병의 예방 또는 치료용 조성물
KR20240052403A (ko) * 2022-10-14 2024-04-23 주식회사 알트메디칼 이소퀴놀린 유도체를 유효성분으로 포함하는 말초신경병증의 예방 또는 치료용 조성물
KR20240054685A (ko) * 2022-10-19 2024-04-26 주식회사 알트메디칼 이소퀴놀린 유도체를 유효성분으로 포함하는 멜라스증후군의 예방 또는 치료용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101113149A (zh) * 2006-07-25 2008-01-30 复旦大学 小檗碱类生物碱的脂肪族有机酸盐及其制备方法和应用
EP2221313A1 (en) * 2009-02-19 2010-08-25 Prodotti Chimici E Alimentari Spa Process for the preparation of ursodeoxycholic acid disodium 3,7-disulfate
CN101935319A (zh) * 2010-09-09 2011-01-05 陕西科技大学 一种黄连素有机酸盐和黄连素有机酸盐包合物及其制备方法
CN103319479A (zh) * 2012-03-20 2013-09-25 王从品 大黄酸小檗碱离子对化合物、制备方法及应用
CN103989677A (zh) * 2013-12-20 2014-08-20 中国药科大学 去亚甲基小檗碱在制备降血糖药物中的应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5529075B2 (ru) * 1971-08-20 1980-07-31
IT1136624B (it) * 1981-05-21 1986-09-03 Erregierre Ind Chim Spa Prodotti di salificazione di acidi colici,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
JPS60163897A (ja) * 1984-02-06 1985-08-26 Tokyo Tanabe Co Ltd ウルソデオキシコ−ル酸メグルミン塩およびその注射剤
JPS6256192A (ja) 1985-09-06 1987-03-11 Hitachi Ltd 感熱転写材
IT1245889B (it) * 1991-04-12 1994-10-25 Alfa Wassermann Spa Formulazioni farmaceutiche per uso orale gastroresistenti contenenti sali di acidi biliari.
JPH06256192A (ja) 1993-03-05 1994-09-13 Nitsusui Seiyaku Kk 液状薬剤の製造法
FR2796551B1 (fr) * 1999-07-23 2003-07-25 Lipha Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant
KR20050081477A (ko) * 2004-02-13 2005-08-19 켐젠주식회사 암로디핀 담즙산염, 그의 제조방법 및 이를 함유하는경구투여용 약학 조성물
CN1759834B (zh) 2004-09-17 2010-06-23 中国医学科学院医药生物技术研究所 黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途
CN1762367A (zh) 2004-10-18 2006-04-26 孙民富 熊去氧胆酸滴丸的处方及其制作方法
WO2007005643A2 (en) 2005-07-01 2007-01-11 Concert Pharmaceuticals Inc. Novel aryloxyphenylpropanamines
WO2007005644A2 (en) 2005-07-01 2007-01-11 Concert Pharmaceuticals Inc. Novel aryloxypropanamines
JP5301991B2 (ja) 2005-07-29 2013-09-25 コンサート ファーマシューティカルズ インコーポレイテッド 新規なベンゾ[d][1,3]−ジオキソール誘導体
EP1909576A4 (en) 2005-07-29 2010-09-01 Concert Pharmaceuticals Inc NEW PHARMACEUTICAL COMPOUNDS
CN100509840C (zh) * 2006-05-10 2009-07-08 华中科技大学 浙贝乙素和胆汁酸的衍生物及药物组合物
JP5325093B2 (ja) * 2007-02-28 2013-10-23 デンカ生研株式会社 小粒子低比重リポ蛋白の定量試薬
CA2698808A1 (en) * 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
EP2300028A4 (en) 2008-05-01 2012-10-17 Afexa Life Sciences Inc PHARMACEUTICAL COMPOSITION COMPRISING EFFICIENT HUANGLIAN (COPTIS SINENSIS) AND KU DING CHA EXTRACTS AS HYPOLIPEMANTS
WO2010106420A1 (en) * 2009-03-17 2010-09-23 Axcan Pharma, Inc. Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid
JP2010246578A (ja) * 2009-04-10 2010-11-04 Utsunomiya Univ 血中コレステロールの検査方法および検査装置
CN101987860B (zh) 2009-08-06 2011-12-14 中山百灵生物技术有限公司 一种熊去氧胆酸的制备方法
CN101879162A (zh) 2010-02-23 2010-11-10 江苏格林生物科技有限公司 一种α-亚麻酸乙酯配伍小檗碱的减肥物
WO2011155705A2 (ko) * 2010-06-10 2011-12-15 (주)애드바이오텍 장 내 콜레스테롤 흡수 억제를 통한 고지혈증 및 비만 억제용 조성물
CN102078418B (zh) * 2011-01-14 2012-04-18 广东药学院 一种防治脂代谢紊乱的复方中药提取物及其制备方法
CN102225961A (zh) * 2011-04-21 2011-10-26 东北林业大学 小檗碱9位偶合胆酸新衍生物及其制备方法
CN102370643A (zh) 2011-07-20 2012-03-14 吉林敖东集团大连药业股份有限公司 盐酸小檗碱药物组合物及其制备方法
EP2766033B1 (en) * 2011-10-14 2019-11-20 Novartis AG Antibodies and methods for wnt pathway-related diseases
CN102580087B (zh) 2012-03-08 2013-08-21 董萍 一种可用于人体局部减肥和美体的原位脂肪细胞系复合抑制剂及其制备方法
US8652518B2 (en) * 2012-04-15 2014-02-18 Jahahreeh Finley Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
CN102702190B (zh) * 2012-07-02 2016-04-27 东北制药集团股份有限公司 一种小檗碱静电复合物及其制备方法
CA2880929A1 (en) * 2012-09-07 2014-03-13 Sanofi Fusion proteins for treating a metabolic syndrome
WO2014183184A1 (en) 2013-05-14 2014-11-20 University Of Prince Edward Island Compositions and methods for treating cardiometabolic diseases and disorders
US20150284406A1 (en) * 2014-04-04 2015-10-08 North American Biomedical Research Center Usa, Inc Berberine-ursodeoxycholic acid conjugate for treating the liver
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
BR112017001623B1 (pt) * 2014-07-29 2022-11-29 Shenzhen Hightide Biopharmaceutical, Ltd Sal de adição ácido-base em uma forma substancialmente pura, composição farmacêutica compreendendo uma quantidade do referido sal e seus usos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101113149A (zh) * 2006-07-25 2008-01-30 复旦大学 小檗碱类生物碱的脂肪族有机酸盐及其制备方法和应用
EP2221313A1 (en) * 2009-02-19 2010-08-25 Prodotti Chimici E Alimentari Spa Process for the preparation of ursodeoxycholic acid disodium 3,7-disulfate
CN101935319A (zh) * 2010-09-09 2011-01-05 陕西科技大学 一种黄连素有机酸盐和黄连素有机酸盐包合物及其制备方法
CN103319479A (zh) * 2012-03-20 2013-09-25 王从品 大黄酸小檗碱离子对化合物、制备方法及应用
CN103989677A (zh) * 2013-12-20 2014-08-20 中国药科大学 去亚甲基小檗碱在制备降血糖药物中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SIQIN GaoWa. et al. "The research progress of pharmacological activity of beberine from coptis", Journal of Medicine & Pharmacy cf Chinese Minorities, No. 1, 31 January 2014 (2014-01-31), pages 49-51 *

Also Published As

Publication number Publication date
IL294063A (en) 2022-08-01
KR102573865B1 (ko) 2023-09-05
US10301303B2 (en) 2019-05-28
US11685735B2 (en) 2023-06-27
MX2022009595A (es) 2022-09-02
SG11201700481YA (en) 2017-02-27
DK3174874T3 (da) 2020-12-07
ES2835874T3 (es) 2021-06-23
CN110179792A (zh) 2019-08-30
EP3174874A1 (en) 2017-06-07
JP7285903B2 (ja) 2023-06-02
CN106687460A (zh) 2017-05-17
JP2023099689A (ja) 2023-07-13
KR20230134598A (ko) 2023-09-21
AU2015296098A1 (en) 2016-11-03
CA2945609C (en) 2023-05-23
JP2017522264A (ja) 2017-08-10
JP6917144B2 (ja) 2021-08-11
MX2019013426A (es) 2020-02-07
US20170037043A1 (en) 2017-02-09
IL250317B (en) 2021-04-29
MX2017001372A (es) 2017-08-21
CA3194562A1 (en) 2016-02-04
EA201790124A1 (ru) 2017-07-31
EP3174874A4 (en) 2019-03-13
EP3174874B1 (en) 2020-09-02
CN106687460B (zh) 2019-05-17
IL282156A (en) 2021-05-31
BR112017001623B1 (pt) 2022-11-29
US20230295151A1 (en) 2023-09-21
US20210300915A1 (en) 2021-09-30
IL282156B (en) 2022-07-01
AU2019222911B2 (en) 2021-05-20
CA2945609A1 (en) 2016-02-04
AU2015296098B2 (en) 2019-06-27
JP2022020854A (ja) 2022-02-01
KR20230019267A (ko) 2023-02-08
US11976063B2 (en) 2024-05-07
US10988471B2 (en) 2021-04-27
JP2020073546A (ja) 2020-05-14
US20190211007A1 (en) 2019-07-11
IL250317A0 (en) 2017-03-30
BR112017001623A2 (pt) 2017-11-21
WO2016015634A1 (en) 2016-02-04
AU2019222911A1 (en) 2019-09-19
NZ728488A (en) 2023-03-31

Similar Documents

Publication Publication Date Title
EA032971B1 (ru) Соль берберина и урсодезоксихолевой кислоты и ее применение
NZ724740A (en) Treatment of nafld and nash
EA201592020A1 (ru) Новая композиция для неалкогольной жировой болезни печени (нажбп)
MX360979B (es) Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico.
PH12017500401A1 (en) Therapeutic compounds as inhibitors of the orexin-1 receptor
EA201500365A1 (ru) Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака
MX2018013221A (es) Compuestos de pirazol disustituidos para el tratamiento de enfermedades.
EA201391737A1 (ru) Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы
NZ709803A (en) Compositions comprising 15-ohepa and methods of using the same
MX2017005861A (es) Metodos para el control transcripcional objetivo en regiones del super mejorador.
MX2014004074A (es) Metodo de tratamiento de condiciones del higado utilizando antagonistas de notch2.
PH12016502352A1 (en) Pharmaceutical composition
BR112014005025A2 (pt) composição farmacêutica para uso no tratamento de uma doença neurodegenerativa
BR112016024020A2 (pt) composição farmacêutica
MX2016008102A (es) Composiciones y métodos para tratar la acumulacion de tejido graso.
EA033264B1 (ru) Новый тритерпенон по с-3 с обратными амидными производными по с-17 в качестве ингибиторов вич
BR112017007138A2 (pt) composto, medicamento, métodos para reduzir proteína 4 de ligação ao retinol e para a profilaxia ou o tratamento de degeneração macular e/ou uma doença, e, uso de um composto.
WO2014170842A3 (en) Substituted alkyl carboxylic acid derivatives as gpr agonists
EP3510014A4 (en) COMPOSITIONS AND METHODS FOR USE OF GAMMA KETOALDEHYD CATCHERS FOR TREATING, PREVENTING OR IMPROVING NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), NASH, ALD, OR DISEASES
MX2017006747A (es) Amidas de acidos grasos para la prevencion y/o tratamiento de la esteatohepatitis.
PH12017501693A1 (en) Compositions for the treatment of kidney and/or liver diseases
EA201791398A1 (ru) Производные фумагиллола
EA201990883A1 (ru) Соли берберина, соли урсодезоксихолевой кислоты и их комбинации, способы получения и применения
BR112014027372A2 (pt) anticorpos anti-il-23p19

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM