JP2010513337A5 - - Google Patents
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- JP2010513337A5 JP2010513337A5 JP2009541801A JP2009541801A JP2010513337A5 JP 2010513337 A5 JP2010513337 A5 JP 2010513337A5 JP 2009541801 A JP2009541801 A JP 2009541801A JP 2009541801 A JP2009541801 A JP 2009541801A JP 2010513337 A5 JP2010513337 A5 JP 2010513337A5
- Authority
- JP
- Japan
- Prior art keywords
- conr
- oxadiazolyl
- proportions
- derivative
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 C*C(*)(CC(*(*)C1C2(C3)C3(**)C3=CC(C)CC1CC23)=O)C(C)(C)C*(C)SC Chemical compound C*C(*)(CC(*(*)C1C2(C3)C3(**)C3=CC(C)CC1CC23)=O)C(C)(C)C*(C)SC 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06292011A EP1935420A1 (en) | 2006-12-21 | 2006-12-21 | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| EP06292011.1 | 2006-12-21 | ||
| PCT/EP2007/010124 WO2008074384A1 (en) | 2006-12-21 | 2007-11-22 | 2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11βETA-HSD1 INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513337A JP2010513337A (ja) | 2010-04-30 |
| JP2010513337A5 true JP2010513337A5 (enExample) | 2013-08-08 |
| JP5546866B2 JP5546866B2 (ja) | 2014-07-09 |
Family
ID=37983344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541801A Expired - Fee Related JP5546866B2 (ja) | 2006-12-21 | 2007-11-22 | 選択的１１β−ＨＳＤ１阻害剤としての２−アダマンチル−ブチルアミド誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8183265B2 (enExample) |
| EP (2) | EP1935420A1 (enExample) |
| JP (1) | JP5546866B2 (enExample) |
| AR (1) | AR064474A1 (enExample) |
| AU (1) | AU2007334983B2 (enExample) |
| CA (1) | CA2673430C (enExample) |
| DK (1) | DK2094263T3 (enExample) |
| ES (1) | ES2442518T3 (enExample) |
| IL (1) | IL199112A (enExample) |
| PL (1) | PL2094263T3 (enExample) |
| PT (1) | PT2094263E (enExample) |
| WO (1) | WO2008074384A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5486928B2 (ja) | 2007-02-26 | 2014-05-07 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックウレアおよびカルバメートインヒビター |
| CA2697168A1 (en) | 2007-07-26 | 2009-02-05 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| WO2009063061A2 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
| JP5734666B2 (ja) | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤 |
| JP5730021B2 (ja) | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| US8592410B2 (en) | 2008-05-01 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 |
| TW201004945A (en) | 2008-05-01 | 2010-02-01 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2722427A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2009134384A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2288596B1 (en) | 2008-05-13 | 2016-11-30 | Boehringer Ingelheim International GmbH | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| EP2318355B1 (en) * | 2008-07-25 | 2018-09-12 | Boehringer Ingelheim International GmbH | 1,1'-diadamantyl carboxylic acids, medicaments containing such compounds and their use |
| ES2432150T3 (es) | 2008-07-25 | 2013-12-02 | Boehringer Ingelheim International Gmbh | Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1 |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010046445A2 (en) | 2008-10-23 | 2010-04-29 | Boehringer Ingelheim International Gmbh | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| EP2348019A4 (en) * | 2008-10-29 | 2012-10-31 | Kowa Co | 1,2-DIAZETIDIN-3-ON DERIVATIVE AND PHARMACEUTICAL ACTIVE INGREDIENTS |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| CA2757866A1 (en) * | 2009-04-20 | 2010-10-28 | Abbott Laboratories | Novel amide and amidine derivatives and uses thereof |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| JP5670440B2 (ja) | 2009-06-02 | 2015-02-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| ES2350077B1 (es) * | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| KR101799429B1 (ko) * | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| EP2585444B1 (en) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| KR20130137628A (ko) | 2010-11-02 | 2013-12-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 대사 장애를 치료하기 위한 약제학적 병용물 |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| KR101465234B1 (ko) * | 2011-03-31 | 2014-12-01 | 한국화학연구원 | 사이클로프로필기를 갖는 아릴설폰아마이드 유도체, 이의 약학적으로 허용 가능한 염 및 이의 제조 방법 |
| WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
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| SI1789398T1 (sl) * | 2004-08-06 | 2011-01-31 | Janssen Pharmaceutica Nv | 2-amino-kinazolinski derivati, uporabni kot inhibitorji b-sekretaze (bace) |
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| CN102816081A (zh) * | 2005-01-05 | 2012-12-12 | 雅培制药有限公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
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| PL1966198T3 (pl) * | 2005-10-25 | 2011-07-29 | Janssen Pharmaceutica Nv | Pochodne 2-amino-3,4-dihydropirydo[3,4-d]pirymidyny do zastosowania jako inhibitory beta-sekretazy (BACE) |
-
2006
- 2006-12-21 EP EP06292011A patent/EP1935420A1/en not_active Withdrawn
-
2007
- 2007-11-22 PL PL07856225T patent/PL2094263T3/pl unknown
- 2007-11-22 AU AU2007334983A patent/AU2007334983B2/en not_active Ceased
- 2007-11-22 PT PT78562253T patent/PT2094263E/pt unknown
- 2007-11-22 JP JP2009541801A patent/JP5546866B2/ja not_active Expired - Fee Related
- 2007-11-22 US US12/520,141 patent/US8183265B2/en not_active Expired - Fee Related
- 2007-11-22 ES ES07856225.3T patent/ES2442518T3/es active Active
- 2007-11-22 CA CA2673430A patent/CA2673430C/en active Active
- 2007-11-22 EP EP07856225.3A patent/EP2094263B1/en active Active
- 2007-11-22 WO PCT/EP2007/010124 patent/WO2008074384A1/en not_active Ceased
- 2007-11-22 DK DK07856225.3T patent/DK2094263T3/da active
- 2007-12-20 AR ARP070105757A patent/AR064474A1/es not_active Application Discontinuation
-
2009
- 2009-06-02 IL IL199112A patent/IL199112A/en active IP Right Grant
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