JP2012532899A5 - - Google Patents
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- Publication number
- JP2012532899A5 JP2012532899A5 JP2012519900A JP2012519900A JP2012532899A5 JP 2012532899 A5 JP2012532899 A5 JP 2012532899A5 JP 2012519900 A JP2012519900 A JP 2012519900A JP 2012519900 A JP2012519900 A JP 2012519900A JP 2012532899 A5 JP2012532899 A5 JP 2012532899A5
- Authority
- JP
- Japan
- Prior art keywords
- het
- conr
- hal
- atoms
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033208.1 | 2009-07-15 | ||
| DE102009033208A DE102009033208A1 (de) | 2009-07-15 | 2009-07-15 | Aminopyridinderivate |
| PCT/EP2010/003659 WO2011006567A1 (de) | 2009-07-15 | 2010-06-17 | Aminopyridinderivate zur behandlung von tumoren und entzündungskrankheiten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532899A JP2012532899A (ja) | 2012-12-20 |
| JP2012532899A5 true JP2012532899A5 (enExample) | 2013-08-29 |
| JP5681182B2 JP5681182B2 (ja) | 2015-03-04 |
Family
ID=42665826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519900A Expired - Fee Related JP5681182B2 (ja) | 2009-07-15 | 2010-06-17 | 腫瘍および炎症性疾患の処置のためのアミノピリジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8648201B2 (enExample) |
| EP (1) | EP2454253B1 (enExample) |
| JP (1) | JP5681182B2 (enExample) |
| CN (1) | CN102471317B (enExample) |
| AR (1) | AR077567A1 (enExample) |
| AU (1) | AU2010272920B2 (enExample) |
| CA (1) | CA2768169C (enExample) |
| DE (1) | DE102009033208A1 (enExample) |
| ES (1) | ES2534095T3 (enExample) |
| IL (1) | IL217467A (enExample) |
| WO (1) | WO2011006567A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG174125A1 (en) * | 2009-04-02 | 2011-10-28 | Merck Serono Sa | Dihydroorotate dehydrogenase inhibitors |
| EP2499117B1 (en) * | 2009-11-12 | 2015-10-21 | Selvita S.A. | A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| EP2509975B1 (en) * | 2009-12-04 | 2014-04-23 | Boehringer Ingelheim International GmbH | Benzimidazole inhibitors of leukotriene production |
| AU2012225805B2 (en) * | 2011-03-04 | 2017-03-02 | Lexicon Pharmaceuticals, Inc. | MST1 kinase inhibitors and methods of their use |
| US20140315881A1 (en) * | 2011-07-29 | 2014-10-23 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| CN104169275B (zh) * | 2012-01-13 | 2017-06-09 | 百时美施贵宝公司 | 用作激酶抑制剂的三唑取代的吡啶化合物 |
| SG11201500005SA (en) * | 2012-07-10 | 2015-01-29 | Ares Trading Sa | Pyrimidine pyrazolyl derivatives |
| US9586948B2 (en) | 2012-10-08 | 2017-03-07 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| EP2903617B1 (en) * | 2012-10-08 | 2019-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| WO2015006181A1 (en) | 2013-07-11 | 2015-01-15 | Merck Sharp & Dohme Corp. | Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4) |
| AU2015220427B2 (en) | 2014-02-19 | 2017-09-21 | Piramal Enterprises Limited | Compounds for use as GPR120 agonists |
| EP3172185B1 (en) | 2014-07-25 | 2020-03-04 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as gpr120 agonists and uses thereof |
| US10214521B2 (en) | 2014-09-11 | 2019-02-26 | Piramal Enterprises Limited | Fused heterocyclic compounds as GPR120 agonists |
| US9359336B2 (en) | 2014-10-09 | 2016-06-07 | Allergan, Inc. | Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors |
| CA2992945A1 (en) | 2015-07-17 | 2017-01-26 | Memorial Sloan-Kettering Cancer Center | Combination therapy using pdk1 and pi3k inhibitors |
| TWI733982B (zh) | 2017-02-16 | 2021-07-21 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒衍生物 |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CN112457308B (zh) | 2019-09-09 | 2024-01-02 | 上海长森药业有限公司 | 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用 |
| US11767321B2 (en) | 2020-10-05 | 2023-09-26 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
| KR20250016079A (ko) * | 2022-03-02 | 2025-02-03 | 항저우 바이오-신세리티 파마-테크 컴퍼니 리미티드 | 히스타민 h3 수용체 길항제 및 이의 약학적 용도 |
| CN121646587A (zh) * | 2024-05-30 | 2026-03-10 | 深圳微芯生物科技股份有限公司 | 一种苯并咪唑类化合物、其制备方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US6818419B2 (en) | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| ES2367422T3 (es) | 2001-10-09 | 2011-11-03 | Amgen Inc. | Derivados de imidazol como agentes antiinflamatorios. |
| RU2004126671A (ru) * | 2002-02-06 | 2005-04-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероарилсоединения, полезные в качестве ингибиторов gsk-3 |
| AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
| US7329678B2 (en) * | 2003-01-28 | 2008-02-12 | Smithkline Beecham Corporation | Chemical compounds |
| WO2006021886A1 (en) | 2004-08-26 | 2006-03-02 | Pfizer Inc. | Aminoheteroaryl compounds as protein tyrosine kinase inhibitors |
| WO2007111904A2 (en) * | 2006-03-22 | 2007-10-04 | Vertex Pharmaceuticals Incorporated | C-met protein kinase inhibitors for the treatment of proliferative disorders |
| ATE528052T1 (de) | 2007-06-29 | 2011-10-15 | Vekoma Rides Eng Bv | Fahrgeschäft-sitzanordnung |
| WO2009024825A1 (en) * | 2007-08-21 | 2009-02-26 | Astrazeneca Ab | 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors |
| JP2011500778A (ja) * | 2007-10-25 | 2011-01-06 | アストラゼネカ・アクチエボラーグ | ピリジン及びピラジン誘導体−０８３ |
| EP2265270A1 (en) | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| KR100979439B1 (ko) | 2008-04-10 | 2010-09-02 | 한국화학연구원 | 신규 피라졸 및 벤즈옥사졸 치환된 피리딘 유도체 또는이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 이상세포 성장 질환의 예방 및치료용 약학적 조성물 |
-
2009
- 2009-07-15 DE DE102009033208A patent/DE102009033208A1/de not_active Withdrawn
-
2010
- 2010-06-17 EP EP10730073.3A patent/EP2454253B1/de not_active Not-in-force
- 2010-06-17 US US13/383,605 patent/US8648201B2/en not_active Expired - Fee Related
- 2010-06-17 WO PCT/EP2010/003659 patent/WO2011006567A1/de not_active Ceased
- 2010-06-17 ES ES10730073.3T patent/ES2534095T3/es active Active
- 2010-06-17 CN CN201080031604.2A patent/CN102471317B/zh not_active Expired - Fee Related
- 2010-06-17 AU AU2010272920A patent/AU2010272920B2/en not_active Ceased
- 2010-06-17 JP JP2012519900A patent/JP5681182B2/ja not_active Expired - Fee Related
- 2010-06-17 CA CA2768169A patent/CA2768169C/en not_active Expired - Fee Related
- 2010-07-14 AR ARP100102541A patent/AR077567A1/es unknown
-
2012
- 2012-01-10 IL IL217467A patent/IL217467A/en active IP Right Grant
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